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公开(公告)号：KR101510315B1
公开(公告)日：2015-04-10
申请号：KR1020130072199
申请日：2013-06-24
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은멜라닌생성억제및 주름개선용화장료조성물에관한것이다. 본발명의멜라닌생성억제및 주름개선용화장료조성물은왕지네()추출물을유효성분으로포함하는것이특징이다. 본발명에의해, 세포독성을일으키지않으면서, 티로시나제(tyrosinase)의글리코실화(glycosylation)반응을방해하여멜라닌생성을효과적으로억제하는멜라닌생성억제용및 엘라스타아제(elastase) 저해하는주름개선용화장료조성물이제공된다.
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公开(公告)号：KR101444261B1
公开(公告)日：2014-09-29
申请号：KR1020130039757
申请日：2013-04-11
Applicant: 대한민국(농촌진흥청장)
IPC: C12N15/12 , C07K14/435 , A61K38/17 , A61P31/04
CPC classification number: Y02A50/473
Abstract: The present invention relates to a novel Scolopendrasin I peptide isolated from Scolopendra subspinipes and a composition thereof. The present invention provides a novel gene (sequence number 1) of an antibacterial and antifungal peptide isolated from Scolopendra subspinipes, or amino acid (sequence number 2) deducted from the gene, and a peptide (sequence number 3) synthesized from the amino acid. The novel Scolopendrasin I peptide isolated from Scolopendra subspinipes and a composition thereof are provided by the present invention. Accordingly, provided are antibiotics, food preservatives, cosmetic preservatives, medicines, etc. which are free from cytotoxicity and are safe for the human body while showing excellent antibacterial activity and antifungal activity.
Abstract translation: 本发明涉及一种分离自Scolopendra subspinipes的新型Scolopendrasin I肽及其组合物。 本发明提供从Scolopendra subspinipes分离的抗菌和抗真菌肽或从该基因中扣除的氨基酸（序列号2）的新基因（序列号1）和从该氨基酸合成的肽（序列号3）。 从Scolopendra subspinipes分离的新型Scolopendrasin I肽及其组合物由本发明提供。 因此，提供了没有细胞毒性的抗生素，食品防腐剂，化妆品防腐剂，药物等，同时具有优异的抗菌活性和抗真菌活性。
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公开(公告)号：KR101444257B1
公开(公告)日：2014-09-26
申请号：KR1020130039758
申请日：2013-04-11
Applicant: 대한민국(농촌진흥청장)
IPC: C12N15/12 , C07K14/435 , A61K38/17 , A61P31/04
CPC classification number: Y02A50/473
Abstract: The present invention relates to a novel Scolopendrasin II peptide isolated from Scolopendra subspinipes and a composition thereof. The present invention provides a novel gene (sequence number 1) of an antibacterial and antifungal peptide isolated from Scolopendra subspinipes, or amino acid (sequence number 2) deducted from the gene, and a peptide (sequence number 3) synthesized from the amino acid. The novel Scolopendrasin II peptide isolated from Scolopendra subspinipes and a composition thereof are provided by the present invention. Accordingly, provided are antibiotics, food preservatives, cosmetic preservatives, medicines, etc. which are free from cytotoxicity and are safe for the human body while showing excellent antibacterial activity and antifungal activity.
Abstract translation: 本发明涉及从Scolopendra subspinipes分离的新型Scolopendrasin II肽及其组合物。 本发明提供从Scolopendra subspinipes分离的抗菌和抗真菌肽或从该基因中扣除的氨基酸（序列号2）的新基因（序列号1）和从该氨基酸合成的肽（序列号3）。 通过本发明提供了从Scolopendra subspinipes分离的新型Scolopendrasin II肽及其组合物。 因此，提供了没有细胞毒性的抗生素，食品防腐剂，化妆品防腐剂，药物等，同时具有优异的抗菌活性和抗真菌活性。
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公开(公告)号：KR1020140073729A
公开(公告)日：2014-06-17
申请号：KR1020120141464
申请日：2012-12-06
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61K38/1767 , A23L33/18 , A61K35/64 , C07K14/43572 , Y10S514/824 , Y10S514/929
Abstract: The present invention relates to a composition for treating or preventing arteriosclerosis and erectile dysfunction, containing, as an active ingredient, a Bombus terrestris larva-derived polypeptide which includes one peptide selected from the group consisting of peptides represented by SEQ ID NOs.: 1 to 14 as an active site, and a health food for ameliorating vascular diseases. A protein having an N-terminal peptide of the Bombus terrestris larva-derived protein as an active site according to the present invention has an ability to regulate nitric oxide production in vascular endothelial cells and spleen cells, thereby predicting a vasodilation effect, and thus being useful in the prevention, treatment, and amelioration of vascular diseases, such as arteriosclerosis and erectile dysfunction which require the vasodilation effect for therapeutic efficacy.
