公开(公告)号：WO1995020353A1

公开(公告)日：1995-08-03

申请号：PCT/US1995001172

申请日：1995-01-26

Applicant: MALLINCKRODT MEDICAL, INC.

Inventor： MALLINCKRODT MEDICAL, INC. ,  DUNN, T., Jeffrey ,  MOORE, Dennis, A. ,  WALLACE, Rebecca, A.

IPC: A61B05/055

CPC classification number: C07D487/08 ,  A61K49/06 ,  C07F9/6524

Abstract: The present invention provides new and structurally diverse compositions comprising compounds of general formula (I), wherein A is N-G or P-G; B is N or P; C is N-G, P-G or -[CH(R7)]q-; D is N or P; E is N-F or P-F; F is -[CH(R8)]p-N(G)2 or -[CH(R8)]p-P(G)2; G is -[CH(R9)]r-X or -[CH(R9)]s-N[CH(R10)t-X]2; X is -CO2H, -OPO3H2, -PO3H2, -SO3H, -SH, -OH, or -CONHOH; R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 may be the same or different and are hydrogen, C1-8 alkyl, or C6-10 aryl, optionally substituted by one or more hydroxy, C1-8 alkyl, C1-8 hydroxyalkyl, C1-8 alkoxy, C6-10 aryl, C6-10 hydroxyaryl, C6-10 aryloxy, -CO2R11, -CONR12R13, or -NR14R15 groups; R11, R12, R13, R14 and R15 may be the same or different and are hydrogen, C1-8 alkyl, C1-8 hydroxyalkyl, or C1-8 alkoxyalkyl; R14 and R15 may form a 5 or 6 membered carbocyclic ring optionally containing singularly or in combination nitrogen, oxygen or sulfur; i, j, k, l, m, n, p, q, r, s and t may be the same or different and are zero to about 5. Methods for imaging using compositions of the invention are also provided.

Abstract translation: 本发明提供包含通式（I）化合物的新的和结构不同的组合物，其中A是N-G或P-G; B是N或P; C是N-G，P-G或 - [CH（R7）] q-; D为N或P; E是N-F或P-F; F是 - [CH（R8）] p-N（G）2或 - [CH（R8）] p-P（G）2; G是 - [CH（R 9）] r -X或 - [CH（R 9）] s -N [CH（R 10）t -X] 2; X是-CO 2 H，-OPO 3 H 2，-PO 3 H 2，-SO 3 H，-SH，-OH或-CONHOH; R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和R 10可以相同或不同，为氢，C 1-8烷基或C 6-10芳基，任选地被一个或多个羟基， C 1-8烷基，C 1-8羟基烷基，C 1-8烷氧基，C 6-10芳基，C 6-10羟基芳基，C 6-10芳氧基，-CO 2 R 11，-CONR 12 R 13或-NR 14 R 15基团; R 11，R 12，R 13，R 14和R 15可以相同或不同，为氢，C 1-8烷基，C 1-8羟基烷基或C 1-8烷氧基烷基; R 14和R 15可以形成任选地单独或组合地含有氮，氧或硫的5或6元碳环; i，j，k，l，m，n，p，q，r，s和t可以相同或不同，为零至约5.还提供使用本发明组合物成像的方法。

公开(公告)号：WO1995009563A1

公开(公告)日：1995-04-13

申请号：PCT/US1993009401

申请日：1993-10-04

Applicant: KRONGRAD, Arnon

IPC: A61B05/055

CPC classification number: A61K49/06

Abstract: A method of enhancing a magnetic resonance signal comprising the steps of administering a quantity of a selected magnetic isotope to a living biological tissue at a concentration greater than the naturally occurring concentration of such isotope and detecting magnetic resonance signal from the administered magnetic isotope in the living biological tissue.

Abstract translation: 一种增强磁共振信号的方法，包括以下步骤：将大量选定的磁同位素以比该同位素天然存在的浓度大的浓度给活体生物组织施用，并检测来自生物中所施用的磁同位素的磁共振信号 生物组织。

公开(公告)号：WO1994027499A1

公开(公告)日：1994-12-08

申请号：PCT/US1994005604

申请日：1994-05-19

Applicant: E-Z-EM, INC. ,  DAVIS, Michael, A. ,  ZWARUN, Andrew, A.

