公开(公告)号：WO2005088470A8

公开(公告)日：2006-09-08

申请号：PCT/EP2005051091

申请日：2005-03-10

Applicant: IBM ,  IBM UK ,  HOHENSEE REINHARD HEINRICH ,  LUEBBE TERRY SCOTT ,  MADER ERIC RICHARD ,  STONE DAVID ,  UMAMAHESWARAN VETTAKKORUMAKANK ,  VARGA JOHN THOMAS

Inventor： HOHENSEE REINHARD HEINRICH ,  LUEBBE TERRY SCOTT ,  MADER ERIC RICHARD ,  STONE DAVID ,  UMAMAHESWARAN VETTAKKORUMAKANK ,  VARGA JOHN THOMAS

IPC: G06F17/21 ,  G06F17/22 ,  G06K15/02

CPC classification number: G06F17/2223 ,  G06F17/214

Abstract: Systems and methods of identifying and processing complex text are provided. If a pre­sentation data stream contains a complex text string, a preselected control in the presentation data stream is inserted before the complex text string. A first parameter has a value indicating a control type for controlling processing of complex text, and a second parameter takes one or more values for enabling and disabling the processing of complex text. In processing complex text, responsive to a first predetermined type of control in a presentation data stream, if the first type of complex text processing is enabled, this processing is applied to a complex text string succeeding the first predetermined type of control in the presentation data stream. The first pre­determined type of control includes a first parameter represented by a corresponding value for controlling the first type of complex text processing.

Abstract translation: 提供了识别和处理复杂文本的系统和方法。 如果呈现数据流包含复杂的文本字符串，则在复合文本字符串之前插入呈现数据流中的预先选择的控件。 第一参数具有指示用于控制复杂文本的处理的控制类型的值，第二参数采用用于启用和禁用复杂文本的处理的一个或多个值。 在处理复杂文本时，响应于呈现数据流中的第一预定类型的控制，如果启用了第一类型的复杂文本处理，则该处理被应用于呈现数据中的第一预定类型的控制之后的复杂文本串 流。 第一预定类型的控制包括由用于控制第一类型的复杂文本处理的相应值表示的第一参数。

公开(公告)号：WO2005036832A1

公开(公告)日：2005-04-21

申请号：PCT/US2004/033794

申请日：2004-10-12

Applicant: CITRIX SYSTEMS, INC. ,  PANASYUK, Anatoliy ,  PEDERSEN, Bradley, Jay ,  STONE, David ,  TREDER, Terry

Inventor： PANASYUK, Anatoliy ,  PEDERSEN, Bradley, Jay ,  STONE, David ,  TREDER, Terry

IPC: H04L12/46

CPC classification number: H04L63/0272 ,  H04L12/4633 ,  H04L63/0428 ,  H04L63/0807

Abstract: The invention relates to network communications. A first protocol that encapsulates a plurality of secondary protocols is used to communicate over a network. Use of the first protocol provides session persistence and a reliable connection between a client and a host service. In one embodiment of this aspect of the inventions,, a second connection is established between the first protocol service and a host service using one of the secondary protocols. Communication between the first protocol service and the host service occurs via one of the secondary protocols. In another embodiment, a plurality of second connections are established between the first protocol service and a plurality of host services using the plurality of the secondary protocols. Specifically, each of the plurality of second connections is established between the first protocol service and a different host service and each of the plurality of second connections is established using one of the plurality of secondary protocols. Communication between the first protocol service and the plurality of host services occurs over each of the plurality of second connections via one of the plurality of secondary protocols. In yet another embodiment, the first connection between the client and the first protocol service is established through an intermadiary node. The first protocol can be communicated over TCP/IP and the secondary protocol can be, for example, HTTP, RDP, ICA, FTP, Oscar or Telnet. Additionally, each virtual channel can include a plurality of protocol packets that enable remote access functionality.

