公开(公告)号：KR101779523B1

公开(公告)日：2017-09-19

申请号：KR1020100078281

申请日：2010-08-13

Applicant: (주)아모레퍼시픽

Inventor： 백흥수

IPC: A61K8/49 ,  A61Q19/08 ,  A61Q19/00 ,  A61Q17/04

Abstract: 본발명은플라보노이드유도체를함유하는화장료조성물에관한것으로, 보다상세하게는플라보노이드유도체를유효성분으로함유함으로써항노화, 항주름, 탄력개선, 보습, 피부장벽개선, 아토피, 항염, 여드름, 항균, 혈색개선, 피부톤개선, 모공개선, 피지조절, 트러블개선, 슬리밍, 자외선차단및 미백효과가우수한화장료조성물에관한것이다.

Abstract translation: 本发明涉及含有类黄酮衍生物，更具体地涉及抗老化，抗皱纹，弹性的改善，保湿剂，阻档层提高，特应性，炎性，痤疮，抗菌，高显色的化妆品组合物通过含有类黄酮衍生物作为有效成分 改善肤色，改善毛孔，控制皮脂，改善烦恼，减肥，防紫外线和美白效果。

公开(公告)号：KR1020160116958A

公开(公告)日：2016-10-10

申请号：KR1020150045435

申请日：2015-03-31

Applicant: (주)아모레퍼시픽

Inventor： 주영협 ,  백흥수 ,  김정환 ,  이창근 ,  임형준 ,  신홍주 ,  김용진 ,  이존환

IPC: A61K8/42 ,  A61K8/34

CPC classification number: A61K31/166 ,  A23G1/42 ,  A23G3/36 ,  A23G4/12 ,  A23G9/36 ,  A23L33/00 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1652 ,  A61K9/2059

Abstract: 본명세서에기재된 5-아다만탄-1-일-N-(2,4-다이하이드록시벤질)-2,4-다이메톡시벤즈아마이드는독성이없으면서우수한항염효과를나타낼수 있다. 예컨대, NO 및 PGE2 중하나이상의생성을저해하거나, 전사인자인 NF-κB 및 AP-1 중하나이상의활성을억제하거나, IL-1β와같은염증성사이토카인을저해함으로써우수한항염효과를나타낸다.

Abstract translation: 本发明公开的5-金刚烷-1-基-N-（2,4-二羟基苄基）-2,4-二甲氧基苯甲酰胺缺乏毒性，可表现出优异的抗炎作用。 通过抑制一种或多种转录因子NF-κB和AP-1的活性或通过抑制促炎细胞因子，例如通过抑制NO和PGE2中的一种或多种的产生，显示出优异的抗炎作用 IL-1β。

公开(公告)号：KR1020160116861A

公开(公告)日：2016-10-10

申请号：KR1020150045201

申请日：2015-03-31

Applicant: (주)아모레퍼시픽

Inventor： 주영협 ,  최수정 ,  백흥수 ,  이창석 ,  김정환 ,  김용진 ,  신홍주 ,  노호식 ,  신송석 ,  이존환

IPC: C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A23L1/30 ,  A61Q19/00

CPC classification number: C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/00 ,  A61Q19/02

Abstract: 본발명은신규벤조산아마이드유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물을개시한다. 상기신규화합물등은멜라닌생성을억제하고, 타이로시나제활성을저해하며, 뛰어난피부미백효과를가진다.

公开(公告)号：KR101252335B1

公开(公告)日：2013-04-08

申请号：KR1020090065107

申请日：2009-07-16

Applicant: (주)아모레퍼시픽

Inventor： 백흥수 ,  김선영 ,  우병영 ,  나용주 ,  박녹현 ,  이지해 ,  김혁 ,  김연준 ,  남미희 ,  주영협 ,  임경민

IPC: A61K8/49 ,  A61Q19/08 ,  A61K31/352 ,  A61P17/18

Abstract: 본 발명은 하기 화학식 1의 화합물, 그것의 이성질체 또는 약제학적으로 허용 가능한 염을 유효 성분으로 포함하는 피부 노화 방지용 조성물에 관한 것이다.
(화학식 1)

본 발명에 따른 조성물에 포함되는 화학식 1의 화합물, 그것의 이성질체 또는 약제학적으로 허용 가능한 염은 피부 자극을 유발하지 않으면서, 신경 통증감각 수용체(TRPV1: Transient Receptor Potential family V 1) 길항제로 작용하여, 매트릭스 메탈로프로티아제(matrix metalloprotease) 활성 억제 효과를 발휘하는 바, 피부 노화 방지용 조성물의 유효 성분으로 적합하게 사용될 수 있다.
피부 노화 방지

