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    DUAL ACTION DENTIFRICE COMPOSITIONS TO PREVENT HYPERSENSITIVITY AND PROMOTE REMINERALIZATION
    41.
    发明申请
    DUAL ACTION DENTIFRICE COMPOSITIONS TO PREVENT HYPERSENSITIVITY AND PROMOTE REMINERALIZATION 审中-公开
    双重作用DENTIFRICE组合物，以防止高度敏感性和促进重新定位

    公开(公告)号：WO2010115039A2

    公开(公告)日：2010-10-07

    申请号：PCT/US2010029684

    申请日：2010-04-01

    Applicant: COLGATE PALMOLIVE CO ,  CHOPRA SUMAN K ,  PRENCIPE MICHAEL ,  ZAIDEL LYNETTE

    Inventor： CHOPRA SUMAN K ,  PRENCIPE MICHAEL ,  ZAIDEL LYNETTE

    IPC: A61K8/19

    CPC classification number: A61Q11/00 ,  A61K8/19 ,  A61K8/20 ,  A61K8/25 ,  A61K2800/412

    Abstract: The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long- term release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.

    Abstract translation: 本发明包括与递送剂例如牙膏，漱口剂和口服凝胶一起使用的生物活性玻璃组合物和钾盐的组合。 在某些实施方案中，本发明的组合物与体液（例如，唾液）形成快速且连续的反应，以促进Ca和P离子的立即和长期释放，以产生沉积在牙质小管上和之上的稳定的晶体层 用于立即和长期减少牙质过敏和牙齿表面再矿化。

    ORAL CARE REGIMEN
    47.
    发明申请
    ORAL CARE REGIMEN 审中-公开
    口腔护理

    公开(公告)号：WO2007134003A2

    公开(公告)日：2007-11-22

    申请号：PCT/US2007/068362

    申请日：2007-05-07

    Applicant: COLGATE-PALMOLIVE COMPANY ,  PRENCIPE, Michael ,  VAN RYCKE, Isabelle ,  LOVELL, Richard

    Inventor： PRENCIPE, Michael ,  VAN RYCKE, Isabelle ,  LOVELL, Richard

    IPC: A61K8/04 ,  A61K8/26 ,  A61Q11/00

    CPC classification number: A61K8/25 ,  A61K2800/28 ,  A61K2800/412 ,  A61K2800/88 ,  A61K2800/884 ,  A61Q11/00

    Abstract: The invention includes methods of cleaning an oral surface, maintaining oral health and/ or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, and contacting the oral surface with a periodic oral care composition at least once within a period of about 42 days. The periodic oral care compositions suitable for use in the method comprise a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. In the periodic oral care compositions, the ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6:1. The periodic oral care compositions are characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200. Additionally or alternatively, the methods may include those where the second abrasive comprises silica and has an oil of absorption of greater than about 90 cm 3 /100g and/ or an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive may be about 1:1.6 to about 1.6:1. The total amount of the first and second abrasives present in the oral composition may be greater than about 25 % by weight of the composition and/ or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.

    Abstract translation: 本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。 这样的方法包括使口腔表面与初级口腔护理组合物每天至少接触一次，并使口腔表面与周期性口腔护理组合物在约42天的时间内至少一次接触。 适用于该方法的定期口腔护理组合物包括具有每100,000次旋转大于约5毫克损失的爱因纳氏硬度的第一研磨剂，以及每100,000次旋转具有小于约5毫克损失的爱因纳氏硬度的第二磨料。 在定期口腔护理组合物中，第一研磨剂与第二研磨剂的比例为约1:1.6至约1.6:1。 定期口腔护理组合物的特征在于大于约100的防护薄膜清洁率和小于约200的放射性牙本质磨损。另外或替代地，所述方法可以包括其中第二磨料包含二氧化硅并具有吸收油的那些 大于约90cm 3 / 100g和/或Einlehner硬度，每100,000次转动时损耗小于约5mg。 第一研磨剂与第二研磨剂的比例可以为约1:1.6至约1.6:1。 存在于口腔组合物中的第一和第二研磨剂的总量可以大于组合物的约25重量％，和/或口腔组合物具有大于约100的防护薄膜清洁率和小于约100的放射性牙本质磨损 约200。

    ABRASIVE SYSTEM FOR ORAL CARE COMPOSITIONS
    49.
    发明申请
    ABRASIVE SYSTEM FOR ORAL CARE COMPOSITIONS 审中-公开
    用于口腔护理组合物的磨砂系统

