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公开(公告)号：US20230321103A1
公开(公告)日：2023-10-12
申请号：US18043419
申请日：2021-09-01
Inventor： Honglin LI , Zhenjiang ZHAO , Yanyan DIAO , Zhuo CHEN
IPC: A61K31/519
CPC classification number: A61K31/519
Abstract: Provided is the use of a series of pteridinones and/or a pharmaceutically acceptable salt and a prodrug thereof as a non-canonical EGFR mutant inhibitor. Specifically, the present invention relates to the use of a series of compounds as represented by formula I and a pharmaceutical composition containing the series of compounds as represented by formula I in the preparation of a drug for treating a disease containing EGFR 20insX mutation, EGFR G719X mutation and ERBB2 mutation.
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42.发明公开公开(公告)号：US20230250501A1
公开(公告)日：2023-08-10
申请号：US18015503
申请日：2020-09-30
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , AVIC MANUFACTURING TECHNOLOGY INSTITUTE
Inventor： Xiancheng ZHANG , Zhiqiang LI , Shuang LIU , Xiaoning HAN , Shulei YAO , Congyang GONG , Lin ZHU , Kaiming ZHANG , Shantung TU
Abstract: The application relates to a robot machining system and control method for ultrasonic surface rolling process of an aircraft engine blade. The robot machining system includes: a robot, to which an ultrasonic surface rolling process device is fixed, the robot drives the ultrasonic surface rolling process device to move; a base provided with a spindle turntable and a three-dimensional mobile lifting device, the spindle turntable being provided with a rotatable blade clamp, and a flexible follow-up support head being fixed to the three-dimensional mobile lifting device; and a control system, which is in electrical connection or communication connection with the robot, the spindle turntable and the three-dimensional mobile lifting device, respectively. According to the application, the robot assists in clamping ultrasonic rolling device and cooperates with the three-dimensional mobile lifting device and the flexible follow-up support head, such that the accurate ultrasonic surface rolling process of blade is realized.
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43.发明公开公开(公告)号：US20230228696A1
公开(公告)日：2023-07-20
申请号：US17951411
申请日：2022-09-23
Inventor： Shenlin Wang , Sha Zhao
IPC: G01N24/08
CPC classification number: G01N24/087
Abstract: An experimental technology for detecting a hydrogen bond based on an ssNMR technology includes: (1) exciting a 1H nucleus of an RNA sample with a π/2 pulse; (2) applying two π pulses every half rotation period on an X_nucleus of the RNA sample; (3) applying a π pulse on the 1H nucleus of the RNA sample; (4) applying two π pulses every half rotation period on the X nucleus of the RNA sample; (5) applying a 90° pulse on 1H and X atoms of the RNA sample; (6) recording a chemical shift of X in indirect dimension; (7) applying the 90° pulse on the 1H and X nuclei of the RNA sample; (8) repeating steps 2, 3, and 4; and (9) collecting the 1H signal in direct dimension; where X is selected from the group consisting of 15N and 13C.
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公开(公告)号：US20230190713A1
公开(公告)日：2023-06-22
申请号：US17905629
申请日：2021-03-02
Inventor： Honglin LI , Ke XU , Shiliang LI , Lili ZHU , Zhenjiang ZHAO
IPC: A61K31/426 , A61P31/14 , A61P31/16 , A61K31/513 , A61K31/427 , A61K31/7056 , A61K31/675 , A61K31/215 , A61K31/351 , A61K31/19 , A61K31/4706
CPC classification number: A61K31/426 , A61K31/19 , A61K31/215 , A61K31/351 , A61K31/427 , A61K31/513 , A61K31/675 , A61K31/4706 , A61K31/7056 , A61P31/14 , A61P31/16
Abstract: An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection.