公开(公告)号：KR1020120021709A

公开(公告)日：2012-03-09

申请号：KR1020100078281

申请日：2010-08-13

Applicant: (주)아모레퍼시픽

Inventor： 백흥수

IPC: A61K8/49 ,  A61Q19/08 ,  A61Q19/00 ,  A61Q17/04

CPC classification number: A61K8/498 ,  A61K2800/74 ,  A61K2800/782 ,  A61Q17/04 ,  A61Q19/005 ,  A61Q19/007 ,  A61Q19/008 ,  A61Q19/08

Abstract: PURPOSE: A cosmetic composition containing flavonoid derivatives is provided to ensure anti-aging, anti-wrinkling, and skin elasticity and to treat atopic dermatitis and acne. CONSTITUTION: A cosmetic composition contains 0.0001-90 wt% of flavonoid derivative of chemical formula 1 as an active ingredient. In chemical formula 1, X is H; and Y1 and Y2 are H. The flavonoid derivative is kazinol A, B, E, or H. The cosmetic composition is used for anti-aging, skin elasticity and treating atopic dermatitis and acne.

Abstract translation: 目的：提供含有黄酮衍生物的化妆品组合物，以确保抗衰老，抗皱和皮肤弹性，并治疗特应性皮炎和痤疮。 构成：化妆品组合物含有0.0001-90重量％的化学式1的类黄酮衍生物作为活性成分。 化学式1中，X为H; Y1和Y2是H.类黄酮衍生物是kazinol A，B，E或H.化妆品组合物用于抗衰老，皮肤弹性和治疗特应性皮炎和痤疮。

公开(公告)号：KR1020100104343A

公开(公告)日：2010-09-29

申请号：KR1020090022704

申请日：2009-03-17

Applicant: (주)아모레퍼시픽

Inventor： 김선영 ,  백흥수 ,  우병영 ,  김혁 ,  서정아 ,  신홍주 ,  김연준 ,  남미희 ,  윤정훈 ,  주영협 ,  임경민

IPC: A61K31/353 ,  A61K8/49 ,  A61P17/10 ,  A61Q19/08

Abstract: PURPOSE: A composition for relieving skin irritation is provided to suppress expression of inflammatory intermediate factor. CONSTITUTION: A composition for relieving skin irritation contains a compound of chemical formula 1, isomer or pharmaceutically acceptable salt thereof as an active ingredient. The composition is used for relieving skin irritation including skin dryness, inflammation, erythema, or itchness. The skin irritation by an external skin ingredient is skin irritation by retinoid or surfactant. The retinoid is retinol, retinal or retinoic acid. An external use skin formulation for treating dermatitis contains the composition.

Abstract translation: 目的：提供缓解皮肤刺激的组合物，以抑制炎性中间因子的表达。 构成：用于缓解皮肤刺激的组合物含有化学式1化合物，其异构体或其药学上可接受的盐作为活性成分。 该组合物用于缓解皮肤刺激，包括皮肤干燥，炎症，红斑或瘙痒。 外用皮肤成分引起的皮肤刺激是类视黄醇或表面活性剂引起的皮肤刺激。 类视色素是视黄醇，视黄醛或视黄酸。 用于治疗皮炎的外用皮肤制剂含有该组合物。

公开(公告)号：KR1020080051235A

公开(公告)日：2008-06-11

申请号：KR1020060121955

申请日：2006-12-05

Applicant: (주)아모레퍼시픽

Inventor： 신의석 ,  신동욱 ,  이형호 ,  김대건 ,  이정아 ,  윤준원 ,  노호식 ,  백흥수

IPC: A61K31/12 ,  A61K31/05 ,  A61K31/136 ,  A61P3/04

Abstract: A pharmaceutical composition for treating and preventing lipid metabolism-related diseases is provided to increase activity of isocitrate dehydrogenase 3alpha(IDH3alpha) promoter and carnitine palmitoyl transferase 1A(CPT1A) promoter, so that blood sugar and neutral fat are reduced. A pharmaceutical composition for treating and preventing lipid metabolism-related diseases comprises compounds represented by the formula(1), wherein R1 is H or C1-C5 alkyl, R2 is H or OH and n is an integer from 1 to 3, and is formulated as tablet, pill, powder, sachet, elixir, suspension, emulsion, solution, syrup, aerosol, soft or hard gelatin capsule, sterile injection solution or sterile powder, wherein the daily dosage of the compounds is 0.1-100 mg/kg. Further, the lipid metabolism-related diseases are obesity, hyperlipemia and diabetes.