    公开(公告)号：WO2007094891A3

    公开(公告)日：2007-11-08

    申请号：PCT/US2006062511

    申请日：2006-12-21

    Applicant: COLGATE PALMOLIVE CO ,  PRENCIPE MICHAEL ,  IBRAHIM SAYED

    Inventor： PRENCIPE MICHAEL ,  IBRAHIM SAYED

    IPC: A61K8/25 ,  A61Q11/00

    CPC classification number: A61K8/18 ,  A61K8/25 ,  A61K8/347 ,  A61K2800/28 ,  A61K2800/412 ,  A61K2800/59 ,  A61K2800/5922 ,  A61Q11/00

    Abstract: Oral compositions comprising a first and a second abrasive are provided. The first abrasive preferably has an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions, and the second abrasive preferably has an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. A ratio of the first abrasive to the second abrasive ranges from about 1:1.6 to about 1.6:1, and the first and second abrasives are preferably present in the oral composition at an amount of about 13% to about 21 % by weight, respectively. The pellicle cleaning ratio of the oral composition is greater than 100 and the radioactive dentin abrasiveness is preferably less than 200, and in certain embodiments, preferably less than about 175. Methods of using the oral compositions are also provided.

    Abstract translation: 提供包含第一和第二研磨剂的口腔组合物。 第一研磨剂优选具有每100,000转大于约5毫克损失的艾因纳氏硬度，并且第二磨料优选具有每100,000转小于约5毫克损失的埃因纳氏硬度。 第一研磨剂与第二研磨剂的比例为约1:1.6至1.6:1，第一和第二研磨剂分别以约13重量％至约21重量％的量存在于口腔组合物中 。 口腔组合物的防护薄膜清洁率大于100，并且放射性牙本质磨蚀性优选小于200，在某些实施方案中优选小于约175.还提供了使用口腔组合物的方法。

    SINGLE PHASE WHITENING DENTIFRICE
    50.
    发明申请
    SINGLE PHASE WHITENING DENTIFRICE 审中-公开
    单相白色干燥剂

    公开(公告)号：WO2007037961A1

    公开(公告)日：2007-04-05

    申请号：PCT/US2006/035278

    申请日：2006-09-12

    Applicant: COLGATE-PALMOLIVE COMPANY ,  CHOPRA, Suman, K. ,  ZAIDEL, Lynette ,  PRENCIPE, Michael

    Inventor： CHOPRA, Suman, K. ,  ZAIDEL, Lynette ,  PRENCIPE, Michael

    IPC: A61Q11/00 ,  A61K8/22 ,  A61K8/88 ,  A61K8/81 ,  A61K8/86 ,  A61K8/25 ,  A61K8/89 ,  A61K8/73 ,  A61K8/46 ,  A61K8/20

    CPC classification number: A61K8/22 ,  A61K8/20 ,  A61K8/25 ,  A61K8/463 ,  A61K8/737 ,  A61K8/8152 ,  A61K8/8176 ,  A61K8/86 ,  A61K8/88 ,  A61K8/89 ,  A61Q11/00

    Abstract: A single phase whitening dentifrice that includes (i) a whitening agent selected from the group consisting of hydrogen peroxide, a bound peroxide and a solid peroxide (ii) an abrasive and (iii) a substantially anhydrous orally acceptable carrier, for example, polyethylene glycol. The bound peroxide may be hydrogen peroxide and a polymer and/or any peroxide compound and a porous cross-linked polymer, such as polymers of polyvinyl pyrrolidone, polyacrylates, a polymethacrylates, and a polyitaconates. The solid peroxide may be sodium perborate or urea peroxide. The invention also provides methods of whitening the tooth surfaces by contacting the surface with the composition.

    Abstract translation: 一种单相增白洁齿剂，其包括（i）选自过氧化氢，结合过氧化物和固体过氧化物的增白剂（ii）研磨剂和（iii）基本上无水的可口服可接受的载体，例如聚乙二醇 。 结合过氧化物可以是过氧化氢和聚合物和/或任何过氧化物化合物和多孔交联聚合物，例如聚乙烯吡咯烷酮聚合物，聚丙烯酸酯，聚甲基丙烯酸酯和多赖氨酸盐。 固体过氧化物可以是过硼酸钠或过氧化脲。 本发明还提供了通过使表面与组合物接触来使牙齿表面变白的方法。

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