公开(公告)号：KR100442681B1

公开(公告)日：2004-08-02

申请号：KR1020010025371

申请日：2001-05-10

Applicant: 주식회사 디지탈바이오테크놀러지 ,  대한민국(관리부서 서울대학교(정밀기계설계공동연구소))

Inventor： 장준근 ,  정찬일 ,  정석 ,  김중경 ,  박준하

IPC: C12Q1/68

Abstract: PURPOSE: A channel unit and a mixing channel device using the same are provided, thereby an accurate mixing ratio of fluid can be accomplished in toxic test, biochemical experiments, medical experiments, and etc. CONSTITUTION: The channel unit which mixes fluid using micro mixing channels comprises a plurality of inlet channels; a cross chamber where the inlet channels are connected; at least one micro mixing channel connected to the cross chamber; and at least one outlet channel connected to the micro mixing channel, wherein the inlet channel, the micro mixing channel and the outlet channel regulate the amount, homogeneity and passage time of fluid by change of section area or length of the channel; and the micro mixing channel has zigzag shape. The mixing channel device comprises a plurality of inlet reservoirs; at least one outlet reservoir; and a channel circuit which connects the inlet reservoir and outlet reservoir, wherein the channel circuit contains at least one channel unit.

Abstract translation: 目的：提供一种通道单元和一种使用该单元的混合通道装置，从而在毒性测试，生物化学实验，医学实验等中实现流体的精确混合比例。构成：使用微混合混合流体的通道单元 通道包括多个入口通道; 进口通道连接的横室; 至少一个微混合通道，连接至所述横室; 以及至少一个与微混合通道连接的出口通道，其中入口通道，微混合通道和出口通道通过改变通道的截面面积或长度来调节流体的量，均匀性和通过时间; 微混合通道呈锯齿形。 混合通道装置包括多个入口储存器; 至少一个出口贮存器; 以及连接入口储存器和出口储存器的通道回路，其中通道回路包含至少一个通道单元。

公开(公告)号：KR100430383B1

公开(公告)日：2004-05-04

申请号：KR1020010025375

申请日：2001-05-10

Applicant: 주식회사 디지탈바이오테크놀러지 ,  대한민국(관리부서 서울대학교(정밀기계설계공동연구소))

Inventor： 이용구 ,  장준근 ,  방현우

IPC: C12Q1/68

Abstract: PURPOSE: A method for producing a mixing channel device and a method for fixing a tube on a panel are provided, therefore the tube can be correctly and stably fixed on a molding plate without damage of the molding plate and other structures. CONSTITUTION: The method for producing the mixing channel device comprises the steps of: (a) preparing the molding plate having embossed shape corresponding to a channel circuit; (b) attaching a magnet in the rear side of the molding plate; (c) positioning a magnetic structure in one side of the tube on the molding plate; (d) molding a first channel element on the molding plate; and (e) separating the magnetic and the molding plate from the first channel element. The method for fixing the tube on the panel comprises the steps of: (a) attaching the magnet in the rear side of the molding plate; (b) positioning the magnetic structure in one side of the tube on the molding plate; (c) molding the panel on the molding plate; and (d) separating the magnetic and the molding plate from the panel.

Abstract translation: 目的：提供一种制造混合通道装置的方法以及将管固定在面板上的方法，因此，管可以正确且稳定地固定在模制板上而不会损坏模制板和其他结构。 本发明的混合通道装置的制造方法包括以下步骤：（a）准备与通道回路对应的具有压花形状的成型板; （b）将磁体安装在模制板的后侧; （c）将磁性结构放置在成型板上的管的一侧; （d）在模制板上模制第一通道元件; 和（e）将磁性模板和模制板从第一通道元件分离。 用于将管固定在面板上的方法包括以下步骤：（a）将磁体附接在模制板的后侧; （b）将所述磁结构定位在所述模制板上的所述管的一侧中; （c）在模制板上模制面板; 和（d）将磁性模板和模板从面板上分开。

