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    High performance fluorescent optical sensor
    41.
    发明专利
    High performance fluorescent optical sensor 未知

    公开(公告)号：AU2002359673B2

    公开(公告)日：2009-01-08

    申请号：AU2002359673

    申请日：2002-12-11

    Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

    Inventor： COLVIN ARTHUR E JR ,  WALTERS STEVEN J

    IPC: G01N21/64 ,  G01N21/77

    Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.

    Optical-based sensing devices
    43.
    发明专利
    Optical-based sensing devices 未知

    公开(公告)号：AU5786799A

    公开(公告)日：2000-03-21

    申请号：AU5786799

    申请日：1999-08-26

    Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

    Inventor： COLVIN ARTHUR E JR ,  DALE GREGORY A ,  ZERWEKH PAUL SAMUEL ,  LESHO JEFFREY C ,  LYNN ROBERT W

    IPC: A61B5/00 ,  G01N21/27 ,  G01N21/64 ,  G01N21/77 ,  G01N33/543 ,  G01N21/55

    Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body (12) with a source of radiation embedded therein (18). A matrix layer is disposed on the surface of the sensor body which layer is permeable to an analyte and comprises fluroescent indicator molecules responsive to the concentration of the analyte. Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e,g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte.

    Systems and methods for extending the useful life of optical sensors
    46.
    发明专利
    Systems and methods for extending the useful life of optical sensors 未知

    公开(公告)号：AU2005238963B2

    公开(公告)日：2011-07-14

    申请号：AU2005238963

    申请日：2005-04-25

    Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

    Inventor： JEFFERY LESHO ,  CARRIE LORENZ ,  ARTHUR COLVIN

    IPC: G01N21/64 ,  A61B5/00

    Abstract: The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.

    Detection of analytes
    50.
    发明申请
    Detection of analytes 审中-公开
    检测分析物

    公开(公告)号：US20020094586A1

    公开(公告)日：2002-07-18

    申请号：US09754219

    申请日：2001-01-05

    Applicant: Sensors for Medicine and Science, Inc.

    Inventor： George Y. Daniloff ,  Aristotle G. Kalivretenos ,  Alexandre V. Nikolaitchik ,  Edwin F. Ullman

    IPC: C07C069/76 ,  C07F005/04

    CPC classification number: G01N33/66

    Abstract: Disclosed are methods for detecting analytes with indicator systems which may undergo a molecular configurational change upon exposure to the analyte. The configurational change affects a detectable quality associated with the indicator system, thereby allowing detection of the presence or concentration of the analyte.

    Abstract translation: 公开了用于用指示剂系统检测分析物的方法，所述指示剂体系在暴露于分析物时可能经历分子结构变化。 配置变化影响与指示剂系统相关的可检测质量，从而允许检测分析物的存在或浓度。

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