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公开(公告)号：KR1020150063206A
公开(公告)日：2015-06-09
申请号：KR1020130147266
申请日：2013-11-29
Abstract: 본발명은사출금형의제조및 이를이용한고분자기판의사출성형에관한것으로, 보다상세하게는실리콘웨이퍼(Si wafer), 석영기판또는유리기판과같이단단하지만외부충격에의해깨지기쉬운기판을이용하여금형코어를제작하고, 상기금형코어를장착한사출금형을이용하여별도의공정없이매끈한면을가지는고분자기판을제조하는방법및 이를적용한고분자기판에관한것이다. 이에본 발명은, 판상의금형코어; 상기판상의금형코어의일면에덧대어져장착되는완충부재; 판상의금형캐비티; 상기판상의금형코어를취부하는형판; 상기판상의금형코어를취부하는형판과대면하며, 상기판상의금형캐비티를취부하는형판;을포함하여구성되며, 상기판상의금형코어및 판상의금형캐비티는실리콘웨이퍼(Si wafer), 석영기판및 유리기판을적용하는것을특징으로하는고분자기판의제조를위한사출금형과이를적용한고분자기판을제공한다. 본발명의실리콘웨이퍼(Si wafer), 석영기판및 유리기판을적용한금형코어를적용하여고분자기판을제작하면, 사출성형과정중 형폐단계에서완충부재에의해충격완화및 형체력분산효과로인하여, 상기의금형코어가깨지는것을방지하며, 패터닝된고분자기판의제조시에도, 상기금형코어에직접패터닝을하여사출하는방법을통해별도의금속스탬프제작을생략하여사출공정과정의단순화및 비용절감의효과가있다.
Abstract translation: 本发明涉及注射模具的制造和使用该注射模具的注射成型聚合物基材。 更具体地说，本发明涉及一种制备具有光滑表面的聚合物基材的方法和与其一起使用的聚合物基材的方法，其中通过使用硬质硅基片（Si晶片）的基底来制造模芯， ，石英基板或玻璃基板，但是可能容易由于外部冲击而破裂，并且通过使用其上安装有模芯的注射模具而不用单独的工艺制造聚合物基板。 本发明的注射模具包括：板状模芯; 缓冲构件放置并安装在所述板状模芯的一个表面上; 板状模腔; 用于安装板状模芯的表面模具; 以及面模模具的面模，用于安装板状模具，并将板状模腔装配在板状模具上，其中将硅晶片（Wi晶片），石英基板和玻璃基板施加到板状模具 芯和板状模腔。 当通过施加硅晶片（Wi晶片），石英基板和玻璃基板来制造聚合物基板时，通过缓冲部件的防冲击缓冲和模具力分配效果来防止模芯破裂 在注射成型过程中的模具精加工步骤。 即使制造图案聚合物基材，通过使用在模芯上直接图案化的注射成型方法来跳过单独的金属印模生产，从而简化注模工艺并降低成本。
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公开(公告)号：KR1020150050770A
公开(公告)日：2015-05-11
申请号：KR1020130131480
申请日：2013-10-31
Applicant: 한국과학기술원
CPC classification number: B01F5/00 , B01J19/00 , G01N37/00 , H01L21/027
Abstract: 본원발명에서는다층미세구조의제조방법으로상부미세구조를제조하는단계, 하부미세구조를제조하는단계, 상기하부미세구조상에상기상부미세구조를부착하는단계, 상기부착된상부미세구조와하부미세구조를관통하는제 1 홀(Hole)을형성하여다층미세구조틀을형성하는단계, 상기다층미세구조틀 상부에제 1 기판을부착하는단계, 상기제 1 기판상에상기상부미세구조형상의오목부분과관통되도록제 2 홀(Hole)을형성하는단계및 상기제 2 홀(Hole)이형성된다층미세구조틀의하부에제 2 기판을부착하는단계를포함한다. 또한, 본원발명의다층미세구조제조방법에의해제조된다층구조는미세형상으로제조하는것이가능하며, 하나의기판을사이에두고두 개이상의미세구조를붙이는적층과정을통해기본다층구조를형성하며, 형성된미세구조에유체가이동할수 있는홀(Hole)을형성하여복층미세구조에유체가자유롭게이동하는것을가능하게한다. 이러한다층미세구조는유연한표면의재질에의부착성을향상시켰다. 또한, 두번의단계를거쳐상기미세구조를경화시키는단계를적용함으로써직물등의흡수성이있는표면에도적용이용이하다.
