公开(公告)号：US20140275209A1

公开(公告)日：2014-09-18

申请号：US13844762

申请日：2013-03-15

Applicant: CoDa Therapeutics, Inc.

Inventor： Anthony Phillips ,  David Eisenbud ,  Scott Bannan ,  David Pool ,  Grove Matsuoka ,  Tracey Sunderland ,  Bradford Duft

IPC: C12N15/113

CPC classification number: A61K31/7088 ,  A61B5/0064 ,  A61B5/0077 ,  A61B5/1072 ,  A61B5/1079 ,  A61B5/1109 ,  A61B5/445 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/7275 ,  A61B2503/40 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/70 ,  A61K31/7105 ,  A61K47/00 ,  A61K47/10 ,  A61K47/38 ,  A61K48/00 ,  C07K14/47 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2320/35

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Abstract translation: 本发明涉及通过施用抗连接蛋白剂，特别是抗连接蛋白43反义多核苷酸治疗慢性伤口的改进的方法，用途和试剂盒。 本发明的方法，用途和试剂盒基于惊人的和意想不到的发现，即在预处理阶段期间，不增加或减少大小超过预定量的慢性伤口比成功治疗更适合于比 在预处理阶段，其大小在目标范围之外变化的伤口。

公开(公告)号：WO2013148736A1

公开(公告)日：2013-10-03

申请号：PCT/US2013/033948

申请日：2013-03-26

Applicant: CODA THERAPEUTICS, INC. ,  DUFT, Bradford, J. ,  BECKER, David, L.

Inventor： DUFT, Bradford, J. ,  BECKER, David, L.

IPC: C12N15/113 ,  A61K31/7088 ,  A61P17/02

CPC classification number: C12N15/1138 ,  A61K31/7105 ,  A61K31/713 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  A61K2300/00

Abstract: Anti-cadherin and anti-ZO-1 agents and compositions, and kits containing them for use in the promotion and/or improvement of wound healing and/or tissue repair, and for anti- scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.

Abstract translation: 抗钙粘蛋白和抗ZO-1剂和组合物，以及含有它们的用于促进和/或改善伤口愈合和/或组织修复以及用于抗瘢痕形成，抗炎，抗纤维化和抗 粘附适应症。

公开(公告)号：WO2009085272A9

公开(公告)日：2010-06-10

申请号：PCT/US2008014023

申请日：2008-12-22

Applicant: CODA THERAPEUTICS INC ,  DUFT BRADFORD J ,  GREEN COLIN R ,  BECKER DAVID L

Inventor： DUFT BRADFORD J ,  GREEN COLIN R ,  BECKER DAVID L

IPC: A61L27/22 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16

CPC classification number: A61K38/08 ,  A61K9/0051 ,  A61K38/10 ,  A61K38/385 ,  A61L17/005 ,  A61L27/54 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/432 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608

Abstract: Medical devices comprising an anti-connexin agent suitable for introduction into a subject.

Abstract translation: 包括适合引入受试者的抗连接蛋白剂的医疗装置。

公开(公告)号：WO2009085277A3

公开(公告)日：2009-11-26

申请号：PCT/US2008014028

申请日：2008-12-22

Applicant: CODA THERAPEUTICS INC ,  BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

Inventor： BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

IPC: A61K31/7088 ,  A61P17/02 ,  A61P27/02 ,  A61P43/00 ,  C12N15/113 ,  C12Q1/00

CPC classification number: A61K31/7088 ,  C12N15/1138 ,  C12N2310/11 ,  G01N33/5008

Abstract: Methods, compounds, compositions, kits and articles of manufacture comprising anti- connexin polynucleotides for prevention and/or treatment of abnormal scars, including keloid scars, hypertrophic scars, atrophic scars, and widespread scars.

