公开(公告)号：EP1281760B9

公开(公告)日：2005-12-28

申请号：EP02017134.4

申请日：1998-10-01

Applicant: MERIAL ,  The Queen's University of Belfast ,  The University of Saskatchewan

Inventor： Allan, Gordon ,  Meehan, Brian ,  Clark, Edward ,  Ellis, John ,  Haines, Deborah ,  Hassard, Lori ,  Harding, John ,  Charreyre, Catherine Elisabeth ,  Chappuis, Gilles Emile ,  Mc Neilly, Francis

IPC: C12N15/34 ,  C07K14/01 ,  A61K39/12 ,  A61K48/00 ,  C12Q1/68 ,  C07K16/08 ,  G01N33/53

CPC classification number: C07K14/005 ,  A23C19/0321 ,  A23C19/0323 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/51 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N2750/10021 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10043

公开(公告)号：EP1382610A3

公开(公告)日：2004-09-15

申请号：EP03023704.4

申请日：1998-12-16

Applicant: The University of Saskatchewan

Inventor： Aich, Palok, Dept. of Biochemistry ,  Lee, Jeremey S., Dept. of Biochemistry

IPC: C07H21/00 ,  C12Q1/68 ,  C07K16/00

CPC classification number: G11C13/0019 ,  B82Y10/00 ,  C07H21/00 ,  C07K16/44 ,  C12Q1/6825 ,  G11C13/0014 ,  H01L51/0077 ,  H01L51/0093 ,  H01L51/0595 ,  C12Q2563/113 ,  C12Q2563/107 ,  C12Q2527/125

Abstract: The invention provides conductive polymers comprising metal-containing nucleic acid duplexes electrically coupled to an electron source. Methods for making conductive metal-containing nucleic acid duplexes are provided, comprising subjecting a nucleic acid duplex to basic conditions in the presence of a divalent metal cation. Methods of using conductive metal-containing nucleic acid duplexes are provided, including methods of genomic analysis, methods of molecular screening and immunological methods that produce antibodies to such molecules.

Abstract translation: 本发明提供了导电聚合物，其包含电耦合到电子源的含金属的核酸双链体。 提供了制备含导电金属的核酸双链体的方法，包括在二价金属阳离子存在下使核酸双链体进行碱性条件。 提供了使用含导电金属的核酸双链体的方法，包括基因组分析方法，分子筛选方法和产生针对这种分子的抗体的免疫学方法。

公开(公告)号：EP1159426A1

公开(公告)日：2001-12-05

申请号：EP00908866.7

申请日：2000-03-10

Applicant: The University of Saskatchewan

Inventor： POTTER, Andrew, A. ,  RIOUX, Clement ,  SCHRYVERS, Anthony, B.

IPC: C12N15/31 ,  C07K14/285 ,  A61K39/102 ,  G01N33/68

CPC classification number: C07K14/285 ,  A61K39/00

Abstract: Cloning and expression of genes encoding H. somnus transferring-binding proteins are described. The transferrin-binding proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections, as well as in diagnostic methods for determining the presence of H. Somnus infections.

公开(公告)号：EP0618766B1

公开(公告)日：2001-06-20

申请号：EP93900142.6

申请日：1992-12-18

Applicant: The University of Saskatchewan

Inventor： ATTREE, Stephen M. ,  FOWKE, Lawrence C.

IPC: A01H7/00 ,  A01H4/00

CPC classification number: A01H7/00 ,  A01H4/006

Abstract: A desiccated mature gymnosperm somatic embryo characterized by having a moisture content which is lower than the moisture content of its corresponding zygotic embryo and a dry weight and per embryo lipid content which are higher than the lipid content and dry weight of its corresponding gymnosperm zygotic embryo. Preferred desiccated gymnosperm somatic embryos are conifer somatic embryos having a moisture content ranging between 10 and 55 %. Also within the scope of the invention is a method for producing desiccated somatic embryos. The method comprises developing immature embryos in a medium comprising at least one non-permeating water stress agent, a metabolizable carbon source and a growth regulator having an influence on embryo development for a period of time sufficient to yield the recovery of mature somatic embryos having a moisture content which is lower than the moisture content of corresponding zygotic embryos. The method can optionally include a secondary desiccation treatment to further reduce the moisture content of the embryos.

