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    Chinon-Derivate und Verfahren zu ihrer Herstellung
    43.
    发明公开
    Chinon-Derivate und Verfahren zu ihrer Herstellung 失效
    Chinon-Derivate und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0233841A1

    公开(公告)日：1987-08-26

    申请号：EP87810083.3

    申请日：1987-02-12

    Applicant: Arai, Tadashi, Prof.

    Inventor： Arai, Tadashi, Prof. Dr.

    IPC: C07D471/18 ,  A61K31/495

    CPC classification number: C07D471/18

    Abstract: Es werden neue Saframycin-Derivate der Formel
    worin R Wasserstoff oder C₁-C₄-Alkyl, R₁ C₁-C₇-Alkyl, Aryl-C₁-C₄-­alkyl oder die Acylgruppe einer organischen Säure und R₂ Wasserstoff oder C₁-C₇-Alkyl darstellen, und Verfahren zur Herstellung dieser Derivate beschrieben. Die neuen Saframycin-Derivate zeigen anti­biotische und anti-Tumor-Wirkung.

    Abstract translation: 式“IMAGE”的新型安全霉素衍生物，其中R表示氢或C1-C4-烷基，R1表示C1-C7-烷基，芳基-C1-C4-烷基或有机酸的酰基，R2表示氢或C1 -C7-烷基显示抗生素和抗肿瘤作用。

    BIOLOGICAL ENTEROBACTERICIDE
    46.
    发明申请
    BIOLOGICAL ENTEROBACTERICIDE 审中-公开
    生物灭菌剂

    公开(公告)号：WO1993012804A1

    公开(公告)日：1993-07-08

    申请号：PCT/JP1987000970

    申请日：1987-12-11

    Applicant: ARAI, Tadashi ,  TANAKA, Mamoru ,  MAEDA, Akio

    IPC: A61K35/74

    CPC classification number: A61K35/742

    Abstract: Cell bodies or endospores of Clostridium butyricum MII588-Sens 1 strain or Clostridium butyricum MII588-Res 1 are effective as biological enterobactericide.

    Abstract translation: 丁酸梭菌MII588-Sens 1菌株或丁酸梭菌MII588-Res 1的细胞体或内生孢子作为生物肠杆菌属是有效的。

    APPARATUS FOR FALLING DOWN REST PIN OF WESTERN-STYLE BOW USING WIRE CABLE
    47.
    发明专利
    APPARATUS FOR FALLING DOWN REST PIN OF WESTERN-STYLE BOW USING WIRE CABLE 失效

    公开(公告)号：JPH10213396A

    公开(公告)日：1998-08-11

    申请号：JP4955597

    申请日：1997-01-28

    Applicant: ARAI TADASHI

    Inventor： ARAI TADASHI

    IPC: F41B5/22 ,  F41B5/00 ,  F41B5/10

    Abstract: PROBLEM TO BE SOLVED: To provide an apparatus for falling down a rest pin in which a function of a rest of a western baw is extended, and its adjustment is easy, and which is accurate and safe. SOLUTION: The present apparatus is adapted such that it drives and controls a push pin unit mounted on a slide shaft 2 and a rest free to fall through a wire cable 7. More specifically, for securely falling the rest pin at an optimum position, the slide shaft 2 and the rest part are connected through the wire cable 7 and are interlocked with a cable slide 5 to freely set the timing the rest pin is fallen.

    ANTIBIOTIC SAFRAMYCIN S AND ITS PREPARATIVE METHOD
    49.
    发明专利
    ANTIBIOTIC SAFRAMYCIN S AND ITS PREPARATIVE METHOD 失效

    公开(公告)号：JPS56135486A

    公开(公告)日：1981-10-22

    申请号：JP3840380

    申请日：1980-03-26

    Applicant: ARAI TADASHI

    Inventor： ARAI TADASHI ,  TAKAHASHI KATSUHIRO ,  ISHIGURO KIMIKO ,  YOKOYAMA KOUJI

    IPC: A61K31/47 ,  A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18

    Abstract: NEW MATERIAL:An antibiotic saframycin S which is assumed to have structures of immonium and alpha-carbinol as given in formula I or II; the color and description: deep yellow, powder; melting point: 107-115 deg.C; specific rotatory power: alphaD = +32.5 (0.5 MeOH); molecular weight: 553; empirical formula: C28H30N3O8 . OH . USE:Antibiotic and anticancer agent: it has the same level of biological activity as saframycin A and is effective on gramnegative and -positive bacteria and acid-fast bacteria. Further, it shows effecacy in mice lymphemia, too. PREPARATION:Saframycin A of formula III (R1 is H; R2 is CN) is heated under reflux and agitation to effect acidolysis and denitration, thus giving saframycin S of formula I or II. The compound of formula III is known and obtained by cultivating Streptomyces lavendulae No.314 (FERM-3218).

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