Abstract translation: 根据本发明，包括多层结构的精细结构的制造方法包括以下步骤：制造精细结构的上部; 制造精细结构的下部; 将精细结构的上部附着在精细结构的下部; 形成多层细微结构框架，由此形成穿过安装的上部和下部精细结构的第一孔; 将所述第一基板安装在所述多层结构框架的上部; 形成第二孔，其中穿过第一基板上的上部微细结构形状的凹部; 将第二基板附接到形成有第二孔的多层细微结构的下部。 此外，通过本发明的多层微细结构的制造方法制造的多层结构可以制造成精细的形状，其中基本的多层结构通过沉积工艺形成，其中两个或更多个精细结构 安装在放置在中间的基板中的一个上，从而形成流体可以在所形成的精细结构中移动的孔，使得流体可以自由移动通过多层结构。 这种多层细微结构改善了柔性表面材料上的粘附特性。 此外，施加通过两个步骤硬化精细结构的步骤，从而可以容易地应用具有诸如织物等吸收剂的表面。
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公开(公告)号：KR1020140015943A
公开(公告)日：2014-02-07
申请号：KR1020120082344
申请日：2012-07-27
Applicant: 한국과학기술원
Abstract: The present invention relates to a microfluid control technology. That is, a method for manufacturing a microfluidic floating block according to one embodiment of the present invention produces a microfluidic floating block by repetitively spraying an adhesive on powdery materials for the microfluidic floating block, forming the shape of the microfluidic floating block by repetitively hardening the adhesive and the materials for forming the microfluidic floating block, and drying the microfluidic floating block extracted by brushing and hardening. [Reference numerals] (AA) Start; (BB) End; (S10) Microfluidic floating block; (S20) Separate to a plurality of two-dimensional planes from the bottom; (S30) Disperse materials to form the block in a powder shape; (S40) Inject adhesive on the materials in the powder shape; (S50) Cure the adhesive and the block configuration materials; (S60) Manufacture a final block shape by repeating the steps of S30-S50; (S70) Separate from non-adhered powder by black blushing; (S80) Cure by putting the separated block in a hardening agent; (S90) Dry the hardened block
Abstract translation: 本发明涉及一种微流体控制技术。 也就是说，根据本发明的一个实施例的微流体浮动块的制造方法通过在用于微流体浮动块的粉末材料上重复地喷涂粘合剂来产生微流体浮动块，通过重复硬化形成微流体浮动块的形状 粘合剂和用于形成微流体浮动块的材料，并且通过刷涂和硬化来干燥提取的微流体浮动块。 （附图标记）（AA）开始; （BB）结束; （S10）微流体浮动块; （S20）从底部分离成多个二维平面; （S30）分散材料以形成粉末形状的块状物; （S40）在粉末形状的材料上注入粘合剂; （S50）固化粘合剂和块状构造材料; （S60）通过重复S30-S50的步骤来制造最终的块形状; （S70）通过黑色脸红与非粘附粉末分离; （S80）将分离的块放入硬化剂中固化; （S90）干燥硬化块
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公开(公告)号：KR1020130109876A
公开(公告)日：2013-10-08
申请号：KR1020120031992
申请日：2012-03-28
Applicant: 한국과학기술원
IPC: G01N33/569 , B05B1/10 , C12Q1/02 , C12N1/21
Abstract: PURPOSE: A microfluidic chip for generating polymer-based microdroplets is provided to form a large amount of microdroplets with a uniform size and shape, in which microorganisms are transduced through a multi-parallel channel process using a high density microstructure. CONSTITUTION: A microfluidic chip (110) for generating polymer-based microdroplets comprises: three oil inlets (101,103,105) for injecting oil; two solution inlets (102,104) for injecting a solution containing water, a sample, and monomers; a droplet generation unit (110) which generates polymer-based microdroplets by connecting five channels (101',102',103',105') connected to each oil inlet and each solution inlet; and a droplet outlet (120) which discharges the polymer-based microdroplets through a droplet discharge channel (120').
