公开(公告)号：AU2005319028A1

公开(公告)日：2006-06-29

申请号：AU2005319028

申请日：2005-12-21

Applicant: ACADEMIA SINICA

Inventor： CHENG YAUN-TSONG ,  CHEN JIN-JER ,  YUAN HSIANG-YU

IPC: C12Q1/68

Abstract: We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the interindividual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

公开(公告)号：CA2591840A1

公开(公告)日：2006-06-29

申请号：CA2591840

申请日：2005-12-21

Applicant: ACADEMIA SINICA

Inventor： CHENG YAUN-TSONG ,  YUAN HSIANG-YU ,  CHEN JIN-JER

IPC: C12Q1/68

Abstract: We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the interindividual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

公开(公告)号：AU2005319028B2

公开(公告)日：2010-09-16

申请号：AU2005319028

申请日：2005-12-21

Applicant: ACADEMIA SINICA

Inventor： CHENG YAUN-TSONG ,  CHEN JIN-JER ,  YUAN HSIANG-YU

IPC: C12Q1/68

Abstract: We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the interindividual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

公开(公告)号：MX2007007568A

公开(公告)日：2008-03-11

申请号：MX2007007568

申请日：2005-12-21

Applicant: ACADEMIA SINICA

Inventor： YUAN HSIANG-YU ,  CHEN JIN-JER ,  CHENG YAUN-TSONG

IPC: C12Q1/00

Abstract: Descubrimos que un polimorfismo en el promotor del gen VKORCI esta asociado con la sensibilidad a la warfarina. Este polimorfismo puede explicar tanto las diferencias entre individuos como las diferencias entre razas en los requerimientos de dosis de warfarina. Adicionalmente, el polimorfismo tambien esta asociado con la actividad del promotor. Asi, la secuencia o actividad del promotor del gen VKORCI de un sujeto se puede utilizar para predecir cuanta warfarina se debe prescribir para el sujeto. Se proporcionan metodos y composiciones relevantes.

公开(公告)号：WO2006069339A2

公开(公告)日：2006-06-29

申请号：PCT/US2005046869

申请日：2005-12-21

Applicant: ACADEMIA SINICA ,  CHENG YAUN-TSONG ,  YUAN HSIANG-YU ,  CHEN JIN-JER

Inventor： CHENG YAUN-TSONG ,  YUAN HSIANG-YU ,  CHEN JIN-JER

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172

Abstract: We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the inter­individual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

Abstract translation: 我们发现VKORCI基因启动子的多态性与华法林敏感性有关。 这种多态性可以解释华法林剂量要求中的个体间和种族间差异。 此外，多态性也与启动子活性相关。 因此，受试者的VKORCI基因的启动子序列或活性可用于预测该受试者应该规定多少华法林。 提供了相关的方法和组合。

公开(公告)号：WO2006069339A3

公开(公告)日：2006-10-12

申请号：PCT/US2005046869

申请日：2005-12-21

Applicant: ACADEMIA SINICA ,  CHENG YAUN-TSONG ,  YUAN HSIANG-YU ,  CHEN JIN-JER

Inventor： CHENG YAUN-TSONG ,  YUAN HSIANG-YU ,  CHEN JIN-JER

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172

Abstract: We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the inter­individual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

Abstract translation: 我们发现VKORCI基因启动子的多态性与华法林的敏感性有关。 这种多态性可以解释华法林剂量要求的个体间和种族间的差异。 此外，多态性也与启动子活性相关。 因此，受试者的VKORCI基因的启动子序列或活性可用于预测该受试者应该规定多少华法林。 提供了相关的方法和组成。