公开(公告)号：WO2009116696A1

公开(公告)日：2009-09-24

申请号：PCT/KR2008/001628

申请日：2008-03-21

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  JEUNG, Jong-Man ,  KIM, Youn-Joong

Inventor： JEUNG, Jong-Man ,  KIM, Youn-Joong

IPC: G01N1/28 ,  H01L21/66

CPC classification number: G01N1/42 ,  G01K1/14 ,  G01K2203/00 ,  H01J37/20 ,  H01J37/26 ,  H01J2237/2001 ,  H01J2237/2065

Abstract: The present invention relates to an apparatus for measuring the temperature of a cryo EM- holder specimen cradle used in a transmission electron microscope (TEM) and a method for measuring the temperature thereof using the same. The apparatus for measuring the temperature of a cryo EM-holder specimen cradle can measure an exact temperature by directly measuring the temperature of the cryo EM-holder specimen cradle used in a transmission electron microscope (TEM), as well as perform an experiment on the cryo EM-holder in the vacuum state as the inside of the TEM, and a method for measuring the temperature thereof using the same.

Abstract translation: 本发明涉及一种用于测量透射电子显微镜（TEM）中使用的低温EM支架样本支架的温度的装置和使用其的测量其温度的方法。 用于测量冷冻EM支架样品支架的温度的装置可以通过直接测量透射电子显微镜（TEM）中使用的低温EM支架样品支架的温度来测量精确温度，以及对 作为TEM的内部的真空状态的低温EM-保持器以及使用其的温度的测定方法。

公开(公告)号：WO2009035208A1

公开(公告)日：2009-03-19

申请号：PCT/KR2008/003591

申请日：2008-06-24

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  MOON, Won Jin ,  PARK, Byung Kyu ,  KIM, Youn Joong ,  LEE, Jee Young ,  LEE, Sang Hee ,  BAE, Dong Sik

Inventor： MOON, Won Jin ,  PARK, Byung Kyu ,  KIM, Youn Joong ,  LEE, Jee Young ,  LEE, Sang Hee ,  BAE, Dong Sik

IPC: G01N1/28 ,  G01N23/22

CPC classification number: H01J37/20 ,  G01N23/046 ,  G01N2223/419 ,  H01J37/26 ,  H01J2237/20292 ,  H01J2237/204 ,  H01J2237/226 ,  H01J2237/2611 ,  H01J2237/2617

Abstract: Disclosed is a moon grid for transmission electron microscopy tomography, including a mesh sheet for protecting an upper objects and a support film formed on the mesh sheet and having nanoparticles dispersed throughout, in which the nanoparticles dispersed throughout the support film are used as reference points in the reconstruction of two-dimensional transmission electron microscopy images into a three-dimensional image, thus omitting a process of attaching markers in the course of preparation of a sample and easily forming reference points even on a sample to which it is impossible to attach markers. A method of fabricating such a moon grid is also provided.

Abstract translation: 公开了一种用于透射电子显微镜断层摄影的月球网格，包括用于保护上部物体的网片和形成在网片上的支撑膜，并且具有分散在其中的纳米颗粒，其中分散在整个支撑膜上的纳米颗粒用作参考点 将二维透射电子显微镜图像重建成三维图像，因此省略了在样品制备过程中附着标记的过程，并且即使在不可能附着标记的样品上也容易形成参考点。 还提供了一种制造这种月球栅格的方法。

公开(公告)号：WO2008140150A1

公开(公告)日：2008-11-20

申请号：PCT/KR2007/003576

申请日：2007-07-25

Applicant: FOOD SCIENCE CO., LTD. ,  KOREA BASIC SCIENCE INSTITUTE ,  KIM, Hwa-Jin ,  RYU, Do-Hyun ,  HWANG, Geum-Sook ,  KIM, Kun-Hong ,  PARK, Jin-Hyun ,  KIM, Kyung-Hwa ,  SIM, Jae-Yi ,  LEE, Mi-Young