Abstract translation: 本发明涉及网络通信。 封装多个辅助协议的第一协议被用于通过网络进行通信。 使用第一个协议提供会话持久性和客户端与主机服务之间的可靠连接。 在本发明的该方面的一个实施例中，使用第二协议之一在第一协议服务和主机服务之间建立第二连接。 第一协议服务和主机服务之间的通信是通过其中一个辅助协议进行的。 在另一个实施例中，在第一协议服务和使用多个辅助协议的多个主机服务之间建立多个第二连接。 具体地，在第一协议服务和不同主机服务之间建立多个第二连接中的每一个，并且使用多个辅助协议中的一个来建立多个第二连接中的每一个。 第一协议服务与多个主机服务之间的通信经由多个辅助协议之一发生在多个第二连接中的每一个上。 在另一个实施例中，客户机和第一协议服务之间的第一连接是通过一个中间节点建立的。 第一个协议可以通过TCP / IP进行通信，辅助协议可以是例如HTTP，RDP，ICA，FTP，Oscar或Telnet。 另外，每个虚拟通道可以包括启用远程访问功能的多个协议分组。

公开(公告)号：WO03076584A8

公开(公告)日：2004-05-21

申请号：PCT/US0306951

申请日：2003-03-06

Applicant: CURAGEN CORP ,  ALSOBROOK JOHN P II ,  BURGESS CATHERINE E ,  EDINGER SHLOMIT R ,  GERLACH VALERIE L ,  JI WEIZHEN ,  KEKUDA RAMESH ,  LI LI ,  MACDOUGALL JOHN R ,  MILLER CHARLES E ,  MILLET ISABELLE ,  PATTURAJAN MEERA ,  PENA CAROL E A ,  RIEGER DANIEL K ,  SCIORE PAUL ,  SHENOY SURESH G ,  SMITHSON GLENNDA ,  SPYTEK KIMBERLY A ,  STONE DAVID J ,  VOSS EDWARD Z ,  ZHONG MEI

Inventor： ALSOBROOK JOHN P II ,  BURGESS CATHERINE E ,  EDINGER SHLOMIT R ,  GERLACH VALERIE L ,  JI WEIZHEN ,  KEKUDA RAMESH ,  LI LI ,  MACDOUGALL JOHN R ,  MILLER CHARLES E ,  MILLET ISABELLE ,  PATTURAJAN MEERA ,  PENA CAROL E A ,  RIEGER DANIEL K ,  SCIORE PAUL ,  SHENOY SURESH G ,  SMITHSON GLENNDA ,  SPYTEK KIMBERLY A ,  STONE DAVID J ,  VOSS EDWARD Z ,  ZHONG MEI

IPC: A61K38/00 ,  C07K14/47 ,  C12N

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2004011830A1

公开(公告)日：2004-02-05

申请号：PCT/AU2003/000974

申请日：2003-07-31

Applicant: DORF CLARK INDUSTRIES LIMITED ,  STONE, David, George ,  EDWARDS, Gary, Bruce

Inventor： STONE, David, George ,  EDWARDS, Gary, Bruce

IPC: F16K1/02

CPC classification number: F16K3/08 ,  E03C1/0412 ,  F16K31/60

Abstract: A tap sub-assembly comprises a cover member (19) and a handle (18) rotatably attached thereto. The handle is adapted for connection with a tap operating spindle (17) extending outwardly from an architectural surface (13). The cover member is apertured for the passage therethrough of the spindle and is formed for attachment to the surface.

Abstract translation: 抽头子组件包括盖构件（19）和可旋转地附接到其上的把手（18）。 手柄适于与从建筑物表面（13）向外延伸的丝锥操作主轴（17）连接。 盖构件用于穿过主轴的通道，并且形成为用于附接到表面。

公开(公告)号：WO2003066881A2

公开(公告)日：2003-08-14

申请号：PCT/US2003/003403

申请日：2003-02-03

Applicant: CURAGEN CORPORATION ,  ANDERSON, David, W. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  GORMAN, Linda ,  JI, Weizhen ,  KEKUDA, Ramesh ,  LI, Li ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr.

Inventor： ANDERSON, David, W. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  GORMAN, Linda ,  JI, Weizhen ,  KEKUDA, Ramesh ,  LI, Li ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr.

