公开(公告)号：KR1020130076975A

公开(公告)日：2013-07-09

申请号：KR1020110145429

申请日：2011-12-29

Applicant: 성균관대학교산학협력단

Inventor： 조재열 ,  양우석 ,  홍성렬 ,  김태웅

IPC: A61K36/48

CPC classification number: A61K36/48 ,  A61K2236/33 ,  A61K2236/37

Abstract: PURPOSE: A pharmaceutical composition for prevention or treatment of inflammation diseases including archidendron clypearia methanol extract is provided to be able to be used in prevention or treatment of inflammation diseases by suppressing the activation of Src, Syk and IRAK-1, which are tyrosine kinase. CONSTITUTION: A pharmaceutical composition for prevention or treatment of inflammation diseases includes archidendron clypearia methanol extract as an active ingredient. The inflammation diseases include chronic inflammation progressed to a disease condition, an inflammation by generally harmless substances such as pollen, and an inflammation by the autoimmune response such as asthma or rheumatoid arthritis. The inflammation diseases are selected from the group consisting of sepsis, dermatitis, allergy, atopic dermatitis, asthma, conjunctivitis, periodontitis, rhinitis, tympanitis, laryngopharyngitis, tonsillitis, pneumonia, gastric ulcer, gastritis, Crohn's disease, colitis, hemorrhoid, gout, ankylosing spondylitis, rheumatic fever, lupus, fibromyalgia, psoriatic arthritis, osteoarthritis, rheumatoid arthritis, periarthritis of shoulder, tendinitis, tenosynovitis, peritendinitis, myositis, hepatitis, cystitis, nephritis, Sjogren’s syndrome, multiple sclerosis, acute inflammation diseases and chronic inflammatory diseases. The methanol extract is extracted by applying the pressure of 1,000-2,000 psi at 40-70deg.C and cultivating for 1-5 days after archidendron clypearia is dipped in methanol.

Abstract translation: 目的：提供一种用于预防或治疗炎性疾病的药物组合物，包括天竺葵甲醇提取物，可通过抑制作为酪氨酸激酶的Src，Syk和IRAK-1的活化而用于预防或治疗炎症疾病。 构成：用于预防或治疗炎症疾病的药物组合物包括作为活性成分的翠柏甘油甲醇提取物。 炎性疾病包括慢性炎症进展到疾病状态，通常是无害物质如花粉的炎症，以及由自身免疫反应如哮喘或类风湿性关节炎引起的炎症。 炎性疾病选自败血症，皮炎，过敏，特应性皮炎，哮喘，结膜炎，牙周炎，鼻炎，鼓膜炎，喉咽炎，扁桃体炎，肺炎，胃溃疡，胃炎，克罗恩病，结肠炎，痔疮，痛风，强直性强 脊柱炎，风湿热，狼疮，纤维肌痛，银屑病关节炎，骨关节炎，类风湿性关节炎，肩关节炎，腱炎，腱鞘炎，青per素炎，肌炎，肝炎，膀胱炎，肾炎，干燥综合征，多发性硬化，急性炎症疾病和慢性炎性疾病。 通过在40-70℃下施加1,000-2,000psi的压力提取甲醇提取物，并在将archidendron clypearia浸入甲醇中后培养1-5天。