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    41.
    发明专利
    未知

    公开(公告)号：DE69212998D1

    公开(公告)日：1996-09-26

    申请号：DE69212998

    申请日：1992-03-13

    Applicant: DADE CHEMISTRY SYSTEMS INC

    Inventor： BUSSIAN RONALD WAYNE ,  RUGLASS JOHN ARTHUR

    IPC: C12Q1/32

    Abstract: The invention is drawn to a diagnostic assay for lactate dehydrogenase isoenzyme LD1 in a sample containing lactate dehydrogenase isoenzymes LD1-LD5. The disclosed assay involves the following steps: (A) adding a high molecular weight polyol, preferably polyethylene glycol having a molecular weight of 8000, to the sample to stabilize isoenzyme LD1 but not isoenzymes LD2-LD5; (B) adding an ionic amphiphile to the sample to selectively inactivate isoenzymes LD2-LD5; (C) adding sodium lactate and NAD to the sample; (D) determining LD1 by measuring a change in absorbance of the sample at 340 mm.

    PREPARATION OF IMMUNOGENS AND OTHER CONJUGATES OF DRUGS
    46.
    发明公开
    PREPARATION OF IMMUNOGENS AND OTHER CONJUGATES OF DRUGS 失效
    工艺用于生产和其它免疫原性药物结合

    公开(公告)号：EP0775128A1

    公开(公告)日：1997-05-28

    申请号：EP96919306.0

    申请日：1996-06-07

    Applicant: Dade Chemistry Systems Inc.

    Inventor： LAU, Hon-Peng, Phillip

    IPC: G01N33 ,  A61K47 ,  C07D213 ,  C07D215 ,  C07D223 ,  C07D295 ,  C07K17

    CPC classification number: C07D295/13 ,  A61K47/646 ,  C07D295/15

    Abstract: The invention provides a reactive derivative of dialkyl amino compounds, particularly dialkyl amino drugs, for facilitating the conjugation of the drug, directly or through a bifunctional spacer, to a carrier compound such as proteinaceous materials. The derivative has formula (a) wherein D is the drug and n is an integer greater than 1, and preferably equal to 2. The drug derivative carrier conjugate can be used as an immunogen for production of antibodies specific to the drug. Additionally, the conjugate can be coupled to a solid support, such as a polymer particle, for use as a particle reagent in immunoassays specific to the drug.

    METHOD FOR SPECIFIC BINDING ASSAYS USING A RELEASABLE LIGAND
    48.
    发明授权
    METHOD FOR SPECIFIC BINDING ASSAYS USING A RELEASABLE LIGAND 失效
    程序使用可释放配体特异性结合测定

    公开(公告)号：EP0579676B1

    公开(公告)日：1996-10-30

    申请号：EP92908269.1

    申请日：1992-03-12

    Applicant: Dade Chemistry Systems Inc.

    Inventor： OBZANSKY, David, Michael ,  SIMONS, Donald, Max ,  TSENG, Susan, Yen-Tee

    IPC: G01N33/543

    CPC classification number: G01N33/54306

    Abstract: Immunoassays and DNA probe assays utilizing a non-immune, reversible binding displacement system are provided. In the assay, a releasable ligand, a binding partner for the releasable ligand, an analyte of interest, an analytically detectable (reporter) group, and at least one binding partner for the analyte, are first attached to an insoluble phase so as to form reporter-labeled complex bound to an insoluble phase, followed by the addition of a displacer ligand which displaces the releasable ligand along with some portion of the reporter-labeled complex, so that the released reporter is analytically detectable in a free liquid medium and can be related to the concentration of analyte in the sample.

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