公开(公告)号：KR1020040012431A

公开(公告)日：2004-02-11

申请号：KR1020030001100

申请日：2003-01-08

Applicant: 주식회사 디지탈바이오테크놀러지

Inventor： 장준근 ,  박성진 ,  정석 ,  김중경 ,  정찬일 ,  단친유알렉세이

IPC: G01N15/14

Abstract: PURPOSE: An apparatus and a method for 3D focusing a fluid flow and an apparatus and a method for analyzing a fluid sample by using the same are provided to easily adjust a width and a height of the fluid flow. CONSTITUTION: A 3D focusing apparatus(200) includes a focusing channel(210), a first buffer channel(220), a second buffer channel(230), and a sample channel(240). The first buffer channel(220) conveys a first buffer flow to the focusing channel(210). The second buffer channel(230) is disposed adjacent to the first buffer channel(220) so as to convey a second buffer flow to the focusing channel(210). The sample channel(240) is positioned between the first and second buffer channels(220,230) in order to convey a sample fluid flow to the focusing channel(210). The sample channel(240) is arranged in line with the focusing channel(210).

Abstract translation: 目的：提供一种用于3D聚焦流体流的装置和方法，以及用于分析流体样品的装置和方法，以便容易地调节流体流动的宽度和高度。 构成：3D聚焦设备（200）包括聚焦通道（210），第一缓冲通道（220），第二缓冲通道（230）和采样通道（240）。 第一缓冲通道（220）将第一缓冲流传送到聚焦通道（210）。 第二缓冲通道（230）被布置为与第一缓冲通道（220）相邻，以便将第二缓冲流传送到聚焦通道（210）。 样品通道（240）位于第一和第二缓冲通道（220,230）之间，以便将样品流体流输送到聚焦通道（210）。 样品通道（240）与聚焦通道（210）成一直排列。

公开(公告)号：KR1020030092680A

公开(公告)日：2003-12-06

申请号：KR1020020030421

申请日：2002-05-30

Applicant: 주식회사 디지탈바이오테크놀러지

Inventor： 김은주 ,  임채승 ,  이용구 ,  장준근

IPC: G01N33/80

Abstract: PURPOSE: A method and an apparatus for determining blood types are provided, thereby accurately determining the blood type using a small amount of blood. CONSTITUTION: A method for determining blood types comprises the steps of: inserting reagents into a plurality of reagent storing chambers; introducing blood into each of the reagent storing chambers and mixing them; filtering the mixture of the blood and reagents or reaction products with micro-filters; and passing the filtered mixture or reaction products through reading channels connected to the micro-filters, wherein the reading channels contain reading chambers. An apparatus(300) for determining blood types comprises a blood introducing chamber(320); a plurality of micro-channels connected to the blood introducing chamber; a plurality of reagent storing chambers(330) connected to the micro-channels; a plurality of micro-filters(340) connected to the reagent storing chamber; and a plurality of reading channels(350) connected to the micro-filters.

Abstract translation: 目的：提供一种用于确定血型的方法和装置，从而使用少量的血液精确地确定血型。 构成：用于测定血型的方法包括以下步骤：将试剂插入多个试剂储存室; 将血液引入每个试剂储存室并混合; 用微量过滤器过滤血液和试剂或反应产物的混合物; 并且通过连接到微滤器的读取通道使经过滤的混合物或反应产物通过，其中读取通道包含阅读室。 用于确定血液类型的装置（300）包括血液引入室（320）; 与血液导入室连接的多个微通道; 连接到微通道的多个试剂储存室（330） 连接到试剂储存室的多个微滤器（340） 以及连接到微滤器的多个读取通道（350）。

