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公开(公告)号：CA2807847C
公开(公告)日：2016-09-20
申请号：CA2807847
申请日：2011-10-12
Applicant: ABBVIE BAHAMAS LTD
Inventor： DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , RANDOLPH JOHN T , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHEL V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , GAO YI , LIU DACHUN , PRATT JOHN K , ROCKWAY TODD W , MARING CLARENCE J , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , TUFANO MICHAEL D , BETEBENNER DAVID A , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBEL H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , CARROLL WILLIAM A
IPC: C07D403/14
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (HCV) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：HRP20160408T1
公开(公告)日：2016-05-20
申请号：HRP20160408
申请日：2016-04-19
Applicant: ABBVIE BAHAMAS LTD
Inventor： RANDOLPH JOHN T , DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , MARING CLARENCE J , TUFANO MICHAEL D , BETEBENNER DAVID A , ROCKWAY TODD W , LIU DACHUN , PRATT JOHN K , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , GAO YI
IPC: A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61P31/14 , C07D401/14 , C07D403/14 , C07D417/14
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公开(公告)号：MX338555B
公开(公告)日：2016-04-20
申请号：MX2012004779
申请日：2010-03-16
Applicant: ABBVIE BAHAMAS LTD
Inventor： BARNES DAVID M , PRATT JOHN K , BETEBENNER DAVID A , DONNER PAMELA L , MARING CLARENCE J , WAGNER ROLF , RANDOLPH JOHN T , DEGOEY DAVID A , FLENTGE CHARLES A , HUANG PEGGY P , HUTCHINSON DOUGLAS K , KRUEGER ALLAN C , HENRY RODGER F , KOTECKI BRIAN J , HAIGHT ANTHONY R , GAO YI , STEWART KENT D , LONGENECKER KENTON L , ROCKWAY TODD W , MOTTER CHRISTOPHER E , TUFANO MICHAEL D , LIU DACHUN , ZHANG GEOFF G Z , LOU XIAOCHUN , SARRIS KATHY , CHEN SHUANG , KATI WARREN M , LIU YAYA , HENGEVELD JOHN E , FRANCZYK THADDEUS S II
IPC: C07D239/54
Abstract: Esta invención se refiere con: (a) compuestos y sales de los mismos que, entre otros, inhiben el HCV; (b) intermediarios de utilidad para la preparación de tales compuestos y sales; (c) composiciones que comprenden tales compuestos y sales; (d) métodos para preparar tales intermediarios, compuestos, sales y composiciones; (e) métodos de uso de tales compuestos, sales y composiciones; y (f) conjuntos de elementos que comprenden tales compuestos, sales y composiciones.
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公开(公告)号：CY1114356T1
公开(公告)日：2016-04-13
申请号：CY131100518
申请日：2013-06-26
Applicant: ABBVIE BAHAMAS LTD
Inventor： RANDOLPH JOHN T , DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER CHARLES A , MARING CLARENCE J , TUFANO MICHAEL D , BETEBENNER DAVID A , ROCKWAY TODD W , LIU DACHUN , PRATT JOHN K , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , YI GAO
IPC: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/4439 , A61P31/14 , C07D401/14 , C07D417/14
Abstract: ΠεριγράφονταιενώσειςαποτελεσματικέςστηναναστολήτηςαντιγραφήςτουιούτηςΗπατίτιδας C ("ΗCV"). Ηπαρούσαεφεύρεσηαναφέρεταιεπίσηςσεδιεργασίεςδημιουργίαςαυτώντωνενώσεων, σεσυνθέσειςπεριλαμβάνουσεςαυτέςτιςενώσειςκαισεμεθόδουςχρήσεωςαυτώντωνενώσεωνγιατηναγωγήτηςμολύνσεωςαπόΗCV.
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公开(公告)号：SI2692346T1
公开(公告)日：2016-03-31
申请号：SI201130697
申请日：2011-10-12
Applicant: ABBVIE BAHAMAS LTD
Inventor： DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , RANDOLPH JOHN T , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHEL V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , GAO YI , LIU DACHUN , PRATT JOHN K , ROCKWAY TODD W , MARING CLARENCE J , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , TUFANO MICHAEL D , BETEBENNER DAVID A , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBEL H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , CARROLL WILLIAM A
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Patent Agency Ranking
公开(公告)号：DK2692346T3
公开(公告)日：2016-02-29
申请号：DK13191041
申请日：2011-10-12
Applicant: ABBVIE BAHAMAS LTD
Inventor： DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , RANDOLPH JOHN T , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHEL V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , GAO YI , LIU DACHUN , PRATT JOHN K , ROCKWAY TODD W , MARING CLARENCE J , FLENTGE CHARLES A , WAGNER ROLF , TUFANO MICHAEL D , BETEBENNER DAVID A , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBEL H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , CARROLL WILLIAM A , HUTCHINSON DOUGLAS K
IPC: A61K31/454 , A61P31/14
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公开(公告)号：UY35266A
公开(公告)日：2015-07-31
申请号：UY35266
申请日：2014-01-13
Applicant: ABBVIE BAHAMAS LTD
Inventor： KRUEGER ALLAN C , DONNER PAMELA L , DEGOEY DAVID A , PATEL SACHIN V , JINKERSON TAMMIE K , DACHUN LIU , PRATT JOHN K , CALIFANO JEAN C , WENKE LI , HUTCHINS CHARLES W , RANDOLPH JOHN T , KATI WARREN M , BETEBENNER DAVID A , MOTTER CHRISTOPHER E , MATULENKO MARK A , FLENTGE CHARLES A , ROLF WAGNER , MARING CLARENCE J , TUFANO MICHAEL D , ROCKWAY TODD W , KATHY SARRIS , WAGAW SEBLE H , CASPI DANIEL D , BELLIZZI MARY E , NELSON LISA T , HUTSHINSON DOUGLAS K , WOLLER KEVIN R , KEDDY RYAN G , CARROLL WILLIAM A , YI GAO
IPC: A61P31/14 , A61K31/4025 , A61K31/404 , A61K31/4184 , C07D209/14 , C07D233/28 , C07D403/14
Abstract: Compuestos eficaces para inhibir la replicación del virus de la hepatitis C (?HCV?); procesos de elaboración de tales compuestos, composiciones que los comprenden y métodos de uso de los mismos para tratar una infección por HCV.
