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1.发明授权REFERENCE LEAK GENERATING DEVICE AND ULTRA-FINE LEAK TESTING DEVICE USING SAME 有权参考泄漏产生装置和使用该装置的超细泄漏测试装置
公开(公告)号：EP2924411B1
公开(公告)日：2017-12-27
申请号：EP13857007.2
申请日：2013-11-12
Inventor： YOSHIDA Hajime , ARAI Kenta , KOBATA Tokihiko
CPC classification number: G01L27/002 , B81B7/0009 , B81B2201/05 , G01M3/007 , G01M3/207 , G01M3/26
Abstract: There is provided a reference leak generating device capable of precisely generating an ultra-fine reference leak. The reference leak generating device adapted to be connected to an upstream side of a measurement chamber includes a chamber connected to the measurement chamber through an orifice or a porous plug having a molecular flow conductance C and a pressure to establish molecular flow conditions which are known in advance, and is characterized in that a pressure p 1 of testing gas to be introduced into the chamber is precisely determined by using a static expansion method once or more times, and a leak rate of a reference leak at the pressure p 1 is obtained in accordance with a product of C and P 1 .
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公开(公告)号：WO2011001185A1
公开(公告)日：2011-01-06
申请号：PCT/GB2010/051092
申请日：2010-07-02
Applicant: CAMBRIDGE ENTERPRISE LIMITED , BAUER, Wolfgang Andreas , HUCK, Wilhelm T. S. , FISCHLECHNER, Martin
Inventor： BAUER, Wolfgang Andreas , HUCK, Wilhelm T. S. , FISCHLECHNER, Martin
IPC: B01L3/00 , B01F13/00 , G01N27/447
CPC classification number: B01L3/502707 , B01F17/00 , B01J2219/00511 , B01J2219/0059 , B01J2219/00637 , B01J2219/00783 , B01J2219/00788 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0097 , B01L2200/0636 , B01L2300/0867 , B01L2300/16 , B01L2300/161 , B05C7/04 , B05D7/22 , B05D7/222 , B81B2201/0214 , B81B2201/05 , B81B2201/052 , B81B2201/058 , B81C1/00119 , B81C1/00206 , Y10T137/8593
Abstract: We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.
Abstract translation: 我们描述了将多层材料层逐层沉积到微流体装置的通道的壁或壁上的方法，该方法包括：将具有一系列溶液段的管装载， 含有待沉积材料的溶液; 将所述管连接到所述微流体装置; 以及将所述溶液段注射到所述微流体装置中，使得所述溶液段又通过所述通道沉积连续的材料层，以在所述通道的所述壁或壁上执行所述逐层沉积。 该方法的实施方案对于塑料的自动表面改性特别有用，例如PDMS（聚（二甲基硅氧烷）），微通道。 我们还描述了形成双重乳液的方法和设备。
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公开(公告)号：WO2013136003A2
公开(公告)日：2013-09-19
申请号：PCT/FR2013/050508
申请日：2013-03-11
Applicant: TOTAL PETROCHEMICALS FRANCE , ECOLE SUPÉRIEURE DE PHYSIQUE ET CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
Inventor： AZIOUNE, Ammar , BARTOLO, Denis , LEVACHE, Bertrand , STUDER, Vincent
CPC classification number: B01L3/502707 , B01L2200/12 , B81B2201/05 , B81C1/00206 , Y10T29/49
Abstract: L'invention a pour objet un procédé de traitement de surface destiné à traiter les parois internes d'un microcanal formé dans un matériau polymère au moins partiellement photo-durci ou thermo-durci. Ce traitement est fait par irradiation sous air à une longueur d'onde inférieure ou égale à 300 nm. L'invention a également pour objet un procédé de fabrication d'un dispositif microfluidique comprenant une telle étape de traitement de surface.
