公开(公告)号：WO1997043045A1

公开(公告)日：1997-11-20

申请号：PCT/US1997008106

申请日：1997-05-12

Applicant: COBE LABORATORIES, INC.

Inventor： COBE LABORATORIES, INC. ,  HLAVINKA, Dennis

IPC: B04B05/04

CPC classification number: B04B5/0442 ,  B04B2005/045 ,  B04B2005/0471

Abstract: A centrifuge separation device is disclosed and includes a rotor (12) configured to be connected to a centrifuge motor (19) for rotation about an axis of rotation (13). A retainer (14) is associated with the rotor (12) and defines a passageway (14) for a separation channel (44). A protrusion (48) formed in one of the passageway walls (15, 16) extends towards and is spaced from the other of the passageway walls (15, 16). The protrusion (48) is sized to substantially block passage of materials in a predetermined density range and to substantially permit passage of materials outside of the predetermined density range. An indentation (51) formed adjacent the protrusion (48) in a wall of the passageway (14) opposite the protrusion (48) is configured to trap fluid during rotation of the rotor (12) and to cooperate with the trapped fluid to maintain a substantially Coriolis-free pathway in a region of the passageway adjacent the protrusion (48).

Abstract translation: 公开了一种离心机分离装置，其包括被配置为连接到离心机马达（19）上用于围绕旋转轴线（13）旋转的转子（12）。 保持器（14）与转子（12）相关联并且限定用于分离通道（44）的通道（14）。 形成在通道壁（15,16）之一中的突起（48）朝着另一个通道壁（15,16）延伸并且与另一个通道壁（15,16）间隔开。 突起（48）的尺寸被设计成基本上阻挡材料在预定的密度范围内的通过并且基本允许材料在预定的密度范围之外的通过。 在与突起（48）相对的通道（14）的壁中邻近突起（48）形成的凹陷（51）构造成在转子（12）旋转期间捕获流体并与捕获的流体协作以维持 在邻近突起（48）的通道的区域中基本上不含有科里奥利的途径。

公开(公告)号：WO1997040942A1

公开(公告)日：1997-11-06

申请号：PCT/US1997006615

申请日：1997-04-24

Applicant: DADE CHEMISTRY SYSTEMS INC.

Inventor： DADE CHEMISTRY SYSTEMS INC. ,  HOWELL, Gary, Wayne

IPC: B04B05/04

CPC classification number: B04B5/0421

Abstract: A swinging bucket-type centrifuge is disclosed which is capable of operating in either swinging bucket or fixed angle mode. The buckets mounted on the rotor have a release bracket which can be automatically actuated to release the tubes mounted in the buckets.

Abstract translation: 公开了能够以摆动铲斗或固定角度模式操作的摆动式斗式离心机。 安装在转子上的铲斗具有释放托架，其可以被自动地致动以释放安装在铲斗中的管子。

公开(公告)号：WO1997023297A1

公开(公告)日：1997-07-03

申请号：PCT/US1996020520

申请日：1996-12-17

Applicant: JORGENSEN, Glenn

IPC: B04B05/04

CPC classification number: B04B9/08 ,  B04B5/0442 ,  B04B2005/0492

Abstract: A centrifuge (10) for rotating a fluid retentive housing (50) having fluid input and output tubing (70) fixedly connected to a rotation axis (40) of the fluid retentive housing, the centrifuge comprising: a frame (20); a first rotatable mechanism (60) having a rotation axis, the fluid retentive housing being coaxially mounted thereon for co-rotation therewith; a second rotatable mechanism (90) having a rotation axis, the first and second rotation mechanism being coaxially mounted on the frame; the second rotatable mechanism having an outer circumferential surface (91) engaged with a drive mechanism (131), the drive mechanism driving the outer circumferential surface such that the second rotatable mechanism rotates at a selected rotational speed X; the first rotatable mechanism being interconnected to the second rotatable mechanism such that the first rotatable mechanism rotates simultaneously with the second rotatable mechanism at a rotational speed of 2X.

Abstract translation: 一种用于旋转流体保持壳体（50）的离心机（10），其具有固定地连接到所述流体保持壳体的旋转轴线（40）的流体输入和输出管道（70），所述离心机包括：框架（20）; 具有旋转轴线的第一可旋转机构（60），所述流体保持壳体同轴地安装在其上以与其共同旋转; 具有旋转轴的第二可旋转机构（90），所述第一和第二旋转机构同轴地安装在所述框架上; 所述第二可旋转机构具有与驱动机构（131）接合的外周面（91），所述驱动机构驱动所述外周面，使得所述第二可旋转机构以选定的转速X旋转; 所述第一可旋转机构与所述第二可旋转机构互连，使得所述第一可旋转机构以2X的转速与所述第二可旋转机构同时旋转。

公开(公告)号：WO1996033023A1

公开(公告)日：1996-10-24

申请号：PCT/US1996005505

申请日：1996-04-18

Applicant: COBE LABORATORIES, INC.

