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公开(公告)号：WO2016135754A1
公开(公告)日：2016-09-01
申请号：PCT/IN2016/050068
申请日：2016-02-25
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD
Inventor： BOMMAGANI, Madhusudhan , BHOWMICK, Subhas Balaram , KANE, Prashant , DUBEY, Vaibhav
CPC classification number: A61K9/146 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/122 , A61K31/65 , A61K47/14 , Y02A50/473
Abstract: The present invention relates to a nanoparticulate topical composition comprising (i) nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm, (ii) one or more wetting agent and (iii) a non-aqueous liquid vehicle, wherein the composition is free of water. The present invention also relates to a method of treating acne, rosacea, impetigo or a skin disease caused by a bacteria, by topical application of a nanoparticulate topical composition comprising nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm.
Abstract translation: 本发明涉及纳米颗粒局部组合物，其包含（i）水溶性和水易感活性成分或其药学上可接受的盐的纳米颗粒，其粒度分布使得90％的颗粒小于1000nm，（ii） 一种或多种润湿剂和（iii）非水液体载体，其中所述组合物不含水。 本发明还涉及通过局部施用包含水溶性和水敏感活性成分或其药学上可接受的盐的纳米颗粒的纳米颗粒局部组合物来治疗由细菌引起的痤疮，红斑痤疮，脓疱病或皮肤病的方法，其具有 使得90％的颗粒小于1000nm的粒度分布。
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公开(公告)号：WO2013088452A2
公开(公告)日：2013-06-20
申请号：PCT/IN2012/000726
申请日：2012-11-06
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： THENNATI, Rajamannar , SAMANTA, Biswajit , PAL, Ranjan Kumar , KUMBHANI, Anil Savajibhai , ADHYAPAK, Jay Prakashchandra , AKOLKAR, Nakul P , PARMAR, Pravin , DUBEY, Megha
IPC: C07D401/12
CPC classification number: C07D401/12 , C07D405/12 , C07D491/04
Abstract: A compound of formula (I), formula (I) or pharmaceutically acceptable salt thereof, as renin inhibitor, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of cardiovascular disorders related to hypertension, in warm-blooded animals. Further the present invention also provides a method for treatment of disorders like congestive heart failure, cardiac hypertrophy, cardiac fibrosis, coronary artery disease, vasculopathy, neuropathy, intraocular hypertension, glaucoma, diabetic nephropathy, abnormal vascular growth, hyperaldosteronism etc.
Abstract translation: 式（I），式（I）化合物或其药学上可接受的盐作为肾素抑制剂，其制备方法，以及该化合物在制备用于治疗与高血压相关的心血管疾病的药物组合物中的用途 在温血动物中。 此外，本发明还提供了治疗诸如充血性心力衰竭，心脏肥大，心脏纤维化，冠状动脉疾病，血管病变，神经病变，眼内高血压，青光眼，糖尿病肾病，异常血管生长，醛固酮增多症等疾病的方法。
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公开(公告)号：WO2011138801A1
公开(公告)日：2011-11-10
申请号：PCT/IN2011/000320
申请日：2011-05-06
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD. , KHOPADE, Ajay Jaysingh , HALDER, Arindam , BHOWMICK, Subhas Balaram
Inventor： KHOPADE, Ajay Jaysingh , HALDER, Arindam , BHOWMICK, Subhas Balaram
IPC: A61K9/00 , A61K31/557 , A61K31/5377 , A61K47/32
CPC classification number: A61K31/216 , A61K9/0048 , A61K9/08 , A61K31/5377 , A61K31/557 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/32 , A61K47/38 , A61K47/44
Abstract: An ophthalmic solution comprising therapeutically effective amount of a prostaglandin or its analog and water soluble excipient(s) dissolved in a pharmaceutically acceptable vehicle, wherein the solution is free of a surfactant.
Abstract translation: 一种眼用溶液，其包含治疗有效量的溶解在药学上可接受的载体中的前列腺素或其类似物和水溶性赋形剂，其中所述溶液不含表面活性剂。
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公开(公告)号：WO2011114355A1
公开(公告)日：2011-09-22
申请号：PCT/IN2011/000178
申请日：2011-03-17
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD. , KANE, Prashant , GOKHALE, Satish Madhukar , GOLE, Nachiket
Inventor： KANE, Prashant , GOKHALE, Satish Madhukar , GOLE, Nachiket
IPC: A61M15/00
CPC classification number: A61M15/009 , A61M15/0075 , A61M15/0081 , A61M15/0091 , A61M2205/276
Abstract: The present invention relates to a metered dose inhaler comprising an actuator being controlled by locking means. Locking means comprises a pendulum rod (6) which is operated by shaking movement of the inhaler.
Abstract translation: 本发明涉及一种计量剂量吸入器，其包括由锁定装置控制的致动器。 锁定装置包括通过吸入器的振动运动操作的摆杆（6）。
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45.发明申请
公开(公告)号：WO2011101866A2
公开(公告)日：2011-08-25
申请号：PCT/IN2011/000099
申请日：2011-02-17
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD., , DHARMADHIKARI, Nitin Bhalachandra , ZALA, Yashoraj Rupsinh
IPC: A61K9/00
CPC classification number: A61K31/197 , A61K9/006 , A61K9/0065 , A61K9/209 , A61K9/4866 , A61K9/4891 , A61K9/5047
Abstract: The present invention discloses a method of treating a disease condition susceptible to baclofen therapy, said method comprising orally administering once-a-day in the evening a controlled release drug delivery system comprising baclofen or its pharmaceutically acceptable salt or its derivatives and pharmaceutically acceptable excipients.