公开(公告)号：EP1094837A2

公开(公告)日：2001-05-02

申请号：EP99932831.3

申请日：1999-06-28

Applicant: MERIAL ,  The Queen's University of Belfast ,  The University of Saskatchewan

Inventor： ALLAN, Gordon, Moore ,  MEEHAN, Brian, Martin ,  ELLIS, John, Albert ,  KRAKOWKA, George, Steven ,  AUDONNET, Jean-Christophe, Francis ,  MCNEILLY, Francis

IPC: A61K39/395 ,  C07K14/01 ,  C12N7/00 ,  C12N15/86

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/14322 ,  C12N2750/14334 ,  Y10S424/815 ,  Y10S435/81

Abstract: The invention relates to antigenic preparations and vaccines directed against the porcine multisystemic wasting syndrome (PMWS), comprising at least one porcine circovirus antigen, preferably type II, and at least one porcine parvovirus antigen.

公开(公告)号：EP0998576A2

公开(公告)日：2000-05-10

申请号：EP98930594.1

申请日：1998-06-23

Applicant: The University of Saskatchewan

Inventor： BABIUK, Lorne, A. ,  TIKOO, Suresh, Kumar ,  REDDY, Police, Seshidar

IPC: C12N15/86 ,  C12N7/01 ,  C07K14/075 ,  C12N5/10 ,  C12Q1/68 ,  C07K16/08 ,  A61K48/00 ,  G01N33/50 ,  A61K39/235

CPC classification number: C12N15/86 ,  A61K39/00 ,  A61K2039/51 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10343

Abstract: In one embodiment, the present invention relates to novel bovine adenovirus expression vector systems which utilize the following regions of the bovine adenovirus genome: nucleotides 4,092-5,234; nucleotides 5,892-17,735; nucleotides 21,198-26,033 and nucleotides 31,133-34,445. These regions can be used, among other things, for insertion of foreign sequences, for provision of DNA control sequences including transcriptional and translational regulatory sequences, or for diagnostic purposes to detect the presence of viral nucleic acids or proteins encoded by these regions, in a subject or biological sample. In another embodiment, the present invention relates to novel methods for the construction, isolation and propagation of recombinant bovine adenovirus (BAV) with deletions (and optionally insertions of heterologous sequence) in the E3 region. Recombinant BAV containing insertions of genes encoding protective determinants of a pathogen stimulate enhanced systemic and mucosal immune responses and protect host animals against challenge by the pathogen.

公开(公告)号：EP0527724A1

公开(公告)日：1993-02-24

申请号：EP90906831.0

申请日：1990-05-25

Applicant: The University of Saskatchewan

Inventor： ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

IPC: A61K39 ,  A61P31 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N15 ,  C12P21 ,  C12R1

CPC classification number: A61K39/102 ,  A61K39/00 ,  C07K14/285

Abstract: L'invention a pour objet de nouvelles protéines et des antigènes de sous-groupes provenant de P. haemolytica, s'utilisant pour stimuler l'immunité contre des maladies respiratoires comme la pneumonie, y compris la pneumonie causée par le transport. Les antigènes de sous-groupes comprennent des séquences immunogènes amino-acides de la protéine periphérifine de P. haemolytica, de la proteine réceptrice de plasmine de P. haemolytica et de la protéine de membrane extérieure 50 K de P. haemolytica ainsi que de la leucotoxine de P. haemolytica. Les antigènes peuvent s'utiliser dans une composition de vaccin, soit seuls soit en combinaison. L'invention se rapporte également à des procédés de vaccination ainsi qu'à des procédés de production des antigènes de sous-groupes

公开(公告)号：EP0478609A1

公开(公告)日：1992-04-08

申请号：EP90909119.0

申请日：1990-06-21

Applicant: The University of Saskatchewan

Inventor： LAARVELD, Bernard ,  KIRKWOOD, Roy, Neville ,  THACKER, Philip, Alfred ,  SORDILLO, Lorraine, M. ,  REDMOND, Mark

IPC: A61K38 ,  A61K39 ,  A61P13 ,  A61P15 ,  A61P37 ,  C07K16

CPC classification number: C07K16/26 ,  A61K39/0005 ,  A61K2039/55505 ,  A61K2039/6081 ,  C07K2317/34

