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1.发明公开4―디메틸아미노―2―메톡시―6―（（메틸―［2―（4―니트로페닐）에틸］아미노）메틸）페놀을 포함하는 항염증용 조성물 有权包含4-二甲基氨基-2-甲氧基-6-（（甲基 - [2-（4-硝基苯基）乙基]氨基）甲基）苯酚用于抗炎的组合物
公开(公告)号：KR1020140018501A
公开(公告)日：2014-02-13
申请号：KR1020120084641
申请日：2012-08-02
Applicant: 성균관대학교산학협력단
Abstract: The present invention relates to a pharmaceutical composition, a food composition, and a cosmetic composition containing 4-dimethylamino-2-methoxy-6-((methyl-[2-(4-nitrophenyl)ethyl]methyl) phenol as an active ingredient for anti-inflammation. The compositions in the present invention have an excellent anti-inflammation effect by basically decreasing the formation of TNF-α, PGE2, and NO from the transcription step. Also the compositions show no cytotoxicity even in case of high-dose treatment, thereby being applicable for medicine, foods, and cosmetics safely. Thus, the compositions are expected to be importantly applicable as an anti-inflammatory drug.
Abstract translation: 本发明涉及含有4-二甲基氨基-2-甲氧基-6 - （（甲基 - [2-（4-硝基苯基）乙基]甲基）苯酚作为活性成分的药物组合物，食品组合物和化妆品组合物 本发明的组合物通过从转录步骤基本上降低TNF-α，PGE2和NO的形成而具有优异的抗炎作用，即使在高剂量治疗的情况下，组合物也不显示细胞毒性 因此安全地适用于医药，食品和化妆品，因此预期该组合物作为抗炎药可以重要地应用。
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公开(公告)号：KR1020130076975A
公开(公告)日：2013-07-09
申请号：KR1020110145429
申请日：2011-12-29
Applicant: 성균관대학교산학협력단
IPC: A61K36/48
CPC classification number: A61K36/48 , A61K2236/33 , A61K2236/37
Abstract: PURPOSE: A pharmaceutical composition for prevention or treatment of inflammation diseases including archidendron clypearia methanol extract is provided to be able to be used in prevention or treatment of inflammation diseases by suppressing the activation of Src, Syk and IRAK-1, which are tyrosine kinase. CONSTITUTION: A pharmaceutical composition for prevention or treatment of inflammation diseases includes archidendron clypearia methanol extract as an active ingredient. The inflammation diseases include chronic inflammation progressed to a disease condition, an inflammation by generally harmless substances such as pollen, and an inflammation by the autoimmune response such as asthma or rheumatoid arthritis. The inflammation diseases are selected from the group consisting of sepsis, dermatitis, allergy, atopic dermatitis, asthma, conjunctivitis, periodontitis, rhinitis, tympanitis, laryngopharyngitis, tonsillitis, pneumonia, gastric ulcer, gastritis, Crohn's disease, colitis, hemorrhoid, gout, ankylosing spondylitis, rheumatic fever, lupus, fibromyalgia, psoriatic arthritis, osteoarthritis, rheumatoid arthritis, periarthritis of shoulder, tendinitis, tenosynovitis, peritendinitis, myositis, hepatitis, cystitis, nephritis, Sjogren’s syndrome, multiple sclerosis, acute inflammation diseases and chronic inflammatory diseases. The methanol extract is extracted by applying the pressure of 1,000-2,000 psi at 40-70deg.C and cultivating for 1-5 days after archidendron clypearia is dipped in methanol.
Abstract translation: 目的：提供一种用于预防或治疗炎性疾病的药物组合物，包括天竺葵甲醇提取物，可通过抑制作为酪氨酸激酶的Src，Syk和IRAK-1的活化而用于预防或治疗炎症疾病。 构成：用于预防或治疗炎症疾病的药物组合物包括作为活性成分的翠柏甘油甲醇提取物。 炎性疾病包括慢性炎症进展到疾病状态，通常是无害物质如花粉的炎症，以及由自身免疫反应如哮喘或类风湿性关节炎引起的炎症。 炎性疾病选自败血症，皮炎，过敏，特应性皮炎，哮喘，结膜炎，牙周炎，鼻炎，鼓膜炎，喉咽炎，扁桃体炎，肺炎，胃溃疡，胃炎，克罗恩病，结肠炎，痔疮，痛风，强直性强 脊柱炎，风湿热，狼疮，纤维肌痛，银屑病关节炎，骨关节炎，类风湿性关节炎，肩关节炎，腱炎，腱鞘炎，青per素炎，肌炎，肝炎，膀胱炎，肾炎，干燥综合征，多发性硬化，急性炎症疾病和慢性炎性疾病。 通过在40-70℃下施加1,000-2,000psi的压力提取甲醇提取物，并在将archidendron clypearia浸入甲醇中后培养1-5天。
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Patent Agency Ranking
公开(公告)号：KR1020090014428A
公开(公告)日：2009-02-11
申请号：KR1020070077882
申请日：2007-08-02
Applicant: 성균관대학교산학협력단
CPC classification number: A61K38/12 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/10 , A61K9/14 , A61K9/20 , A61K9/48 , A61K2039/585
Abstract: An anti-cancer composition comprising surfactin is provided to inhibit the cell proliferation, and the proliferation of the human colon carcinoma cell by inducing pro-apoptotic activity and suppressing the differentiation and proliferation of LoVo cell by inhibiting cell cycle. The composition for treating cancer comprises surfactin and further comprises the pharmaceutically acceptable carrier selected from diluent, lubricant, binder, disintegrant, sweetener, stabilizer and antiseptic, and additive selected from perfume and vitamin B.
