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    PRESSURE CYCLING SYSTEMS AND RELATED METHOD
    41.
    发明申请
    PRESSURE CYCLING SYSTEMS AND RELATED METHOD 审中-公开
    压力循环系统及相关方法

    公开(公告)号：WO2008092102A2

    公开(公告)日：2008-07-31

    申请号：PCT/US2008/052089

    申请日：2008-01-25

    Applicant: PRESSURE BIOSCIENCES INC. ,  TING, Edmund, Y.

    Inventor： TING, Edmund, Y.

    CPC classification number: B01J3/00 ,  B01J3/03 ,  B01J2219/00065 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00213 ,  B01J2219/00231

    Abstract: A pressure cycling system includes a reaction chamber configured to receive a sample and a charge pump in fluid communication with the reaction chamber. The charge pump is operable to convey a fluid from a fluid source toward the reaction chamber. The system also includes a check valve disposed between the charge pump and the reaction chamber. The check valve is operable to inhibit the flow of fluid from the reaction chamber toward the charge pump. A pressure intensifier is in fluid communication with the reaction chamber. The pressure intensifier is pneumatically operable to adjust a pressure in the reaction chamber. A controller is configured to control operation of the charge pump and the pressure intensifier. The controller is configured to pressurize the reaction chamber to a first pressure through operation of the charge pump. The controller is also configured to fluctuate the pressure in the reaction chamber between a second pressure and a third pressure through operation of the pressure intensifier.

    Abstract translation: 压力循环系统包括配置成接收样本的反应室和与反应室流体连通的电荷泵。 电荷泵可操作以将流体从流体源传送到反应室。 该系统还包括设置在电荷泵和反应室之间的止回阀。 止回阀可操作以阻止流体从反应室流向电荷泵。 增压器与反应室流体连通。 增压器可气动地操作以调节反应室中的压力。 控制器被配置为控制电荷泵和增压器的操作。 控制器构造成通过操作电荷泵将反应室加压至第一压力。 该控制器还被配置为通过所述增压器的操作，以在波动第二压力和第三压力之间的反应室中的压力。

    Ultrahigh pressure compact valve with throttling capability
    42.
    发明专利
    Ultrahigh pressure compact valve with throttling capability 未知

    公开(公告)号：AU2016318955B2

    公开(公告)日：2021-10-21

    申请号：AU2016318955

    申请日：2016-09-08

    Applicant: PRESSURE BIOSCIENCES INC

    Inventor： TING EDMUND Y ,  LAZAREV ALEXANDER ,  MA JUN

    IPC: F16K3/24 ,  F16K1/12 ,  F16K1/38 ,  F16K31/62

    Abstract: A high pressure valve includes a lever and a variable force generator for facilitating control of opening and closing the valve at high pressures. The high pressure valve includes a housing having a chamber providing fluid communication between a first port and a second port, a pin movable within the chamber between an open position and a closed position. A first end of a lever is coupled to the pin and a second end of the lever is coupled to a variable force generator. The lever pivots about a pivot point. A controller coupled to the variable force generator is configured to adjust a force applied to the second end of the lever by the variable force generator to control the movement of the pin between the open position and the closed position.

    System for high pressure, high shear processing of fluids
    45.
    发明专利
    System for high pressure, high shear processing of fluids 未知

    公开(公告)号：AU2016243553B2

    公开(公告)日：2020-10-08

    申请号：AU2016243553

    申请日：2016-03-28

    Applicant: PRESSURE BIOSCIENCES INC

    Inventor： TING EDMUND Y

    IPC: F04B9/115 ,  A23L3/015 ,  F04B9/10 ,  F04B9/103 ,  F04B9/107 ,  F04B15/00

    Abstract: A method for high fluid shear processing of a fluid uses an isolator that has a first sub-chamber for containing a first fluid and a second sub-chamber for containing a second fluid defined by a separator positioned in the chamber and movable between a first end of the chamber and a second end of the chamber. The two sub-chambers are in pressure communication with each other but are not in fluid communication with each other. A first fluid is pumped at an ultrahigh pressure into the first-sub chamber, and the pressure in the first sub-chamber causes a second fluid to be processed to be discharged from the second sub-chamber into a processing valve. A system is also provided for performing the steps of this method.

    Sample preparation devices and methods
    47.
    发明专利
    Sample preparation devices and methods 未知

    公开(公告)号：AU2015266700A1

    公开(公告)日：2016-12-15

    申请号：AU2015266700

    申请日：2015-05-29

    Applicant: PRESSURE BIOSCIENCES INC

    Inventor： GROSS VERA ,  TING EDMUND Y ,  LAZAREV ALEXANDER ,  SCHUMACHER RICHARD T

    IPC: C12N1/06 ,  C12M3/08 ,  G01N1/28

    Abstract: Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.

    48.
    发明专利
    未知

    公开(公告)号：AT492343T

    公开(公告)日：2011-01-15

    申请号：AT98956405

    申请日：1998-10-30

    Applicant: PRESSURE BIOSCIENCES INC

    Inventor： LAUGHARN JAMES ,  HESS ROBERT ,  TAO FENG

    IPC: B01L99/00 ,  B01L3/00 ,  B32B27/04 ,  C07H1/00 ,  C12M1/33 ,  C12N1/06 ,  C12N15/10 ,  G01N1/14 ,  G01N27/447 ,  G01N30/00 ,  G01N30/02 ,  G01N30/14 ,  G01N30/28 ,  G01N30/52 ,  G01N30/60 ,  G01N30/88

    Abstract: The invention is based on the discovery that hyperbaric, hydrostatic pressure reversibly alters the partitioning of biomolecules between certain adsorbed and solvated phases relative to partitioning at ambient pressure. The new methods and devices disclosed herein make use of this discovery for highly selective and efficient, low salt isolation and purification of nucleic acids from a broad range of sample types, including forensic samples, blood and other body fluids, and cultured cells.In one embodiment, the invention features a pressure-modulation apparatus. The apparatus includes an electrode array system having at least two (i.e., two, three, four, or more) electrodes; and a conduit interconnecting the electrodes. The conduit contains an electrically conductive fluid in contact with a phase positioned in a pressure chamber. The phase can be, for example, a binding medium or stationary phase.

    SAMPLE PREPARATION DEVICES AND METHODS
    49.
    发明专利
    SAMPLE PREPARATION DEVICES AND METHODS 未知

    公开(公告)号：CA2950739A1

    公开(公告)日：2015-12-03

    申请号：CA2950739

    申请日：2015-05-29

    Applicant: PRESSURE BIOSCIENCES INC

    Inventor： GROSS VERA ,  TING EDMUND Y ,  LAZAREV ALEXANDER ,  SCHUMACHER RICHARD T

    IPC: C12N1/06 ,  C12M3/08 ,  G01N1/28

    Abstract: Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.

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