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公开(公告)号:JP2009502364A
公开(公告)日:2009-01-29
申请号:JP2008524266
申请日:2006-07-28
Applicant: カーネギー メロン ユニバーシティ
Inventor: リー イー. ウェイス, , フィル キャンベル, , プラシャント クムタ, , デイビッド エム. サイプ, , ジェイソン スミス, , グレゴリー ダブリュー. フィッシャー,
CPC classification number: C09D11/30 , A61L27/225 , A61L27/50 , C08J3/24 , C08J5/18 , C08J9/0066 , C08J9/26 , C08J2201/024 , C08J2201/0446 , C08J2201/046 , C08J2207/10 , C08J2300/16 , C08J2389/00 , C08L5/00 , C08L89/00 , C09D7/65 , C09D11/08
Abstract: 組成物およびポリマーを製造するための方法が開示される。 組成物は、生物学的に適合性および生分解性があるポリマーマトリクスを含むフィルムおよび造形品を含む、新規プラスチックを含む。 このようなプラスチックは、天然源に由来するポリマーを含みうる。 さらに、このようなプラスチックは、創傷修復、インプラント、ステント、薬物カプセル化および薬物送達、ならびに他の用途に対する生体系において有用である。 開示された方法は、各種添加剤、たとえば生物活性タンパク質、糖、脂質などが、続く処理中の生物活性の損失なしにポリマーマトリクス内に包含されうるような緩和な製造プロセスを含む。 加えて、このようなプラスチックの力学的特性、たとえば弾性、柔軟性、および多孔性を制御するための製造方法が開示される。
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公开(公告)号:JP2008520817A
公开(公告)日:2008-06-19
申请号:JP2007543384
申请日:2005-11-18
Applicant: メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ
Inventor: ブラッドフォード エル. カリアー, , マイケル ジェイ. ヤスゼンスキー, , リーシュン ルー, , シャンフェン ワン,
IPC: C08G81/00 , A61L27/00 , C08L101/16
CPC classification number: A61L27/56 , A61L27/18 , A61L27/46 , B33Y70/00 , B33Y80/00 , C08G63/08 , C08G63/60 , C08G2261/126 , C08J9/26 , C08J2201/024 , C08J2201/0446 , C08J2367/06 , C08L67/06
Abstract: ポリ(プロピレンフマレート)をポリ(カプロラクトン)ジオールと共重合させて、ポリ(プロピレンフマレート)とポリ(カプロラクトン)とのブロックコポリマーを製造する。 ポリ(プロピレンフマレート)とポリ(カプロラクトン)との生体適合性、生体吸収性ブロックコポリマーは、組織および/または骨格再構成用の、注入でき、その場で硬化するスカフォードの作製に有用である。 本ブロックコポリマーは、追加の架橋剤を用いてまたは用いずに、酸化還元または光開始により架橋させることができる。 従って、本コポリマーは、(架橋剤の使用を一切伴わず)自己架橋性でもあり、(UV光などの光子の存在下で)光架橋性でもある。
Abstract translation: 聚(丙烯酸富马酸酯)与聚(己内酯)二醇共聚以制备聚(丙烯酸富马酸酯)和聚(己内酯)的嵌段共聚物。 聚(丙烯酸富马酸酯)和聚(己内酯)的生物相容性和生物可吸收的嵌段共聚物可用于制备用于组织和/或骨骼重建的可注射和原位硬化支架。 嵌段共聚物可以通过氧化还原或光引发交联,具有或不具有另外的交联剂。 因此,共聚物既可自交联(不使用任何交联剂)和光可交联(在诸如紫外光的光子存在下)。
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公开(公告)号:KR1020040012816A
公开(公告)日:2004-02-11
申请号:KR1020037014673
申请日:2002-04-18
Applicant: 나노시스템스 리써치 인코포레이티드
Inventor: 네델즈코그보즈딕
IPC: C08J9/28
CPC classification number: C08J9/26 , C08J2201/0446
Abstract: 가교된, 셀룰러 수화겔과 그의 제조방법이 개시된다. 셀룰러 물질은 고도로 탄력이 있으며, 광범위한 용도를 갖는 친수성 물질이다. 본 발명의 셀룰러 물질은 발포된 폴리머를 물리적으로 가교시킨 다음 셀루러 물질 형성시 제거가능한 물질을 사용함으로써 제공된 셀룰러 포어를 갖는 물질을 제공함으로써 제조된다.