Abstract translation: 目的：提供用于产生基于聚合物的微滴的微流控芯片以形成具有均匀尺寸和形状的大量微滴，其中微生物通过使用高密度微结构的多平行通道工艺转导。 构成：用于产生基于聚合物的微滴的微流体芯片（110）包括：用于注入油的三个油入口（101,103,105） 用于注入含有水，样品和单体的溶液的两个溶液入口（102,104）; 液滴产生单元，其通过连接到每个油入口和每个溶液入口的五个通道（101'，102'，103'，105'）产生基于聚合物的微滴; 以及通过液滴排出通道（120'）排出基于聚合物的微滴的液滴出口（120）。
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公开(公告)号：KR100680132B1
公开(公告)日：2007-02-07
申请号：KR1020040032278
申请日：2004-05-07
Applicant: 한국과학기술원
Abstract: 본 발명은 카르복실기가 노출된 탄소나노튜브(carbon nanotubes; CNT)에 자기성 물질을 결합시키고, 상기 자기성 물질이 고정된 CNT를 기질 상에 위치시킨 다음, 수직 또는 수평 방향으로 자기장을 인가하여 CNT를 기질상에 어레이하는 것을 특징으로 하는 수직 또는 수평으로 정렬된 CNT 어레이의 제조방법에 관한 것이다. 본 발명은 또한, 상기의 CNT 어레이에 바이오 리셉터를 결합시키는 것을 특징으로 하는 CNT-바이오칩의 제조방법 및 이에 의해 제조된 CNT-바이오칩을 이용하는 것을 특징으로 하는 바이오 리셉터와 결합하거나 반응하는 표적 바이오물질 또는 유기화합물의 검출방법에 관한 것이다.
본 발명에 따르면, 종래의 화학합성방법(chemical vapor deposition)에 의한 성장 또는 마이크로 패턴(micro pattern)에 의한 어레이 방법에 비하여 결함이 적으면서도 고도로 CNT를 수직 또는 수평 방향으로 어레이할 수 있다.
탄소나노튜브(CNT), 어레이, 자기장, 바이오칩, 검출방법, 바이오물질-
Patent Agency Ranking
公开(公告)号：KR100481390B1
公开(公告)日：2005-04-11
申请号：KR1020030015966
申请日：2003-03-14
Applicant: 한국과학기술원
IPC: C07K19/00
Abstract: 본 발명은 폴리하이드록시알카노이트 (PHA) 마이크로스피어에 목적단백질 또는 목적리간드가 부착되어 있는 결합체에 있어서, 목적단백질 또는 목적리간드와 PHA 마이크로스피어 사이에 PHA 분해효소의 기질결합 영역이 링커로 삽입되어 있어 목적단백질 또는 목적리간드가 상기 링커를 통해 PHA 마이크로스피어에 연결되어 있는 결합체에 관한 것이다. 본 발명에서 제공되는 PHA 마이크로스피어의 결합체는 목적단백질-반응단백질간의 반응, 목적단백질-반응리간드간의 반응, 목적리간드-반응단백질간의 반응 또는 목적리간드-반응리간드 간의 반응을 효율적으로 검출하는 데 유용하다.
