公开(公告)号：US10376497B2

公开(公告)日：2019-08-13

申请号：US15492828

申请日：2017-04-20

Applicant: INTERMUNE, INC.

Inventor： Brad O. Buckman ,  John Beamond Nicholas ,  Johnnie Y. Ramphal ,  Kumaraswamy Emayan ,  Scott D. Seiwert

IPC: C07D213/02 ,  A61K31/437 ,  C07D513/04 ,  C07D495/04 ,  C07D211/86 ,  C07D401/04 ,  C07D221/04 ,  C07D471/04 ,  C07D498/04 ,  C07D295/125 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D223/10 ,  C07D405/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D213/64 ,  C07D217/24 ,  A61K9/00

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US20190183872A1

公开(公告)日：2019-06-20

申请号：US16283270

申请日：2019-02-22

Applicant: INTERMUNE, INC.

Inventor： Williamson Z. Bradford ,  Javier Szwarcberg

IPC: A61K31/4418 ,  A61K45/06 ,  A61K31/44 ,  A61K31/135 ,  A61K36/752 ,  A61K31/15

CPC classification number: A61K31/4418 ,  A61K31/135 ,  A61K31/15 ,  A61K31/44 ,  A61K36/752 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/475

Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.

公开(公告)号：US20190144467A1

公开(公告)日：2019-05-16

申请号：US16249024

申请日：2019-01-16

Applicant: INTERMUNE, INC.

Inventor： Johnnie Y. Ramphal ,  Brad Owen Buckman ,  Kumaraswamy Emayan ,  John Beamond Nicholas ,  Scott D. Seiwert

IPC: C07D498/04 ,  C07D487/04 ,  C07C25/18 ,  C07D413/02 ,  C07D417/10 ,  C07D213/69 ,  C07D213/64 ,  C07D417/12 ,  C07D417/04 ,  C07D413/04 ,  C07D405/04 ,  C07D401/12 ,  C07D401/04 ,  C07D213/75 ,  C07D213/74 ,  C07D405/14 ,  C07D401/14 ,  C07D211/76 ,  C07D513/04 ,  C07D209/34 ,  C07D495/04 ,  C07D471/04 ,  C07C225/20 ,  C07D221/04 ,  C07D405/02

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US20190000821A1

公开(公告)日：2019-01-03

申请号：US16125299

申请日：2018-09-07

Applicant: INTERMUNE, INC.

Inventor： Williamson Z. Bradford

IPC: A61K31/4418 ,  A61K31/4412 ,  A61J1/03

Abstract: The invention relates to methods for decreasing adverse events associated with pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) therapy. The invention discloses an optimized dose escalation scheme that results in the patient having increased tolerance to adverse events associated with the administration of pirfenidone. The invention also discloses a starter pack that may be used in conjunction with the dose escalation scheme.

公开(公告)号：US10010536B2

公开(公告)日：2018-07-03

申请号：US15387537

申请日：2016-12-21

Applicant: InterMune, Inc.

Inventor： Lawrence M. Blatt ,  Scott D. Seiwert ,  Leonid D. Beigelman ,  Ramachandran Radhakrishnan ,  Karl Kossen ,  Vladimir Serebryany

IPC: A61K31/4412 ,  A61K31/44 ,  A61K31/444

CPC classification number: A61K31/4412 ,  A61K31/44 ,  A61K31/444 ,  A61K31/45 ,  A61K31/4704 ,  A61K31/7052 ,  A61K47/56 ,  A61K47/58 ,  C07D213/16 ,  C07D213/26 ,  C07D213/63 ,  C07D213/64 ,  C07D213/69 ,  C07D215/227 ,  C07H15/26 ,  C07K1/1077 ,  C08F289/00 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/475

Abstract: Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

公开(公告)号：US20170314074A1

公开(公告)日：2017-11-02

申请号：US15351719

申请日：2016-11-15

Applicant: Intermune, Inc.

