公开(公告)号：GB0913558D0

公开(公告)日：2009-09-16

申请号：GB0913558

申请日：2008-05-30

Applicant: ACADEMIA SINICA

Abstract: A conserved cluster of oligomannose glycans on gp120 has been identified as the epitope recognized by the broadly HIV-1-neutralizing monoclonal antibody 2G12. Oligomannose glycans are also the ligands for DC-SIGN, a C-type lectin found on the surface of dendritic cells. Multivalency is fundamental for carbohydrate-protein interactions, and mimicking of the high glycan density on the virus surface has become essential for designing carbohydrate-based HIV vaccines and antiviral agents. Synthesis of oligomannose dendrons, which display multivalent oligomannoses in high density, and characterize their interaction with 2G12 and DC-SIGN by a glycan microarray binding assay is disclosed. These glycodendrons inhibit the binding of gp120 to 2G12 and recombinant dimeric DC-SIGN with IC50 in the nanomolar range. A second-generation Man9 dendron was identified as a potential immunogen for HIV vaccine development and as a potential antiviral agent.

公开(公告)号：CA2678013A1

公开(公告)日：2008-08-21

申请号：CA2678013

申请日：2008-02-12

Applicant: ACADEMIA SINICA ,  UNIV NAT TAIWAN

Inventor： LIN CHIN-TARNG ,  WU HAN-CHUNG ,  CHANG DE-KUAN

IPC: A61K9/127 ,  A61K47/48 ,  C07K7/04 ,  C12N15/09

Abstract: The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target lung canc er and were identified by phage display. Targeting phage PC5-2 and synthetic peptide SP5-2 were both able to recognize human pulmonary tumor specimens f rom lung cancer patients. In SCID mice bearing NSCLC xenografts, the targeti ng phage was able to target tumor masses specifically. When the peptide was coupled to liposomes containing the anti-cancer drugs vinorelbine or doxorub icin, the efficacy of these drugs against human lung cancer xenografts was i mproved, the survival rate increased, and the drug toxicity was reduced.

公开(公告)号：GB0809919D0

公开(公告)日：2008-07-09

申请号：GB0809919

申请日：2008-05-30

Applicant: ACADEMIA SINICA

Abstract: A conserved cluster of oligomannose glycans on gp120 has been identified as the epitope recognized by the broadly HIV-1-neutralizing monoclonal antibody 2G12. Oligomannose glycans are also the ligands for DC-SIGN, a C-type lectin found on the surface of dendritic cells. Multivalency is fundamental for carbohydrate-protein interactions, and mimicking of the high glycan density on the virus surface has become essential for designing carbohydrate-based HIV vaccines and antiviral agents. Synthesis of oligomannose dendrons, which display multivalent oligomannoses in high density, and characterize their interaction with 2G12 and DC-SIGN by a glycan microarray binding assay is disclosed. These glycodendrons inhibit the binding of gp120 to 2G12 and recombinant dimeric DC-SIGN with IC50 in the nanomolar range. A second-generation Man9 dendron was identified as a potential immunogen for HIV vaccine development and as a potential antiviral agent.

公开(公告)号：CA2678051A1

公开(公告)日：2008-02-21

申请号：CA2678051

申请日：2008-02-12

Applicant: ACADEMIA SINICA ,  UNIV NAT TAIWAN

Inventor： WU HAN-CHUNG ,  LIN CHIN-TARNG ,  LEE TONG-YOUNG ,  KUO SZU-YAO

IPC: A61K9/127 ,  A61K47/48 ,  C07K7/04 ,  C12N15/09

Abstract: The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovascul ature and were identified by in vivo phage display. One such peptide, SP5-52 , recognized the neovasculature of multiple tumors in SCED mice, but did not target normal blood vessels. This peptide also binds to blood vessels of hu man lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubici n enhanced the efficacy of the drug against multiple human cancer xenografts in SCED mice.