IPC: C12Q

CPC classification number: C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及对多肽特异的新多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明进一步公开了诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

公开(公告)号：WO2003057854A3

公开(公告)日：2003-07-17

申请号：PCT/US2003/000253

申请日：2003-01-06

Applicant: CURAGEN CORPORATION ,  ANDERSON, David, W. ,  BALLINGER, Robert, A. ,  BAUMGARTNER, Jason, C. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CHANT, John, S. ,  BERGHS, Constance ,  GANGOLLI, Esha, A. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  FURTAK, Katarzyna ,  GERLACH, Valerie, L. ,  GILBERT, Jennifer, A. ,  GUNTHER, Erik ,  GORMAN, Linda ,  GUO, Xiaojia ,  JI, Weizhen ,  LI, Li ,  LIU, Xiaohong ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  RASTELLI, Luca ,  MACDOUGALL, John, R. ,  MISHRA, Vishnu, S. ,  PENA, Carol, E, A. ,  SPADERNA, Steven, K. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  SHENOY, Suresh, G. ,  ORT, Tatiana. ,  TAUPIER, Raymond, J, Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A, M. ,  WOLENC, Adam, R. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

Inventor： ANDERSON, David, W. ,  BALLINGER, Robert, A. ,  BAUMGARTNER, Jason, C. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CHANT, John, S. ,  BERGHS, Constance ,  GANGOLLI, Esha, A. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  FURTAK, Katarzyna ,  GERLACH, Valerie, L. ,  GILBERT, Jennifer, A. ,  GUNTHER, Erik ,  GORMAN, Linda ,  GUO, Xiaojia ,  JI, Weizhen ,  LI, Li ,  LIU, Xiaohong ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  RASTELLI, Luca ,  MACDOUGALL, John, R. ,  MISHRA, Vishnu, S. ,  PENA, Carol, E, A. ,  SPADERNA, Steven, K. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  SHENOY, Suresh, G. ,  ORT, Tatiana. ,  TAUPIER, Raymond, J, Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A, M. ,  WOLENC, Adam, R. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

IPC: C07K1/00

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO0246409A3

公开(公告)日：2003-07-10

申请号：PCT/US0146586

申请日：2001-12-06

Applicant: CURAGEN CORP ,  GUO XIAOJIA ,  LI LI ,  PATTURAJAN MEERA ,  SHIMKETS RICHARD A ,  CASMAN STACIE J ,  MALYANKAR URIEL M ,  TCHERNEV VELIZAR T ,  VERNET CORINNE A M ,  SPYTEK KIMBERLY A ,  SHENOY SURESH G ,  ALSOBROOK JOHN P II ,  EDINGER SCHLOMIT ,  PEYMAN JOHN A ,  STONE DAVID J ,  ELLERMAN KAREN ,  GANGOLLI ESHA A ,  BOLDOG FERENC L ,  COLMAN STEVEN D ,  EISEN ANDREW J ,  LIU XIAOHONG ,  PADIGARU MURALIDHARA ,  SPADERNA STEVEN K ,  ZERHUSEN BRYAN D

Inventor： GUO XIAOJIA ,  LI LI ,  PATTURAJAN MEERA ,  SHIMKETS RICHARD A ,  CASMAN STACIE J ,  MALYANKAR URIEL M ,  TCHERNEV VELIZAR T ,  VERNET CORINNE A M ,  SPYTEK KIMBERLY A ,  SHENOY SURESH G ,  ALSOBROOK JOHN P II ,  EDINGER SCHLOMIT ,  PEYMAN JOHN A ,  STONE DAVID J ,  ELLERMAN KAREN ,  GANGOLLI ESHA A ,  BOLDOG FERENC L ,  COLMAN STEVEN D ,  EISEN ANDREW J ,  LIU XIAOHONG ,  PADIGARU MURALIDHARA ,  SPADERNA STEVEN K ,  ZERHUSEN BRYAN D

IPC: A01K67/027 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61P1/00 ,  A61P1/04 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P5/14 ,  A61P7/06 ,  A61P9/10 ,  A61P13/08 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  A61K38/17 ,  A61K48/00 ,  G01N33/68

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

Abstract translation: 公开了编码它们的多肽和核酸。 还公开了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

