公开(公告)号：CA2288432A1

公开(公告)日：1998-11-05

申请号：CA2288432

申请日：1998-04-16

Applicant: BASF AG

Inventor： LORENZ GISELA ,  AMMERMANN EBERHARD ,  BUTTERFIELD EARLE ,  LERCHL JENS ,  MOELLER ACHIM ,  CONRAD UDO ,  SCHMIDT RALF-MICHAEL ,  RABE UDO

IPC: A01H5/00 ,  C07K14/00 ,  C07K16/44 ,  C12N15/09 ,  C12N15/13 ,  C12N15/82 ,  C12P21/02 ,  A01N63/00

Abstract: The invention relates to a method for producing fungicide-tolerant plants by expressing a fungicide-binding antibody therein.

公开(公告)号：AU4553097A

公开(公告)日：1998-03-26

申请号：AU4553097

申请日：1997-09-04

Applicant: BASF AG

Inventor： LERCHL JENS ,  SCHMIDT RALF-MICHAEL ,  SCHIFFER HELMUT ,  SONNEWALD UWE ,  BADUR RALF

IPC: A01H5/00 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/82 ,  C12R1/125 ,  C12N15/52

公开(公告)号：PL207026B1

公开(公告)日：2010-10-29

申请号：PL36290501

申请日：2001-02-08

Applicant: BASF AG

Inventor： HEINZ ERNST ,  ZANK THORSTEN ,  ZAEHRINGER ULRICH ,  LERCHL JENS ,  RENZ ANDREAS

IPC: A01H5/00 ,  C12N15/82 ,  A01K67/027 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/92 ,  A61K31/201 ,  A61K31/202 ,  A61K38/45 ,  A61P3/02 ,  A61P3/06 ,  A61P9/10 ,  A61P29/00 ,  C07K16/40 ,  C11B1/00 ,  C11C1/00 ,  C11C3/00 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12P7/64 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/573

公开(公告)号：AU2001256173B2

公开(公告)日：2006-05-04

申请号：AU2001256173

申请日：2001-03-01

Applicant: BASF AG

Inventor： RITTER TINA MARIA ,  ZRENNER RITA ,  LERCHL JENS ,  NIGEL MARC STITT ,  EHRHARDT THOMAS

IPC: A01H5/00 ,  C12N15/54 ,  C12N9/10 ,  C12N15/09 ,  C12N15/82 ,  C12Q1/02 ,  C12Q1/48 ,  C12R1/91 ,  G01N33/15

公开(公告)号：PL362905A1

公开(公告)日：2004-11-02

申请号：PL36290501

申请日：2001-02-08

Applicant: BASF AG

Inventor： HEINZ ERNST ,  ZANK THORSTEN ,  ZAEHRINGER ULRICH ,  LERCHL JENS ,  RENZ ANDREAS

IPC: A01H5/00 ,  A01K67/027 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/92 ,  A61K31/201 ,  A61K31/202 ,  A61P3/02 ,  A61P3/06 ,  A61P9/10 ,  A61P29/00 ,  C07K16/40 ,  C11C3/00 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C12Q1/02 ,  G01N33/573 ,  A61K38/45

Abstract: The invention relates to novel elongase genes with the sequences stated in sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or their homologs, derivatives or analogs, to a gene construct comprising this gene or its homologs, derivatives and analogs, and to its use. The invention also relates to vectors or transgenic organisms comprising an elongase gene with the sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or its homologs, derivatives and analogs. The invention furthermore relates to the use of the elongase gene sequences alone or in combination with further elongases and/or further fatty acid biosynthesis genes. The present invention relates to a novel elongase gene with the sequence SEQ ID NO:1 or its homologs, derivatives and analogs. Furthermore, the invention relates to a process for the preparation of polyunsaturated fatty acids and to a process for introducing DNA into organisms which produce large amounts of oils and, in particular, oils with a high content of unsaturated fatty acids. Moreover, the invention relates to an oil and/or a fatty acid preparation with a higher content of polyunsaturated fatty acids with at least two double bonds and/or a triacylglycerol preparation with a higher content of polyunsaturated fatty acids with at least two double bonds.

公开(公告)号：BR0108875A

公开(公告)日：2003-03-18

申请号：BR0108875

申请日：2001-03-01

Applicant: BASF AG

Inventor： EHRHARDT THOMAS ,  LERCHL JENS ,  NIGEL MARC STITT ,  ZRENNER RITA ,  RITTER TINA MARIA

IPC: A01H5/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12Q1/02 ,  C12Q1/48 ,  C12R1/91 ,  G01N33/15

公开(公告)号：DE10023893A1

公开(公告)日：2001-11-22

申请号：DE10023893

申请日：2000-05-17

Applicant: BASF AG

Inventor： HEINZ ERNST ,  ZANK THORSTEN ,  RENZ ANDREAS ,  LERCHL JENS

IPC: C12N1/21 ,  C12N9/10 ,  C12N15/82 ,  C12P7/64 ,  C07H21/00 ,  A01H5/00 ,  A23K1/00 ,  A23L1/00 ,  A61K7/00 ,  A61K31/23 ,  C07K14/00 ,  C12N9/00