Abstract translation: 提供了用于治疗和预防脂质代谢相关疾病的药物组合物，以增加异柠檬酸脱氢酶3α（IDH3alpha）启动子和肉碱棕榈酰转移酶1A（CPT1A）启动子的活性，从而降低血糖和中性脂肪。 用于治疗和预防脂质代谢相关疾病的药物组合物包括由式（1）表示的化合物，其中R 1为H或C 1 -C 5烷基，R 2为H或OH，n为1至3的整数， 作为片剂，丸剂，粉末，香囊，酏剂，悬浮液，乳剂，溶液，糖浆，气溶胶，软或硬明胶胶囊，无菌注射溶液或无菌粉末，其中化合物的日剂量为0.1-100mg / kg。 此外，脂质代谢相关疾病是肥胖，高脂血症和糖尿病。

公开(公告)号：KR1020080014279A

公开(公告)日：2008-02-14

申请号：KR1020060075755

申请日：2006-08-10

Applicant: (주)아모레퍼시픽

Inventor： 백흥수 ,  유재원 ,  노호식 ,  김덕희

IPC: C07C233/10 ,  C07C233/11 ,  C07C235/36

CPC classification number: C07C235/36 ,  C07C231/02

Abstract: A hydroxycinnamic acid derivative compound is provided to realize improved anti-oxidation property and skin permeability, effects of inhibiting active oxygen and melanin generation and stimulating procollagen generation, thereby providing a cosmetic composition for improving wrinkles and whitening. A hydroxycinnamic acid derivative compound has an adamantyl amide linking group and is represented by the following formula I. In formula I, R1 is H or a C1-C7 alkyl group; and A is -CH=CH- or -CH2-CH2-. The hydroxycinnamic acid derivative compound is obtained by the method comprising the steps of: (1) substituting the hydroxyl group of hydroxycinnamic acid with an acetyl group to provide an acetylated compound; (2) reacting the acetylated compound with ethyl chloroformate and oleophilic group-containing adamantanamine to provide an amide compound; and (3) hydrolyzing the acetyl group of the amide compound.

Abstract translation: 提供羟基肉桂酸衍生物以提高抗氧化性和皮肤渗透性，抑制活性氧和黑色素产生的作用，刺激前胶原生成，从而提供改善皱纹和美白的化妆品组合物。 羟基肉桂酸衍生物具有金刚烷基酰胺连接基团，由下式I表示。在式I中，R 1为H或C 1 -C 7烷基; A是-CH = CH-或-CH 2 -CH 2 - 。 通过包括以下步骤的方法获得羟基肉桂酸衍生物化合物：（1）用乙酰基取代羟基肉桂酸的羟基以提供乙酰化合物; （2）使乙酰化化合物与氯甲酸乙酯和含亲油基团的金刚烷胺反应，得到酰胺化合物; 和（3）水解酰胺化合物的乙酰基。

公开(公告)号：KR100740575B1

公开(公告)日：2007-07-18

申请号：KR1020060029631

申请日：2006-03-31

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  백흥수 ,  노호식 ,  김덕희 ,  장이섭

IPC: C07D319/18 ,  C07D317/60

Abstract: 2,3-Dihydroxybenzoic acid derivatives, a preparation method thereof, and a skin-whitening cosmetic composition containing the same compounds are provided to inhibit activity of tyrosinase and melanin formation while cytotoxicity of the compounds is very low, so that the compounds are useful for improvement of pigmentation in the skin. The method for preparing the 2,3-dihydroxybenzoic acid derivatives represented by the formula(1) comprises the steps of: (A) reacting 2,3-dihydroxybenzoic acid with acetic acid anhydride in the presence of base to prepare a 2,3-diacetyloxybenzoic acid compound represented by the formula(2); (B) preparing an amide compound represented by the formula(3) from the 2,3-diacetyloxybenzoic acid compound by using ethylchloroformate and amine having a lipophilic group; and (C) hydrolyzing an acetyl group of the amide compound represented by formula (3) to prepare 2,3-dihydroxybenzoic acid represented by the formula (1), wherein R is 4-ethoxyphenyl, 2-cyclohexenylethyl, cycloheptyl, cyclohexyl, tert-octyl, 4-isopropylphenyl, 2,3-dihydrobenzo[1,4]dioxin-7-yl, benzo[1,3]-dioxol-6-yl or adamantyl-1-yl; and the amine having the lipophilic group is an amine selected from 4-ethoxyphenylamine, 2-cyclohexenylethylamine, cycloheptylamine, cyclohexylamine, tert-octylamine, 4-isopropylphenylamine, 2,3-dihydrobenzo[1,4]dioxin-7-amine, benzo[1,3]-dioxol-6-amine or adamantyl-1-amine. The skin-whitening cosmetic composition contains 0.01-20 wt.% of the 2,3-dihydroxybenzoic acid derivatives represented by the formula(1).