Abstract translation: 包括用于预防和/或治疗异常瘢痕的抗连接蛋白多核苷酸的方法，化合物，组合物，试剂盒和制品，包括瘢痕疙瘩，肥大性瘢痕，萎缩性瘢痕和广泛的瘢痕。

公开(公告)号：WO2009085277A2

公开(公告)日：2009-07-09

申请号：PCT/US2008/014028

申请日：2008-12-22

Applicant: CODA THERAPEUTICS, INC. ,  BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

Inventor： BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

IPC: A61K48/00

CPC classification number: A61K31/7088 ,  C12N15/1138 ,  C12N2310/11 ,  G01N33/5008

Abstract: Methods, compounds, compositions, kits and articles of manufacture comprising anti- connexin polynucleotides for prevention and/or treatment of abnormal scars, including keloid scars, hypertrophic scars, atrophic scars, and widespread scars.

Abstract translation: 包括用于预防和/或治疗异常瘢痕的抗连接蛋白多核苷酸的方法，化合物，组合物，试剂盒和制品，包括瘢痕疙瘩，肥大性瘢痕，萎缩性瘢痕和广泛的瘢痕。

公开(公告)号：WO2009085275A2

公开(公告)日：2009-07-09

申请号：PCT/US2008014026

申请日：2008-12-22

Applicant: CODA THERAPEUTICS INC ,  DUFT BRADFORD J

Inventor： DUFT BRADFORD J

IPC: A61K48/00 ,  C12N15/113

CPC classification number: C12N15/1138 ,  A61K38/177 ,  C12N2310/11 ,  A61K2300/00

Abstract: Compositions, articles, devices and methods for the treatment of fibrosis and fibrotic diseases, disorders, and conditions in humans and non-human animals.

Abstract translation: 用于治疗人和非人动物中的纤维化和纤维化疾病，病症和病症的组合物，制品，装置和方法。

公开(公告)号：WO2009085273A3

公开(公告)日：2009-07-09

申请号：PCT/US2008/014024

申请日：2008-12-22

Applicant: CODA THERAPEUTICS, INC. ,  BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

Inventor： BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

IPC: C12N15/11 ,  A61K9/00 ,  A61L24/00 ,  A61P41/00

Abstract: Connexin modulation for the treatment of surgical adhesions, and associated methods, compositions, and articles.

公开(公告)号：WO2009085272A2

公开(公告)日：2009-07-09

申请号：PCT/US2008/014023

申请日：2008-12-22

Applicant: CODA THERAPEUTICS, INC. ,  DUFT, Bradford, J. ,  GREEN, Colin, R. ,  BECKER, David, L.

Inventor： DUFT, Bradford, J. ,  GREEN, Colin, R. ,  BECKER, David, L.

IPC: A61L27/22 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16

CPC classification number: A61K38/08 ,  A61K9/0051 ,  A61K38/10 ,  A61K38/385 ,  A61L17/005 ,  A61L27/54 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/432 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608

Abstract: Medical devices comprising an anti-connexin agent suitable for introduction into a subject.

Abstract translation: 包括适合引入受试者的抗连接蛋白剂的医疗装置。

公开(公告)号：WO2009085269A3

公开(公告)日：2009-07-09

申请号：PCT/US2008/014020

申请日：2008-12-22

Applicant: CODA THERAPEUTICS, INC. ,  BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

Inventor： BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

IPC: C12N15/11 ,  A61K38/17 ,  A61K39/395 ,  A61P41/00

Abstract: Methods, compounds, compositions, kits and articles of manufacture comprising anti- connexin agents for treatment of orthopedic disorder, disease, or condition, and promoting post-surgical wound-healing.

公开(公告)号：WO2008060622A9

公开(公告)日：2008-11-27

申请号：PCT/US2007024085

申请日：2007-11-15

Applicant: CODA THERAPEUTICS INC ,  GREEN COLIN R ,  DUFT BRADFORD J ,  BECKER DAVID L

Inventor： GREEN COLIN R ,  DUFT BRADFORD J ,  BECKER DAVID L

IPC: A61K38/18 ,  A61K31/711

CPC classification number: A61K31/711 ,  A61K35/33 ,  A61K35/36 ,  A61K38/1754 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K45/06 ,  C12N15/1138 ,  C12N2310/11 ,  A61K2300/00

Abstract: Methods and compositions comprising combinations of one or more anti-connexin agents and one or more other agents useful for the promotion and/or improvement of wound healing and/or tissue repair.