Abstract translation: 提供包含表面活化素的抗癌组合物，通过诱导促凋亡活性并通过抑制细胞周期抑制LoVo细胞的分化和增殖来抑制细胞增殖和人结肠癌细胞的增殖。 用于治疗癌症的组合物包括表面活性素，并且还包含选自稀释剂，润滑剂，粘合剂，崩解剂，甜味剂，稳定剂和防腐剂的药学上可接受的载体，以及选自香料和维生素B的添加剂。
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4.发明授权4―디메틸아미노―2―메톡시―6―（（메틸―［2―（4―니트로페닐）에틸］아미노）메틸）페놀을 포함하는 항염증용 조성물 有权包含4-二甲基氨基-2-甲氧基-6 - （（甲基 - [2-（4-硝基苯基）乙基]氨基）甲基）苯酚用于抗炎的组合物
公开(公告)号：KR101453607B1
公开(公告)日：2014-10-27
申请号：KR1020120084641
申请日：2012-08-02
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 4-디메틸아미노-2-메톡시-6-((메틸-[2-(4-니트로페닐)에틸]아미노)메틸)페놀을 유효성분으로 함유하는 항염증용 약학적 조성물, 식품 조성물 및 화장료 조성물에 관한 것이다. 본 발명의 조성물은 염증관련 인자인 TNF-α, PGE
2 , NO의 생성을 전사 단계에서부터 근본적으로 감소시켜 우수한 소염 효과를 가진다. 또한 고농도로 처리한 경우에도 세포독성을 보이지 않아서 의약품 , 식품 및 화장료에 안전하게 적용할 수 있다. 따라서 항염증제로서 중요하게 응용될 수 있을 것으로 기대된다.-
公开(公告)号：KR1020140017199A
公开(公告)日：2014-02-11
申请号：KR1020120083743
申请日：2012-07-31
Applicant: 성균관대학교산학협력단
IPC: A61K31/122 , A61P29/00
CPC classification number: A61K31/122 , A23L33/10 , A23V2002/00 , A23V2200/324 , A61K8/355 , A61Q19/00
Abstract: The present invention relates to a pharmaceutical composition, a food composition, and a cosmetic composition for anti-inflammation, containing 2,3-Bis[(2-hydroxyethyl)thio]-1,4-naphthoquinone as an active ingredient. The composition of the present invention fundamentally reduces the generation of TNF-α, PGE_2, and NO, which are inflammation-related factors, from the transcriptional stage, thereby exhibiting excellent anti-inflammatory effect. Further, the composition of the present invention can be safely applied to medicines, food, and cosmetics since it does not exhibit cytotoxicity in spite of treatment at high concentration. Accordingly, the composition of the present invention is expected to be significantly applied as an anti-inflammatory agent.
Abstract translation: 本发明涉及含有2,3-双[（2-羟乙基）硫代] -1,4-萘醌作为活性成分的药物组合物，食品组合物和抗炎化妆品组合物。 本发明的组合物从转录阶段基本上降低了作为炎症相关因子的TNF-α，PGE_2和NO的产生，从而表现出优异的抗炎作用。 此外，本发明的组合物可以安全地应用于药物，食品和化妆品，因为尽管在高浓度下处理不具有细胞毒性。 因此，预期本发明的组合物可以显着地用作抗炎剂。
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公开(公告)号：KR1020090034131A
公开(公告)日：2009-04-07
申请号：KR1020070099331
申请日：2007-10-02
Applicant: 성균관대학교산학협력단
Abstract: A transgenic potato is provided to produce mistletoe lectin by using mistletoe lectin with a gene of the mistletoe lectin and to produce the mistletoe lectin having anti-cancer and immune enhancing effects massively. A recombinant plant expression vector includes a gene inserted by operation of 2 of a sequence number encoding Korean mistletoe lectin protein. A transgenic potato is acquired by transforming the potato into the recombinant plant expression vector by using the agrobacterium. A composition for treating cancer includes the Korean mistletoe lectin protein from the recombinant plant expression vector.
Abstract translation: 提供转基因马铃薯，通过使用槲寄生凝集素与槲寄生凝集素的基因产生槲寄生凝集素，并大量生产具有抗癌和免疫增强作用的槲寄生凝集素。 重组植物表达载体包括通过操作2个编码韩国槲寄生凝集素蛋白的序列号插入的基因。 通过使用农杆菌将马铃薯转化成重组植物表达载体获得转基因马铃薯。 用于治疗癌症的组合物包括来自重组植物表达载体的韩国槲寄生凝集素蛋白。
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公开(公告)号：KR101388776B1
公开(公告)日：2014-04-23
申请号：KR1020120083743
申请日：2012-07-31
Applicant: 성균관대학교산학협력단
IPC: A61K31/122 , A61P29/00
Abstract: 본 발명은 2,3-Bis[(2-hydroxyethyl)thio]-1,4-naphthoquinone을 유효성분으로 함유하는 항염증용 약학적 조성물, 식품 조성물 및 화장료 조성물에 관한 것이다. 본 발명의 조성물은 염증관련 인자인 TNF-α, PGE
2 , NO의 생성을 전사 단계에서부터 근본적으로 감소시켜 우수한 소염 효과를 가진다. 또한 고농도로 처리한 경우에도 세포독성을 보이지 않아서 의약품 , 식품 및 화장료에 안전하게 적용할 수 있다. 따라서 항염증제로서 중요하게 응용될 수 있을 것으로 기대된다.
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