公开(公告)号：WO1998008481A2

公开(公告)日：1998-03-05

申请号：PCT/US1997014994

申请日：1997-08-26

Applicant: ARCH DEVELOPMENT CORPORATION ,  ROTMENSCH, Jacob ,  WHITLOCK, Jenny, L. ,  HINES, John, J. ,  HARPER, Paul, V.

Inventor： ARCH DEVELOPMENT CORPORATION

IPC: A61K00/00

CPC classification number: G21G1/001 ,  A61K51/1282 ,  G21G1/0005 ,  G21G2001/0084

Abstract: A process for producing substantially radio-impurity-free Bi-212 is disclosed. An acidic feed solution containing Pb-212 is contacted with an extraction medium to bind the Pb-212 thereto. The extraction medium is rinsed with a second acid solution to remove impurities therefrom, leaving a substantially impurity-free Pb-212-laden extraction medium. The Pb-212 grows on the extraction medium to form Bi-212 by radioactive decay. The Bi-212 is then eluted from the extraction medium with an acid solution to form a substantially radio-impurity-free Bi-212 acid solution. An apparatus for carrying out this process and a process for the therapeutic use thereof are also disclosed.

Abstract translation: 公开了一种生产基本上不含杂质的Bi-212的方法。 将含有Pb-212的酸性进料溶液与萃取介质接触以将Pb-212与其结合。 萃取介质用第二酸溶液冲洗以除去杂质，留下基本上无杂质的含Pb-212的提取介质。 Pb-212在萃取介质上生长，通过放射性衰变形成Bi-212。 然后用酸溶液从萃取介质中洗脱Bi-212，以形成基本上不含杂质的Bi-212酸溶液。 还公开了一种用于实施该方法的装置及其治疗用途的方法。

公开(公告)号：WO1998007878A2

公开(公告)日：1998-02-26

申请号：PCT/US1997014764

申请日：1997-08-22

Applicant: ARCH DEVELOPMENT CORPORATION ,  LEIDEN, Jeffery

Inventor： ARCH DEVELOPMENT CORPORATION

IPC: C12N15/86

CPC classification number: A61K48/0075 ,  A61K38/1816 ,  A61K38/27 ,  A61K48/00 ,  C07K14/505 ,  C12N2799/022

Abstract: A process for increasing the circulating levels of gene products in a primate for extended period of time is provided. In accordance with that process, muscle cells of the mammal are transformed with an expression vector that contains a polynucleotide that encodes the gene product and which vector drives expression in the muscle.

Abstract translation: 提供了一种在长时间内增加灵长类动物基因产物的循环水平的方法。 根据该过程，用含有编码基因产物的多核苷酸的表达载体转化哺乳动物的肌肉细胞，并且该载体驱动肌肉中的表达。

公开(公告)号：WO1997049011A1

公开(公告)日：1997-12-24

申请号：PCT/US1997010430

申请日：1997-06-13

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  GROSS, Kenneth, C. ,  WEGERICH, Stephan ,  SINGER, Ralph, M. ,  MOTT, Jack

IPC: G05B13/02

CPC classification number: G05B23/0254 ,  G05B23/0262

Abstract: A system (10) and method for monitoring an industrial process and/or industrial data source (10). The system (10) includes a time correlation module (20), a training module (30), a system state estimation module (40) and a pattern recognition module (50). The system (10) generating time varying data sources, processing the data to obtain time correlation of the data (20), determining the range of data, determining learned states of normal operation (30) and using these states to generate expected values to identify a current state of the process closest to a learned, normal state (40); generating a set of modeled data, and processing the modeled data to identify a data pattern and generating an alarm (50) upon detecting a deviation from normalcy.

Abstract translation: 一种用于监测工业过程和/或工业数据源（10）的系统（10）和方法。 系统（10）包括时间相关模块（20），训练模块（30），系统状态估计模块（40）和模式识别模块（50）。 所述系统（10）产生时变数据源，处理数据以获得数据（20）的时间相关性，确定数据范围，确定正常操作的学习状态（30）并使用这些状态来产生期望值以识别 该过程的当前状态最接近学习的正常状态（40）; 生成一组建模数据，并且在检测到与正常偏差之后处理建模数据以识别数据模式并产生报警（50）。

公开(公告)号：WO1997010349A1

公开(公告)日：1997-03-20

申请号：PCT/US1996014147

申请日：1996-08-29

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  ROIZMAN, Bernard ,  CHOU, Joany ,  HE, Bin

IPC: C12N15/86

CPC classification number: C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N2710/16622 ,  C12N2710/16643

Abstract: This invention relates to methods for the prevention or treatment of programmed cell death, or apoptosis, in neuronal cells for therapy in connection with neurodegenerative diseases, as well as methods of treatment of cancer and other tumorigenic diseases and herpesvirus infection. The invention also relates to assay methodologies allowing for the identification of substances capable of modulating the effects of the gamma 134.5 gene or modified gamma 134.5 gene or their protein expression products (ICP34.5) or modified, i.e., substances capable of potentiating, inducing, or inhibiting their effects. Additionally, the invention also relates to assay methodologies desinged to identify candidate substances able to mimic either gamma 134.5 expression or the activity of ICP34.5. The invention also relates to methods of delivering genes to cells for gene therapy.