Inventor： COBE LABORATORIES, INC. ,  HLAVINKA, Dennis ,  CORBIN, Frank ,  LANGLEY, Robert ,  TAYLOR, Linda, A. ,  WALKER, John, C.

IPC: B04B05/04

CPC classification number: A61M1/3693 ,  A61M1/0227 ,  A61M1/0236 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3696 ,  B04B5/0428 ,  B04B5/0442 ,  B04B2005/0471

Abstract: An apparatus and method are disclosed for filtering or separating particles. The apparatus has a centrifuge rotor (12) rotatable about an axis of rotation. A fluid chamber (22) rotates with the rotor. A substance is supplied to the inlet (28) of the chamber. A saturated fluidized bed of first particles forms within the fluid chamber and obstructs flow of second particles through the chamber. In an embodiment of the invention, additives substances alter sedimentation velocity of the first particles to modify the filtration characteristics of the saturated fluidized bed. The fluid chamber includes a wall extending between an inlet (28) and outlet (32) to form a fluid chamber interior. The interior converges from a position of maximum cross-sectional area toward the inlet. A groove or a step may be formed on an inner surface of the fluid chamber wall to improve particle separation within the fluid chamber.

Abstract translation: 公开了用于过滤或分离颗粒的装置和方法。 该设备具有可围绕旋转轴线旋转的离心机转子（12）。 流体室（22）与转子一起旋转。 物质被供应到腔室的入口（28）。 第一颗粒的饱和流化床在流体室内形成并阻止第二颗粒流过室。 在本发明的一个实施方案中，添加剂物质改变第一颗粒的沉降速度以改变饱和流化床的过滤特性。 流体室包括在入口（28）和出口（32）之间延伸以形成流体室内部的壁。 内部从最大横截面积的位置朝向入口收敛。 可以在流体室壁的内表面上形成凹槽或台阶以改善流体室内的颗粒分离。

公开(公告)号：WO1995001842A1

公开(公告)日：1995-01-19

申请号：PCT/SE1994000638

申请日：1994-06-28

Applicant: OMEGA MEDICINTEKNIK AB ,  UNGER, Peter ,  WESTBERG, Eric

Inventor： OMEGA MEDICINTEKNIK AB

IPC: B04B05/04

CPC classification number: B04B5/0428 ,  B04B2005/045

Abstract: Bag-system for centrifugal separation, comprising an outer, essentially ring-shaped outer bag (1) and a central inner bag (2) which is formed from the central part of the ring and preferably being detachable from the ring, and one or several connnecting channels between the interiors of said bags. According to the invention the bag-system has a rigid, circular centre part (16) on which the outer bag is mounted in a position for centrifugation, whereby the outer bag is given a conical shape around the centre part by means of a ring-shortened contraction of said bag. The inner bag is positioned in a cavity (17) in the centre part, which cavity is arranged to restrict the radial spreading of the inner bag but to allow an axial expansion of the inner bag when it is filled with a liquid. The invention also relates to the use of the bag-system for obtaining thrombocyte suspensions from buffycoat fractions by centrifugal separation and for recovering bone marrow cells from bone marrow suspensions by centrifugal separation.

Abstract translation: 用于离心分离的袋系统，包括外部基本上环形的外袋（1）和由环的中心部分形成的中心内袋（2），并且优选地与环可拆卸，并且一个或多个 在所述袋的内部之间连接通道。 根据本发明，袋系统具有刚性的圆形中心部分（16），外袋安装在其上用于离心的位置，由此外袋通过环形部分围绕中心部分被赋予圆锥形形状， 缩短所述袋的收缩。 内袋定位在中心部分的空腔（17）中，该空腔设置成限制内袋的径向展开，但是当内袋充满液体时允许内袋的轴向膨胀。 本发明还涉及袋系统用于通过离心分离从血白蛋白级分获得血细胞悬浮液并通过离心分离从骨髓悬浮液中回收骨髓细胞的用途。

公开(公告)号：WO1993008675A1

公开(公告)日：1993-04-29

申请号：PCT/US1992009104

申请日：1992-10-21

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  GLEN, Stefan, J. ,  CARSTENS, Bradley, D.

IPC: B04B05/04

CPC classification number: B04B5/0414 ,  B04B2007/025

Abstract: A hybrid composite sample holder (14) utilized to improve overall strength-to-weight of a centrifuge rotor. The holder (14) comprises a body having a metal neck (62) and a fiber composite base (60) portion integrally attached.

Abstract translation: 用于提高离心机转子整体强度重量的混合复合样品架（14）。 保持器（14）包括具有金属颈部（62）和整体连接的纤维复合基底（60）部分的主体。

公开(公告)号：WO1985005568A1

公开(公告)日：1985-12-19

申请号：PCT/US1985001032

申请日：1985-05-31

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  SUTTON, John, H., III

IPC: B04B05/04

CPC classification number: B04B5/0421

Abstract: A centrifuge rotor (18) is presented having a pivotal mount (26) for a sample container (10) upwardly offset from the radial plane (A-A') of maximal strength of the rotor (18) permitting a smaller diameter rotor (18) container (10) assembly and reducing exposed surface area of the rotor (18) container assembly.