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公开(公告)号:KR1020150008058A
公开(公告)日:2015-01-21
申请号:KR1020147027570
申请日:2013-03-28
Applicant: 세키스이가가쿠 고교가부시키가이샤
IPC: C08J9/04 , C08J3/24 , C08F210/18 , C08L23/16 , C08L83/14 , C08K5/5419 , C08J9/12
CPC classification number: C08J9/142 , C08J9/0042 , C08J9/0061 , C08J9/0066 , C08J9/12 , C08J9/141 , C08J9/26 , C08J2201/026 , C08J2201/0446 , C08J2203/12 , C08J2203/14 , C08J2205/05 , C08J2205/06 , C08J2207/00 , C08J2323/16 , C08J2423/16 , C09K3/1006 , C09K2200/0642
Abstract: 에틸렌과 α-올레핀과 비공액 디엔의 공중합체를 가교하여 이루어지는 수지의 다공질체로서, 공극 비율이 50∼95vol%이고, 당해 다공질체의 50% 압축시의 강도가 300kPa 이하이며, 당해 다공질체의 온도 80℃, 상대 습도 90% 분위기 하에서의 압축 영구 변형 (A)가 20% 이하인 것을 특징으로 하는 다공질체.
Abstract translation: 提供一种多孔体,其由通过使乙烯,α-烯烃和非共轭二烯的共聚物交联而获得的树脂形成,其中多孔体的孔隙率在50体积%至95体积%的范围内, 50%压缩时多孔体的强度为300kPa以下,在80℃,相对湿度90%的气氛下,压缩永久变形(A)为20%以下。
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公开(公告)号:US11672637B2
公开(公告)日:2023-06-13
申请号:US17003075
申请日:2020-08-26
Applicant: NuVasive, Inc.
Inventor: Wei-Hsiang Chang , Stephen Laffoon , Christopher S. D. Lee , David Lee Safranski
IPC: A61F2/00 , A61L31/06 , B29C67/20 , A61L27/18 , C08J9/00 , C08J9/26 , A61B90/00 , A61B6/00 , A61F2/44 , A61L27/50 , A61L27/56 , B29C44/04 , B29C44/34 , A61B6/12 , B29K71/00 , B29L31/00
CPC classification number: A61F2/0077 , A61B6/12 , A61B6/50 , A61B90/39 , A61F2/44 , A61L27/18 , A61L27/50 , A61L27/56 , A61L31/06 , B29C44/0461 , B29C44/3415 , B29C67/202 , C08J9/0085 , C08J9/26 , A61B2090/3966 , A61F2002/0081 , A61F2002/0086 , A61F2210/0071 , A61F2250/0098 , A61L2430/38 , B29K2071/00 , B29L2031/753 , B29L2031/7546 , C08J2201/0446 , C08J2371/00 , A61L27/18 , C08L71/00
Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.
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公开(公告)号:US20180272260A1
公开(公告)日:2018-09-27
申请号:US15468224
申请日:2017-03-24
Applicant: Celanese Acetate LLC
Inventor: Raymond M. Robertson , Ronald F. Hughes
CPC classification number: B01D39/1661 , A24D3/062 , B01D39/14 , B01D39/2075 , B01D2239/0407 , B01D2239/10 , B01D2239/1258 , C01D3/04 , C02F1/001 , C02F1/283 , C02F2305/08 , C08J9/24 , C08J9/26 , C08J2201/0446 , C08J2323/06
Abstract: A method may comprise: sintering a particulate mixture comprising binder particles at about 5% to about 75% by weight of the particulate mixture and fugitive particles at about 25% to about 90% by weight of the particulate mixture, thereby forming a porous mass; and substantially removing the fugitive particles from the porous mass, thereby forming an ultra-low pressure drop (ULPD) porous mass with fugitive particles at 0% to about 5% by weight of the ULPD porous mass.