公开(公告)号：KR1020030032811A

公开(公告)日：2003-04-26

申请号：KR1020020030430

申请日：2002-05-30

Applicant: 장준근 ,  방현우 ,  주식회사 디지탈바이오테크놀러지

Inventor： 장준근 ,  방현우 ,  정찬일 ,  조한상 ,  이용구

IPC: B81B7/00

CPC classification number: B81B1/002 ,  B81B1/006 ,  B81B2201/05 ,  B81C1/00071

Abstract: PURPOSE: A minute channel device for mixing fluid using a minute channel and a mixing method thereof are provided to achieve plural mixtures having a predetermined density ratio by utilizing resistance of fluid, which is varied depending on a size of the minute channel. CONSTITUTION: A minute channel device includes a first storing region(120), a second storing region, a first minute channel structure(140) and a second minute channel structure(160). The first minute channel structure(140) includes a first inlet(150), into which fluid(A) is introduced, a first inlet channel(143) connected to the first inlet(150), a first branch area(180) formed at one end of the first inlet channel(143), first and second branch channels(146,149) branched from the first branch area(180), a first outlet(153) and a second outlet(156). The second minute channel structure(160) includes a second inlet(170), into which fluid(B) is introduced, a second inlet channel(163) connected to the second inlet(170), a second branch area(190) formed at one end of the second inlet channel(163), third and fourth branch channels(166,169) branched from the second branch area(190), a third outlet(173) and a fourth outlet(176).

Abstract translation: 目的：提供用于使用微通道混合流体的微通道装置及其混合方法，以通过利用流体的阻力来实现具有预定密度比的多种混合物，其根据微通道的尺寸而变化。 构成：微通道装置包括第一存储区域（120），第二存储区域，第一微通道结构（140）和第二微通道结构（160）。 第一分钟通道结构（140）包括第一入口（150），流体（A）被引入到该第一入口中，连接到第一入口（150）的第一入口通道（143） 第一入口通道（143）的一端，从第一分支区域（180）分支的第一和第二分支通道（146,149），第一出口（153）和第二出口（156）。 第二分钟通道结构（160）包括第二入口（170），流体（B）被引入其中，第二入口通道（163）连接到第二入口（170），第二分支区域（190）形成在 第二入口通道（163）的一端，从第二分支区域（190）分支的第三和第四分支通道（166,169），第三出口（173）和第四出口（176）。

公开(公告)号：KR1020020085902A

公开(公告)日：2002-11-18

申请号：KR1020010025371

申请日：2001-05-10

Applicant: 주식회사 디지탈바이오테크놀러지 ,  대한민국(관리부서 서울대학교(정밀기계설계공동연구소))

Inventor： 장준근 ,  정찬일 ,  정석 ,  김중경 ,  박준하

IPC: C12Q1/68

Abstract: PURPOSE: A channel unit and a mixing channel device using the same are provided, thereby an accurate mixing ratio of fluid can be accomplished in toxic test, biochemical experiments, medical experiments, and etc. CONSTITUTION: The channel unit which mixes fluid using micro mixing channels comprises a plurality of inlet channels; a cross chamber where the inlet channels are connected; at least one micro mixing channel connected to the cross chamber; and at least one outlet channel connected to the micro mixing channel, wherein the inlet channel, the micro mixing channel and the outlet channel regulate the amount, homogeneity and passage time of fluid by change of section area or length of the channel; and the micro mixing channel has zigzag shape. The mixing channel device comprises a plurality of inlet reservoirs; at least one outlet reservoir; and a channel circuit which connects the inlet reservoir and outlet reservoir, wherein the channel circuit contains at least one channel unit.

Abstract translation: 目的：提供通道单元和使用该通道单元的混合通道装置，从而可以在有毒试验，生化实验，医学实验等方面实现精确的流体混合比。构成：使用微混合混合流体的通道单元 通道包括多个入口通道; 连接入口通道的交叉室; 至少一个微型混合通道连接到所述交叉室; 以及连接到微混合通道的至少一个出口通道，其中入口通道，微混合通道和出口通道通过改变通道的截面积或长度来调节流体的量，均匀性和通过时间; 微混合通道具有锯齿状。 混合通道装置包括多个入口容器; 至少一个出口储存器; 以及连接入口储存器和出口储存器的通道电路，其中通道电路包含至少一个通道单元。