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公开(公告)号：US20230141978A1
公开(公告)日：2023-05-11
申请号：US17794801
申请日：2020-07-18
Inventor： Zejian Wang , Daqi Gao , Bo Li , Xiaoqin Zhang , Fang Cai , Jianhua Li , Mingjian Cheng
CPC classification number: G01N30/88 , G01N33/0032 , G01N33/0034 , G01N33/0062 , G06N3/045 , G01N2030/8804 , G01N2030/8809
Abstract: Provided is a method for multi-information fusion of gas sensitivity and chromatography and on-site detection and analysis of flavor substances using an electronic nose instrument. The electronic nose instrument includes a gas sensor array module (I), a capillary gas chromatographic column module (II), an automatic headspace sampling module (III), a computer control and data analysis module (IV), an automatic lifter (V) for headspace sampling, a large-volume headspace vapor generation device (VI) and two auxiliary gas sources (VII-1, VII-2). The electronic nose instrument detects a large number of odorous samples to establish a big odor data. On this basis, the normalization fusion preprocessing is done, and the cascade machine learning model realizes both an on-site recognition of many foods, condiments, fragrances and flavors, and petroleum waxes and a real-time quantitative prediction of their odor quality grades and many key component concentrations.
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Patent Agency Ranking
公开(公告)号：US11590109B2
公开(公告)日：2023-02-28
申请号：US16306465
申请日：2017-06-02
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
Inventor： Ke Xu , Honglin Li , Yufang Xu , Zhenjiang Zhao , Lili Zhu , Wenlin Song , Yi Tong
IPC: A61K31/426 , A61P31/12 , C07D277/50
Abstract: Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection:
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公开(公告)号：US11555860B2
公开(公告)日：2023-01-17
申请号：US17301894
申请日：2021-04-19
Inventor： Weiling Luan , Ying Chen , Senming Wu , Haofeng Chen
IPC: G01R31/00 , G01R31/392 , H01M10/04 , H01M10/0525 , H01M10/0569 , H01M10/42
Abstract: A method for testing a mechanical performance of a lithium ion battery electrode based on a nano-indentation technology includes following steps: connecting an assembled lithium ion battery with an electrochemical test device and setting different test working conditions, so that cyclic charge and discharge experiments are performed on the battery to obtain an attenuation curve of a battery capacity; disassembling the battery and taking out the electrode; scraping some powder from a surface of the cyclic electrode plate and an initial uncyclic electrode plate, and laying down the powder in cold mounting molds separately, pouring the cold mounting solution into the molds; taking out the samples from the molds respectively after the liquid is completely cured and cooled; detecting a mechanical performance after polishing the samples surfaces and analyzing the mechanical performance decay rule of the electrodes.
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公开(公告)号：US20220335443A1
公开(公告)日：2022-10-20
申请号：US17311378
申请日：2020-10-12
Inventor： Weihong Zhu , Zhigang Zheng , Huijun Li , Honglong HU
Abstract: The present disclosure discloses a novel multi-stable and erasable anti-counterfeiting technology with controlled reflection color and the application thereof in optical coding. The method and use are characterized by high thermal stability and robust fatigue resistance, and the realization thereof relies on the material system composed of an intrinsic chiral diarylethene molecule based on steric hindrance ethene bridge and a liquid crystal (LC) material disclosed herein. The diarylethene based on steric hindrance ethene bridge has the following structural feature: The material system composed of a diarylethene compound based on steric hindrance ethene bridge and an LC can be prepared by a simple preparation process from cheap raw materials, can achieve a wide spectral color adjustment range, and has excellent thermal stability and fatigue resistance, which is expected to be further widely used in the fields of dual erasable anti-counterfeiting and optical information encoding with high thermal stability and strong fatigue resistance.
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公开(公告)号：US11274988B2
公开(公告)日：2022-03-15
申请号：US16236399
申请日：2018-12-29
Inventor： Fuzhen Xuan
Abstract: The disclosure relates to a dual-criterion diagram for designing and assessing the life and strength of high-temperature rotating components and its establishment. In addition, the disclosure relates to a method for designing and assessing the life and strength of high-temperature rotating components based on the dual-criterion diagram for designing and assessing the life and strength of high-temperature rotating components. The advantages of the disclosure include a simple design and assessment process, high operability, and reliable assessment results. The invention is expected to be applied finally to assessment and evaluation of high-cycle fatigue life of rotating components at high temperatures.
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公开(公告)号：US11001866B2
公开(公告)日：2021-05-11
申请号：US16620529
申请日：2017-10-25
Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A strain of Burkholderia is Burkholderia glathei ECU0712, with an accession number of CGMCC NO. 14464. With the strain or its extract as the biocatalyst, thioether is catalyzed to be oxidized asymmetrically to chiral sulfoxide, with significant advantages that the obtained product has a high optical purity, and benefits of a simple reaction system, short preparation time of the catalyst and a high yield of the product.
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