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公开(公告)号：DK2455376T3
公开(公告)日：2015-03-02
申请号：DK12155991
申请日：2010-06-10
Applicant: ABBVIE BAHAMAS LTD
Inventor： BETEBENNER DAVID A , LIU DACHUN , RANDOLPH JOHN T , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , MARING CLARENCE J , TUFANO MICHAEL D , ROCKWAY TODD W , DEGOEY DAVID A , PRATT JOHN K , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , GAO YI , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V
IPC: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/4439 , A61P31/14 , C07D401/14 , C07D417/14
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公开(公告)号：ES2523864T3
公开(公告)日：2014-12-02
申请号：ES11171399
申请日：2008-09-17
Applicant: ABBVIE BAHAMAS LTD
Inventor： FLENTGE CHARLES , HUTCHINSON DOUGLAS K , BETEBENNER DAVID A , DEGOEY DAVID A , DONNER PAMELA L , KATI WARREN M , KRUEGER ALLAN C , LIU DACHUN , LIU YAYA , LONGENECKER KENTON L , MARING CLARENCE J , MOTTER CHRISTOPHER E , PRATT JOHN K , RANDOLPH JOHN T , ROCKWAY TODD W , STEWART KENT D , WAGNER ROLF , BARNES DAVID M , CHEN SHUANG , FRANCZYK II THADDEUS S , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , KOTECKI BRIAN J , LOU XIAOCHUN , ZHANG GEOFF G Z
IPC: C07D239/22 , A61K31/513 , A61P31/12 , C07D239/54 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10
Abstract: Una forma cristalina de N-(6-(3-terc-butil-5-(2,4-dioxo-3,4-dihidropirimidin-1(2H)-il)-2-metoxifenil)naftalen- 2-il)metanosulfonamida o una forma cristalina de una sal de N-(6-(3-terc-butil-5-(2,4-dioxo- 3,4-dihidropirimidin-1(2H)-il)-2-metoxifenil)naftalen-2-il)metanosulfonamida.
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公开(公告)号：NZ600371A
公开(公告)日：2014-07-25
申请号：NZ60037108
申请日：2008-09-17
Applicant: ABBVIE BAHAMAS LTD
Inventor： WAGNER ROLF , TUFANO MICHAEL D , STEWART KENT D , ROCKWAY TODD W , LIU DACHUN , RANDOLPH JOHN T , PRATT JOHN K , MOTTER CHRISTOPHER E , MARING CLARENCE J , LIU YAYA , KATI WARREN M , HUTCHINSON DOUGLAS K , DONNER PAMELA L , DEGOEY DAVID A , BETEBENNER DAVID A , LONGENECKER KENTON L , KRUEGER ALLAN C , ZHANG GEOFF G Z , HUANG PEGGY P , FRANCZYK II THADDEUS S , HAIGHT ANTHONY R , LOU XIAOCHUN , SARRIS KATHY , FLENTGE CHARLES A , BARNES DAVID M , GAO YI , CHEN SHUANG , HENGEVELD JOHN E , HENRY RODGER F , KOTECKI BRIAN J
IPC: C07D417/10 , A61K31/513 , A61P31/12 , C07D239/22 , C07D239/54 , C07D401/10 , C07D403/10 , C07D409/10 , C07D413/10
Abstract: Disclosed are Uracil or Thymine derivatives of formula (I-L0). Examples of a compounds of formula (I) are: N-(6-(3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl) methanesulfonamide; N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide; and N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)quinolin-2-yl)methanesulfonamide. Also disclosed are pharmaceutical compositions comprising a compound of formula (I-L0); the use of a compound of formula (I-L0) in the manufacture of a medicament; and the process of making compounds of formula (I-L0) and the starting compound (where R6 of (I-L0) is halo). The medicament is useful in the treatment of Hepatitis C virus.
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