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公开(公告)号：KR1020040081238A
公开(公告)日：2004-09-21
申请号：KR1020030015966
申请日：2003-03-14
Applicant: 한국과학기술원
IPC: C07K19/00
CPC classification number: C07K17/02 , C12N9/16 , C12Y301/01
Abstract: PURPOSE: A conjugate of PHA microsphere and target protein or ligand and a method for detecting reactions are provided, thereby stably and high efficiently detecting a reaction between target protein and reaction protein, a reaction between target protein and reaction ligand, a reaction between target ligand and reaction protein or a reaction between target ligand and reaction ligand, and cheaply producing the PHA microsphere. CONSTITUTION: The conjugate of PHA microsphere and target protein or ligand contains a substrate-binding site of PHA depolymerase as a linker between the PHA microsphere and target protein or ligand, wherein the target protein is fused in the substrate-binding site of PHA depolymerase; the substrate-binding site of PHA depolymerase is fused with the C-terminal, N-terminal or intermediate of the N-C terminals of the target protein; the target protein is an enzyme or an antibody; the target ligand is low molecular weight compound, nucleic acid, peptide, carbohydrate, fatty acid or lipid which reacts with protein or peptide; the PHA is polymer, copolymer or polymer blend containing C3-C12 monomer; and the substrate-binding site of PHA depolymerase is derived from Alcaligenes faecalis. The method for detecting reactions comprises using the conjugate of PHA microsphere and target protein or ligand, wherein the reaction is detected by using fluorescence-labeled antibody.
Abstract translation: 目的：提供PHA微球和靶蛋白或配体的缀合物和检测反应的方法，从而稳定高效地检测靶蛋白与反应蛋白之间的反应，靶蛋白与反应配体之间的反应，靶配体之间的反应 和反应蛋白质或靶配体与反应配体之间的反应，并且廉价地生产PHA微球。 构成：PHA微球和靶蛋白或配体的缀合物含有PHA解聚酶的底物结合位点，作为PHA微球和靶蛋白或配体之间的接头，其中靶蛋白融合在PHA解聚酶的底物结合位点中; PHA解聚酶的底物结合位点与靶蛋白的N末端的C-末端，N-末端或中间体融合; 靶蛋白是酶或抗体; 靶配体是与蛋白质或肽反应的低分子量化合物，核酸，肽，碳水化合物，脂肪酸或脂质; PHA是含有C 3 -C 12单体的聚合物，共聚物或聚合物共混物; PHA解聚酶的底物结合位点来源于粪产碱杆菌。 检测反应的方法包括使用PHA微球和靶蛋白或配体的缀合物，其中通过使用荧光标记的抗体检测反应。
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公开(公告)号：KR1020040069386A
公开(公告)日：2004-08-06
申请号：KR1020030005730
申请日：2003-01-29
Applicant: 한국과학기술원
IPC: G01N33/543
Abstract: PURPOSE: A protein chip using substrate specificity of polyhydroxyalkanonate depolymerase is provided, thereby inhibiting nonspecific protein binding, so that cost for production of the protein chip can be reduced. CONSTITUTION: The protein chip using substrate specificity of polyhydroxyalkanonate depolymerase comprises a substrate, PHA(polyhydroxyalkanonate) fixed on the substrate, a substrate binding domain of PHA depolymerase, and a fusion protein of a target protein, wherein the substrate is glass slide; the PHA is spin coated on the substrate; the PHA has 4 to 12 of carbon number; the binding domain of PHA depolymerase is fused with the N-terminal, C-terminal or the intermediate of N-C of a target protein; and the binding domain of PHA depolymerase is isolated from Alcaligenes faecalis.