Abstract: An isolated nucleic acid from a plant or algae which encodes a polypeptide which extends a C16, C18 or C20 fatty acid having at least two double bonds by at least two carbon atoms, is new. Independent claims are also included for the following: (1) an isolated nucleic acid encoding a polypeptide which extends a C16, C18 or C20 fatty acid having at least two double bonds by at least two carbon atoms, and having the 1192, 687, 955 or 708 base pair (bp) sequence fully defined in the specification, a genetic code degenerate or derivative of one of those sequences, or encoding the 290, 195, 297 or 214 amino acid sequence fully defined in the specification, or a sequence with at least 50% homology to one of those sequences where the enzymatic activity is not substantially reduced; (2) a gene construct comprising one of the above nucleic acids linked to one or more regulatory sequences; (3) amino acid sequences encoded by the above nucleic acids or construct; (4) a vector comprising the above nucleic acids or construct; (5) an organism comprising the above nucleic acids, construct or vector; (6) an antibody which specifically binds to the product of the above nucleic acids; (7) an antisense nucleic acid molecule complementary to one of the above nucleic acids; (8) producing polyunsaturated fatty acids (PUFAs), comprising breeding organisms containing the above nucleic acids, construct or vector, encoding a polypeptide which extends a C16, C18 or C20 fatty acid having at least two double bonds by at least two carbon atoms, under PUFA forming conditions; (9) an oil, lipid, fatty acid or its fraction, produced by the above method; (10) an oil, lipid or fatty acid composition containing PUFAs from transgenic plants, preferably where the transgenic plant comprises the above nucleic acids, construct or vector; (11) identifying an elongase (ant)agonist comprising contacting cells expressing the polypeptide of the invention with a candidate compound, testing PSE activity and comparing activity with a control standard.

公开(公告)号：CA2400766A1

公开(公告)日：2001-09-07

申请号：CA2400766

申请日：2001-03-01

Applicant: BASF AG

Inventor： LERCHL JENS ,  ZRENNER RITA ,  STITT NIGEL MARC ,  RITTER TINA MARIA ,  EHRHARDT THOMAS

IPC: A01H5/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12Q1/02 ,  C12Q1/48 ,  C12R1/91 ,  G01N33/15 ,  C12N15/11

Abstract: The present invention relates to the use of DNA sequences of plant origin. Said sequences code for a polypeptide with aspartate carbamyltransferase (E.C.2.1.3.2) activity. The aim of the invention is to produce a test system for finding inhibitors of the aspartate carbamyltransferase. According to th e invention, it has been proven for the first time and by means of the antisen se technology that aspartate carbamyltransferase is a herbicidal target.

公开(公告)号：DE10005973A1

公开(公告)日：2001-08-16

申请号：DE10005973

申请日：2000-02-09

Applicant: BASF AG

Inventor： HEINZ ERNST ,  ZANK THORSTEN ,  ZAEHRINGER ULRICH ,  LERCHL JENS

IPC: C12N9/10 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C07H21/00 ,  A23K1/00 ,  A23L1/00 ,  A61K7/00 ,  A61K31/20 ,  A61K31/23 ,  C12P7/40

Abstract: Isolated nucleic acid (I), of plant origin, encoding a polypeptide (II) that extends C18 fatty acids, containing at least to double bonds, by at least two carbon atoms. Independent claims are also included for the following: (a) (II) encoded by (I); (b) gene construct containing a 1192 bp sequence (1; reproduced), functionally linked to regulatory signals; (c) vector containing (I) or the construct of (b); (d) organisms containing (I), the construct of (b) or the vector of (c); (e) method for producing polyunsaturated fatty acids (PUFAs) by growin organisms of (d); (f) oils, lipids, fatty acids or their fractions produced by method (e); and (g) oils, lipids and fatty acid compositions containing PUFAs and derived from transgenic plants. ACTIVITY : Hypocholesterolemic; cardiovascular. MECHANISM OF ACTION : None given.

公开(公告)号：CA2399349A1

公开(公告)日：2001-08-16

申请号：CA2399349

申请日：2001-02-08

Applicant: BASF AG

Inventor： RENZ ANDREAS ,  LERCHL JENS ,  ZAHRINGER ULRICH ,  ZANK THORSTEN ,  HEINZ ERNST

IPC: A01H5/00 ,  A01K67/027 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/92 ,  A61K31/201 ,  A61K31/202 ,  A61P3/02 ,  A61P3/06 ,  A61P9/10 ,  A61P29/00 ,  C07K16/40 ,  C11C3/00 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C12Q1/02 ,  C11B1/00 ,  C11C1/00 ,  A61K38/45 ,  C12Q1/48 ,  G01N33/573

Abstract: The invention relates to a novel elongase gene comprising the sequences cite d in sequence SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 and SEQ ID NO:7 or to homologues, derivatives or analogues thereof. The invention also relates to a gene construct containing these genes or homologues, derivatives or analogue s thereof, and to its use. The invention additionally relates to the vectors o r transgenic organisms containing an elongase gene comprising the sequence SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 and SEQ ID NO:7 or containing homologues, derivatives or analogues thereof. The invention relates to the use of the elongase sequences alone or in combination with additional elongases and/or with additional fatty acid biosynthesis genes. The invention relates to a novel elongase gene comprising the sequence SEQ ID NO:1 or to homologues, derivatives or analogues thereof. The invention also relates to a method for producing multiple-unsaturated fatty acids and to a method for introducing D NA into organisms which produce large quantities of oils and, in particular, oi ls having a high content of unsaturated fatty acids. The invention further relates to an oil and/or to a fatty acid preparation having a high content o f multiple-unsaturated fatty acids that contain at least two double bonds and/ or to a triacylglycerin preparation having a high content of multiple-unsaturat ed fatty acids that contain at least two double bonds.