Abstract translation: 本发明涉及用于预防或治疗与神经变性疾病有关的治疗的神经元细胞中程序性细胞死亡或细胞凋亡的方法，以及治疗癌症和其它致瘤性疾病和疱疹病毒感染的方法。 本发明还涉及允许鉴定能够调节γ134.5基因或修饰的γ134.5基因或其蛋白质表达产物（ICP34.5）或修饰的物质（即能够增强，诱导， 或抑制它们的作用。 此外，本发明还涉及旨在鉴定能够模拟γ134.5表达或ICP34.5的活性的候选物质的测定方法。 本发明还涉及将基因递送至细胞进行基因治疗的方法。

公开(公告)号：WO1996032484A2

公开(公告)日：1996-10-17

申请号：PCT/US1996005095

申请日：1996-04-12

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  HASELKORN, Robert ,  GORNICK, Piotr

IPC: C12N15/52

CPC classification number: C12N9/93 ,  C12N15/8247 ,  C12N15/8274

Abstract: The present invention provides isolated and purified polynucleotides that encode plant and cyanobacterial polypeptides that participate in the carboxylation of acetyl-CoA. Isolated cyanobacterial and plant polypeptides that catalyze acetyl-CoA carboxylation are also provided. Processes for altering acetyl-CoA carboxylation, increasing herbicide resistance of plants and identifying herbicide resistant variants of acetyl-CoA carboxylase are also provided.

Abstract translation: 本发明提供分离和纯化的多核苷酸，其编码参与乙酰辅酶A羧化的植物和蓝细菌多肽。 还提供了分离的蓝细菌和催化乙酰辅酶A羧化的植物多肽。 还提供了改变乙酰辅酶A羧化，增加植物的除草剂抗性和鉴定乙酰辅酶A羧化酶的除草剂抗性变体的方法。

公开(公告)号：WO1996015245A1

公开(公告)日：1996-05-23

申请号：PCT/US1995015191

申请日：1995-11-13

Applicant: ARCH DEVELOPMENT CORPORATION ,  LEIDEN, Jeffrey, M. ,  BARR, Eliav

Inventor： ARCH DEVELOPMENT CORPORATION

IPC: C12N15/12

CPC classification number: C07K14/4736 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4746 ,  C07K14/82 ,  C12N2799/022

Abstract: The present invention relates to the use of gene transfer to inhibit non-neoplastic pathological cell proliferation. An eukaryotic expression vector comprising a polynucleotide sequence that codes for a dominant-negative cell cycle regulatory protein is delivered to a proliferating cell. Delivery is accomplished by infusing the expression vector into an artery that perfuses or contains the proliferating cell.

Abstract translation: 本发明涉及使用基因转移来抑制非肿瘤性病理细胞增殖。 将包含编码显性负性细胞周期调节蛋白的多核苷酸序列的真核表达载体递送至增殖细胞。 通过将表达载体注入到灌注或含有增殖细胞的动脉中来完成递送。

公开(公告)号：WO1995026682A1

公开(公告)日：1995-10-12

申请号：PCT/US1995003640

申请日：1995-03-30

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  GIGER, Maryellen, L. ,  BAE, Kyongtae (Ty) ,  DOI, Kunio

IPC: A61B06/03

CPC classification number: G06T7/0012 ,  G06T2207/10081 ,  G06T2207/30064 ,  Y10S378/901

Abstract: A method and system for the automated detection of lesions in computed tomographic images, including generating image data from at least one selected portion of an object, for example, from CT images of the thorax. The image data are then analyzed in order to produce the boundary of the thorax. The image data within the thoracic boundary is then further analyzed to produce boundaries of the lung regions using predetermined criteria. Features within the lung regions are then extracted using multi-gray-level thresholding and correlation between resulting multi-level threshold images and between at least adjacent sections. Classification of the features as abnormal lesions or normal anatomic features is then performed using geometric features yielding a likelihood of being an abnormal lesion along with its location in either the 2-D image section or in the 3-D space of the object.