公开(公告)号：CA2651954A1

公开(公告)日：2007-11-22

申请号：CA2651954

申请日：2007-05-11

Applicant: ACADEMIA SINICA ,  PHARMIGENE INC

Inventor： CHEN WEI-HSUAN ,  LIN HSIN-YU ,  CHANG CHI-FENG ,  SHEN CHIH-LUNG ,  HUNG SHUEN-LU ,  CHEN YUAN-TSONG

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/02

Abstract: This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B*1502 or HLA-B*5801, and a kit for carrying out t his method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, or hypersensitivity syndrome) based on the pres ence or absence of a genetic marker (e.g., HLA-B*1502, HLA-B*5801, or HLA-B* 4601).

公开(公告)号：CA2591840A1

公开(公告)日：2006-06-29

申请号：CA2591840

申请日：2005-12-21

Applicant: ACADEMIA SINICA

Inventor： CHENG YAUN-TSONG ,  YUAN HSIANG-YU ,  CHEN JIN-JER

IPC: C12Q1/68

Abstract: We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the interindividual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

公开(公告)号：DE69829824T2

公开(公告)日：2006-01-12

申请号：DE69829824

申请日：1998-08-24

Applicant: ACADEMIA SINICA TAIPEH T AI PE

Inventor： YU SU-MAY ,  CHAN MING-TSAIR

IPC: C12N9/32 ,  C12N15/29 ,  C12N15/56 ,  C12N15/67 ,  C12N15/82 ,  C12N15/84 ,  C12P21/02

Abstract: An expression vector comprising a promoter capable of directing expression of a coding sequence in an angiosperm cell, and a 3' untranslated region of a rice alpha -amylase gene, wherein, after the coding sequence is inserted into the vector, the 3' untranslated region and the coding sequence are transcribed into a single mRNA. Also featured are methods of producing a polypeptide in angiosperm cells using such a vector.

公开(公告)号：DE69829824D1

公开(公告)日：2005-05-25

申请号：DE69829824

申请日：1998-08-24

Applicant: ACADEMIA SINICA TAIPEH T AI PE

Inventor： YU SU-MAY ,  CHAN MING-TSAIR

IPC: C12N9/32 ,  C12N15/29 ,  C12N15/56 ,  C12N15/84 ,  C12N15/82 ,  C12N15/67 ,  C12P21/02

Abstract: An expression vector comprising a promoter capable of directing expression of a coding sequence in an angiosperm cell, and a 3' untranslated region of a rice alpha -amylase gene, wherein, after the coding sequence is inserted into the vector, the 3' untranslated region and the coding sequence are transcribed into a single mRNA. Also featured are methods of producing a polypeptide in angiosperm cells using such a vector.

公开(公告)号：AU2003244587A1

公开(公告)日：2005-01-27

申请号：AU2003244587

申请日：2003-07-14

Applicant: ACADEMIA SINICA

Inventor： YANG NING-SUN ,  SHYUR LIE-FEN ,  WANG SHENG-YANG ,  SUN SHOW-JANE ,  KANG PEI-LING

IPC: A61P35/00 ,  B01D11/04 ,  A61K35/78

公开(公告)号：NO20040966L

公开(公告)日：2004-04-22

申请号：NO20040966

申请日：2004-03-05

Applicant: ACADEMIA SINICA

Inventor： HUEY-LANG YANG ,  YU JAMES CHEIN-CHIH ,  LIN JOHN HAN-YOU

IPC: A61K39/00 ,  A01N63/16 ,  A01N63/20 ,  A61K39/02 ,  A61K39/104 ,  A61K47/00 ,  A61P31/04 ,  C12N15/09 ,  C12N15/63

Abstract: This invention features an oral vaccine that includes a multiple-cell organism for use as food for an aquatic animal to be vaccinated, and a single-cell organism fed to, and as a result, bioencapsulated by, the multiple-cell organism. The single-cell organism has been transformed to express a recombinant antigen that induces an immune response in the aquatic animal and thereby vaccinates the aquatic animal (e.g., a fish or a shrimp).