公开(公告)号：US09364469B1

公开(公告)日：2016-06-14

申请号：US14925996

申请日：2015-10-29

Applicant: Macau University of Science and Technology

Inventor： Lai-Han Leung ,  Xiao-Jun Yao ,  Kam Wai Wong ,  Liang Liu ,  Xi Chen

IPC: A61K31/4439

CPC classification number: A61K31/4439

Abstract: The present invention discloses a method of treating gefitinib-resistant non-small-cell lung cancer, comprising administering an effective amount of D561-0775. A pharmaceutical composition comprising D561-0775 admixed with a pharmaceutical carrier for treating Gefitinib-resistant non-small-cell lung cancer is also disclosed therein.

Abstract translation: 本发明公开了一种治疗耐吉非替尼的非小细胞肺癌的方法，包括给予有效量的D561-0775。 还公开了包含D561-0775的药物组合物，其与药物载体混合以治疗吉非替尼耐药性非小细胞肺癌。

公开(公告)号：US20160158163A1

公开(公告)日：2016-06-09

申请号：US14624574

申请日：2015-02-17

Applicant: Macau University of Science and Technology

Inventor： Lai-Han LEUNG ,  Xing-Xing FAN ,  Liang LIU ,  Zebo JIANG

IPC: A61K31/09

CPC classification number: A61K31/09

Abstract: The present invention relates to a method for treating gefitinib-resistant non-small-cell lung cancer (NSCLC) comprising administering an effective amount of a resveratrol analogue, (Z)3,4,5,4′-tetramethoxystilbene (TMS), to a subject in need thereof. The present invention also relates to a method for inducing apoptosis in gefitinib-resistant NSCLC cells comprising contacting the resveratrol analogue to the cells at an effective amount. The present methods are mediated by different signaling pathways connected to cell proliferation and differentiation such as mTOR, JNK, and certain EGFR phosphorylated tyrosine kinase.

Abstract translation: 本发明涉及一种治疗吉非替尼耐药性非小细胞肺癌（NSCLC）的方法，包括将有效量的白藜芦醇类似物（Z）3,4,5,4'-四甲氧基二苯乙烯（TMS）给予 有需要的科目。 本发明还涉及一种诱导吉非替尼耐药NSCLC细胞凋亡的方法，包括以有效量将白藜芦醇类似物与细胞接触。 本发明的方法是通过与细胞增殖和分化相关的不同信号通路介导的，例如mTOR，JNK和某些EGFR磷酸化酪氨酸激酶。

公开(公告)号：US20150373742A1

公开(公告)日：2015-12-24

申请号：US14308713

申请日：2014-06-19

Applicant: Macau University of Science and Technology

Inventor： Qinglin Zhao ,  Zhijie Ma

IPC: H04W74/08

CPC classification number: H04W74/0833 ,  H04W74/0816 ,  H04W74/0875 ,  H04W84/12

Abstract: A method for scheduling a random-access communication system having high-priority (HP) and low-priority (LP) nodes is provided, where the scheduling is configured such that the system provides an absolute throughput guarantee for the HP nodes, and a proportional throughput guarantee for the LP nodes. The method is based on obtaining a length of a contention window assigned to an individual node, which is either a HP or a LP node, from a per-slot attempt rate of this individual node. In particular, the attempt rate of each individual node is determined by an algorithm configured such that a resultant sum of the per-slot attempt rates of all the individual nodes is a fixed value independent of the number of the individual nodes. By this scheduling method, the maximum system throughput is approached. The method can be advantageously used in a wireless local area network (WLAN).

Abstract translation: 提供了一种用于调度具有高优先级（HP）和低优先级（LP）节点的随机接入通信系统的方法，其中调度被配置为使得系统为HP节点提供绝对吞吐量保证，并且成比例 LP节点的吞吐量保证。 该方法基于从该单独节点的每时隙尝试速率获得分配给单个节点（即HP或LP节点）的争用窗口的长度。 具体地，每个单独节点的尝试速率由配置为使得所有单个节点的每时隙尝试速率的合成和是独立于各个节点的数量的固定值的算法来确定。 通过该调度方法，接近最大系统吞吐量。 该方法可以有利地用于无线局域网（WLAN）。