Abstract: La présente invention décrit des compositions et des procédés permettant de moduler l'activité du facteur inhibiteur de libération de somatotropine (SRIF), ainsi que d'améliorer les performances reproductives et la fonction immunologique chez des vertébrés. Les compositions contenant de tels peptides apparentés au facteur SRIF ou des anticorps de ces peptides peuvent être administrés à des animaux, en vue d'obtenir une modulation de l'activité du facteur SRIF endogène. Ces peptides apparentés au facteur SRIF peuvent être liés à un excipient, tel que l'ovalbumine, et administrés dans un adjuvant d'AL(OH)3, pour accroître l'immunogénicité des peptides apparentés au facteur SRIF.

公开(公告)号：EP0437505A4

公开(公告)日：1991-11-13

申请号：EP89911651

申请日：1989-10-06

Applicant: THE UNIVERSITY OF SASKATCHEWAN ,  HEISE-QUALTIERE, JANETTE

Inventor： HEISE-QUALTIERE, JANETTE DEPT. OF MICROBIOLOGY ,  LAWMAN, MICHAEL DEPT IMM.&MEDIC.MICROBIO. ,  OHMANN, HELLE, BIELEFELDT ,  ATTAH-POKU, SAMUEL, K.

IPC: C12N15/09 ,  A61K35/12 ,  A61K38/00 ,  A61K39/395 ,  A61P7/00 ,  A61P37/00 ,  A61P43/00 ,  C07K1/22 ,  C07K14/435 ,  C07K14/52 ,  C07K14/53 ,  C07K16/00 ,  C07K16/18 ,  C12N5/0789 ,  C12N5/10 ,  C12N15/02 ,  C12N15/12 ,  C12P21/00 ,  C12R1/91 ,  C12N5/00 ,  A61K35/00 ,  A61K37/00 ,  C07K13/00 ,  C12N15/00

CPC classification number: C07K14/53 ,  A61K38/00 ,  A61K2035/124 ,  C07K16/18 ,  C12N5/0647 ,  C12N2502/11 ,  C12N2502/1394

Abstract: The invention derives from the discovery of cells, NA cells, which have properties indicating that they may be pluripotent lymphohematopoietic progenitor cells. These cells, and the stromal cells derived from bone marrow cultures, produce factors which stimulate the growth of primitive cell colonies, as reflected in their stimulation of the growth of colonies of NA cells. These primitive cell colony stimulating factors (PC-CSFs) may be useful in the treatment of disorders which can be alleviated by the proliferation of desired cells. In addition, the NA cells and/or PC-CSFs) may provide an alternative and/or supplementary method to bone marrow transplantation to alleviate hematopoietic disorders.

公开(公告)号：EP0437505A1

公开(公告)日：1991-07-24

申请号：EP89911651.0

申请日：1989-10-06

Applicant: The University of Saskatchewan ,  HEISE-QUALTIERE, Janette

Inventor： HEISE-QUALTIERE, Janette Dept. of Microbiology ,  LAWMAN, Michael Dept Imm.&Medic.Microbio. ,  OHMANN, Helle, Bielefeldt ,  ATTAH-POKU, Samuel, K.

IPC: C12N15 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61P7 ,  A61P37 ,  A61P43 ,  C07K1 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12P21 ,  C12R1

CPC classification number: C07K14/53 ,  A61K38/00 ,  A61K2035/124 ,  C07K16/18 ,  C12N5/0647 ,  C12N2502/11 ,  C12N2502/1394

Abstract: The invention derives from the discovery of cells, NA cells, which have properties indicating that they may be pluripotent lymphohematopoietic progenitor cells. These cells, and the stromal cells derived from bone marrow cultures, produce factors which stimulate the growth of primitive cell colonies, as reflected in their stimulation of the growth of colonies of NA cells. These primitive cell colony stimulating factors (PC-CSFs) may be useful in the treatment of disorders which can be alleviated by the proliferation of desired cells. In addition, the NA cells and/or PC-CSFs) may provide an alternative and/or supplementary method to bone marrow transplantation to alleviate hematopoietic disorders.