Inventor： KIM, Hwa-Jin ,  RYU, Do-Hyun ,  HWANG, Geum-Sook ,  KIM, Kun-Hong ,  PARK, Jin-Hyun ,  KIM, Kyung-Hwa ,  SIM, Jae-Yi ,  LEE, Mi-Young

IPC: C07D307/93 ,  C07D307/77 ,  C07D493/10

CPC classification number: C07D307/93 ,  C07D493/10 ,  C07D519/00

Abstract: The present invention relates to novel octahydro indeno derivatives, pharmaceutically acceptable salts, hydrates, solvates and stereoisomers thereof, and pharmaceutical compositions for treating or preventing cancer comprising the same. Since the compounds according to the present invention have high cytotoxicity against cancer cells, they may be usefully used as medical uses such as anticancer agents or antibiotics.

Abstract translation: 本发明涉及新颖的八氢茚并衍生物，其药学上可接受的盐，水合物，溶剂化物和立体异构体，以及用于治疗或预防包含其的癌症的药物组合物。 由于根据本发明的化合物对癌细胞具有高的细胞毒性，所以它们可以有用地用作抗癌剂或抗生素等医疗用途。

公开(公告)号：WO2008056891A1

公开(公告)日：2008-05-15

申请号：PCT/KR2007/004971

申请日：2007-10-11

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  KIM, Hae Jin ,  LEE, Jin Bae ,  LEE, Soon Chang

Inventor： KIM, Hae Jin ,  LEE, Jin Bae ,  LEE, Soon Chang

IPC: B82B3/00

CPC classification number: H01M4/485 ,  C01B3/001 ,  C01B33/12 ,  C01B33/18 ,  C04B35/14 ,  C04B35/62227 ,  C04B35/6224 ,  H01M8/04216 ,  Y02E60/324 ,  Y02P70/56

Abstract: Disclosed herein are a method of preparing Li-doped silica nanotubes using an anodic aluminum oxide (AAO) template, and a method of storing energy using the prepared Li-doped silica nanotubes. Unlike prior methods for preparing metal nanotubes, according to the disclosed preparation method, the Li-doped silica nanotubes having a uniform size can be easily obtained in mild conditions using a lithium precursor, a silica sol and an anodic aluminum oxide template. The preparation method comprises adsorbing the lithium precursor and the silica sol on the surface of the AAO template, drying the lithium precursor and the silica sol, adsorbed onto the AAO template, in a vacuum, to form nanotubes, and then drying the nanotubes. The Li-doped silica nanotubes prepared according to the disclosed method can be used as economical hydrogen storage materials, electrode materials for lithium secondary batteries, or energy storage sources for automobiles or other transportation means.

Abstract translation: 本文公开了使用阳极氧化铝（AAO）模板制备掺杂锂的二氧化硅纳米管的方法，以及使用制备的Li掺杂的二氧化硅纳米管来储存能量的方法。 与现有的制备金属纳米管的方法不同，根据所公开的制备方法，可以使用锂前体，二氧化硅溶胶和阳极氧化铝模板在温和条件下容易地获得具有均匀尺寸的Li掺杂二氧化硅纳米管。 该制备方法包括将锂前体和二氧化硅溶胶吸附在AAO模板的表面上，在真空中干燥吸附在AAO模板上的锂前体和二氧化硅溶胶，形成纳米管，然后干燥纳米管。 根据所公开的方法制备的掺杂Li的二氧化硅纳米管可以用作经济的储氢材料，锂二次电池的电极材料，或用于汽车或其他运输工具的储能源。

公开(公告)号：WO2007139244A1

公开(公告)日：2007-12-06

申请号：PCT/KR2006/002087

申请日：2006-05-30

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  LEE, Ha Jin ,  LEE, Haeseong ,  NGUYEN, Tinh

Inventor： LEE, Ha Jin ,  LEE, Haeseong ,  NGUYEN, Tinh

IPC: C01B31/02 ,  B82B3/00

CPC classification number: B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C01B2202/02 ,  C01B2202/06 ,  C01B2202/28

Abstract: Disclosed is a carbon nanotube having a modified surface through transition metal coordination. The carbon nanotube includes a carbon nanotube having a surface where a π-electron exists, and a transition metal ion being coordinate-bonded by electron -sharing of the π-electron existing in the surface of the carbon nanotube. A carbon nanotube further includes an organic material coordinate-bonded to the transition metal ion. A method of manufacturing the carbon nanotube is also disclosed.