Abstract translation: 提供了2,3-二羟基苯甲酸衍生物，其制备方法和含有相同化合物的美白化妆品组合物，以抑制酪氨酸酶的活性和黑色素形成，同时化合物的细胞毒性非常低，使得该化合物可用于 改善皮肤色素沉着。 制备式（1）代表的2,3-二羟基苯甲酸衍生物的方法包括以下步骤：（A）使2,3-二羟基苯甲酸与乙酸酐在碱存在下反应，制得2,3-二羟基苯甲酸衍生物， 由式（2）表示的二乙酰氧基苯甲酸化合物; （B）使用氯甲酸乙酯和具有亲油性基团的胺，由2,3-二乙酰氧基苯甲酸化合物制备式（3）所示的酰胺化合物; （C）水解式（3）所示的酰胺化合物的乙酰基，制备式（1）所示的2,3-二羟基苯甲酸，其中R为4-乙氧基苯基，2-环己烯基乙基，环庚基，环己基，叔丁基 - 辛基，4-异丙基苯基，2,3-二氢苯并[1,4]二氧杂环己烯-7-基，苯并[1,3] - 二氧杂环戊烯-6-基或金刚烷基-1-基; 具有亲脂性基团的胺是选自4-乙氧基苯胺，2-环己烯基乙胺，环庚胺，环己胺，叔辛胺，4-异丙基苯胺，2,3-二氢苯并[1,4]二氧杂环己烯-7-胺，苯并[ 1,3] - 二氧六环-6-胺或金刚烷基-1-胺。 该美白化妆品组合物含有0.01-20重量％的由式（1）表示的2,3-二羟基苯甲酸衍生物。

公开(公告)号：KR100706475B1

公开(公告)日：2007-04-10

申请号：KR1020060031749

申请日：2006-04-07

Applicant: (주)아모레퍼시픽

Inventor： 백흥수 ,  노호식 ,  김덕희 ,  장이섭

IPC: C07D407/12

Abstract: 본 발명은 강력한 미백효과를 가지며 하기 화학식 1로 표시되는 신규 히드록시피라논 이합체 또는 하기 화학식 2로 표시되는 그의 염 화합물, 이의 제조방법 및 이를 함유하는 피부 미백용 조성물에 관한 것으로, 하기 화학식 1 또는 2의 화합물은 멜라닌 생성을 억제함으로써 피부의 색소침착을 개선시켜 미백 효과를 나타내는 효능이 있으므로, 이를 함유하는 피부 미백용 조성물은 화장료 조성물로써 유용하게 이용될 수 있다.
[화학식 1]

(상기 식 중,
R1 는 CH
2 -CH
2 , CH
2 -CH
2 -CH
2 , CH
2 -CH
2 -CH
2 -CH
2 또는 CH(CH
3 )-CH(CH
3 )이다.)
[화학식 2]

(상기 식 중,
R1 는 CH
2 -CH
2 , CH
2 -CH
2 -CH
2 , CH
2 -CH
2 -CH
2 -CH
2 또는 CH(CH
3 )-CH(CH
3 )이고,
R2 는 Na, Ca, K, Cu 또는 Zn 이다.)
히드록시피라논 이합체, 멜라닌, 미백, 화장료

Abstract translation: 本发明涉及它们的盐，似乎有强烈的美白效果到新羟甲基 - 吡非二聚体或式（2）由通式（1）化合物，其制造方法及用于皮肤的组合物表示增白含有它们，于式（1）或 2通过抑制黑色素的产生和改善皮肤色素沉着，因此效力表示美白效果的化合物中，对于皮肤增白组合物包含它们可以用作化妆品组合物是有用的。