公开(公告)号：KR1020020035696A

公开(公告)日：2002-05-15

申请号：KR1020000065954

申请日：2000-11-07

Applicant: 김종현 ,  문신용 ,  양상식 ,  장준근 ,  한동철 ,  이승기 ,  이장무 ,  주식회사 디지탈바이오테크놀러지

Inventor： 김종현 ,  이장무 ,  장준근 ,  이승기 ,  양상식 ,  문신용 ,  한동철

IPC: A61B1/005

Abstract: PURPOSE: A controlling apparatus of a travel direction adjustment operating device of an endoscope is provided to increase a bending angle of an operating device of the endoscope and give a function for adjusting the travel direction to the operating device. CONSTITUTION: A controlling apparatus of a travel direction adjustment operating device of an endoscope comprises coordinate reading units(60,62), a first and a second non-inverting amplifiers(28,30), a first to a third inverting amplifiers(32,34,36), a first to a seventh summing inverters(38-50), a trigonal wave generator(52), and a first to a third comparators(54,56,58). The non-inverting amplifiers(28,30) multiply an X value from the reading unit(60) with two multipliers, respectively. The inverting amplifiers(32,34,36) invert the multiplied values from the non-inverting amplifiers(28,30) and a Y value from the reading unit(62). The first to the fourth summing inverters(38-44) add the Y value and the outputs of the inverting amplifiers(32,36) and the non-inverting amplifier(28), and output the inverted sums, respectively. The fifth to the seventh summing inverters(46-50) add the outputs of the non-inverting amplifier(30), the first to the fourth summing inverters(38-44), and the inverting amplifier(34), and output the inverted sums, respectively. The comparators(54-58) compare the outputs of the fifth to the seventh summing inverters(46-50) with the output of the trigonal wave generator(52), respectively.

Abstract translation: 目的：提供内窥镜的行进方向调整操作装置的控制装置，以增加内窥镜的操作装置的弯曲角度，并且具有调整到操作装置的行进方向的功能。 构成：内窥镜的行进方向调整操作装置的控制装置，包括坐标读取单元（60,62），第一和第二非反相放大器（28,30），第一至第三反相放大器（32， 34,36），第一至第七求和逆变器（38-50），三角波发生器（52）和第一至第三比较器（54,56,58）。 非反相放大器（28,30）分别与来自读取单元（60）的X值乘以两个乘法器。 反相放大器（32,34,36）将来自非反相放大器（28,30）的倍增值和来自读取单元（62）的Y值反相。 第一到第四求和反相器（38-44）将Y值和反相放大器（32,36）和非反相放大器（28）的输出相加，并分别输出反相和。 第五至第七求和反相器（46-50）将非反相放大器（30），第一至第四求和反相器（38-44）和反相放大器（34）的输出相加，并输出反相放大器 分别。 比较器（54-58）分别将第五到第七求和反相器（46-50）的输出与三角波发生器（52）的输出进行比较。

公开(公告)号：KR100886187B1

公开(公告)日：2009-02-27

申请号：KR1020070119543

申请日：2007-11-22

Applicant: 주식회사 디지탈바이오테크놀러지

Inventor： 박준하 ,  이창섭 ,  정현주 ,  임현창 ,  박지영 ,  정찬일 ,  장준근

IPC: G01N35/00

CPC classification number: B01L3/50273 ,  B01L2200/0636 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0822

Abstract: A chip for the analysis of fluid is provided to inhibit the generation of bubbles in a fluid sample by allowing a fluid sample to flow with a uniform pattern, thereby reducing the error of measurement remarkably. A chip for the analysis of fluid comprises a body part; a fluid input hole(130) which is formed at the one terminal part of the body part; a path conversion part(160) which is formed at the other terminal part of the body part; and a path which is formed in the body part to be connected with the fluid input hole and is provided with a first channel(141) of a first depth extending from the fluid input hole to the path conversion part and a second channel(142) of a second depth extending parallel with the first channel, wherein the second depth has the depth(h1) larger than the first depth(h2) from the terminal part of the fluid input hole side to the one point of the downstream of the fluid input hole, and the second depth decreases from the one point of the downstream of the fluid input hole to the path conversion part so as to have the height identical to the first depth at the path conversion part.

