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    MICROMIXING CHAMBER, MICROMIXER COMPRISING A PLURALITY OF SUCH MICROMIXING CHAMBERS, METHODS FOR MANUFACTURING THEREOF, AND METHODS FOR MIXING
    44.
    发明公开
    MICROMIXING CHAMBER, MICROMIXER COMPRISING A PLURALITY OF SUCH MICROMIXING CHAMBERS, METHODS FOR MANUFACTURING THEREOF, AND METHODS FOR MIXING 有权
    微混合室微混合器具有多个这样的微观混合腔室和工艺及其生产

    公开(公告)号：EP2089144A1

    公开(公告)日：2009-08-19

    申请号：EP07834592.3

    申请日：2007-11-05

    Applicant: Micronit Microfluidics B.V.

    Inventor： BLOM, Marko, Theodoor ,  MULDER, Michaël Christiaan ,  MACLEOD MACINNES, Jordan ,  ALLEN, Raymond William Kenneth

    IPC: B01F5/00 ,  B01F13/00 ,  B01F5/06

    CPC classification number: B01F13/0064 ,  B01F5/0057 ,  B01F5/0646 ,  B01F5/0652 ,  Y10T29/49826

    Abstract: Micromixing chamber, roughly in the form of an hourglass which is provided at a first outer end with a tangential inflow opening (3a, 3c) and at a second outer end with a tangential outflow opening (5a, 5d), which mixing chamber in the overall flow direction first narrows more or less gradually and subsequently widens more or less abruptly. Also micromixer comprising a plurality of such micromixing chambers connected fluidically in series. Also methods for manufacturing such a micromixing chamber or such a micromixer. Also methods for mixing by means of such a micromixing chamber or by means of such a micromixer. A circulating flow in the form of a helix is formed in such a micromixing chamber. A circulating movement forming the beginning of the helix is created in a first part. The circulating movement is gradually accelerated by the more or less gradual narrowing. The gradualness is important in keeping the overall pressure drop over the micromixing chamber within limits. A more or less abrupt widening of the rapidly rotating helix then takes place which is found to provide an additionally good mixing. It is thus found possible to achieve a very efficient and rapid mixing. A micromixing chamber or micromixer according to the invention compatible with known microfluidic devices can be manufactured here from materials usual for the purpose, such as glass, preferably by means of techniques usual in the relevant field, such as powder blasting, etching and bonding.

    Method of fabrication of a microfluidic device
    45.
    发明公开
    Method of fabrication of a microfluidic device 有权
    维尔法赫恩·赫斯特伦

    公开(公告)号：EP1362827A1

    公开(公告)日：2003-11-19

    申请号：EP02076937.8

    申请日：2002-05-16

    Applicant: Micronit Microfluidics B.V.

    Inventor： Schlautmann, Stefan ,  Gardeniers, Johannes Gerardus Elisabeth ,  Van den Berg, Albert

    IPC: B81B1/00 ,  B81C1/00

    CPC classification number: B81C1/00119 ,  B01L3/502707 ,  B01L2200/10 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0418 ,  B81B2201/0214 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C2201/0104 ,  G01N33/48707 ,  Y10T137/2191

    Abstract: The present invention relates to a method of fabricating a microfluidic device including at least two substrates provided with a fluid channel, comprising the steps of:

    a) etching at least a channel and one or more fluid ports in a first and/or a second substrate;
    b) depositing a first layer on a surface of the second substrate;
    c) partially removing the first layer in accordance with a predefined geometry;
    d) depositing a second layer on top of the first layer and the substrate surface;
    e) planarizing the second layer so as to smooth the upper surface thereof;
    f) aligning the first and second substrate;
    g) bonding the first substrate on the planarized second layer of the second substrate.

    Abstract translation: 本发明涉及一种制造微流体装置的方法，该微流体装置包括设置有流体通道的至少两个基板，包括以下步骤：a）至少蚀刻第一和/或第二基板中的通道和一个或多个流体端口 ; b）在第二基板的表面上沉积第一层; c）根据预定几何部分去除第一层; d）在第一层和衬底表面的顶部上沉积第二层; e）平面化第二层以平滑其上表面; f）对准所述第一和第二基板; g）将第一衬底接合在第二衬底的平坦化的第二层上。

    DEVICE AND METHOD FOR MEASURING A VOLUME OF A LIQUID AND METHOD AND DEVICE FOR CALIBRATING A LIQUID DISPENSING SYSTEM
    46.
    发明公开
    DEVICE AND METHOD FOR MEASURING A VOLUME OF A LIQUID AND METHOD AND DEVICE FOR CALIBRATING A LIQUID DISPENSING SYSTEM 审中-公开
    设备和方法测量液体数量和方法及装置校准液供给系统

    公开(公告)号：EP3087354A1

    公开(公告)日：2016-11-02

    申请号：EP14828351.8

    申请日：2014-12-24

    Applicant: Micronit Microfluidics B.V.