公开(公告)号：US20150156211A1

公开(公告)日：2015-06-04

申请号：US14201942

申请日：2014-03-10

Applicant: Macau University of Science and Technology

Inventor： HON Chi Tin ,  XU Jia Hua

IPC: H04L29/06

CPC classification number: H04L63/1408 ,  G06F21/55 ,  G06F21/552 ,  H04L41/147 ,  H04L63/1416 ,  H04L63/1425 ,  H04L63/1441 ,  H04L63/20

Abstract: A method of detecting an internet attack against a computing device is disclosed. The method of detecting an internet attack against a computing device comprising the steps of receiving a plurality of incoming network packets; extracting a plurality of incoming feature packets based on the plurality of incoming network packets; predicting a predicted incoming feature packet based on the plurality of incoming feature packets; obtaining a first classification data based on one of the incoming feature packets using a first classifier; obtaining a second classification data based on the predicted incoming feature packet by using a second classifier; and performing at least one remedy action if the first classification data or the second classification data identifies the internet intrusion attack; wherein each of the plurality of incoming feature packets and the predicted incoming feature packet comprise a plurality of incoming features and a plurality of predicted features respectively.

Abstract translation: 公开了一种检测针对计算设备的因特网攻击的方法。 一种检测针对计算设备的因特网攻击的方法，包括以下步骤：接收多个传入网络分组; 基于所述多个传入网络分组来提取多个输入特征分组; 基于所述多个输入特征分组来预测预测的进入特征分组; 使用第一分类器基于所述输入特征分组之一获得第一分类数据; 通过使用第二分类器基于预测的进入特征分组获得第二分类数据; 以及如果所述第一分类数据或所述第二分类数据识别所述互联网入侵攻击，则执行至少一种补救措施; 其中所述多个输入特征分组和所述预测输入特征分组中的每一个分别包括多个输入特征和多个预测特征。

公开(公告)号：US20150031050A1

公开(公告)日：2015-01-29

申请号：US14455951

申请日：2014-08-11

Applicant: Macau University of Science and Technology

Inventor： Liang LIU ,  Ting LI ,  Kam Wai WONG ,  Zhihong JIANG ,  Hua ZHOU

IPC: G01N33/573

CPC classification number: G01N33/573 ,  A61K31/352 ,  A61K31/4188 ,  G01N33/574 ,  G01N2333/91205 ,  G01N2333/91215 ,  G01N2500/04 ,  G01N2800/102 ,  G01N2800/44

Abstract: Uses and applications derived from the discovery of a novel binding site of IKK-β, such as method of screening a therapeutic agent as drug candidate for treating cancer, inflammation, or other diseases/disorders, are provided.

Abstract translation: 提供了从发现IKK-和bgr的新结合位点衍生的用途和应用，例如筛选治疗剂作为治疗癌症，炎症或其它疾病/障碍的候选药物的方法。

公开(公告)号：US20140315867A1

公开(公告)日：2014-10-23

申请号：US14251664

申请日：2014-04-14

Applicant: Macau University of Science and Technology

Inventor： Liang LIU ,  Ting LI ,  Fenggen YAN

IPC: A61K31/353 ,  A61K31/573

CPC classification number: A61K31/353 ,  A61K31/573 ,  A61K2300/00

Abstract: This invention provides a method of preventing and/or treating thymus degeneration comprising administering an effective amount of dihydromyricetin to a subject in need thereof, in which the degeneration is induced by dexamethasone. In one embodiment, the thymus degeneration is induced during the course of treatment of inflammation by dexamethasone.

Abstract translation: 本发明提供了一种预防和/或治疗胸腺变性的方法，包括向有需要的受试者施用有效量的二氢黄芪素，其中由地塞米松引起变性。 在一个实施方案中，在用地塞米松治疗炎症过程中诱导胸腺变性。