Abstract translation: 公开了具有通过过渡金属配位的改性表面的碳纳米管。 碳纳米管包括具有p电子存在的表面的碳纳米管和通过存在于碳纳米管表面的p电子的电子共享来配位的过渡金属离子。 碳纳米管还包括与过渡金属离子配位键合的有机材料。 还公开了制造碳纳米管的方法。

公开(公告)号：WO2005075993A1

公开(公告)日：2005-08-18

申请号：PCT/KR2004/000256

申请日：2004-02-10

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  AHN, Yeong Hee ,  YOO, Jong Shin ,  KIM, Jin Young ,  CHO, Kun

Inventor： AHN, Yeong Hee ,  YOO, Jong Shin ,  KIM, Jin Young ,  CHO, Kun

IPC: G01N33/53

CPC classification number: G01N33/6848 ,  A61K31/155 ,  G01N33/6803 ,  G01N33/6842 ,  G01N2458/15

Abstract: Disclosed is a method of analyzing mass of the phosphoproteins or phosphopeptides and of analyzing phosphorylated positions at a phosphoprotein or phosphopeptide, comprising the steps of: 1) dephosphorylating at least one Ser and/or Thr residue of the phosphoprotein or phosphopeptide; 2) tagging the dephosphorylated amino acid residues with a tag having a R-L-G moiety wherein R is a nucleophilic functional group that selectively bind with dephosphorylated amino acid residues, G is selected from the group consisting of guanidine moiety or protected guanidine moiety such as a mono-N-protected guanidino group, a di-N,N'-protected guanidino group and an N'-protected guanidino group, and L is a linker linking the R and the G; and 3) subjecting the tagged proteins or peptides to mass spectrometry. The method is capable of precisely analyzing mass of phosphoproteins of trace amounts as well as positions of phosphoryated amino acids.

Abstract translation: 公开了一种分析磷蛋白或磷酸肽的质量并分析磷蛋白或磷酸肽的磷酸化位置的方法，包括以下步骤：1）使磷酸蛋白或磷酸肽的至少一个Ser和/或Thr残基去磷酸化; 2）用具有RLG部分的标签标记去磷酸化的氨基酸残基，其中R是与去磷酸化的氨基酸残基选择性结合的亲核官能团，G选自胍部分或被保护的胍部分，例如单 - N-保护的胍基，二-N，N'保护的胍基和N'保护的胍基，L是连接R和G的连接基团; 和3）对标记的蛋白质或肽进行质谱分析。 该方法能够精确分析痕量的磷蛋白质量以及磷酸化氨基酸的位置。

公开(公告)号：WO2003104775A1

公开(公告)日：2003-12-18

申请号：PCT/KR2002/001659

申请日：2002-09-02

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  HA, Kwon, Soo ,  YUK, Jong, Seol ,  YI, Sun, Ju ,  LEE, Hyeon, Gon ,  KWON, Kyung, Hoon

Inventor： HA, Kwon, Soo ,  YUK, Jong, Seol ,  YI, Sun, Ju ,  LEE, Hyeon, Gon ,  KWON, Kyung, Hoon

IPC: G01N21/25

CPC classification number: G01N21/553

Abstract: The present invention provides a method for protein chip analysis by using surface plasmon resonance spectroscopic image technology. A protein chip with a plurality of spots, arranged at a specific interval in vertical and horizontal directions, is mounted on a x-y stage, and p-polarized beams that passed through a prism are sequentially irradiated on each spot of the protein chip. The light signal reflected from each spot of the protein chip is collected into a spectrometer and its surface plasmon resonance wavelength is determined. This surface plasmon resonance wavelength value is represented by a color at the position of each protein spot to obtain a two dimensional image. Otherwise, the surface plasmon resonance wavelength value is allocated to a z-coordinate value to obtain a three-dimensional image.

