公开(公告)号：US20040262512A1

公开(公告)日：2004-12-30

申请号：US10494335

申请日：2004-04-30

Inventor： Tomoyuki Tobita ,  Toshihiro Ishizuka ,  Masaru Tomioka ,  Kiyomi Yoshinari ,  Masami Sakamoto

IPC: H01J049/00

CPC classification number: H01J49/067 ,  H01J49/044

Abstract: In a mass spectrometer utilizing an atmospheric pressure ion source, the amount of un-vaporized droplets that reach a mass spectrometric section is reduced. A mass spectrometer comprises: an ionization section for ionizing a sample at substantially atmospheric pressure; a first and a second intermediate pressure section in which the pressure is maintained lower than the pressure in said ionization section; a high vacuum section in which the pressure is maintained lower than the pressure in said intermediate pressure section and in which a mass spectrometric means for subjecting ions to mass spectrometry is disposed; a first pore electrode disposed between said ionization section and said first intermediate pressure section; an intermediate pore electrode disposed between said first intermediate pressure section and said second intermediate pressure section; and a second pore electrode disposed between said second intermediate pressure section and said high vacuum section. A first converging electrode is provided in the first intermediate pressure section, the first converging electrode having an opening towards the first pore electrode and another opening towards the intermediate pore electrode. The opening towards the first pore electrode has a larger diameter than the opening towards the intermediate pore electrode, such that the first converging electrode has a tapered shape.

Abstract translation: 在使用大气压离子源的质谱仪中，达到质谱分析的未汽化液滴的量减少。 质谱仪包括：用于在基本上大气压下电离样品的电离部分; 第一和第二中间压力段，其中所述压力保持低于所述电离部分中的压力; 其中压力保持低于所述中压部分中的压力并且其中设置用于使离子进行质谱分析的质谱装置的高真空部分; 设置在所述电离部和所述第一中间压部之间的第一孔电极; 设置在所述第一中间压力部分和所述第二中间压力部分之间的中间孔电极; 以及设置在所述第二中间压力部分和所述高真空部分之间的第二孔电极。 第一会聚电极设置在第一中间压力部分中，第一会聚电极具有朝向第一孔电极的开口和朝向中间孔电极的另一开口。 朝向第一孔电极的开口具有比朝向中间孔电极的开口更大的直径，使得第一会聚电极具有锥形形状。

公开(公告)号：US20020113207A1

公开(公告)日：2002-08-22

申请号：US09788837

申请日：2001-02-20

Inventor： Milton L. Lee ,  David C. Collins

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/044 ,  G01N27/622 ,  H01J49/165

Abstract: A high voltage ion propulsion field is applied across the length of an ion mobility spectrometer that is divided by a barrier wall into a desolvation region and a drift tube. A plume of ions and solvent is electrosprayed into the desolvation region, and ions are propelled from the desolvation region through the drift tube to an ion target. Drift gas flows through the drift tube in the opposite direction to oppose the ion flow. A portal in the barrier wall permits ions to move from the desolvation region into the drift tube, and restricts flow of drift gas from the drift tube into the desolvation region. The resulting drift gas velocity increase effects desolvation without requiring elevated temperature or decreased pressure. An ion gate is located near the portal and an aperture grid is located near the ion target. The drift gas flow rate is varied to change the ionization spectra to alter selectivity.

Abstract translation: 将高压离子推进场施加在离子迁移谱仪的长度上，隔离壁被隔离区域和漂移管分隔开。 离子和溶剂的羽流电喷雾到去溶剂化区域，离子从去溶剂化区域通过漂移管推进到离子靶。 漂移气体在相反方向流过漂移管，以反对离子流。 阻挡壁中的入口允许离子从去溶剂化区域移动到漂移管中，并且将漂移气体从漂移管的流动限制到去溶剂化区域中。 所产生的漂移气体速度增加了脱溶剂的作用，而不需要升高的温度或降低的压力。 离子门位于门口附近，孔格栅位于离子靶附近。 改变漂移气体流速以改变电离光谱以改变选择性。

