公开(公告)号：JPH10504843A

公开(公告)日：1998-05-12

申请号：JP50170697

申请日：1996-06-07

Applicant: DADE CHEMISTRY SYSTEMS INC

Inventor： WANG CHENGRONG

IPC: G01N33/53 ,  A61K39/00 ,  C07D223/22 ,  C07D223/26 ,  C07D223/32 ,  G01N33/532 ,  G01N33/94

公开(公告)号：WO1997040943A1

公开(公告)日：1997-11-06

申请号：PCT/US1997006579

申请日：1997-04-21

Applicant: DADE CHEMISTRY SYSTEMS INC.

Inventor： DADE CHEMISTRY SYSTEMS INC. ,  HOWELL, Gary, Wayne

IPC: B04B09/12

CPC classification number: F16F15/02 ,  B04B9/12 ,  B04B9/146 ,  F16C27/00 ,  F16F15/1492 ,  F16F15/305 ,  F16F15/315 ,  Y10S29/901 ,  Y10T29/49012 ,  Y10T74/2109 ,  Y10T74/2131 ,  Y10T464/50

Abstract: The method and apparatus of this invention accommodate vibrations that occur in a body rotating about its geometric axis when the body passes through critical speed by maintaining the moment of inertia of the body while allowing the body to shift its rotational axis to that of its mass center. A disk (40) is bearing mounted on the drive shaft (11) of the rotating body and supported in its peripheral position by sliding bearings (60, 64, 68).

Abstract translation: 本发明的方法和装置适应当身体通过临界速度绕其几何轴线转动的身体中发生的振动，通过保持身体的惯性矩，同时允许身体将其旋转轴线移动到其质心中心 。 圆盘（40）是轴承安装在旋转体的驱动轴（11）上并通过滑动轴承（60,64,68）支撑在其周边位置。

公开(公告)号：WO1997040942A1

公开(公告)日：1997-11-06

申请号：PCT/US1997006615

申请日：1997-04-24

Applicant: DADE CHEMISTRY SYSTEMS INC.

Inventor： DADE CHEMISTRY SYSTEMS INC. ,  HOWELL, Gary, Wayne

IPC: B04B05/04

CPC classification number: B04B5/0421

Abstract: A swinging bucket-type centrifuge is disclosed which is capable of operating in either swinging bucket or fixed angle mode. The buckets mounted on the rotor have a release bracket which can be automatically actuated to release the tubes mounted in the buckets.

Abstract translation: 公开了能够以摆动铲斗或固定角度模式操作的摆动式斗式离心机。 安装在转子上的铲斗具有释放托架，其可以被自动地致动以释放安装在铲斗中的管子。

公开(公告)号：WO1997039359A1

公开(公告)日：1997-10-23

申请号：PCT/US1997005779

申请日：1997-04-08

Applicant: DADE CHEMISTRY SYSTEMS INC.

Inventor： DADE CHEMISTRY SYSTEMS INC. ,  PARRIS, Norman, Alfred

IPC: G01N35/08

CPC classification number: G01N35/08 ,  Y10T436/117497 ,  Y10T436/118339

Abstract: An analyzer apparatus for analyzing components of a sample has a conduit and an electrochemical sensor in the conduit. The sample is passed through the conduit using a carrier liquid that is immiscible with the sample and non-wetting of the inner wall of the conduit to reduce instabilities in the apparatus due to undue fluid movement.

Abstract translation: 用于分析样品组分的分析装置在管道中具有导管和电化学传感器。 样品通过使用与样品不混溶并且不润湿导管内壁的载液通过导管，以减少由于不适当的流体运动而在装置中的不稳定性。

公开(公告)号：WO9640664A3

公开(公告)日：1997-03-13

申请号：PCT/US9609834

申请日：1996-06-07

Applicant: DADE CHEMISTRY SYSTEMS INC

Inventor： LAU HON-PENG PHILLIP

IPC: G01N33/53 ,  A61K47/48 ,  C07D213/56 ,  C07D215/46 ,  C07D223/28 ,  C07D295/13 ,  C07D295/14 ,  C07D295/15 ,  C07K17/02 ,  C07D295/08

CPC classification number: C07D295/13 ,  A61K47/646 ,  C07D295/15

Abstract: The invention provides a reactive derivative of dialkyl amino compounds, particularly dialkyl amino drugs, for facilitating the conjugation of the drug, directly or through a bifunctional spacer, to a carrier compound such as proteinaceous materials. The derivative has formula (a) wherein D is the drug and n is an integer greater than 1, and preferably equal to 2. The drug derivative carrier conjugate can be used as an immunogen for production of antibodies specific to the drug. Additionally, the conjugate can be coupled to a solid support, such as a polymer particle, for use as a particle reagent in immunoassays specific to the drug.

公开(公告)号：WO1997039344A1

公开(公告)日：1997-10-23

申请号：PCT/US1997005878

申请日：1997-04-09

Applicant: DADE CHEMISTRY SYSTEMS INC.

Inventor： DADE CHEMISTRY SYSTEMS INC. ,  PARRIS, Norman, Alfred

IPC: G01N27/327

CPC classification number: C12Q1/005

Abstract: Degradation of multielectrochemical sensors in a common flow stream is averted by positioning any sensors having as its associated enzyme an oxidoreductase enzyme capable of producing, as a result of interaction with its respective substrate, an oxidizing agent downstream of the other enzyme sensors not having such oxidoreductase enzyme.

