公开(公告)号：KR1020140048905A

公开(公告)日：2014-04-24

申请号：KR1020140024156

申请日：2014-02-28

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  우희철 ,  김형락 ,  손유경

IPC: A61K31/409 ,  A61K36/02 ,  A61P3/10 ,  A61P27/02

CPC classification number: A61K36/03 ,  A23V2200/328 ,  A23V2250/202 ,  A61K2236/33 ,  A61K2236/39 ,  Y10S514/866 ,  Y10S514/912 ,  Y10S514/914

Abstract: The present invention relates to a pharmaceutical composition or a health food comprising a Laminaria japonica extract or a porpyrin-related compound isolated therefrom which has inhibitory activity for diabetic complications. The extract shows inhibitory activity generation of aldose reductase and advanced glycation end-products and is ensured as a natural medicine; thereby can be used as a pharmaceutical composition and a food composition for preventing or treating the diabetic complications.

Abstract translation: 本发明涉及含有海带提取物或从中分离的卟啉相关化合物的药物组合物或健康食品，其对糖尿病并发症具有抑制活性。 该提取物显示出醛糖还原酶和晚期糖基化终产物的抑制活性，并确保其作为天然药物; 由此可以用作用于预防或治疗糖尿病并发症的药物组合物和食物组合物。

公开(公告)号：KR1020130031971A

公开(公告)日：2013-04-01

申请号：KR1020110095573

申请日：2011-09-22

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  이민섭 ,  신태선 ,  박시향 ,  우희철

IPC: A61K8/97 ,  A61K8/34 ,  A61Q19/02 ,  A61Q19/00

CPC classification number: A61K8/9706 ,  A61K2800/805 ,  A61Q19/02

Abstract: PURPOSE: A pharmaceutical composition containing an alcohol extract of Sargassum fulvellum, and an n-hexane soluble extract or a dichloromethane soluble extract is provided to suppress melanogenesis induced by alpha-MSH, and to ensure a skin whitening effect. CONSTITUTION: A cosmetic composition for skin whitening contains one or more extracts selected from an alcohol extract of Sargassum fulvellum, an n-hexane soluble extract, and a dichloromethane soluble extract. A pharmaceutical composition for treating pigmentary skin disorders contains one or more extracts selected from the alcohol extract of Sargassum fulvellum, the n-hexane soluble extract, and the dichloromethane soluble extract. Functional food for skin whitening contains one or more extracts selected from the alcohol extract of Sargassum fulvellum, the n-hexane soluble extract, and the dichloromethane soluble extract. [Reference numerals] (AA) Sargassum fulvellum; (BB) Drying in the shade; (CC) Powder; (DD) Reflux condensing extraction(Repeating 3 times); (EE) Using ethanol; (FF) Extraction; (GG) Vacuum filtration; (HH) Vacuum rotary concentration; (II) 40°C(Removing an organic solvent); (JJ) Crude extract(Ethanol extract); (KK) Organic solvent soluble fraction(Repeating 3-4 times); (LL) N-hexane soluble extract; (MM,OO) Water soluble fraction; (NN) Dichloromethane soluble extract;

Abstract translation: 目的：提供含有马鞭草醇提取物和正己烷可溶性提取物或二氯甲烷可溶性提取物的药物组合物，以抑制由α-MSH诱导的黑素生成，并确保皮肤美白效果。 构成：用于皮肤美白的化妆品组合物含有一种或多种提取物，其选自马鞭草醇提取物，正己烷可溶提取物和二氯甲烷可溶提取物。 用于治疗色素性皮肤病的药物组合物含有一种或多种选自马鞭草酒精提取物，正己烷可溶提取物和二氯甲烷可溶提取物的提取物。 用于皮肤美白的功能性食品包含一种或多种选自马鞭草醇提取物，正己烷可溶提取物和二氯甲烷可溶提取物的提取物。 （附图标记）（AA）马鞭草 （BB）在树荫下干燥; （CC）粉; （DD）回流冷凝萃取（重复3次）; （EE）使用乙醇; （FF）提取; （GG）真空过滤; （HH）真空旋转浓度; （II）40℃（去除有机溶剂）; （JJ）粗提取物（乙醇提取物）; （KK）有机溶剂可溶成分（重复3-4次）; （LL）N-己烷可溶提取物; （MM，OO）水溶性成分; （NN）二氯甲烷可溶提取物;

公开(公告)号：KR1020120054577A

公开(公告)日：2012-05-30

申请号：KR1020120038386

申请日：2012-04-13

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  김아름 ,  권미성 ,  최재수 ,  신태선 ,  변대석 ,  우희철

IPC: C07D493/04 ,  A61K36/03 ,  A61K31/357 ,  A61P29/00

Abstract: PURPOSE: A composition containing phlorotannins derived from Ecklonia stolonifera and Ecklonia cava extract is provided to suppress iNOS and COX-2 expression and to prevent and treat inflammatory diseases. CONSTITUTION: A phlorofucofuroeckol A compound of chemical formula I is isolated from Ecklonia stolonifera and Ecklonia cava extract. A method for isolating and purifying the compound of chemical formula I comprises: a step of extracting ethanol extract of Ecklonia stolonifera and Ecklonia cava with n-hexane to prepare hexane water soluble extract; a step of extracting the hexane water soluble extract with ethyl acetate. The Ecklonia stolonifera and Ecklonia cava extract includes crude extract or non-polar solvent soluble extract. The crud extract is prepared using water, ethanol, methanol, butanol, or mixture thereof.

Abstract translation: 目的：提供一种含有源自Ecklonia stolonifera和Ecklonia cava提取物的光合色素的组合物，以抑制iNOS和COX-2的表达，并预防和治疗炎症性疾病。 化学式I化学式I化合物是从Ecklonia stolonifera和Ecklonia cava提取物中分离出来的。 用于分离和纯化化学式I化合物的方法包括：用正己烷萃取Ecklonia stolonifera和Ecklonia cava的乙醇提取物以制备己烷水溶性提取物的步骤; 用乙酸乙酯萃取己烷水溶性提取物的步骤。 Ecklonia stolonifera和Ecklonia cava提取物包括粗提物或非极性溶剂可溶性提取物。 粗提取物用水，乙醇，甲醇，丁醇或其混合物制备。