公开(公告)号：US20140057860A1

公开(公告)日：2014-02-27

申请号：US13972889

申请日：2013-08-21

Applicant: Macau University of Science and Technology

Inventor： Tao YI ,  Liang LI ,  Wai Kei Christopher LAM

IPC: A61K31/7048

CPC classification number: A61K31/7048

Abstract: The present invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and the method of preparation thereof. The aforesaid pharmaceutical composition is prepared by the following components in weight percent: 0.1%-0.3% scutellarin, 20%-25% co-surfactant, 40-50% surfactant, and 25-30% oil. The method of preparing the aforesaid pharmaceutical composition comprises the steps of: (1) dispersing scutellarin in co-surfactant and surfactant to obtain a mixture; (2) dispersing the mixture from step (1) in oil, and thermostatically and magnetically stirring the dispersion mixture under the temperature of 25° C. to 37° C., such that the components thereof are completely dissolved to obtain the pharmaceutical composition. Through the use of the selected pharmaceutical adjuvants having the ability to inhibit MRP2, the aforesaid pharmaceutical composition effectively improves absorption and bioavailability of scutellarin. The preparation of the aforesaid pharmaceutical composition is simple and convenient, and the pharmaceutical composition can be processed into a variety of dosage forms for oral administration.

Abstract translation: 本发明涉及一种治疗心血管和脑血管疾病的药物组合物及其制备方法。 上述药物组合物由以下重量百分比的组分制备：0.1％-0.3％的灯盏花乙素，20％-25％的辅助表面活性剂，40-50％的表面活性剂和25-30％的油。 制备上述药物组合物的方法包括以下步骤：（1）将灯盏花乙素分散在辅助表面活性剂和表面活性剂中以获得混合物; （2）将来自步骤（1）的混合物分散在油中，并在25℃至37℃的温度下对该分散混合物进行恒温和磁力搅拌，使其组分完全溶解，得到药物组合物。 通过使用具有抑制MRP2能力的所选择的药物佐剂，上述药物组合物有效地改善了灯盏花乙素的吸收和生物利用度。 上述药物组合物的制备简单方便，可以将药物组合物加工成多种口服给药形式。

公开(公告)号：US20250019696A1

公开(公告)日：2025-01-16

申请号：US18260789

申请日：2022-11-17

Applicant: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Zhihong JIANG ,  Yuan MA ,  Fei REN

IPC: C12N15/113 ,  A61K36/074 ,  A61P11/06

Abstract: A use of ganoderma fungal RNA molecules, a drug, a drug composition and a delivery carrier are provided. It has been proved that the tRFs derived from the ganoderma traditional Chinese medicine has an obvious inhibiting effect on airway smooth muscle cell phenotype change (proliferation, abnormal secretion and the like) induced by TGF-β1 and AHR, inflammation and remodeling of asthma mice induced by Dermatophagoides pteronyssinus in the experiments of the present disclosure, which suggests that the tRFs derived from the ganoderma traditional Chinese medicine and a pharmaceutical composition can be a brand new medicine for treating asthma. The drug comprises the RNA molecule and a pharmaceutically acceptable carrier, diluent and/or excipient. The present disclosure is helpful for the research and development of asthma treatment drugs and provides reference for the research and development of other respiratory system disease treatment drugs.

公开(公告)号：US20220127220A1

公开(公告)日：2022-04-28

申请号：US17110567

申请日：2020-12-03

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Nanshan Zhong ,  Zifeng Yang ,  Jingrong Wang ,  Qitong Feng ,  Xiaobo Zhou ,  Beixian Zhou

IPC: C07C233/87

Abstract: A compound including a structure of Formula (I) and a preparation method thereof, wherein R1 is —OH, —CH2OH, or —OCOCH3; R2, R3, and R4 are independently —H, —CH3 or —F, and at least one of R2, R3, and R4 is —F. A method for treating a subject suffering from a viral disease includes administering an effective amount of said compound or a solvate thereof to the subject.

公开(公告)号：US10580150B2

公开(公告)日：2020-03-03

申请号：US15894956

申请日：2018-02-13

Applicant: Macau University of Science and Technology

Inventor： Zhanchuan Cai ,  Wei Cao

IPC: G06T7/44 ,  G06T17/05 ,  G06F17/16 ,  G06F17/11

Abstract: Example embodiments include a method that improves calculations of surface roughness that map a planetary surface. The method includes calculating a V-system matrix with a size of α×α in an interval [0,1]; transforming the V-system matrix into an orthogonal matrix; improving calculations of the surface roughness of the planetary surface by calculating the surface roughness of a digital elevation model generated from data captured from the planetary surface; and generating a map of the planetary surface based on the surface roughness.