Inventor： E-Z-EM, INC.

IPC: A61B05/055

CPC classification number: G01R33/5601 ,  A61K49/1806 ,  Y10T436/24

Abstract: A negative contrast agent for MRI is an aqueous suspension having a quantity of barium sulfate between 25 and 40 percent by weight and a quantity of bentonite between two and four percent by weight. Such a negative contrast agent provides dark imaging in a T2 weighted pulse sequence; namely a relative signal intensity (RSI) approaching zero. It also provides a relative signal intensity (RSI) of under thirty percent of that of a reference that approximates tissue in a T1 weighted pulse sequence.

Abstract translation: 用于MRI的负造影剂是具有25至40重量％的硫酸钡的量和2-4重量％之间的膨润土的量的水性悬浮液。 这种负面造影剂在T2加权脉冲序列中提供暗影像; 即相对信号强度（RSI）接近零。 它还提供了在T1加权脉冲序列中接近组织的参考值的30％以下的相对信号强度（RSI）。

公开(公告)号：WO1994023648A1

公开(公告)日：1994-10-27

申请号：PCT/FR1994000454

申请日：1994-04-21

Applicant: "e;O.D.A.M."e; OFFICE DE DISTRIBUTION D'APPAREILS MEDICAUX S.A. ,  FELBLINGER, Jacques ,  BOESCH, Chris ,  MULLER, Gérard ,  KRAEMER, Michel

Inventor： "e;O.D.A.M."e; OFFICE DE DISTRIBUTION D'APPAREILS MEDICAUX S.A.

IPC: A61B05/055

CPC classification number: A61B5/6831 ,  A61B5/02438 ,  A61B5/0404 ,  A61B5/0428 ,  A61B5/055 ,  A61B2562/182 ,  G01R33/5673 ,  Y10S128/908

Abstract: The sensor device is intended to be implemented at the vicinity or inside a nuclear magnetic resonance apparatus, and more particularly on a patient inside the canal of the magnet of a magnetic resonance imager (MRI), characterized in that it is essentially comprised of, on the one hand, at least two non-metal electrodes (1) intended to be applied to the skin of a patient (2), and on the other hand, of an electro-optical conversion, amplification and filtering module (3) for the electric signals received from the heart by means of the electrodes (1), said module being arranged in a shielded casing (4) forming a Faraday cage, and optically connected to a display and/or monitoring apparatus and, finally, comprising a support body (6) made of non-magnetic material, carrying the electrode (1) and the shielded casing (4) containing the module (3).

Abstract translation: 传感器装置旨在在核磁共振装置的附近或内部，更具体地，在磁共振成像器（MRI）的磁体的运河内的患者身上实施，其特征在于，其基本上由 一方面，旨在施加到患者（2）的皮肤的至少两个非金属电极（1），另一方面，用于电光转换，放大和过滤模块（3），用于 通过电极（1）从心脏接收的电信号，所述模块布置在形成法拉第笼的屏蔽壳体（4）中，并且光学连接到显示器和/或监视装置，并且最终包括支撑体 （6）由非磁性材料制成，承载包含模块（3）的电极（1）和屏蔽壳体（4）。

公开(公告)号：WO1994022368A1

公开(公告)日：1994-10-13

申请号：PCT/US1994002477

申请日：1994-03-09

Applicant: MOLECULAR BIOSYSTEMS, INC.

Inventor： MOLECULAR BIOSYSTEMS, INC. ,  LOHRMANN, Rolf ,  KRISHNAN, Ashwin

IPC: A61B05/055

CPC classification number: C07F9/10 ,  A61K49/06 ,  C07C17/14 ,  C07C17/26 ,  C07C45/00 ,  C07C57/58 ,  C07C69/65 ,  C07C211/29 ,  C07C229/36 ,  C07C229/42 ,  C07C237/06 ,  Y10S514/832 ,  Y10T436/24 ,  C07C25/02 ,  C07C25/13 ,  C07C47/55