公开(公告)号：US6075243A

公开(公告)日：2000-06-13

申请号：US827184

申请日：1997-03-27

Applicant: Takayuki Nabeshima ,  Minoru Sakairi ,  Yasuaki Takada ,  Yukiko Hirabayashi ,  Hideaki Koizumi

Inventor： Takayuki Nabeshima ,  Minoru Sakairi ,  Yasuaki Takada ,  Yukiko Hirabayashi ,  Hideaki Koizumi

IPC: G01N27/62 ,  G01N30/72 ,  H01J49/02 ,  H01J49/26 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/424 ,  H01J49/044 ,  H01J49/4255

Abstract: A mass spectrometer in which, in order to reduce noise due to other particles (large charge droplets, neutral particles, photons, or the like), the orbit of ions and the orbit of other particles are separated from each other in the inside of a mass analysis region so as to make it possible to prevent the other particles from reaching an ion detection region without using any deflector.

Abstract translation: 一种质谱仪，其中为了减少由于其它颗粒（大电荷液滴，中性粒子，光子等）引起的噪声，离子的轨道和其它颗粒的轨道在一个 质量分析区域，使得可以防止其他颗粒在不使用任何偏转器的情况下到达离子检测区域。

公开(公告)号：US5994697A

公开(公告)日：1999-11-30

申请号：US61699

申请日：1998-04-16

Applicant: Yoshiaki Kato

Inventor： Yoshiaki Kato

IPC: G01N27/62 ,  H01J49/04 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/424 ,  H01J49/044 ,  H01J49/0481

Abstract: In the operation of a ion trap mass spectrometer, a high temperature gas at about 300.degree. C. is introduced as a buffer gas. As a result, water molecules absorbed on the inner wall of the quadrupole electrodes of the ion trap mass spectrometer are desorbed and evacuated. Further, the quadrupole electrodes themselves and vacuum chamber are also heated. As the high temperature gas is introduced into the ion trap space, the time necessary for evacuating the ion trap space is shortened and the noise during the measurement time is effectively reduced. During the measurement time, the temperature is controlled to be low, and the thermal degradation of the sample is prevented.

Abstract translation: 在离子阱质谱仪的操作中，引入约300℃的高温气体作为缓冲气体。 结果，吸附在离子阱质谱仪的四极电极的内壁上的水分子解吸和抽真空。 此外，四极电极本身和真空室也被加热。 当高温气体被引入到离子阱空间中时，疏散离子阱空间所需的时间被缩短，并且有效地降低了测量时间期间的噪声。 在测量时间期间，将温度控制得较低，并且可以防止样品的热降解。

公开(公告)号：US5352892A

公开(公告)日：1994-10-04

申请号：US9063

申请日：1993-01-26

Applicant: Alex Mordehai ,  Gerard Hopfgartner ,  John D. Henion

Inventor： Alex Mordehai ,  Gerard Hopfgartner ,  John D. Henion

IPC: G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/067 ,  G01N30/7266 ,  H01J49/044 ,  G01N30/7246 ,  G01N30/7273

Abstract: A novel atmospheric pressure ionization device for the transport of charged particle produced by at atmospheric pressure to a mass analyzer includes a liquid shield between the particle source and the sample inlet into the mass analyzer. The liquid shield may be in the form of a disk with a central aperture and acts as a spray splitter and aerofocusing device which increases the flow rate of a liquid sample into the analyzer. The mass analyzer is located in a high vacuum region and an intermediate low vacuum region is provided between the sample inlet and the analyzer. An ion optical system includes electrostatic lens assemblies in said vacuum regions for transporting charged particles from the inlet to the analyzer.

