INHIBITORS OF 5-ALPHA-TESTOSTERONE REDUCTASE
    42.
    发明公开
    INHIBITORS OF 5-ALPHA-TESTOSTERONE REDUCTASE 失效
    睾酮5-α还原酶抑制剂。

    公开(公告)号:EP0641356A1

    公开(公告)日:1995-03-08

    申请号:EP93902691.0

    申请日:1992-12-18

    Applicant: GLAXO INC.

    CPC classification number: C07J73/005

    Abstract: The present invention relates to certain substituted 17β-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), especially those of formula (IG) wherein R?1 and R1¿ are: i) independently hydrogen or lower alkyl and the bond between the carbons bearing R?1 and R2¿ is a single or a double bond, or ii) taken together are a -CH¿2?- group to form a cyclopropane ring, and the bond between the carbons bearing R?1 and R2¿ is a single bond; R3c is hydrogen; R4c is hydrogen, lower alkyl, lower cycloalkyl, lower alkenyl, alkanoyl of 2-6 carbons, -(CH¿2?)mCO2R?16¿, -(CH¿2)mAr?a, -(CH¿2?)n'CONR?17R18¿, -(CH¿2?)n'NR?17R18¿ or -(CH¿2?)n'OR?16¿, wherein R16 is hydrogen, lower alkyl or lower alkenyl; R?17 and R18¿ are independly hydrogen, lower alkyl lower cycloalkyl or lower alkenyl; Ara is an aromatic group of 6 to 12 carbons; n' is 0 or an integer from 1 to 5; m is an integer from 1 to 5; R?19 and R20¿ are independently hydrogen or lower alkyl, or taken together R?19 and R20¿ form a carbonyl group(=O); R5c is lower alkyl, lower alkenyl, lower cycloalkyl, lower alkoxy, or NR21R22, wherein R?21 and R22¿ are independently hydrogen, lower alkyl or lower alkenyl; and pharmaceutically acceptable salts thereof, their preparation, medical use and pharmaceutical formulations.

    AEROSOL DRUG FORMULATIONS
    43.
    发明公开
    AEROSOL DRUG FORMULATIONS 失效
    气雾剂药物配方。

    公开(公告)号:EP0536250A1

    公开(公告)日:1993-04-14

    申请号:EP91912299.0

    申请日:1991-06-27

    Applicant: GLAXO INC.

    CPC classification number: A61K9/008

    Abstract: Compositions en aérosol comprenant un médicament d'inhalation, 1,1,1,2-tétrafluoroéthane (P134a) ainsi qu'un agent actif de surface soluble dans du 1,1,1,2-tétrafluoroéthane.

    SEQUENTIAL DOSING OF ANTIFUNGAL AND ANTIINFLAMMATORY COMPOSITIONS
    50.
    发明公开
    SEQUENTIAL DOSING OF ANTIFUNGAL AND ANTIINFLAMMATORY COMPOSITIONS 失效
    顺序给药抗真菌和抗炎组合物

    公开(公告)号:EP0577760A1

    公开(公告)日:1994-01-12

    申请号:EP92910796.0

    申请日:1992-03-09

    Applicant: GLAXO INC.

    Abstract: Médicament à dosage séquentiel pour le traitement topique d'infections fongiques qui comprend une première composition pharmaceutique contenant un agent antifongique et un agent anti-inflammatoire, par ex. un stéroïde, et une seconde composition pharmaceutique séparée contenant uniquement un agent antifongique en tant que substance active. Un procédé pour ledit dosage séquentiel, utilisant en particulier l'oxiconazole comme agent antifongique et le fluticasone comme stéroïde, est également décrit.

    Abstract translation: 用于局部治疗真菌感染的序贯剂量药物,其包含含有抗真菌剂和抗炎剂例如抗炎剂的第一药物组合物。 类固醇以及仅含有抗真菌剂作为活性物质的第二种分开的药物组合物。 还描述了用于所述顺序测定的方法,特别是使用奥昔康唑作为抗真菌剂和氟替卡松作为类固醇。

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