Abstract translation: 一种用于自动检测计算机断层图像中的病变的方法和系统，包括从诸如胸部的CT图像的对象的至少一个选定部分生成图像数据。 然后分析图像数据以产生胸部的边界。 然后进一步分析胸部边界内的图像数据，以使用预定标准产生肺部区域的边界。 然后使用多灰度阈值和所得到的多级阈值图像之间和至少相邻部分之间的相关性来提取肺区域内的特征。 然后使用几何特征进行特征作为异常损伤或正常解剖特征的分类，其产生可能性为异常损伤的可能性以及其位于对象的2D图像部分或3D图像部分中的位置。

公开(公告)号：WO1995015536A1

公开(公告)日：1995-06-08

申请号：PCT/US1994013294

申请日：1994-11-30

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  GIGER, Maryellen, L. ,  ARMATO, Samuel ,  MACMAHON, Heber

IPC: G06K09/00

CPC classification number: G06T7/0012 ,  G06T7/68 ,  G06T2207/10116 ,  G06T2207/30061

Abstract: A method for the automated detection of gross abnormalities and asymmetries in chest images (10), including generating image data from radiographic images of the thorax. The image data are then analyzed in order to produce the boundaries of the aerated lung regions in the thorax. This analysis comprises location of the mediastinum and lung apices, iterative global thresholding (11) with centroid testing of contours, local thresholding (12) on regions along initial contours of the aerated lung, correction (13) for regions near the costo and cardiophrenic angles in the chest, analysis (15) of the areas and density distribution within the aerated lung regions in the chest and determination (16) of the likelihood of the presence of a gross abnormality or asymmetry. Finat ouptut could be the computer determined contours of the lungs or the likelihood for abnormality.

Abstract translation: 一种用于自动检测胸部图像（10）中的总体异常和不对称的方法，包括从胸部的放射照相图像生成图像数据。 然后分析图像数据以产生胸部中充气肺区域的边界。 该分析包括纵隔和肺顶点的位置，具有轮廓重心测试的迭代全局阈值（11），在充气肺的初始轮廓区域的局部阈值（12），针对邻近区域和心脏心脏角度的区域的校正（13） 胸部分析（15）胸部充气肺部区域和密度分布，确定（16）存在严重异常或不对称的可能性。 Finat ouptut可能是计算机确定的肺部轮廓或异常的可能性。

公开(公告)号：WO1995014431A1

公开(公告)日：1995-06-01

申请号：PCT/US1994013280

申请日：1994-11-29

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  GIGER, Maryellen, L. ,  DOI, Kunio

IPC: A61B05/103

CPC classification number: G06T7/0012 ,  A61B6/4042 ,  A61B6/482 ,  A61B6/505 ,  A61B6/583 ,  G06T2207/10116 ,  G06T2207/30008 ,  G06T2207/30012

Abstract: A computerized method and system for the radiographic analysis of bone structure. Techniques include texture analysis for use in quantitating the bone structure and risk of fracture. Texture analysis of the bone structure incorporates directionality information, for example, in terms of the angular dependence of the RMS variation and first moment of the power spectrum of a ROI in a bony region. The system includes using dual energy imaging to obtain measures of both mass and bone structure with one exam. Specific applications are given for the analysis of regions within the vertebral bodies on conventional spine radiographs. Techniques include novel features that characterize the power spectrum of the bone structure and allow extraction of directionality features with which to characterize the spatial distribution and thickness of the bone trabeculae. These features are then merged using artifical neural networks in order to yield a likelihood of risk of future fracture.

Abstract translation: 一种用于骨结构射线照相分析的计算机化方法和系统。 技术包括用于定量骨结构和骨折风险的纹理分析。 骨骼结构的纹理分析包括方向性信息，例如，根据RMS变化的角度依赖性和在骨区域中的ROI的功率谱的第一时刻。 该系统包括使用双能量成像，通过一次考试获得质量和骨骼结构的测量。 给出了常规脊柱X光照片对椎体内部区域进行分析的具体应用。 技术包括表征骨骼结构的功率谱的新特征，并且允许提取用于表征骨小梁的空间分布和厚度的方向性特征。 然后，使用人造神经网络将这些特征合并，以产生未来骨折风险的可能性。

公开(公告)号：WO1995013373A1

公开(公告)日：1995-05-18

申请号：PCT/US1994012883

申请日：1994-11-08

Applicant: ARCH DEVELOPMENT CORPORATION ,  LIAO, Shutsung ,  SONG, Ching

Inventor： ARCH DEVELOPMENT CORPORATION

IPC: C12N15/12

CPC classification number: C07K14/70567 ,  C07K2319/00

Abstract: The invention relates generally to compositions of and methods for obtaining ubiquitous, nuclear receptor (UR) polypeptides. The invention also relates to polynucleotides encoding UR polypeptides, recombinant host cells and vectors containing UR-encoding polynucleotide sequences, and recombinant UR polypeptides. By way of example, the invention discloses the cloning and functional expression of at least two different UR polypeptides. The invention also includes methods for using the isolated, recombinant receptor polypeptides in assays designed to select substances which interact with UR polypeptides for use in diagnostic, drug design and therapeutic applications.

Abstract translation: 本发明一般涉及获得普遍存在的核受体（UR）多肽的组合物和方法。 本发明还涉及编码UR多肽的多核苷酸，重组宿主细胞和含有编码UR的多核苷酸序列的载体和重组UR多肽。 举例来说，本发明公开了至少两种不同的UR多肽的克隆和功能表达。 本发明还包括在分析设计用于选择与UR多肽相互作用以用于诊断，药物设计和治疗应用的物质的测定中使用分离的重组受体多肽的方法。