Abstract: Organic compounds for diagnostic imaging which contain at least one aryl group which has been derivatized to contain at least one perfluoro-1H,1H-neopentyl moiety are provided. The perfluoro-1H, 1H-neopentyl groups produce a single magnetic resonance to insure a maximum signal to noise ratio. One compound disclosed is 2-O-oleoylglycerol 1,3-bis(7'-{3",5"-di[2"',2"'-di(trifluoromethyl)3"',3"',3"'-trifluoropropyl]phenyl}heptanoate). In the preferred embodiment, a lipid emulsion is provided as a carrier vehicle to deliver the derivitized analog to a mammalian recipient. Methods to use these compounds in MRI and computerized tomography are provided.

Abstract translation: 提供了含有至少一个衍生化为含有至少一个全氟-1H，1-新戊基部分的芳基的用于诊断成像的有机化合物。 全氟-1H，1H-新戊基产生单个磁共振以确保最大的信噪比。 公开的一种化合物是2-O-油酰甘油1,3-双（7' - {3“，5” - 二[2“'，2”' - 二（三氟甲基）3“'，3”'，3“ 三氟丙基]苯基}庚酸酯）在优选的实施方案中，提供脂质乳剂作为载体载体以将衍生的类似物递送到哺乳动物受体。提供了在MRI和计算机断层摄影中使用这些化合物的方法。

公开(公告)号：WO1994003109A1

公开(公告)日：1994-02-17

申请号：PCT/US1993007321

申请日：1993-08-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  BARTZOKIS, George ,  PHELAN, Carolanne, K.

IPC: A61B05/055

CPC classification number: A61B5/055 ,  A61B5/416 ,  G01R33/465 ,  G01R33/4828 ,  Y10T436/24

Abstract: The invention provides a specific measure of iron stores in vivo using magnetic resonance imaging. T2 relaxation times in both lower-to-mid field strength magnetic resonance imaging instruments and a higher field strength instrument is evaluated. T2 obtained at the higher field strength instrument is subtracted from T2 obtained at the lower field strength instrument. This difference, T, is then correlated with a quantitative measure of the iron stores in vivo in the scanned tissue. A two-dimensional or multidimensional map of the scanned tissue is then constructed on the basis of T to visually identify different tissue types as being normal or abnormal, either through a visual determination based on gray scales or a numeric comparison based on quantitative measure. The introduction of artificial or nonbiological substances as opposed to natural ferritin, is permitted for further diagnostic use by application of this methodology.

Abstract translation: 本发明提供使用磁共振成像在体内铁贮存器的具体测量。 评估了低中场强磁共振成像仪器和较高场强仪器的T2弛豫时间。 在较低场强度仪器获得的T2中，从下场强度仪器获得的T2中减去T2。 然后将该差异T与扫描的组织中体内铁储存物的定量测量相关联。 然后基于T构建扫描的组织的二维或多维图，以通过基于灰度的视觉确定或基于定量测量的数值比较来将不同组织类型视觉识别为正常或异常。 引入人造或非生物物质而不是天然铁蛋白，允许通过应用该方法进一步诊断。

公开(公告)号：WO1993024051A1

公开(公告)日：1993-12-09

申请号：PCT/JP1993000697

申请日：1993-05-25

Applicant: YOKOGAWA MEDICAL SYSTEMS, LTD. ,  INOUE, Yuji

Inventor： YOKOGAWA MEDICAL SYSTEMS, LTD.

IPC: A61B05/055

CPC classification number: B23C5/207 ,  B23C2200/201 ,  B23C2200/205 ,  C23C30/005 ,  G01R33/385

Abstract: A coil unit for generating a gradient magnetic field on an opposed type magnet comprises two coils through which spiral currents flow in opposite directions. The two coils are disposed on opposite sides of a region where a gradient magnetic field is generated. The linearity of the gradient magnetic field is improved without increasing inductance of the coil. Each of the mutually opposed coils includes a plurality of substantially circular and substantially concentric current paths, which are connected to form a spiral coil. The coil has a current distribution in which current density is low near its center and high near its periphery. The pitch of the spiral is substantially inversely proportional to the current distribution.