公开(公告)号：WO2003040329A3

公开(公告)日：2003-05-15

申请号：PCT/US2002/035535

申请日：2002-11-05

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHANT, John, S. ,  CHAPOVAL, Andrei ,  CHAUDHURI, Amitabha ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GUO, Xiaojia ,  JI, Weizhen ,  KHRAMTSOV, Nikolai, V. ,  LEITE, Mario, W. ,  LI, Li ,  MEZES, Peter, S. ,  MILLET, Isabelle ,  OOI, Chean, Eng ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E.A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  QUINN SENGER, Kerry, E. ,  SMITHSON, Glennda ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TWOMLOW, Nancy ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHANT, John, S. ,  CHAPOVAL, Andrei ,  CHAUDHURI, Amitabha ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GUO, Xiaojia ,  JI, Weizhen ,  KHRAMTSOV, Nikolai, V. ,  LEITE, Mario, W. ,  LI, Li ,  MEZES, Peter, S. ,  MILLET, Isabelle ,  OOI, Chean, Eng ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E.A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  QUINN SENGER, Kerry, E. ,  SMITHSON, Glennda ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TWOMLOW, Nancy ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

IPC: C12N9/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO0190187A3

公开(公告)日：2003-03-13

申请号：PCT/US0117114

申请日：2001-05-24

Applicant: CURAGEN CORP ,  PADIGARU MURALIDHARA ,  SPYTEK KIMBERLY A ,  MAJUMDER KUMUD ,  TCHERNEV VELIZAR T ,  GROSSE WILLIAM M ,  SZERKERES EDWARD D ,  ALSOBROOK JOHN P II ,  BURGESS CATHERINE E ,  SHIMKETS RICHARD A ,  TAUPIER RAYMOND J ,  CASMAN STACIE J ,  GANGOLLI ESHA A ,  MACDOUGALL JOHN R ,  STONE DAVID J ,  SMITHSON GLENNDA

Inventor： PADIGARU MURALIDHARA ,  SPYTEK KIMBERLY A ,  MAJUMDER KUMUD ,  TCHERNEV VELIZAR T ,  GROSSE WILLIAM M ,  SZERKERES EDWARD D ,  ALSOBROOK JOHN P II ,  BURGESS CATHERINE E ,  SHIMKETS RICHARD A ,  TAUPIER RAYMOND J ,  CASMAN STACIE J ,  GANGOLLI ESHA A ,  MACDOUGALL JOHN R ,  STONE DAVID J ,  SMITHSON GLENNDA

IPC: C07K14/705 ,  C12N15/12 ,  C07K14/72 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/68

CPC classification number: C07K14/705

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003010327A3

公开(公告)日：2003-02-06

申请号：PCT/US2002/014199

申请日：2002-05-02

Applicant: CURAGEN CORPORATION ,  MILLER, Charles, E. ,  KEKUDA, Ramesh ,  MALYANKAR, Uriel, M. ,  LI, Li ,  PENA, Carol, E., A. ,  SPYTEK, Kimberly, A. ,  GORMAN, Linda ,  GUO, Xiaojia ,  FERNANDES, Elma, R. ,  SMITHSON, Glennda ,  STONE, David, J. ,  ZERHUSEN, Bryan, D. ,  PATTURAJAN, Meera ,  ANDERSON, David, W. ,  MEZES, Peter, S. ,  PEYMAN, John, A. ,  MACDOUGALL, John, R. ,  PADIGARU, Muralidhara ,  RASTELLI, Luca ,  SHENOY, Suresh, G. ,  GERLACH, Valerie, L. ,  SHIMKETS, Richard, A. ,  ZHONG, Mei ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen

Inventor： MILLER, Charles, E. ,  KEKUDA, Ramesh ,  MALYANKAR, Uriel, M. ,  LI, Li ,  PENA, Carol, E., A. ,  SPYTEK, Kimberly, A. ,  GORMAN, Linda ,  GUO, Xiaojia ,  FERNANDES, Elma, R. ,  SMITHSON, Glennda ,  STONE, David, J. ,  ZERHUSEN, Bryan, D. ,  PATTURAJAN, Meera ,  ANDERSON, David, W. ,  MEZES, Peter, S. ,  PEYMAN, John, A. ,  MACDOUGALL, John, R. ,  PADIGARU, Muralidhara ,  RASTELLI, Luca ,  SHENOY, Suresh, G. ,  GERLACH, Valerie, L. ,  SHIMKETS, Richard, A. ,  ZHONG, Mei ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen

IPC: C12P21/06

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment ofa broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.