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公开(公告)号：KR1020140123034A
公开(公告)日：2014-10-21
申请号：KR1020140124120
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844
Abstract: Disclosed is a biomarker of which gene expression levels are specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention contains one or more gene selected from a group consisting of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group consisting of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.
Abstract translation: 公开了一种生物标志物，其敏感性皮肤基因表达水平被特异地增加或降低。 敏感皮肤特异性的生物标志物用于敏感皮肤的诊断试剂盒和刺激物的筛选方法。 根据本发明的敏感性皮肤诊断用生物标志物含有选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A ，FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB， H19，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。
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公开(公告)号：KR1020080011546A
公开(公告)日：2008-02-05
申请号：KR1020060071988
申请日：2006-07-31
Applicant: (주)아모레퍼시픽
IPC: A61K8/97
Abstract: A cosmetic composition is provided to be able to remove irritation caused by a chemical preservative by including an extract of Lonicera flos instead of a conventional chemical preservative and show excellent skin safety with having the preserving capacity as it is. A low-irritating skin external application composition comprises 0.001-5 wt.% of an extract of Lonicera flos, which is obtained by supercritical fluid extracting the Lonicera flos using CO2 and water as a solvent, extracting the Lonicera flos using a polar solvent such as ethanol and methanol or a mixture solvent of the polar solvent and distilled water with heating or concentrating it under reduced pressure. The composition is a basic cosmetic composition such as skin, astringent, nutritive lotion, cream, essence, pack, cleansing foam and gel, a make-up cosmetic composition such as foundation, mascara and eye-liner, a hair cosmetic composition such as shampoo, rinse, hair-cream, hair styling gel, hair arranging agent, and hair-growing agent, a medicine such as ointment or a quasi-drug such as toothpaste or mouthwash.
Abstract translation: 提供化妆品组合物以能够通过包括忍者金属的提取物而不是常规的化学防腐剂来消除由化学防腐剂引起的刺激，并且具有优异的皮肤安全性，同时具有保存能力。 低刺激性皮肤外用组合物包含0.001-5重量％的忍冬提取物，其通过超临界流体使用CO 2和水作为溶剂萃取金银花提取物，使用极性溶剂如 乙醇和甲醇或极性溶剂和蒸馏水的混合溶剂，加热或减压浓缩。 该组合物是基本的化妆品组合物，如皮肤，收敛剂，营养洗剂，霜剂，精华，包装，清洁泡沫和凝胶，化妆品组合物如地基，睫毛膏和眼线膏，美发组合物如洗发剂 漂洗剂，发乳，头发定型凝胶，头发调配剂和生发剂，药膏如软膏或准药如牙膏或漱口剂。
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公开(公告)号：KR101543181B1
公开(公告)日：2015-08-07
申请号：KR1020140124117
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: 민감성피부에대해서특이적으로유전자발현량이증가또는억제되는바이오마커가개시된다. 상기민감성피부에특이적인바이오마커를이용하여민감성피부진단키트및 자극감완화제의스크리닝방법등에활용할수 있다.
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公开(公告)号：KR101543179B1
公开(公告)日：2015-08-07
申请号：KR1020140124114
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: 민감성피부에대해서특이적으로유전자발현량이증가또는억제되는바이오마커가개시된다. 상기민감성피부에특이적인바이오마커를이용하여민감성피부진단키트및 자극감완화제의스크리닝방법등에활용할수 있다.
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公开(公告)号：KR101543175B1
公开(公告)日：2015-08-07
申请号：KR1020140124110
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: 민감성피부에대해서특이적으로유전자발현량이증가또는억제되는바이오마커가개시된다. 상기민감성피부에특이적인바이오마커를이용하여민감성피부진단키트및 자극감완화제의스크리닝방법등에활용할수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020140130378A
公开(公告)日：2014-11-10
申请号：KR1020140124108
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: 민감성 피부에 대해서 특이적으로 유전자 발현량이 증가 또는 억제되는 바이오 마커가 개시된다. 상기 민감성 피부에 특이적인 바이오 마커를 이용하여 민감성 피부 진단 키트 및 자극감 완화제의 스크리닝 방법 등에 활용할 수 있다.