Abstract translation: 本发明涉及一种用于治疗或预防动脉硬化和勃起功能障碍的组合物，其含有作为活性成分的来自地窖幼虫来源的多肽，其包含选自SEQ ID NO：1至 14作为活性部位，以及用于改善血管疾病的保健食品。 具有根据本发明的作为活性部位的熊蜂幼虫来源蛋白质的N-末端肽的蛋白质具有调节血管内皮细胞和脾细胞中的一氧化氮产生的能力，从而预测血管舒张作用，因此 可用于预防，治疗和改善需要血管舒张作用以治疗功效的血管疾病如动脉硬化和勃起功能障碍。
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45.发明公开산화질소생성을 유도하는 자이리톨유도체의 반복단위구조를 가지는 뒤영벌유충 유래 다당폴리머 有权衍生自E.TERRESTRIS LARVAE的GLYCAN聚合物诱导生产具有ZYLITOL衍生物的重复单元的NITRIX OXIDE
公开(公告)号：KR1020140073000A
公开(公告)日：2014-06-16
申请号：KR1020120140500
申请日：2012-12-05
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61K35/63
Abstract: The present invention relates to a polysaccharide polymer derived from Bombus terrestris larvae having a repeating unit structure of a zylitol derivative which induces nitric oxide production, and a use thereof and, more specifically, to a polysaccharide polymer which has a nitric oxide production inducing activity forming a honeycomb structure array and has a repeating unit structure of 1,5-anhydro-xylitol polysaccharide manufactured via gel filtration chromatography, anion exchange chromatography, distilled water dialysis, and lyophilization of precipitates and supernatant after grinding the Bombus terrestris larvae, precipitating protein by treating with ammonium sulfate and centrifuging; and a nitric oxide producing agent or a vasodilator and a relaxant using the polysaccharide polymer.
Abstract translation: 本发明涉及一种衍生自具有诱导一氧化氮生成的木糖醇衍生物的重复单元结构的熊is幼虫的多糖聚合物及其用途，更具体地说，涉及具有一氧化氮生产诱导活性形成的多糖聚合物 具有通过凝胶过滤色谱法，阴离子交换色谱法，蒸馏水透析法制造的1,5-脱水木糖醇多糖的重复单元结构，研磨后的沉淀物和上清液冷冻干燥后，通过处理沉淀蛋白质 用硫酸铵离心; 和一氧化氮生成剂或血管扩张剂和使用多糖聚合物的松弛剂。
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Patent Agency Ranking
公开(公告)号：KR1020130127691A
公开(公告)日：2013-11-25
申请号：KR1020120051394
申请日：2012-05-15
Applicant: 대한민국(농촌진흥청장)
IPC: C07K14/435 , C12N15/12 , A61K38/17 , A61P35/00
Abstract: The present invention relates to a cancer therapeutic or antibacterial composition containing peptides isolated from larvae or derivatives thereof as active ingredients and, more specifically, to a peptide with a sequence of either sequence number 3 or 4; a polynucleotide with a base sequence encoding the peptide; an antibacterial pharmaceutical composition containing the peptide as active ingredient; a pharmaceutical composition containing the peptide with an amino acid sequence of sequence number 4 as an active ingredient for preventing or treating cancer. The Harmonia axyridis larva-derived peptides and the derivatives thereof of the present invention have antibacterial activities and suppress proliferation of cancer cells through apoptosis. In addition, the peptides and the derivatives do not have cytotoxicity, thereby effectively manufacturing an antibacterial or cancer therapeutic pharmaceutical composition.