Inventor： Karl Kossen ,  Sharlene R. Lim ,  Scott D. Seiwert ,  Donald Ruhrmund

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  A61K31/7088 ,  A61K45/06 ,  C12Q2600/118 ,  C12Q2600/158 ,  G16B99/00 ,  Y02A50/411 ,  Y02A90/24 ,  Y02A90/26

Abstract: Provided herein are, inter alia, methods and biomarkers to determine if a patient has or is at risk for developing an LPA-associated disease, to indicate the progressiveness of the disease, and/or to facilitate evaluation of responsiveness to therapy. Compositions and kits including the biomarker proteins and biomarker RNAs provided herein are further provided.

公开(公告)号：US09726677B2

公开(公告)日：2017-08-08

申请号：US14213970

申请日：2014-03-14

Applicant: Intermune, Inc.

Inventor： Karl Kossen ,  Xiaoli Qin ,  Sharlene R. Lim ,  Scott S. Seiwert ,  Donald Ruhrmund

IPC: A61K38/44 ,  G01N33/68 ,  C12Q1/68

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/6854 ,  G01N2800/12

Abstract: Provided herein are novel biomarkers for the identification, prediction or monitoring of fibrotic pulmonary diseases (e.g. idiopathic pulmonary fibrosis (IPF)). The biomarkers provided herein may further be used for therapeutic treatment of IPF.

公开(公告)号：US09675593B2

公开(公告)日：2017-06-13

申请号：US15162214

申请日：2016-05-23

Applicant: InterMune, Inc.

Inventor： Brad Owen Buckman ,  John Beamond Nicholas ,  Johnnie Y. Ramphal ,  Kumaraswamy Emayan ,  Scott D. Seiwert

IPC: A61K31/437 ,  C07D513/04 ,  C07D495/04 ,  C07D211/86 ,  C07D401/04 ,  C07D221/04 ,  C07D471/04 ,  C07D498/04 ,  C07D295/125 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D223/10 ,  C07D405/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D213/64 ,  C07D217/24 ,  A61K9/00

CPC classification number: A61K31/437 ,  A61K9/007 ,  C07D211/86 ,  C07D213/64 ,  C07D217/24 ,  C07D221/04 ,  C07D223/10 ,  C07D295/125 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

公开(公告)号：US20170128429A1

公开(公告)日：2017-05-11

申请号：US15412923

申请日：2017-01-23

Applicant: INTERMUNE, INC.

Inventor： Williamson Z. Bradford ,  Javier Szwarcberg

IPC: A61K31/4418 ,  A61K31/15 ,  A61K36/752 ,  A61K45/06

CPC classification number: A61K31/4418 ,  A61K31/135 ,  A61K31/15 ,  A61K31/44 ,  A61K36/752 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/475

Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.

公开(公告)号：US09359379B2

公开(公告)日：2016-06-07

申请号：US14043121

申请日：2013-10-01

Applicant: InterMune, Inc.

Inventor： Brad Owen Buckman ,  John Beamond Nicholas ,  Johnnie Y. Ramphal ,  Kumaraswamy Emayan ,  Scott D. Seiwert

IPC: C07D401/14 ,  A61K31/437 ,  C07D513/04 ,  C07D495/04 ,  C07D211/86 ,  C07D401/04 ,  C07D221/04 ,  C07D471/04 ,  C07D498/04 ,  C07D295/125 ,  C07D405/14 ,  C07D413/14 ,  C07D223/10 ,  C07D405/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D213/64 ,  C07D217/24

CPC classification number: A61K31/437 ,  A61K9/007 ,  C07D211/86 ,  C07D213/64 ,  C07D217/24 ,  C07D221/04 ,  C07D223/10 ,  C07D295/125 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

Abstract translation: 公开了吡啶酮化合物，这些化合物的制备方法和治疗纤维化疾病的方法。