Abstract translation: 本发明涉及一种用于处理由至少部分光固化或热固性的聚合材料制成的微通道的内壁的表面处理方法。 所述处理通过在空气中以小于或等于300nm的波长的照射进行。 本发明还涉及一种用于制造包括这种表面处理步骤的微流体装置的方法。
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公开(公告)号：WO2013136003A3
公开(公告)日：2014-03-13
申请号：PCT/FR2013050508
申请日：2013-03-11
Applicant: TOTAL PETROCHEMICALS FRANCE , ECOLE SUPERIEURE DE PHYSIQUE ET CHIMIE IND DE LA VILLE DE PARIS
Inventor： AZIOUNE AMMAR , BARTOLO DENIS , LEVACHE BERTRAND , STUDER VINCENT
IPC: B81C1/00
CPC classification number: B01L3/502707 , B01L2200/12 , B81B2201/05 , B81C1/00206 , Y10T29/49
Abstract: The invention relates to a surface treatment method for treating the inner walls of a microchannel made from a polymeric material that is at least partially photocured or thermoset. Said treatment is carried out via irradiation in the air at a wavelength of less than or equal to 300 nm. The invention also relates to a method for manufacturing a microfluidic device including such a surface treatment step.
Abstract translation: 本发明涉及一种用于处理由至少部分光固化或热固性的聚合材料制成的微通道的内壁的表面处理方法。 所述处理通过在空气中以小于或等于300nm的波长的照射进行。 本发明还涉及一种用于制造包括这种表面处理步骤的微流体装置的方法。
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公开(公告)号：WO2014080798A1
公开(公告)日：2014-05-30
申请号：PCT/JP2013/080551
申请日：2013-11-12
Applicant: 独立行政法人産業技術総合研究所
CPC classification number: G01L27/002 , B81B7/0009 , B81B2201/05 , G01M3/007 , G01M3/207 , G01M3/26
Abstract: 超微小な参照リークを正確に発生可能な参照リーク発生装置を提供する。 測定室の上流側に接続するための参照リーク発生装置であって、分子流コンダクタンスＣと分子流条件が成り立つ圧力が予め既知であるオリフィス又は多孔質体を介して前記測定室に接続される室を備え、当該室に導入される試験ガスの圧力ｐ 1 を１回以上の静的膨張法により正確に定めて、圧力ｐ 1 における参照リークのリーク量をＣとｐ 1 の積で求めることを特徴とする参照リーク発生装置。
Abstract translation: 提供能够精确地产生超细参考泄漏的参考泄漏产生装置。 用于连接到测量室的上游侧的参考泄漏产生装置包括经由孔或多孔体连接到测量室的腔室，其中分子流动电导（C）和满足分子流的压力 条件是预先知道的，其特征在于，使用静态膨胀法一次或多次精确设定引入到室内的试验气体的压力（p1），并将压力下的基准泄漏的泄漏量（ p1）由（C）和（p1）的乘积找到。
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Patent Agency Ranking
公开(公告)号：US20240301395A1
公开(公告)日：2024-09-12
申请号：US18653435
申请日：2024-05-02
Applicant: Purigen Biosystems, Inc.
Inventor： Lewis A. Marshall , Amy L. Hiddessen , Nathan P. Hoverter , Klint A. Rose , Juan G. Santiago
IPC: C12N15/10 , B01L3/00 , B81B1/00 , B81B7/00 , C12Q1/6806 , G01N27/447
CPC classification number: C12N15/101 , B01L3/502753 , C12N15/10 , C12Q1/6806 , G01N27/4473 , G01N27/44739 , G01N27/44791 , G01N27/44795 , B01L3/502738 , B01L2300/0627 , B01L2300/0867 , B81B1/004 , B81B7/0087 , B81B2201/0278 , B81B2201/05 , B81B2203/0338 , G01N27/44704
Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.
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公开(公告)号：US12006496B2
公开(公告)日：2024-06-11
申请号：US18141641
申请日：2023-05-01
Applicant: Purigen Biosystems, Inc.
Inventor： Lewis A. Marshall , Amy L. Hiddessen , Nathan P. Hoverter , Klint A. Rose , Juan G. Santiago
IPC: G01N27/453 , B01L3/00 , C12N15/10 , C12Q1/6806 , G01N27/447 , B81B1/00 , B81B7/00
CPC classification number: C12N15/101 , B01L3/502753 , C12N15/10 , C12Q1/6806 , G01N27/4473 , G01N27/44739 , G01N27/44791 , G01N27/44795 , B01L3/502738 , B01L2300/0627 , B01L2300/0867 , B81B1/004 , B81B7/0087 , B81B2201/0278 , B81B2201/05 , B81B2203/0338 , G01N27/44704 , C12N15/101 , C12Q2565/125
Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.