Abstract translation: 公开了具有基因表达的生物标志物，其对于敏感性皮肤特异性地增加或减少。 敏感皮肤特异性的生物标志物用于敏感皮肤的这种诊断试剂盒和刺激释放剂的筛选方法。 所述诊断试剂盒包含：一种或多种作为NFκB1转录因子多核苷酸的多核苷酸或其片段，其中所述片段包含十个或更多个连续核苷酸，或与片段互补的多核苷酸和多核苷酸; 和具有多核苷酸结合表面的固体支持物。
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公开(公告)号：KR1020140123032A
公开(公告)日：2014-10-21
申请号：KR1020140124111
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: Disclosed is a biomarker having the amount of gene expression be specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention one or more gene selected from a group composed of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group composed of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.
Abstract translation: 公开了对敏感性皮肤具有特异性增加或减少的基因表达量的生物标志物。 敏感性皮肤特异性生物标志物用于这种用于敏感性皮肤的诊断试剂盒和中枢刺激剂的筛选方法。 根据本发明的用于诊断敏感性皮肤的生物标志物选自由HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A， FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB，H19 ，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。
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公开(公告)号：KR1020140118972A
公开(公告)日：2014-10-08
申请号：KR1020140124107
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: Disclosed is a biomarker by which the amount of gene expression is increased or the gene expression is inhibited specifically with respect to sensitive skin. The biomarker can be used for a kit for testing sensitive skin and a method for screening an agent for alleviating irritation. The test kit includes: a polynucleotide of a TNFRSF19 gene, one or more polynucleotides which are fragments of the polynucleotide of the TNFRSF19 gene and include 10 or more serial nucleotides, or a polynucleotide complementary to the polynucleotide stated earlier and fragments thereof; and a solid scaffold having the surface on which the polynucleotides are bound.
Abstract translation: 公开了一种基因表达量增加或相对于敏感皮肤特异性抑制基因表达的生物标志物。 生物标志物可用于测试敏感性皮肤的试剂盒和用于筛选试剂以减轻刺激性的方法。 测试试剂盒包括：TNFRSF19基因的多核苷酸，一种或多种多核苷酸，其是TNFRSF19基因的多核苷酸的片段，并且包括10个或更多个序列核苷酸，或与前述多核苷酸互补的多核苷酸及其片段; 和具有结合多核苷酸的表面的固体支架。
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公开(公告)号：KR1020140089505A
公开(公告)日：2014-07-15
申请号：KR1020140081131
申请日：2014-06-30
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: The present invention discloses a biomarker of which a gene expression level increases or decreases specifically with respect to sensitive skin. The biomarker specific to sensitive skin can be applied to a kit for identifying sensitive skin and a screening method of an irritation reliever. The biomarker for identifying sensitive skin includes one or more genes selected from a group constituted by HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A,FKBP5, PI3, PSPH, HORMAD1, SPRR2G and ACTR2.
Abstract translation: 本发明公开了相对于敏感性皮肤特异性地基因表达水平升高或降低的生物标志物。 敏感皮肤特异性的生物标志物可用于鉴定敏感皮肤的试剂盒和刺激缓解剂的筛选方法。 识别敏感皮肤的生物标志物包括选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A，FKBP5，PI3，PSPH组成的组中的一种或多种基因 ，HORMAD1，SPRR2G和ACTR2。
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公开(公告)号：KR100916153B1
公开(公告)日：2009-09-08
申请号：KR1020070120339
申请日：2007-11-23
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 계면활성제를 다량 포함하고 있는 샴푸 등 두피 세정 제품의 실제 사용 조건에서의 미약한 피부 자극에 의한 각질층의 두께를 측정하여 두피의 손상 정도를 평가하는 방법에 관한 것으로서, 보다 상세하게는 기존의 첩포시험(patch test)을 개선하고 생체 공초점 레이저 주사현미경(in vivo confocal microscopy)과 이미지 분석 프로그램을 이용하여 객관적이고 시각적으로 피부 각질층의 손상 정도를 측정하여 두피 손상 정도를 평가하는 방법에 관한 것이다.
샴푸, 두피 세정 제품, 두피, 생체 공초점 레이저 주사현미경(in vivo laser confocal microscopy), 이미지 분석, 워시-오프(wash-off)
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