Abstract translation: 用于将通过大气压产生的带电粒子输送到质量分析器的新型大气压电离装置包括在粒子源和质量分析器的样品入口之间的液体屏蔽。 液体屏蔽可以是具有中心孔的盘的形式，并且用作喷雾分离器和空气聚焦装置，其将液体样品的流速增加到分析器中。 质量分析仪位于高真空区域，并且在样品入口和分析仪之间提供中间低真空区域。 离子光学系统包括在所述真空区域中的静电透镜组件，用于将带电粒子从入口传送到分析器。

公开(公告)号：WO2015100233A8

公开(公告)日：2016-02-18

申请号：PCT/US2014071885

申请日：2014-12-22

Applicant: WATERS TECHNOLOGIES CORP

Inventor： JARRELL JOSEPH A

IPC: B05B5/025 ,  H01J37/08 ,  H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0404 ,  H01J49/044 ,  H01J49/165

Abstract: An interface for a mass spectrometer system is provided. The interface can include an inner ceramic tube fabricated from a first ceramic material and an outer tube fabricated from a second ceramic material surrounding the inner ceramic tube. The inner ceramic tube can have high electrical resistivity and high thermal conductivity and the intermediate ceramic tube can have an electrical resistivity that is at least an order of magnitude higher than the electrical resistivity of the first ceramic material and a thermal conductivity that is at least an order of magnitude higher than the thermal conductivity of the first ceramic material.

Abstract translation: 提供了用于质谱仪系统的界面。 界面可以包括由第一陶瓷材料制成的内陶瓷管和由围绕内陶瓷管的第二陶瓷材料制成的外管。 内部陶瓷管可以具有高电阻率和高导热性，并且中间陶瓷管可以具有比第一陶瓷材料的电阻率高至少一个数量级的电阻率和至少为 数量级高于第一陶瓷材料的热导率。

公开(公告)号：WO2015100233A3

公开(公告)日：2015-10-15

申请号：PCT/US2014071885

申请日：2014-12-22

Applicant: WATERS TECHNOLOGIES CORP

Inventor： JARRELL JOSEPH A

IPC: B05B5/025 ,  H01J37/08 ,  H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0404 ,  H01J49/044 ,  H01J49/165

Abstract: An interface for a mass spectrometer system is provided. The interface can include an inner ceramic tube fabricated from a first ceramic material and an outer tube fabricated from a second ceramic material surrounding the inner ceramic tube. The inner ceramic tube can have high electrical resistivity and high thermal conductivity and the intermediate ceramic tube can have an electrical resistivity that is at least an order of magnitude higher than the electrical resistivity of the first ceramic material and a thermal conductivity that is at least an order of magnitude higher than the thermal conductivity of the first ceramic material.

Abstract translation: 提供质谱仪系统的接口。 界面可以包括由第一陶瓷材料制造的内部陶瓷管和由围绕内部陶瓷管的第二陶瓷材料制造的外部管。 内部陶瓷管可以具有高电阻率和高热导率，并且中间陶瓷管可以具有比第一陶瓷材料的电阻率高至少一个数量级的电阻率和至少为 其数量级高于第一陶瓷材料的导热率。

公开(公告)号：WO2015040383A1

公开(公告)日：2015-03-26

申请号：PCT/GB2014/052815

申请日：2014-09-17

Applicant: MICROMASS UK LIMITED

Inventor： HESS, Anthony ,  O'BRIEN, Steve ,  TRIVETT, Ian

IPC: H01J49/04 ,  H01J49/02 ,  H01J49/10

CPC classification number: H01J49/02 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/044 ,  H01J49/049 ,  H01J49/10

Abstract: Amass spectrometer or ion mobility spectrometer is disclosed comprising: an ion block(2)for receiving ions;a heater (8) for heating the ion block(2); a vacuum housing(6); and an interface block (4) arranged between the ion block (2) and the vacuum housing(6); wherein the interface block (4) is formed from a polymer. The polymer interface block (4) inhibits the heat transfer from the ion block (2) to the vacuum housing(6) and also electrically isolates the ion block (2) and vacuum housing(6). The interface block (4) further comprises at least one conduit (12) through the body of the interface block (4). This enables gas to be transmitted through the interface block (4) to the ion block (2), and also enables the interface block (4) to be cooled.