Abstract translation: 用于在相对型磁体上产生梯度磁场的线圈单元包括两个线圈，螺旋电流通过该线圈沿相反方向流动。 两个线圈设置在产生梯度磁场的区域的相对侧。 在不增加线圈的电感的情况下，梯度磁场的线性度得到改善。 每个相互相对的线圈包括多个基本上圆形且基本上同心的电流路径，其连接形成螺旋线圈。 线圈具有电流分布，其中电流密度在其中心附近较低并且在其周边附近较高。 螺旋的间距与电流分布基本成反比。

公开(公告)号：WO1993008733A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009380

申请日：1992-10-30

Applicant: BRIGHAM & WOMEN'S HOSPITAL

Inventor： BRIGHAM & WOMEN'S HOSPITAL ,  KANDARPA, Krishna ,  JAKAB, Peter

IPC: A61B05/055

CPC classification number: G01R33/31 ,  A61B2090/374 ,  A61F7/00 ,  A61F2007/009 ,  G01R33/4804

Abstract: The present invention relates to apparatus and a method for imaging and heating body tissues with one probe (100), through use of a magnetic resonance imaging radio frequency source (110). The device may also be configured with a thermocouple (360) to provide temperature-controlled heat therapy with sufficient image definition to control that therapy.

Abstract translation: 本发明涉及通过使用磁共振成像射频源（110）用一个探针（100）对身体组织进行成像和加热的装置和方法。 该装置还可以配置有热电偶（360），以提供具有足够图像定义的温度控制热疗来控制该治疗。

公开(公告)号：WO1993003671A1

公开(公告)日：1993-03-04

申请号：PCT/US1991005757

申请日：1991-08-13

Applicant: MOLECULAR BIOSYSTEM, INC.

Inventor： MOLECULAR BIOSYSTEM, INC. ,  WIDDER, Kenneth, J. ,  BARNHART, James, L.

IPC: A61B05/055

CPC classification number: G01R33/5601 ,  A61K49/1821 ,  G01R33/563

Abstract: A method of magnetic resonance imaging (MRI) is disclosed which employs a diamagnetic contrast agent comprising gas-carrying, non-magnetic microparticles, which are preferably microspheres consisting of minute gas bubbles encapsulated by stabilized bicompatible material. The method is especially useful in imaging the vascular system as in angiography or venography.

Abstract translation: 公开了一种磁共振成像（MRI）的方法，其采用包含气体携带的非磁性微粒的抗磁性造影剂，其优选为由稳定的双相容材料包封的微小气泡构成的微球。 该方法在血管造影或静脉造影术中对血管系统成像尤其有用。

公开(公告)号：WO1991001684A1

公开(公告)日：1991-02-21

申请号：PCT/JP1990000984

申请日：1990-08-02

Applicant: HITACHI MEDICAL CORPORATION ,  HITACHI, Ltd. ,  TAKEUCHI, Hiroyuki ,  NOZOKIDO, Tatsuo ,  SEKIHARA, Kensuke ,  KURODA, Masao ,  TAKESHIMA, Hirotaka ,  NAKAMURA, Chikako

Inventor： HITACHI MEDICAL CORPORATION ,  HITACHI, Ltd.

IPC: A61B05/055

CPC classification number: G01R33/56518 ,  A61B2017/00287

Abstract: Measurement positions of measured magnetic resonance signals on a Fourier plane form a distorted square matrix due to influence of an inclined magnetic field which changes non-linearly due to eddy currents. According to present invention, the distortion is corrected by interpolation in order to obtain virtual data on a square matrix, the data corresponding to the measurement positions of magnetic resonance signals obtained when an idel inclined magnetic field is applied; and image data free from blur is obtained by Fourier transformation of the virtual data.

Abstract translation: 由傅里叶平面测量的磁共振信号的测量位置由于涡流引起的非线性变化的倾斜磁场的影响而形成失真的方阵。 根据本发明，通过内插来校正失真，以获得正方形矩阵上的虚拟数据，该数据对应于当施加空载倾斜磁场时获得的磁共振信号的测量位置; 并且通过虚拟数据的傅里叶变换获得没有模糊的图像数据。