Abstract translation: 目的：提供使用聚羟基链烷酸酯解聚酶的底物特异性的蛋白质芯片，从而抑制非特异性蛋白质结合，从而可以降低生产蛋白质芯片的成本。 构成：使用聚羟基链烷酸酯解聚酶的底物特异性的蛋白质芯片包括固定在底物上的底物PHA（聚羟基卡那酸），PHA解聚酶的底物结合结构域和靶蛋白的融合蛋白，其中所述底物是玻璃载片; 将PHA旋涂在基材上; PHA有4到12个碳数; PHA解聚酶的结合域与靶蛋白的N末端，C-末端或中间体融合; 并且从粪产碱杆菌中分离出PHA解聚酶的结合结构域。
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公开(公告)号：KR1020040063058A
公开(公告)日：2004-07-12
申请号：KR1020030000464
申请日：2003-01-04
Applicant: 한국과학기술원
IPC: G01N33/543
CPC classification number: C40B30/04 , C07K1/1077 , C07K14/5759 , C12N9/0006 , G01N33/54353 , G01N33/6803
Abstract: PURPOSE: A protein chip for analyzing interaction between protein and substrate peptide therefor is provided, thereby rapidly and enormously analyzing interaction between protein and substrate peptide therefor by improving interaction between small molecular weight of peptides and large molecular weight of enzyme proteins, and between peptides and reactive antibodies. CONSTITUTION: The protein chip for analyzing interaction between protein and substrate peptide therefor is prepared by fixing a substrate peptide on a substrate such as aldehyde slide via a linker protein such as leptin or malic enzyme, wherein the substrate peptide is fused with the linker protein in a type of peptide monomer, dimmer of monomer-proline-monomer, or proline-linked polymer; and the peptide monomer is Camtide having the amino acid sequence set forth in SEQ ID NO: 1 or Ab1 having the amino acid sequence set forth in SEQ ID NO: 8. The method for analyzing interaction between protein and substrate peptide therefor comprises the steps of: adding a protein such as enzyme or antibody which specifically binds to the substrate peptide fixed on a protein chip into the protein chip; and detecting the interaction between the protein and substrate peptide therefor by using a fluorescence-labeled enzyme.
Abstract translation: 目的：提供用于分析蛋白质与底物肽之间相互作用的蛋白质芯片，从而通过改善肽与小分子量酶蛋白之间的相互作用，以及肽和底物肽之间的相互作用，快速而极大地分析蛋白质与底物肽之间的相互作用 反应性抗体。 构成：用于分析蛋白质和底物肽之间的相互作用的蛋白质芯片通过将底物肽通过接头蛋白如瘦素或苹果酸固定在底物如醛载体上而制备，其中底物肽与接头蛋白质融合 一类肽单体，单体 - 脯氨酸单体的二聚体，或脯氨酸交联的聚合物; 并且肽单体是具有SEQ ID NO：1所示氨基酸序列的Camtide或具有SEQ ID NO：8所示的氨基酸序列的Ab1。分析蛋白质与底物肽之间相互作用的方法包括以下步骤： ：将固定在蛋白质芯片上的底物肽特异性结合到蛋白质芯片中的蛋白质如酶或抗体; 并通过使用荧光标记的酶检测蛋白质和底物肽之间的相互作用。
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公开(公告)号：KR1020210001479A
公开(公告)日：2021-01-06
申请号：KR1020190077640
申请日：2019-06-28
Applicant: 한국과학기술원
Abstract: 본발명의실시예에따른미세유체장치제조용사출성형장치는일면에유체가흐르는유로가형성되고, 타면에상기유로와연통되어상기유로를통해흐르는유체를안내하여액적형태로낙하시키도록구성되는노즐부가형성되는미세액적생성장치등과같이표면에미세패턴이형성되는미세유체장치를제조하기위해사용되는미세유체장치제조용사출성형장치로서, 내측에적어도하나의채널을구비하는스탬프가설치되어, 사출시 사출물의일면에상기유로를형성하는제1 금형; 상기제1 금형에대향배치되고, 내측에사출시 상기사출물의타면에상기노즐부를형성하는사출홈이형성되는제2 금형; 및상기제1 금형의평면상에서상기스탬프의위치를 X축방향및 Y축방향으로조정가능한정렬부;를포함한다. 본발명의실시예에따르면, 스탬프가금형에설치된경우, 금형에충격을가하거나, 스탬프를재설치하지않고, 스탬프의외면을가압하여스탬프를 X축방향및 Y축방향으로미세하게이동시켜스탬프의위치를조정함으로써, 스탬프를정확한설정위치에배치시킬수 있음은물론, 작업시간을단축시킬수 있고, 금형의변형및 파손을예방할수 있다.
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