Abstract translation: 离心机转子（18）具有用于样品容器（10）的枢转安装件（26），该样品容器（10）向上偏离转子（18）的最大强度的径向平面（A-A'），允许较小直径的转子 ）容器（10）组件并减小转子（18）容器组件的暴露表面积。

公开(公告)号：WO1983004379A1

公开(公告)日：1983-12-22

申请号：PCT/US1983000319

申请日：1983-03-07

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  WRIGHT, Herschel, E.

IPC: B04B05/04

CPC classification number: F16D1/092 ,  B04B5/0414 ,  B04B9/08 ,  B04B2007/025 ,  B04B2009/085 ,  F16B21/088

Abstract: A rotor attachment assembly to provide efficient and secure connection between a rotor (10) and a centrifuge drive mechanism (18). The assembly is designed in such a manner that not only attachment, but also disconnection is accomplished in a convenient one-step operation. The utilization of a single connecting shaft (24) with flexible fingers (30) contributes to the ease of operation as well as the ease of manufacture of the assembly.

Abstract translation: 一种用于在转子（10）和离心机驱动机构（18）之间提供有效和可靠的连接的转子附接组件。 组件的设计方式不仅在方便的一步操作中不仅附接，而且断开。 利用具有柔性指状物（30）的单个连接轴（24）有助于操作的容易性以及组件的易于制造。

公开(公告)号：WO1998026875A1

公开(公告)日：1998-06-25

申请号：PCT/EP1997007189

申请日：1997-12-05

Applicant: FIRMA ANDREAS HETTICH ,  EBERLE, Günter

Inventor： FIRMA ANDREAS HETTICH

IPC: B04B05/04

CPC classification number: B04B5/0414 ,  B04B2007/025

Abstract: The invention relates to a centrifuge for measuring haematocrit, designed to receive capillary tubes (27) which are inserted in the rotor (1) and distributed in a star shape around its circumference and whose outer ends, which are facing the outside, rest on the inner rim of the rotor. The interior space of the rotor is formed by separate chambers (14) which are sealed off from each other, whereby each chamber is designed to receive one capillary tube. If a capillary tube breaks, the contents and pieces of the tube cannot enter the neighbouring chambers.

Abstract translation: 本发明涉及一种血细胞比容离心机，用于接收分布在星形的转子（1）的外周毛细管（27）拾取的，并与它们的外，分别抵靠外端熊面在转子的内边缘。 所述转子的内部由个体彼此，形成腔室（14），其中，在每个腔室中的毛细管被容纳密封形成。 在毛细管中的损坏的情况下防止了毛细管的内容和片段进入相邻的腔室中。

公开(公告)号：WO1996032199A1

公开(公告)日：1996-10-17

申请号：PCT/US1996005146

申请日：1996-04-12

Applicant: COBE LABORATORIES, INC.

Inventor： COBE LABORATORIES, INC. ,  HLAVINKA, Dennis ,  FELT, Thomas, J.

IPC: B04B05/04

CPC classification number: B04B5/0442 ,  B04B2005/045

Abstract: A centrifuge apparatus is used for collecting white blood cells (WBC), primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. MNC fluid is allowed to pool behind the barrier before collection is started. To collect the MNC pool, the stratified red blood cell layer is raised from below the interface level by slowing or reversing flow in the RBC exit line thereby causing the MNC pool to spill over the barrier into a well in which a collect line is positioned. Collection ceases when a desired percentage of the pool is removed and the normal position of the interface is reestablished; thereafter the pool builds again. By raising the MNC pool from below, improvements in purity and collect volume are achieved. The collection procedure can be useful for harvesting granulocytes and, in general, any sparse stratified component of a centrifuged solution where the sparse component is layered between more dense and less dense strata.

Abstract translation: 离心机用于从分层成层的全血中收集白细胞（WBC），主要是单核细胞。 在红细胞和血浆的界面处形成薄单核（MNC）层。 隔离物位于离心机的分离容器中，以拦截薄层。 允许MNC流体在收集开始之前集中在障碍物后面。 为了收集MNC池，分层的红细胞层通过减缓或逆转RBC出口线中的流动而从界面水平以下升高，从而导致MNC池溢出障碍物进入收集线所在的井中。 当池的所需百分比被移除并且界面的正常位置被重新建立时，集合停止; 此后池再次建成。 通过从下方提高MNC池，实现了纯度和收集量的提高。 采集程序可用于收获粒细胞和一般来说，离心溶液的任何稀疏的分层组分，其中稀疏组分分层在更致密和较不密集的层之间。