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公开(公告)号:US20180086002A1
公开(公告)日:2018-03-29
申请号:US15702779
申请日:2017-09-13
Applicant: ADA Foundation
IPC: B29C64/393 , B33Y70/00 , B33Y10/00 , B33Y80/00 , G02B1/04 , A61K6/083 , A61K6/00 , C08K5/08 , C08K5/18 , C08K3/36 , C08K3/22 , C08J9/26 , B33Y50/02
CPC classification number: B29C64/393 , A61K6/0002 , A61K6/0052 , A61K6/0073 , A61K6/0088 , A61K6/083 , B29C64/00 , B29C64/106 , B29C64/336 , B29C64/386 , B29K2067/04 , B29K2071/00 , B29K2105/0002 , B29K2105/0005 , B29K2105/0085 , B29K2105/04 , B29K2309/02 , B29L2011/0016 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y50/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , C08J9/0061 , C08J9/26 , C08J2201/026 , C08J2201/0422 , C08J2201/0446 , C08J2201/0462 , C08J2207/10 , C08J2329/10 , C08J2335/02 , C08J2425/06 , C08K3/22 , C08K3/36 , C08K5/08 , C08K5/18 , C08K2003/2227 , C08K2003/2241 , G02B1/04 , G02B1/041
Abstract: A computer-controlled method for forming a composition-controlled product using 3D printing includes disposing two or more liquid reactant compositions in respective two or more reservoirs; and mixing the two or more liquid reactant compositions, which in turn includes controlling by the computer a mass ratio of the mixed two or more liquid reactant compositions. The computer-controlled method further includes scanning, under control of the computer, a mixed liquid reactants nozzle over a substrate; depositing the mixed liquid reactant compositions onto the substrate; and operating, under control of the computer, a light source to polymerize the deposited mixed liquid reactant compositions.
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公开(公告)号:US09855709B2
公开(公告)日:2018-01-02
申请号:US15405477
申请日:2017-01-13
Applicant: Vertera, Inc.
Inventor: Wei-Hsiang Chang , Stephen Lee Laffoon , Christopher S. D. Lee , David Lee Safranski
CPC classification number: B29C67/202 , A61F2/02 , A61F2/32 , A61F2/38 , A61F2002/30065 , A61F2002/30316 , A61F2210/0076 , A61F2240/001 , B29K2071/00 , B29K2105/04 , C08J9/0085 , C08J9/26 , C08J9/32 , C08J2201/0446 , C08J2361/16 , C08J2371/00
Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature below a melting point of the polymer and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.
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公开(公告)号:US20170129190A1
公开(公告)日:2017-05-11
申请号:US15405477
申请日:2017-01-13
Applicant: Vertera, Inc.
Inventor: Wei-Hsiang CHANG , Stephen Lee LAFFOON , Christopher S.D. LEE , David Lee SAFRANSKI
CPC classification number: B29C67/202 , A61F2/02 , A61F2/32 , A61F2/38 , A61F2002/30065 , A61F2002/30316 , A61F2210/0076 , A61F2240/001 , B29K2071/00 , B29K2105/04 , C08J9/0085 , C08J9/26 , C08J9/32 , C08J2201/0446 , C08J2361/16 , C08J2371/00
Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature below a melting point of the polymer and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.
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公开(公告)号:US08829096B2
公开(公告)日:2014-09-09
申请号:US13762964
申请日:2013-02-08
Applicant: Invibio Limited
Inventor: Marcus Jarman-Smith
CPC classification number: C08K3/40 , B29C67/202 , C08J9/26 , C08J2201/0446 , C08J2207/10 , C08J2371/12
Abstract: An upright column is packed with particles of a first material so the particles touch one another and a network of voids is defined between the particles. The network will be substantially continuous. A second material is then introduced into the column so the second material penetrates the network and fills the voids. The mixture of first and second materials is then consolidated using heat to melt the first or second material, while the other one of the first or second material remains in a solid state and acts as a space holder. Thereafter, the material which acts as the space holder may be removed thereby to leave a substantially continuous porous network defined by the material which was melted. It is found that, by use of the method, a substantially continuous network of the material which is melted can be formed and that the other material can readily be removed and/or is more easily removed compared to if a mixture of first and second materials was formed prior to packing in a column or mold.
Abstract translation: 竖立的柱子填充有第一材料的颗粒,使得颗粒彼此接触,并且在颗粒之间限定空隙网络。 网络将基本连续。 然后将第二材料引入柱中,使得第二材料渗透网络并填充空隙。 然后使用热量固化第一和第二材料的混合物以熔化第一或第二材料,而第一或第二材料中的另一个保持固体状态并用作空间保持器。 此后,作为空间保持器的材料可以被去除,从而留下由被熔化的材料限定的基本连续的多孔网。 发现通过使用该方法,可以形成熔融材料的基本上连续的网络,并且与第一和第二材料的混合物相比,可以容易地除去和/或更容易地除去其它材料 在包装在柱子或模具中之前形成。
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