Abstract translation: 本发明公开了一种治疗对巴氯芬治疗敏感的疾病状况的方法，所述方法包括在晚上一天一次口服给予包含巴氯芬或其药学上可接受的盐或其衍生物和药学上可接受的赋形剂的控释药物递送系统。
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Patent Agency Ranking
公开(公告)号：WO2010122574A3
公开(公告)日：2010-10-28
申请号：PCT/IN2010/000242
申请日：2010-04-15
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD. , ZALA, Yashoraj Rupsinh , DHARMADHIKARI, Nitin Bhalachandra
Abstract: The present invention relates to coated capsules comprising therapeutically active ingredient and pharmaceutically acceptable carrier and the coating composition (4) comprising a hydrophobic polymer and a hydrophilic substance, wherein the said coating composition is applied directly to the capsule and wherein the coated capsules upon contact with the aqueous environment (1) break open into the cap (2) and the body (3) and thereby providing a programmed release of the therapeutically active ingredient.
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公开(公告)号：WO2010079499A2
公开(公告)日：2010-07-15
申请号：PCT/IN2009/000112
申请日：2009-02-12
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD., , PATEL, Jiten Ranchhodbhai , PATEL, GopalKumar Chimanlal , SHETH, Gaurav Sanjivkumar , CHITTURI, Trinadha Rao , THENNATI, Rajamannar
Inventor： PATEL, Jiten Ranchhodbhai , PATEL, GopalKumar Chimanlal , SHETH, Gaurav Sanjivkumar , CHITTURI, Trinadha Rao , THENNATI, Rajamannar
IPC: C07D305/14
CPC classification number: C07D305/14
Abstract: The present invention relates to compounds of formula I or salts thereof, wherein, R 1 is selected from the group consisting of hydrogen and R 4 ; R 2 is selected from the group consisting of hydrogen, acetyl and R 4 ; R 3 is selected from the group consisting of alkyl, -O-alkyl,-NH-alkyl, aryl and heterocyclyl; R 4 represents a moiety (A) wherein, X is selected from the group consisting of a single bond, alkylene, alkenylene, alkynylene, arylene or a heterocyclylene moiety; R 5 and R 6 are same or different and are independently selected from hydrogen, alkyl, aryl or heterocyclyl; or R 5 and R 6 may form together with the nitrogen atom to which they are attached a heterocyclyl ring system.
Abstract translation: 本发明涉及式I化合物或其盐，其中R 1选自氢和R 4; R2选自氢，乙酰基和R4; R 3选自烷基，-O-烷基，-NH-烷基，芳基和杂环基; R4表示部分（A），其中X选自单键，亚烷基，亚烯基，亚炔基，亚芳基或亚杂环基; R5和R6相同或不同，独立地选自氢，烷基，芳基或杂环基; 或者R 5和R 6可以与它们所连接的氮原子一起形成杂环基环系。
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公开(公告)号：WO2009109991A2
公开(公告)日：2009-09-11
申请号：PCT/IN2009/000057
申请日：2009-01-22
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD., , SENGUPTA, Prabal , PURI, Chetan Surjitsingh , CHOKSHI, Hemantkumar , CHITTURI, Trinadha Rao , THENNATI, Rajamannar
Inventor： SENGUPTA, Prabal , PURI, Chetan Surjitsingh , CHOKSHI, Hemantkumar , CHITTURI, Trinadha Rao , THENNATI, Rajamannar
IPC: C07D401/04 , C07D401/14 , C07D403/00
CPC classification number: C07D409/14 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D417/04
Abstract: The present invention relates to compounds of formula (I), and salts thereof, wherein P represents a 5 or 6-membered heteroaryl ring; R 1 is aryl or unsaturated heterocyclyl radical optionally substituted by one or more identical or different radicals R 5.
Abstract translation: 本发明涉及式（I）化合物及其盐，其中P表示5或6元杂芳基环; R 1是任选被一个或多个相同或不同基团R 5取代的芳基或不饱和杂环基。
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公开(公告)号：WO2021005583A1
公开(公告)日：2021-01-14
申请号：PCT/IB2020/056580
申请日：2020-07-13
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： PATEL, Jiten Ranchhodbhai , PATEL, Gopalkumar Chimanlal , GORE, Omkar Prakash , SENGUPTA, Prabal , CHITTURI, Trinadha Rao
IPC: C07D491/22 , A61K31/497 , A61P35/00
Abstract: This invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof (wherein X, Y, Z and n are defined herein). These compounds are useful in the treatment of diseases mediated by topoisomerase I enzyme such as cancers. The present invention also provides processes for the preparation of compounds of Formula I. The compounds of the present invention are more water soluble, stable in buffer solution at various pH, and exhibit better anti-tumor activity and rapid release of SN-38 in tumor microenvironments.
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公开(公告)号：WO2016013031A1
公开(公告)日：2016-01-28
申请号：PCT/IN2015/050073
申请日：2015-07-23
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： BHOWMICK, Subhas , UMRETHIA, Manish Kumar , MAITI, Kuntal , HADIA, Jayesh Kumar , PATEL, Nitesh Kumar
IPC: A61K9/127 , A61K9/107 , A61K31/4178
CPC classification number: A61K31/4178 , A61K9/0019 , A61K9/1271 , A61K31/41 , A61K31/4184 , A61K31/4245
Abstract: The present invention relates to a method of loading an ionizable drug having a group selected from (Formule I or Formule II) or pharmaceutically acceptable salts thereof into a liposome and the liposomal composition of drug produced therewith.
Abstract translation: 本发明涉及一种将具有选自（Formule I或Formule II）或其药学上可接受的盐的可离子化药物加载到脂质体中的方法和由其制备的药物的脂质体组合物。
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