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    NOVEL ELONGASE GENE AND METHOD FOR PRODUCING MULTIPLE-UNSATURATED FATTY ACIDS
    1.
    发明申请
    NOVEL ELONGASE GENE AND METHOD FOR PRODUCING MULTIPLE-UNSATURATED FATTY ACIDS 审中-公开
    新的长链脂肪酸和生产多种不饱和脂肪酸的方法

    公开(公告)号：WO0159128A2

    公开(公告)日：2001-08-16

    申请号：PCT/EP0101346

    申请日：2001-02-08

    Applicant: BASF AG ,  HEINZ ERNST ,  ZANK THORSTEN ,  ZAEHRINGER ULRICH ,  LERCHL JENS ,  RENZ ANDREAS

    Inventor： HEINZ ERNST ,  ZANK THORSTEN ,  ZAEHRINGER ULRICH ,  LERCHL JENS ,  RENZ ANDREAS

    IPC: A01H5/00 ,  A01K67/027 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/92 ,  A61K31/201 ,  A61K31/202 ,  A61P3/02 ,  A61P3/06 ,  A61P9/10 ,  A61P29/00 ,  C07K16/40 ,  C11C3/00 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C12Q1/02 ,  A61K38/45 ,  C11B1/00 ,  C11C1/00 ,  C12Q1/48 ,  G01N33/573

    CPC classification number: C12N9/1029 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6472

    Abstract: The invention relates to a novel elongase gene comprising the sequences cited in sequence SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 and SEQ ID NO:7 or to homologues, derivatives or analogues thereof. The invention also relates to a gene construct containing these genes or homologues, derivatives or analogues thereof, and to its use. The invention additionally relates to the vectors or transgenic organisms containing an elongase gene comprising the sequence SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 and SEQ ID NO:7 or containing homologues, derivatives or analogues thereof. The invention relates to the use of the elongase sequences alone or in combination with additional elongases and/or with additional fatty acid biosynthesis genes. The invention relates to a novel elongase gene comprising the sequence SEQ ID NO:1 or to homologues, derivatives or analogues thereof. The invention also relates to a method for producing multiple-unsaturated fatty acids and to a method for introducing DNA into organisms which produce large quantities of oils and, in particular, oils having a high content of unsaturated fatty acids. The invention further relates to an oil and/or to a fatty acid preparation having a high content of multiple-unsaturated fatty acids that contain at least two double bonds and/or to a triacylglycerin preparation having a high content of multiple-unsaturated fatty acids that contain at least two double bonds.

    Abstract translation: 本发明涉及一种在序列SEQ ID NO与一个NEUS延长酶基因：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：序列或7-称他们的同系物，衍生物或类似物，涉及一种基因构建体，这些基因或 他们的同系物，衍生物或类似物，以及它的用途。 本发明还涉及到与序列SEQ ID NO载体或转基因生物的延长酶基因：含有7或它的同系物，衍生物或类似物：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO。 此外，本发明涉及单独或与其他延伸酶和/或其他脂肪酸生物合成基因组合使用延长分支酶。 本发明涉及具有序列SEQ ID NO：1或其同系物，衍生物或类似物的新型延伸酶基因。 此外，本发明涉及生产多不饱和脂肪酸的方法，以及将DNA引入生产大量油类，特别是具有高含量不饱和脂肪酸的油类的生物中的方法。 此外，本发明提供了油和/或与多不饱和脂肪酸具有至少两个双键和/或三酰甘油制剂用的多不饱和脂肪酸含量较高具有至少两个双键的涉及高含量的脂肪酸制备。

    2.
    发明专利
    未知

    公开(公告)号：EE200200443A

    公开(公告)日：2003-12-15

    申请号：EEP200200443

    申请日：2001-02-08

    Applicant: BASF AG

    Inventor： HEINZ ERNST ,  ZANK THORSTEN ,  ZAEHRINGER ULRICH ,  LERCHL JENS ,  RENZ ANDREAS

    IPC: A01H5/00 ,  A01K67/027 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/92 ,  A61K31/201 ,  A61K31/202 ,  A61P3/02 ,  A61P3/06 ,  A61P9/10 ,  A61P29/00 ,  C07K16/40 ,  C11C3/00 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C12Q1/02 ,  A61K38/45 ,  C11B1/00 ,  C11C1/00 ,  C12Q1/48 ,  G01N33/573