Abstract translation: 本发明提供了使用表面等离子体共振光谱图像技术进行蛋白质芯片分析的方法。 将具有多个点的蛋白质芯片以垂直和水平方向的特定间隔安装在x-y平台上，并且通过棱镜的p偏振光束依次照射在蛋白质芯片的每个点上。 从蛋白质芯片的每个点反射的光信号被收集到光谱仪中，并且确定其表面等离子体共振波长。 该表面等离子体共振波长值由每个蛋白点的位置处的颜色表示，以获得二维图像。 否则，将表面等离子体共振波长值分配给z坐标值以获得三维图像。

公开(公告)号：US20250123474A1

公开(公告)日：2025-04-17

申请号：US18813759

申请日：2024-08-23

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Dong Uk Kim ,  Ki Soo Chang ,  I Jong Kim ,  Chan Bae Jeong ,  Dongmok Kim ,  Ilkyu Han

IPC: G02B21/08 ,  G02B21/26 ,  G02B26/06

Abstract: A variable coherence illumination device is disclosed. The variable coherence illumination device includes a light source generator configured to emit a beam and configured to control a wavelength of the beam, a focusing lens configured to focus the beam, a first diffuser on which a beam passing through the focusing lens is incident, a second diffuser facing the first diffuser and rotatable around a rotation axis of the second diffuser, in which a focusing region on which the beam passing through the first diffuser is focused by the focusing lens is formed on the second diffuser, in which the focusing region of the second diffuser is spaced apart from the rotation axis of the second diffuser.

公开(公告)号：US12274705B2

公开(公告)日：2025-04-15

申请号：US17416883

申请日：2019-12-19

Applicant: Korea Basic Science Institute

Inventor： Gun Hwa Kim ,  Min Ji Lee ,  Koon Soon Kim ,  Hyo Kyun Chung ,  Ji Hoon Lee ,  Se Jin Jung ,  Da Rong Kim

IPC: A61K31/496 ,  A61K31/635 ,  A61P1/16 ,  A61P3/10

Abstract: The present invention relates to a composition comprising a CYP4A-inhibiting compound as an active ingredient for preventing or treating metabolic diseases, more specifically to a composition comprising the compound expressed by chemical formula 1 of the present invention or pharmaceutically acceptable salt thereof as an active ingredient for preventing, ameliorating or treating metabolic diseases.

公开(公告)号：US20250057767A1

公开(公告)日：2025-02-20

申请号：US18807111

申请日：2024-08-16

Applicant: COSMECCA KOREA CO., LTD. ,  GFC Life Science Co., Ltd. ,  KOREA BASIC SCIENCE INSTITUTE

Inventor： Ji Soo Ryu ,  A Reum Jang ,  Jae Yong Seo ,  Hyun Dae Cho ,  Hee Cheol Kang ,  Mi Jung Kim ,  En Young Jeong ,  Hye Sun Park ,  Kwan Soo Hong ,  Hyunseung Lee

IPC: A61K9/127 ,  A61K8/14 ,  A61K8/9789 ,  A61K9/50

Abstract: The present invention relates to hybrid exosomes, a use of the same, and a preparation method of the same, and the hybrid exosomes provided from the present invention have excellent skin inflammation amelioration, skin wrinkle amelioration, skin moisturization efficacy, and skin regeneration efficacy compared to using hydrangea-derived exosomes and liposomes alone, and thus can be effectively utilized as a cosmetic composition containing the same as an active ingredient. In addition, the hybrid exosomes have better stability and biocompatibility compared to existing exosomes.