Abstract translation: 本发明涉及含有分离自幼虫或其衍生物作为活性成分的肽的癌症治疗或抗菌组合物，更具体地，涉及序列号为3或4的序列的肽; 具有编码该肽的碱基序列的多核苷酸; 含有肽作为活性成分的抗菌药物组合物; 含有具有序列号4的氨基酸序列的肽作为预防或治疗癌症的活性成分的药物组合物。 本发明的欧洲蛔虫幼虫衍生肽及其衍生物具有抗菌活性，通过细胞凋亡抑制癌细胞的增殖。 此外，肽和衍生物不具有细胞毒性，从而有效地制备抗菌或癌症治疗药物组合物。
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公开(公告)号：KR101200422B1
公开(公告)日：2012-11-14
申请号：KR1020110085594
申请日：2011-08-26
Applicant: 대한민국(농촌진흥청장)
IPC: A61K31/726 , A61K35/64 , A23L1/30 , A61K9/20
Abstract: 본 발명은 곤충글라이코자미노글라이칸의 소염, 항당뇨, 항응혈, 항암, 혈관신생억제 용도, 및/또는 혈관확장반응의 기능장애로 인한 질환 치료 및/또는 예방 용도와 곤충글라이코자미노글라이칸 제조방법을 제공한다. 본 발명의 곤충글라이코자미노글라이칸에 의해 소염, 항당뇨, 항응혈, 항암, 혈관신생억제, 및/또는 혈관확장반응의 기능장애로 인한 질환 치료 및/또는 예방할 수 있으며, 본 발명의 제조방법에 의해 곤충글라이코자미노글라이칸을 효과적으로 제조할 수 있다.
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公开(公告)号：KR1020110107304A
公开(公告)日：2011-09-30
申请号：KR1020110085619
申请日：2011-08-26
Applicant: 대한민국(농촌진흥청장)
IPC: A61K31/726 , A61K35/64 , A61K38/48 , A61K9/19
CPC classification number: A61K31/726 , A61K9/19 , A61K35/63 , A61K38/48
Abstract: 본 발명은 곤충글라이코자미노글라이칸의 소염, 항당뇨, 항응혈, 항암, 혈관신생억제 용도, 및/또는 혈관확장반응의 기능장애로 인한 질환 치료 및/또는 예방 용도와 곤충글라이코자미노글라이칸 제조방법을 제공한다. 본 발명의 곤충글라이코자미노글라이칸에 의해 소염, 항당뇨, 항응혈, 항암, 혈관신생억제, 및/또는 혈관확장반응의 기능장애로 인한 질환 치료 및/또는 예방할 수 있으며, 본 발명의 제조방법에 의해 곤충글라이코자미노글라이칸을 효과적으로 제조할 수 있다.
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49.发明授权누에 수번데기로부터 아데노신 유도체 화합물을 정제하는방법 및 아데노신 유도체 화합물을 포함하는 발기부전치료용 조성물 有权用于纯化源自蚕的腺苷衍生物的方法和用于治疗血管性阳a的组合物，其包含腺苷衍生物
公开(公告)号：KR100801550B1
公开(公告)日：2008-02-11
申请号：KR1020050092244
申请日：2005-09-30
Applicant: 대한민국(농촌진흥청장)
IPC: A61K31/7076 , A61P15/10
Abstract: 본 발명은 누에 수번데기로부터 아데노신 유도체 화합물을 추출, 정제하는 방법 및 추출된 아데노신 유도체 화합물을 포함하는 발기부전 치료용 조성물에 관한 것이다. 구체적으로, 본 발명은 누에 수번데기를 유기용매로 분획하여 농축추출한 후 다시 음이온교환 젤여과 크로마토그래피, 선택적으로 탈염과정 및 선택적으로 역상 HPLC를 수행함으로써 누에 수번데기로부터 아데노신 유도체 화합물을 추출정제하는 방법 및 이를 포함하는 발기부전 치료용 조성물에 관한 것이다.
누에 수번데기, 아데노신 유도체 화합물, 발기부전-
公开(公告)号：KR1020050045982A
公开(公告)日：2005-05-17
申请号：KR1020050036489
申请日：2005-04-30
Applicant: 문창현 , 대한민국(농촌진흥청장)
IPC: A23L1/29
CPC classification number: A23L33/00 , A23L2/38 , A23L33/105
Abstract: 본 발명은 애매미유충눈꽃동충하초 자체, 수용성 추출물 또는 알콜 추출물을 유효성분으로 하는 혈압강하용 조성물 및 체중감소용 조성물에 관한 것이다.
본 발명의 조성물은 혈압상승에 의해 야기되는 각종 질환 및 체중증가에 의해 야기되는 각종 질환의 예방 및 치료제로 사용할 수 있다.
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