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公开(公告)号：US20230404777A1
公开(公告)日：2023-12-21
申请号：US18043438
申请日：2021-08-27
Applicant: CAMBRIDGE ENTERPRISE LIMITED
Inventor： Sohini KAR-NARAYAN , Qingshen JING , Jehangir CAMA , Liam IVES , Vikas KHANDUJA
CPC classification number: A61F2/468 , G01L1/142 , G01L1/02 , B81B3/0075 , B81B7/0025 , B81C1/00674 , B81C2203/032 , B81B2203/0338 , B81B2203/04 , B81B2207/115 , B81C2201/0185 , B81C2201/034 , B81B2201/05
Abstract: A microfluidic sensor comprising: a first substrate; a second substrate; a cavity formed between the first substrate and the second substrate, the cavity comprising a reservoir portion and a channel portion extending from the reservoir portion; a capacitive element disposed between the first substrate and the second substrate, the capacitive element being at least partially disposed in the channel portion of the cavity; and a dielectric sensing liquid provided in the reservoir portion. Upon application of a force to the first substrate adjacent the reservoir portion, the reservoir portion is configured to deform and displace the sensing liquid along the channel portion, so as to change the capacitance of the capacitive element within the channel portion.
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公开(公告)号：US20140349078A1
公开(公告)日：2014-11-27
申请号：US14455745
申请日：2014-08-08
Applicant: Honeywell International Inc.
Inventor： Robert Jon Carlson
CPC classification number: B29C33/3842 , B29C41/00 , B29C59/14 , B29C59/16 , B29K2909/00 , B29K2995/0037 , B81B7/00 , B81B2201/05 , B81B2201/058 , B81B2203/0127 , B81C99/009 , B81C2201/0132 , B81C2201/0143 , B81C2201/034 , C23F1/02 , H01L21/30604 , Y10T428/24496
Abstract: The invention is directed to a patterned aerogel-based layer that serves as a mold for at least part of a microelectromechanical feature. The density of an aerogel is less than that of typical materials used in MEMS fabrication, such as poly-silicon, silicon oxide, single-crystal silicon, metals, metal alloys, and the like. Therefore, one may form structural features in an aerogel-based layer at rates significantly higher than the rates at which structural features can be formed in denser materials. The invention further includes a method of patterning an aerogel-based layer to produce such an aerogel-based mold. The invention further includes a method of fabricating a microelectromechanical feature using an aerogel-based mold. This method includes depositing a dense material layer directly onto the outline of at least part of a microelectromechanical feature that has been formed in the aerogel-based layer.
Abstract translation: 本发明涉及用作至少部分微机电特征的模具的图案化气凝胶基层。 气凝胶的密度小于MEMS制造中使用的典型材料的密度，例如多晶硅，氧化硅，单晶硅，金属，金属合金等。 因此，可以以明显高于在较致密的材料中形成结构特征的速率的速率在气凝胶层中形成结构特征。 本发明还包括一种图案化气凝胶层以产生这种基于气凝胶的模具的方法。 本发明还包括使用基于气凝胶的模具制造微机电特征的方法。 该方法包括将致密材料层直接沉积在已经形成在气凝胶层中的微机电特征的至少一部分的轮廓上。
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公开(公告)号：EP2448678B1
公开(公告)日：2018-10-03
申请号：EP10732736.3
申请日：2010-07-02
Applicant: Cambridge Enterprise Limited
Inventor： BAUER, Wolfgang Andreas , HUCK, Wilhelm T. S. , FISCHLECHNER, Martin
IPC: B01L3/00 , B01F13/00 , G01N27/447
CPC classification number: B01L3/502707 , B01F17/00 , B01J2219/00511 , B01J2219/0059 , B01J2219/00637 , B01J2219/00783 , B01J2219/00788 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0097 , B01L2200/0636 , B01L2300/0867 , B01L2300/16 , B01L2300/161 , B05C7/04 , B05D7/22 , B05D7/222 , B81B2201/0214 , B81B2201/05 , B81B2201/052 , B81B2201/058 , B81C1/00119 , B81C1/00206 , Y10T137/8593
Abstract: We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.
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