公开(公告)号：ES555459A0

公开(公告)日：1987-12-01

申请号：ES555459

申请日：1986-05-29

Applicant: ARAI TADASHI

IPC: A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/56

Abstract: Disclosed are compounds of the formulawherein R represents hydrogen or C 1 -C 4 -alkyl. These compounds are obtained by fermentation of the known saframycin A producing strain Streptomyces lavendulae No. 314 and by reaction with the amino acids L-tyrosine, L-methionine, glycine and HOOC - (CH)NH 2 -CH 2 -R. When R is hydrogen, saframycin Y 3 and when R is methyl, saframycein Y d-1 are produced.

公开(公告)号：ES546574A0

公开(公告)日：1986-11-16

申请号：ES546574

申请日：1985-08-30

Applicant: ARAI TADASHI

IPC: A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/56 ,  C07D471/14

Abstract: Disclosed are compounds of the formulawherein R represents hydrogen or C 1 -C 4 -alkyl. These compounds are obtained by fermentation of the known saframycin A producing strain Streptomyces lavendulae No. 314 and by reaction with the amino acids L-tyrosine, L-methionine, glycine and HOOC - (CH)NH 2 -CH 2 -R. When R is hydrogen, saframycin Y 3 and when R is methyl, saframycein Y d-1 are produced.

公开(公告)号：DD239611A5

公开(公告)日：1986-10-01

申请号：DD28012185

申请日：1985-08-29

Applicant: ARAI TADASHI

Inventor： ARAI TADASHI ,  MIKAMI YUZURU

IPC: A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/56 ,  C12P15/00 ,  C12P17/12

Abstract: Disclosed are compounds of the formulawherein R represents hydrogen or C 1 -C 4 -alkyl. These compounds are obtained by fermentation of the known saframycin A producing strain Streptomyces lavendulae No. 314 and by reaction with the amino acids L-tyrosine, L-methionine, glycine and HOOC - (CH)NH 2 -CH 2 -R. When R is hydrogen, saframycin Y 3 and when R is methyl, saframycein Y d-1 are produced.

公开(公告)号：NO853396A

公开(公告)日：1986-03-03

申请号：NO853396

申请日：1985-08-29

Applicant: ARAI TADASHI

Inventor： ARAI TADASHI ,  MIKAMI YUZURU

IPC: A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/56 ,  C12P

CPC classification number: C07D471/18 ,  C12P17/182 ,  C12R1/465 ,  C12R1/56 ,  Y10S435/899

公开(公告)号：GR852097B

公开(公告)日：1986-01-02

申请号：GR850102097

申请日：1985-08-29

Applicant: ARAI TADASHI

Inventor： ARAI TADASHI ,  MIKAMI VUZURU

IPC: A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/56

Abstract: Disclosed are compounds of the formulawherein R represents hydrogen or C 1 -C 4 -alkyl. These compounds are obtained by fermentation of the known saframycin A producing strain Streptomyces lavendulae No. 314 and by reaction with the amino acids L-tyrosine, L-methionine, glycine and HOOC - (CH)NH 2 -CH 2 -R. When R is hydrogen, saframycin Y 3 and when R is methyl, saframycein Y d-1 are produced.

公开(公告)号：ES8506096A1

公开(公告)日：1985-06-16

申请号：ES535547

申请日：1984-08-30

Applicant: ARAI TADASHI

IPC: C07G11/00 ,  A61K35/74 ,  A61P31/04 ,  C07H19/01 ,  C12P1/06 ,  C12P19/02 ,  C12R1/465 ,  C12P13/00

Abstract: PROCEDIMIENTO PARA LA OBTENCION DE NEOCOPIAMICINA A Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLE.COMPRENDE EL CULTIVO DE UNA CAPA DE STREPTOMYCES HYGROSCOPICUS PRODUCTORA DE NEOCOPIAMICINA A EN UN MEDIO ACUOSO, QUE CONTIENE FUENTES DE CARBONO Y NITROGENO ASIMILABLES, EN CONDICIONES AEROBIAS; SEGUIDO DE LA EXTRACCION DE LA NEOCOPIAMICINA A PRODUCIDA.ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICO.

公开(公告)号：ZA856598B

公开(公告)日：1986-04-30

申请号：ZA856598

申请日：1985-08-29

Applicant: ARAI TADASHI

Inventor： ARAI TADASHI ,  MIKAMI YUZURU

IPC: A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/56 ,  C07C ,  C07D ,  A61K

Abstract: Disclosed are compounds of the formulawherein R represents hydrogen or C 1 -C 4 -alkyl. These compounds are obtained by fermentation of the known saframycin A producing strain Streptomyces lavendulae No. 314 and by reaction with the amino acids L-tyrosine, L-methionine, glycine and HOOC - (CH)NH 2 -CH 2 -R. When R is hydrogen, saframycin Y 3 and when R is methyl, saframycein Y d-1 are produced.

公开(公告)号：ZA8506598B

公开(公告)日：1986-04-30

申请号：ZA8506598

申请日：1985-08-29

Applicant: ARAI TADASHI

Inventor： ARAI TADASHI ,  MIKAMI YUZURU

IPC: A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/56 ,  C07C ,  A61K ,  C07D

CPC classification number: C07D471/18 ,  C12P17/182 ,  C12R1/465 ,  C12R1/56 ,  Y10S435/899

公开(公告)号：AU4688885A

公开(公告)日：1986-03-06

申请号：AU4688885

申请日：1985-08-29

Applicant: ARAI TADASHI

Inventor： ARAI TADASHI ,  MIKAMI YUZURU

IPC: A61K31/495 ,  C07D471/18 ,  C12P17/12

公开(公告)号：ZA8406589B

公开(公告)日：1985-10-30

申请号：ZA8406589

申请日：1984-08-23

Applicant: ARAI TADASHI

Inventor： ARAI TADASHI

IPC: C07G11/00 ,  A61K35/74 ,  A61P31/04 ,  C07H19/01 ,  C12P1/06 ,  C12P19/02 ,  C12R1/465 ,  A61K ,  C07G ,  C12P ,  C12R

CPC classification number: C12P19/02 ,  C07H19/01 ,  C12P1/06 ,  C12R1/55

Abstract: A new antibiotic, designated as neocopiamycin A, is useful as antifungal agent. Neocopiamycin A is fermentatively produced as a minor component, in addition to copiamycin, by a microorganism Streptomyces hygroscopicus var. crystallogenes (FERM BP-576) which is known to produce the known antibiotic copiamycin.