公开(公告)号：EP1042506A1

公开(公告)日：2000-10-11

申请号：EP98964067.7

申请日：1998-12-16

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C12N15/12 ,  C12N5/10 ,  C07K16/18 ,  C07K14/47 ,  G01N33/574

CPC classification number: C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS135 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS135-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS135 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP1027459A1

公开(公告)日：2000-08-16

申请号：EP98934224.1

申请日：1998-06-30

Applicant: Abbott Laboratories

Inventor： CAPLE, Kimberlee, S. ,  CUNNINGHAM, David, S. ,  EASON, Reginald, L. ,  GORDON, Julian ,  HENNING, Timothy, P. ,  STROUPE, Stephen, D.

IPC: C12Q1/70 ,  G01N33/53 ,  G01N33/543 ,  G01N33/564 ,  H04M1/64 ,  H04M3/00 ,  H04M3/42 ,  H04M11/00 ,  H04M11/04

CPC classification number: A61B5/0022 ,  A61B3/02 ,  A61B5/12 ,  A61B5/16 ,  A61B5/4088 ,  A61B5/411 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/40 ,  G16H10/60 ,  G16H15/00 ,  Y02A90/22 ,  Y02A90/26

Abstract: Automatic test tracking analysis and reporting are provided by an automated process and computer system, which can provide a global communications network, for the convenience of patients, health care providers and public health agencies to lower health care costs. Advantageously, the speedy accurate process and system can be used to detect many types of infectious diseases, chronic diseases, genetic diseases, nutritional deficiency, environmental and general health problems, fertility, mental disorders, drug abuse, allergies, etc., as well as to automatically administer non-invasive tests, such as vision tests, hearing tests, and cognitive function tests to monitor the progress of Alzheimer's disease. Samples to be tested can be conveniently collected by the patient or by others and placed in a test kit at the patient's home or other location remote from a medical facility. The sample can be tested in a laboratory or at the patient home or other remote site. The test results and patient profile medical history can be inputted into the system or network and compared with data bases of diseases, disorders, treatments, care plans, nutritional supplements, and medicine. The process and system can transmit an analysis and proposed treatment to the patient's physician or health care provider for approval or change before the test report and recommended medicine and treatment are sent to the patient. The process and system are also useful for automatic test tracking and reporting to public health organizations.

公开(公告)号：EP0986652A1

公开(公告)日：2000-03-22

申请号：EP98925283.8

申请日：1998-06-05

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D. ,  YU, Hong

IPC: C12Q1/68 ,  C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  G01N33/574 ,  C12N5/12

CPC classification number: C07K14/47 ,  C07K16/18 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57438 ,  G01N33/57484

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BL172 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to BL172-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BL172 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.

公开(公告)号：EP0986643A1

公开(公告)日：2000-03-22

申请号：EP98932792.9

申请日：1998-06-19

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  RUSSELL, John, C. ,  SCHEFFEL, Christi, P. ,  STROUPE, Stephen, D. ,  YU, Hong

IPC: C12N15/12 ,  C07K14/47 ,  C12Q1/68 ,  C12N15/85 ,  C12N5/10 ,  C07K16/18 ,  G01N33/574

CPC classification number: C07K14/47

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS124 and transcribed from breast tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to a BS124-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS124 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP0749583A1

公开(公告)日：1996-12-27

申请号：EP95912800.0

申请日：1995-03-06

Applicant: Abbott Laboratories

Inventor： KIM, Young, Ran ,  STROUPE, Stephen, D.

IPC: G01N33

CPC classification number: G01N33/5094 ,  G01N33/721 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/25375

Abstract: A cyanide-free method and reagent for determining the concentration of total hemoglobin in a whole blood sample accurately in less than 10 seconds comprising a ligand selected from the group consisting of imidazole, imidazole derivatives, N-hydroxyacetamide, N-hydroxyl amine, pyridine, oxazole, thiazole, pyrazole, pyrimidine, purine, quinoline, and isoquinoline, and a surfactant with strong erythrolytic capability selected from the group consisting of lauryl dimethylamine oxide and octylphenoxy polyethoxyethanol. The reagent pH is adjusted to about 11 to about 14. Rapid mixing of the reagent with a blood sample leads to the formation of a stable chromogen whose absorbance can be measured between 540 and 550 nm. The cyanide-free reagent is ideal for use on an automated high through-put clinical hematology analyzer.

公开(公告)号：EP0641442A1

公开(公告)日：1995-03-08

申请号：EP92911929.0

申请日：1992-04-10

Applicant: ABBOTT LABORATORIES

Inventor： JOU, Yi-Her ,  STROUPE, Stephen, D.

IPC: G01N33

CPC classification number: G01N33/558 ,  G01N33/538 ,  G01N33/54366 ,  G01N33/57473

Abstract: This invention presents novel assay devices employing a capture reagent, involving a specific binding member attached to a charged substance, and a porous material containing a capture or reaction zone that is oppositely charged with respect to the capture reagent. In one embodiment, a test sample suspected of containing the analyte of interest is contacted with the capture reagent to form a charged capture reagent/analyte complex. The complex is then contacted to the oppositely charged capture or reaction zone to attract, attach, and immobilize the capture reagent/analyte complex. With an appropriate indicator reagent, both sandwich and competitive assays can be performed.

公开(公告)号：EP0227795B1

公开(公告)日：1993-12-15

申请号：EP86904513.8

申请日：1986-06-13

Applicant: AMGEN INC. ,  ABBOTT LABORATORIES

Inventor： SNITMAN, David, L. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  G01N33/53 ,  C12N15/00

CPC classification number: G01N33/54353 ,  C12Q1/6804 ,  C12Q1/6813 ,  C12Q1/705 ,  G01N33/532

Abstract: A method and a kit for the isolation and quantitative detection of a selected target nucleic acid sequence from solution employing two probes. A first probe is complementary to one portion of the target and is covalently attached to a first complexing agent (e.g., either an antigen or an antibody). The second probe is complementary to a different portion of the target and is associated with a reporter group. Following hybridization of the target and two probes in solution, a solid support coated with a second complexing agent (i.e., a corresponding antibody or antigen) capable of binding to the first complexing agent on the first probe is employed to immobilize the target-probe hybrid complex. A plurality of types of first probes may be used. Each type is attached to the same sort of complexing agent but each includes a nucleic acid sequence which is complementary to a different portion of the target.

公开(公告)号：EP0570535A1

公开(公告)日：1993-11-24

申请号：EP92908113.0

申请日：1992-02-28

Applicant: ABBOTT LABORATORIES

Inventor： STROUPE, Stephen, D.

IPC: C12Q1 ,  G01N33

CPC classification number: C12Q1/6825 ,  B82Y35/00 ,  G01N33/53 ,  G01N33/54373

Abstract: Procédés et kits d'analyse servant à détecter la présence d'un analyte dans un spécimen, procédant molécule par molécule, au moyen de la microscopie par sonde à balayage, dans lesquels le spécimen susceptible de contenir l'analyte recherché est exposé à un élément d'analyse auquel on a fixé une substance spécifique à l'analyte et on analyse ledit élément au moyen de la microscopie à sonde d'analyse pour déterminer la présence ou l'absence de l'analyte.