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公开(公告)号：CA2352554A1
公开(公告)日：2000-06-08
申请号：CA2352554
申请日：1999-11-23
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , SCHULT SABINE , MULLER REINHOLD , GRANDEL ROLAND , HOGER THOMAS
IPC: A61K20060101 , A61K31/4184 , A61K31/454 , A61K31/496 , A61P20060101 , A61P3/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D235/30 , C07D401/04 , C07D401/14 , C07D403/04
Abstract: The invention relates to compounds of general formula (1a) or (1b) wherein R 1 and R4 are hydrogen or defined substituents, A is a saturated or monoethenoi d heterocyclic ring with 4 to 8 members which contains one or two nitrogen atoms, wherein additionally one oxygen or sulfur atom can be present. Said ring can be further substituted. The invention also relates to their tautome r forms, possible enantiomer and diastereomer forms, their prodrugs, as well a s possible physiologically acceptable salts. The invention also relates to the use of said compounds for treating diseases related to a pathologically increased activity of PARP.
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公开(公告)号：HRP20010484B1
公开(公告)日：2010-08-31
申请号：HRP20010484
申请日：2001-06-26
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , SCHULT SABINE , GRANDEL ROLAND , MUELLER REINHOLD
IPC: C07D235/30 , A61K20060101 , A61K31/4184 , A61K31/454 , A61K31/496 , A61P20060101 , A61P3/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D401/04 , C07D401/14 , C07D403/04
Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.
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公开(公告)号：BG65513B1
公开(公告)日：2008-10-31
申请号：BG10599301
申请日：2001-10-09
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , SCHULT SABINE , MUELLER REINHOLD
IPC: C07D235/08 , A61K31/4184 , A61K31/4427 , A61K31/4523 , A61K31/496 , A61K31/551 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P43/00 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D401/08 , C07D403/08
Abstract: The invention relates to a compound of formula or wherein A represents a saturated or mono-unsaturated carbocycle containing 3 to 8 carbon atoms which can also have a condensed benzol ring, whereby the rings can also be substituted with one or two different or identical radical; R1 represents hydrogen, chlorine, fluorine, bromine, iodine, branched and unbranched C1-C6-alkyl, OH, nitro, CF3, CN, NR11R12, NH-CO-R13, O-C1-C4 alkyl; and R2 represents hydrogen, branched and unbranched C1-C6 alkyl, C1-C4 alkyl-phenyl. The invention also relates to the tautomeric forms, possible enantiomeric and diasteometric forms, possible cis-trans isomers on the rings in A and their prodrugs. The submitted benzimidazoles are inhibitors of poly(ADP-ribose)polymerase (PARP), or poly(ADP-ribose)synthase (PARS), as it is also known and can be used for the treatment or prophylaxis of diseases which are associated with the increased enzyme activity of this enzyme.
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公开(公告)号：ZA200108204B
公开(公告)日：2004-05-26
申请号：ZA200108204
申请日：2001-10-05
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , SCHULT SABINE , MUELLER REINHOLD
IPC: C07D235/08 , A61K31/4184 , A61K31/4427 , A61K31/4523 , A61K31/496 , A61K31/551 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P43/00 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D401/08 , C07D403/08 , C07D , A61K , A61P
Abstract: Compounds of the formula I or IIand their tautomeric forms, possible enantiomeric and diastereomeric forms, possible cistrans isomers on the rings in A and prodrugs thereof, pharmaceutical compositions containing these compounds and methods of treating neurodegenerative diseases or neuronal damage with these compounds.
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公开(公告)号：UA61158C2
公开(公告)日：2003-11-17
申请号：UA01064494
申请日：1999-11-23
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , GRANDEL ROLAND , MUELLER REINHOLD
IPC: A61K20060101 , A61K31/4184 , A61K31/454 , A61K31/496 , A61P20060101 , A61P3/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D235/30 , C07D401/04 , C07D401/14 , C07D403/04
Abstract: Винахідвідноситьсядосполукзагальноїформули (1а) чи (1б), де R1 і R4 означаютьатомводнючивизначенізамісники, Аозначаєнасиченийчиоднократноненасиченийвідчотирьох- довосьмичленногогетероцикл, щоміститьодинчидваатомиазоту, причомудодатковощеможевключатиатомкиснючисірки, що, далі, можебутизаміщений, атакождоїхніхтаутомернихформ, можливихенантіомернихі діастереомернихформ, їхпроліків, атакождоможливихфізіологічноприйнятнихсолей. Винахідтакожвідноситьсядозастосуванняцихсполукдлялікуваннязахворювань, приякихвиникаєпатологічнопідвищенаактивністьполі(аденозиндифосфатрибоза)полімерази. (1a) (1б)
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Patent Agency Ranking
公开(公告)号：AU764216B2
公开(公告)日：2003-08-14
申请号：AU3034300
申请日：1999-11-23
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOGER THOMAS , SCHULT SABINE , GRANDEL ROLAND , MULLER REINHOLD
IPC: A61K20060101 , A61K31/4184 , A61K31/454 , A61K31/496 , A61P20060101 , A61P3/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D235/30 , C07D401/04 , C07D401/14 , C07D403/04
Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.
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公开(公告)号：PL351558A1
公开(公告)日：2003-05-05
申请号：PL35155800
申请日：2000-04-27
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , HOLZENKAMP UTA , SCHULT SABINE , MUELLER REINHOLD
IPC: A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/496 , C07D235/20 , A61K31/497 , A61P3/10 , A61P9/00 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D235/18 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , A61K31/4164
Abstract: The present invention relates to novel benzimidazoles, their preparation and their use as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30) for producing drugs.
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公开(公告)号：PL351557A1
公开(公告)日：2003-05-05
申请号：PL35155700
申请日：2000-04-11
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , SCHULT SABINE , MUELLER REINHOLD
IPC: C07D235/08 , A61K31/4184 , A61K31/4427 , A61K31/4523 , A61K31/496 , A61K31/551 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P43/00 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D401/08 , C07D403/08 , C07D235/06 , A61K31/4164
Abstract: Compounds of the formula I or IIand their tautomeric forms, possible enantiomeric and diastereomeric forms, possible cistrans isomers on the rings in A and prodrugs thereof, pharmaceutical compositions containing these compounds and methods of treating neurodegenerative diseases or neuronal damage with these compounds.
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公开(公告)号：HRP20010484A2
公开(公告)日：2003-04-30
申请号：HRP20010484
申请日：2001-06-26
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , SCHULT SABINE , GRANDEL ROLAND , MUELLER REINHOLD
IPC: A61K20060101 , A61K31/4184 , A61K31/454 , A61K31/496 , A61P20060101 , A61P3/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D235/30 , C07D401/04 , C07D401/14 , C07D403/04
Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.
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公开(公告)号：HU0200859A2
公开(公告)日：2002-11-28
申请号：HU0200859
申请日：2000-04-11
Applicant: BASF AG
Inventor： GRANDEL ROLAND , HOERGER THOMAS , KOCK MICHAEL , LUBISCH WILFRIED , MUELLER REINHOLD , SCHULT SABINE
IPC: C07D235/08 , A61K31/4184 , A61K31/4427 , A61K31/4523 , A61K31/496 , A61K31/551 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P43/00 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D401/08 , C07D403/08 , C07D235/06
Abstract: Compounds of the formula I or IIand their tautomeric forms, possible enantiomeric and diastereomeric forms, possible cistrans isomers on the rings in A and prodrugs thereof, pharmaceutical compositions containing these compounds and methods of treating neurodegenerative diseases or neuronal damage with these compounds.
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