    Inventor： VAN 'T OEVER, Ronny ,  BLOM, Marko Theodoor ,  NUTMA, Adriaan Johannes ,  BLOK, Herman Jacobus

    IPC: G01F13/00 ,  G01B13/00 ,  G01B11/00 ,  G01N33/49

    CPC classification number: G01F25/0007 ,  G01B13/00 ,  G01F13/00 ,  G01F25/0092

    Abstract: The invention relates to a device for measuring a volume of a liquid, said device comprising: - a receptacle for receiving said liquid, said receptacle comprising an inlet opening and an outlet opening, and - a capillary channel having capillary action, which capillary channel has a predetermined internal transverse cross-section, wherein an inlet opening of the capillary channel at an first end thereof is in liquid through flow connection with the outlet opening of the receptacle and wherein the other, second end of the capillary channel comprises an opening; wherein: - the inlet opening of the receptacle has a larger transverse cross-section than the inlet opening of said capillary channel, and - a length of a liquid slug in the capillary channel is a measure for said volume. The invention further relates to a method for measuring a volume of a liquid using such a device, a method for calibrating a liquid dispensing system using such a device, a calibrating system for calibrating a liquid dispensing system using such a device and a support for supporting a plurality of such devices.

    Method of bonding two substrates and device manufactured thereby
    48.
    发明公开
    Method of bonding two substrates and device manufactured thereby 审中-公开
    Verfahren zum Bonden zweier基督徒和死亡者Verfahren hergestellte Vorrichtung

    公开(公告)号：EP2608255A1

    公开(公告)日：2013-06-26

    申请号：EP11195720.5

    申请日：2011-12-23

    Applicant: Micronit Microfluidics B.V.

    Inventor： Van 't Oever, Ronny ,  Blom, Marko Theodoor ,  Haneveld, Jeroen ,  Oonk, Johannes ,  Olde Riekerink, Marinus Bernardus ,  Tijssen, Peter ,  Tigelaar, Hendrik Jan Hildebrand ,  Fehr, Jean-Noël ,  Roulet, Jean-Christophe ,  Gupta, Amitava

    IPC: H01L23/10 ,  B81C1/00 ,  H01L21/50

    CPC classification number: B81C1/00269 ,  B81B2201/058 ,  B81C3/001 ,  B81C2201/0132 ,  B81C2203/0118 ,  B81C2203/019 ,  C23F1/02 ,  H01L21/50 ,  H01L23/10 ,  H01L2924/0002 ,  Y10T428/239 ,  H01L2924/00

    Abstract: The invention relates to method for bonding at least two substrates, for example made from glass, silicon or ceramic, by using an intermediate thin film metal layer for providing the bonding, said method comprising the following steps of:
    a) providing said two substrates;
    b) depositing said thin film metal layer on at least a part of a surface of a first substrate of the two substrates;
    c) bringing a surface of the second substrate into contact with said thin film metal layer on said surface of the first substrate such that a bonding between the second substrate and the thin film metal layer on the first substrate is provided; and
    d) at least locally strengthening the bonding between the second substrate and the thin film metal layer on the first substrate.
    The invention also relates to a device comprising two substrates, for example made from glass, silicon or ceramic, and an intermediate thin film metal layer.

    Abstract translation: 本发明涉及通过使用用于提供粘合的中间薄膜金属层来将至少两个基板（例如由玻璃，硅或陶瓷制成）接合的方法，所述方法包括以下步骤：a）提供所述两个基板; b）在所述两个基板的第一基板的表面的至少一部分上沉积所述薄膜金属层; c）使所述第二基板的表面与所述第一基板的所述表面上的所述薄膜金属层接触，从而提供所述第一基板上的所述第二基板与所述薄膜金属层之间的接合; 以及d）至少局部加强第一基板上的第二基板和薄膜金属层之间的接合。 本发明还涉及包括例如由玻璃，硅或陶瓷制成的两个基底和中间薄膜金属层的器件。

    ASSEMBLY OF AT LEAST ONE MICROFLUIDIC DEVICE AND A MOUNTING PIECE, MOUNTING PIECE AND METHODS FOR MANUFACTURE AND USE OF SUCH AN ASSEMBLY
    50.
    发明公开
    ASSEMBLY OF AT LEAST ONE MICROFLUIDIC DEVICE AND A MOUNTING PIECE, MOUNTING PIECE AND METHODS FOR MANUFACTURE AND USE OF SUCH AN ASSEMBLY 有权
    至少一个微流体设备和固定部，安装部和方法，为生产和使用这种装置的安排

    公开(公告)号：EP2063987A2

    公开(公告)日：2009-06-03

    申请号：EP07808512.3

    申请日：2007-08-31

    Applicant: Micronit Microfluidics B.V.

    Inventor： VAN'T OEVER, Ronny ,  BLOM, Marko, Theodoor

    IPC: B01L3/00

    CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/5635 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2300/0645

    Abstract: The invention relates to an assembly comprising at least one microfluidic device and a mounting piece, this microfluidic device comprising at least one material layer and at least one first fluidic port, which first fluidic port is situated at least partially in an end surface of the material layer and which mounting piece comprises at least one fluidic component, wherein the mounting piece is coupled to the microfluidic device by means of first coupling means provided for this purpose such that the fluidic component is connected to the first fluidic port. The invention also relates to such a mounting piece. The invention further relates to a method for manufacturing such an assembly and a method for use thereof. What is essential is that external fluidic components, in particular reservoirs or wells, are not connected, as is usual, to ports in the 'upper surface' of a microchip, but to ports in an outer end or side surface thereof, and that more space thereby remains available on the 'upper surface' and 'lower surface' of the microchip, for instance for visual inspection or other operations, or that the 'upper surface' and 'lower surface' of the microchip can thereby be smaller and the device or the system can thus be given a more compact form. Furthermore, an additional process such as powder-blasting or drilling is then often no longer necessary.

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