Abstract translation: 通过将具有其相关联的酶的任何传感器定位为能够产生与其各自底物相互作用的结果的氧化还原酶，在不具有这种氧化还原酶的其它酶传感器下游的氧化剂，可以避免常见流动中的多电化学传感器的降解 酶。

公开(公告)号：WO1996040664A2

公开(公告)日：1996-12-19

申请号：PCT/US1996009834

申请日：1996-06-07

Applicant: DADE CHEMISTRY SYSTEMS INC.

Inventor： DADE CHEMISTRY SYSTEMS INC. ,  LAU, Hon-Peng, Phillip

IPC: C07D295/14

CPC classification number: C07D295/13 ,  A61K47/646 ,  C07D295/15

Abstract: The invention provides a reactive derivative of dialkyl amino compounds, particularly dialkyl amino drugs, for facilitating the conjugation of the drug, directly or through a bifunctional spacer, to a carrier compound such as proteinaceous materials. The derivative has formula (a) wherein D is the drug and n is an integer greater than 1, and preferably equal to 2. The drug derivative carrier conjugate can be used as an immunogen for production of antibodies specific to the drug. Additionally, the conjugate can be coupled to a solid support, such as a polymer particle, for use as a particle reagent in immunoassays specific to the drug.

Abstract translation: 本发明提供二烷基氨基化合物，特别是二烷基氨基药物的反应性衍生物，用于促进药物直接或通过双功能间隔区与载体化合物如蛋白质材料的缀合。 该衍生物具有式（a），其中D是药物，n是大于1，优选等于2的整数。药物衍生物载体缀合物可以用作制备针对该药物的抗体的免疫原。 此外，缀合物可以偶联到固体支持物，例如聚合物颗粒，用作药物特异性免疫测定中的颗粒试剂。

公开(公告)号：WO1997041445A1

公开(公告)日：1997-11-06

申请号：PCT/US1997006936

申请日：1997-04-25

Applicant: DADE CHEMISTRY SYSTEMS INC.

Inventor： DADE CHEMISTRY SYSTEMS INC. ,  KEGELMAN, Joseph, Edward ,  MIZZER, John, Paul ,  NUZZACI, Edward, Anthony ,  CHOW, Allan, Tit-Shing

IPC: G01N35/02

CPC classification number: G01N35/0098 ,  G01N2035/0453 ,  Y10T436/11 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A pre-processor for use in performing heterogeneous immunoassays on samples for analyses in the sample employing concentrically positioned incubating and processing carousels. A single transfer station permits reaction vessels containing sample and reagents to be moved between the carousels. The samples are separated, washed and mixed on the processing carousel and incubated on the incubating carousel thus speeding up processing throughput.

Abstract translation: 用于在样品上进行非均相免疫测定的预处理器，用于使用同心位置的孵育和加工转盘的样品进行分析。 单个转运站允许含有样品和试剂的反应容器在转盘之间移动。 将样品分离，洗涤并在加工转盘上混合，并在孵育转盘上孵育，从而加快加工量。

公开(公告)号：WO1997006438A1

公开(公告)日：1997-02-20

申请号：PCT/US1996012618

申请日：1996-08-02

Applicant: DADE CHEMISTRY SYSTEMS INC.

Inventor： DADE CHEMISTRY SYSTEMS INC. ,  CHU, Victor, Pichai ,  CRAIG, Alan, Robert

IPC: G01N33/543

CPC classification number: G01N33/54313 ,  G01N33/54353 ,  Y10S435/962 ,  Y10S436/815 ,  Y10T428/2991

Abstract: A method is provided for enhancing the stability and increasing the activity of polymer particle reagents by incubating a polymer particle which has been covalently bound to a compound of biological interest, such as a drug, with a modifying agent that will place a negative charge on the surface of the polymer particle and reduce residual functional groups. The modifying agent is preferably an anionic nucleophile selected from the group consisting of beta -mercaptoacetic acid and the thiosulfates.

Abstract translation: 提供一种方法，用于通过将已经共价结合到具有生物学意义的化合物的聚合物颗粒（例如药物）与将在其上放置负电荷的改性剂一起孵育来提高聚合物颗粒试剂的稳定性和增加活性 降低残留的官能团。 改性剂优选为选自β-巯基乙酸和硫代硫酸盐的阴离子亲核试剂。

公开(公告)号：WO1996040642A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009373

申请日：1996-06-07

Applicant: DADE CHEMISTRY SYSTEMS INC.

Inventor： DADE CHEMISTRY SYSTEMS INC. ,  WANG, Chengrong

IPC: C07D223/22

CPC classification number: G01N33/532 ,  C07D223/22 ,  C07D223/32 ,  G01N33/9473 ,  G01N33/9486 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/823 ,  Y10S530/806 ,  Y10T436/171538

Abstract: The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having general formula (1). The present invention also provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has general structure (2), where X is C=O, CH2 or SO2; Y is C=O, CH2, SO2; R is an alkyl and P is a protein or a hapten.

Abstract translation: 本发明提供了具有通式（1）的适用于与聚合物颗粒试剂共价连接的新型卡马西平酰肼化合物。 本发明还提供了一种新颖的卡马西平酸化合物，适用于与用于生产卡马西平免疫原的蛋白质相连。 本发明的卡马西平抗原具有通式（2），其中X为C = O，CH 2或SO 2; Y为C = O，CH 2，SO 2; R是烷基，P是蛋白质或半抗原。