Abstract translation: 提供用于分析流体的芯片，以通过允许流体样品​​以均匀的图案流动来抑制流体样品中的气泡的产生，从而显着降低测量误差。 用于分析流体的芯片包括主体部分; 流体输入孔（130），其形成在所述主体部分的一个端部; 路径转换部（160），其形成在所述主体部的另一端部; 以及形成在所述主体部分中以与所述流体输入孔连接并且设置有从所述流体输入孔延伸到所述路径转换部分的第一深度的第一通道（141）和第二通道（142）的路径， 第二深度与第一通道平行延伸的第二深度，其中第二深度具有大于从流体输入孔侧的端部到流体输入的下游的一个点的第一深度（h2）的深度（h1） 并且第二深度从流体输入孔的下游的一点到达路径转换部分，从而具有与路径转换部分处的第一深度相同的高度。

公开(公告)号：KR100878229B1

公开(公告)日：2009-01-12

申请号：KR1020070119506

申请日：2007-11-22

Applicant: 주식회사 디지탈바이오테크놀러지

Inventor： 박준하 ,  이창섭 ,  정현주 ,  임현창 ,  박지영 ,  정찬일 ,  장준근

IPC: G01N35/00 ,  G01N33/53 ,  G01N33/50 ,  G01N33/48

CPC classification number: G01N35/00029 ,  B01L3/502723 ,  B01L3/502746 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/089 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/5304 ,  G01N2035/00158

Abstract: A chip for the fluid analysis is provided to prevent the leakage of fluid into the extended part when a sample is flown into a microchannel for the reaction, thereby obtaining the wall-free effect due to extended part. A chip for the fluid analysis comprises an input hole(11) where a sample for analysis is injected; a first reservoir(12) where the injected sample is filled firstly; a second reservoir(13) where the injected sample is filled secondly; a first reaction part(14) where the injected sample reacts with the labelled material; and a second reactive part(15) where the labelled sample reacts by specific reaction such as the antigen-antibody reaction.

Abstract translation: 提供用于流体分析的芯片，以防止当样品流入用于反应的微通道中时流体泄漏到延伸部分中，从而获得由于延伸部分而产生的无壁效应。 用于流体分析的芯片包括其中注入用于分析的样品的输入孔（11） 首先填充注入的样品的第一储存器（12）; 第二储存器（13），其中注入的样品被二次填充; 第一反应部分（14），其中注射的样品与标记的材料反应; 和第二反应性部分（15），其中标记的样品通过特异性反应如抗原 - 抗体反应进行反应。

公开(公告)号：KR100844350B1

公开(公告)日：2008-07-07

申请号：KR1020070002436

申请日：2007-01-09

Applicant: 주식회사 디지탈바이오테크놀러지

Inventor： 허대성 ,  정찬일 ,  전승화 ,  장준근

IPC: A61B5/00 ,  G01N33/543

CPC classification number: A61B5/0059 ,  A61B5/14546

Abstract: A micro-channel chip for counting specific micro-particles among floating mixed micro-particles by an optical method and a method for counting micro-particles by using the same are provided to obtain a clear image without overlapping by setting up a depth of micro-channel to a depth of field in the micro-channel chip. A micro-channel chip for counting specific micro-particles among floating mixed micro-particles by an optical method includes a micro-channel to receive a sample including the micro-particles. The micro-channel chip counts the number of micro-particles in the micro-channel by taking photographs of inner parts of the micro-channel. The depth of the micro-channel is a depth of field to detect subjects clearly, wherein the depth of field is a range of focus.

Abstract translation: 提供了一种用于通过光学方法计数漂浮的混合微粒子中的特定微粒子的微通道芯片以及通过使用该微通道微粒子计数微粒子的方法，以通过设置微孔的深度来获得清晰的图像而不重叠， 通道到微通道芯片的景深。 用于通过光学方法计数浮动混合微粒子中的特定微粒子的微通道芯片包括用于接收包含微粒子的样品的微通道。 微通道芯片通过拍摄微通道的内部部分来计算微通道中的微粒数量。 微通道的深度是用于清晰地检测物体的景深，其中景深是焦距范围。