Abstract translation: 公开了一种Amass光谱仪或离子迁移谱仪，包括：用于接收离子的离子块（2）;用于加热离子块（2）的加热器（8）; 真空壳体（6）; 和布置在离子块（2）和真空壳体（6）之间的界面块（4）; 其中所述界面块（4）由聚合物形成。 聚合物界面块（4）抑制从离子块（2）到真空壳体（6）的热传递，并且电离离子块（2）和真空壳体（6）。 接口块（4）还包括穿过接口块（4）的主体的至少一个导管（12）。 这使得气体能够通过界面块（4）传递到离子块（2），并且还使接口块（4）能够被冷却。

公开(公告)号：WO2012047465A1

公开(公告)日：2012-04-12

申请号：PCT/US2011/051543

申请日：2011-09-14

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD. ,  COVEY, Thomas, R. ,  POTYRALA, Stanislaw ,  SCHNEIDER, Bradley, B.

Inventor： COVEY, Thomas, R. ,  POTYRALA, Stanislaw ,  SCHNEIDER, Bradley, B.

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/02 ,  H01J49/044

Abstract: A system and method for mass spectrometry including a curtain gas chamber defined by a curtain plate having an aperture for receiving ions from an ion source and an orifice plate having an inlet into a mass spectrometer. At least one barrier separates the curtain chamber into a first curtain gas chamber region and a second curtain gas chamber region. At least one gas source provides a gas inflow into the second curtain gas chamber region and a gas outflow into the first curtain gas chamber region, a portion of the gas outflow directed out of the aperture. A heating element heats the gas inflow, a portion of the heated gas inflow directed into the inlet of the mass spectrometer wherein the portion of the heated gas inflow can be at a substantially higher temperature than the portion of the gas outflow.

Abstract translation: 一种用于质谱的系统和方法，包括由具有用于从离子源接收离子的孔的幕板限定的帘式气室和具有入口进入质谱仪的孔板。 至少一个屏障将幕帘室分隔成第一帘式气体室区域和第二帘式气体室区域。 至少一个气体源提供气体流入第二帘式气体室区域，并且气体流入第一帘式气体室区域，一部分气体流出物被引导出孔。 加热元件加热气体流入，一部分加热气体流入引导到质谱仪的入口，其中加热气体流入的部分可以处于比气体流出部分显着更高的温度。

公开(公告)号：WO1998011595A1

公开(公告)日：1998-03-19

申请号：PCT/US1997015968

申请日：1997-09-10

Applicant: ANALYTICA OF BRANFORD, INC. ,  WHITEHOUSE, Craig, M. ,  ANDRIEN, Bruce, A., Jr. ,  SANSONE, Michael, A. ,  CATALANO, Clement

Inventor： ANALYTICA OF BRANFORD, INC.

IPC: H01J49/10

CPC classification number: H01J49/0477 ,  H01J49/0404 ,  H01J49/044

Abstract: An Atmospheric Pressure Ion (API) source (1) operates Electrospray (ES) and Atmospheric Pressure Chemical Ionization (APCI) modes. The API source (1) includes a multipurpose heater assembly (10) mounted in an API source chamber (6). The multipurpose heater assembly (10) supplies heat to an API chamber endplate (8), a bath gas, and an entrance end (24) of a capillary orifice (28) into vacuum. An additional heater (15) is at the exit end (32) of the capillary (11) into vacuum. The bath gas, endplate (8) and capillary entrance (24) temperature can set independent of gas flow rate.

Abstract translation: 大气压离子（API）源（1）操作电喷雾（ES）和大气压化学电离（APCI）模式。 API源（1）包括安装在API源室（6）中的多用途加热器组件（10）。 多用途加热器组件（10）向API室端板（8），毛细管孔（28）的入口端（24）和真空中提供热量。 另外的加热器（15）在毛细管（11）的出口端（32）处成真空。 浴气，端板（8）和毛细管入口（24）的温度可独立于气体流量设定。