    Abstract: The invention relates to novel elongase genes with the sequences stated in sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or their homologs, derivatives or analogs, to a gene construct comprising this gene or its homologs, derivatives and analogs, and to its use. The invention also relates to vectors or transgenic organisms comprising an elongase gene with the sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or its homologs, derivatives and analogs. The invention furthermore relates to the use of the elongase gene sequences alone or in combination with further elongases and/or further fatty acid biosynthesis genes. The present invention relates to a novel elongase gene with the sequence SEQ ID NO:1 or its homologs, derivatives and analogs. Furthermore, the invention relates to a process for the preparation of polyunsaturated fatty acids and to a process for introducing DNA into organisms which produce large amounts of oils and, in particular, oils with a high content of unsaturated fatty acids. Moreover, the invention relates to an oil and/or a fatty acid preparation with a higher content of polyunsaturated fatty acids with at least two double bonds and/or a triacylglycerol preparation with a higher content of polyunsaturated fatty acids with at least two double bonds.

    New elongase gene extends 16, 18 and 20 carbon fatty acids, useful to manipulate plants to produce polyunsaturated fatty acids for the foodstuffs, cosmetics and pharmaceutical industries
    5.
    发明专利
    New elongase gene extends 16, 18 and 20 carbon fatty acids, useful to manipulate plants to produce polyunsaturated fatty acids for the foodstuffs, cosmetics and pharmaceutical industries 未知

    公开(公告)号：DE10063387A1

    公开(公告)日：2002-09-12

    申请号：DE10063387

    申请日：2000-12-19

    Applicant: BASF AG

    Inventor： HEINZ ERNST ,  ZANK THORSTEN ,  RENZ ANDREAS ,  LERCHL JENS

    IPC: C12N9/10 ,  C12N15/29 ,  C12N15/82 ,  C12P7/64 ,  A01H5/00 ,  C07H21/04 ,  C07K14/415 ,  C07K16/00 ,  C12N1/00 ,  C12N9/00 ,  C12N15/52 ,  C12Q1/00

    Abstract: An isolated nucleic acid from a plant or algae which encodes a polypeptide which extends a C16, C18 or C20 fatty acid having at least two double bonds by at least two carbon atoms, is new. Independent claims are also included for the following: (1) an isolated nucleic acid encoding a polypeptide which extends a C16, C18 or C20 fatty acid having at least two double bonds by at least two carbon atoms, and having the 1192, 687, 955 or 708 base pair (bp) sequence fully defined in the specification, a genetic code degenerate or derivative of one of those sequences, or encoding the 290, 195, 297 or 214 amino acid sequence fully defined in the specification, or a sequence with at least 50% homology to one of those sequences where the enzymatic activity is not substantially reduced; (2) a gene construct comprising one of the above nucleic acids linked to one or more regulatory sequences; (3) amino acid sequences encoded by the above nucleic acids or construct; (4) a vector comprising the above nucleic acids or construct; (5) an organism comprising the above nucleic acids, construct or vector; (6) an antibody which specifically binds to the product of the above nucleic acids; (7) an antisense nucleic acid molecule complementary to one of the above nucleic acids; (8) producing polyunsaturated fatty acids (PUFAs), comprising breeding organisms containing the above nucleic acids, construct or vector, encoding a polypeptide which extends a C16, C18 or C20 fatty acid having at least two double bonds by at least two carbon atoms, under PUFA forming conditions; (9) an oil, lipid, fatty acid or its fraction, produced by the above method; (10) an oil, lipid or fatty acid composition containing PUFAs from transgenic plants, preferably where the transgenic plant comprises the above nucleic acids, construct or vector; (11) identifying an elongase (ant)agonist comprising contacting cells expressing the polypeptide of the invention with a candidate compound, testing PSE activity and comparing activity with a control standard.

    6.
    发明专利
    未知

    公开(公告)号：NO20023757D0

    公开(公告)日：2002-08-08

    申请号：NO20023757

    申请日：2002-08-08

    Applicant: BASF AG

    Inventor： HEINZ ERNST ,  ZANK THORSTEN ,  ZAEHRINGER ULRICH ,  LERCHL JENS ,  RENZ ANDREAS

    IPC: A01H5/00 ,  A01K67/027 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/92 ,  A61K31/201 ,  A61K31/202 ,  A61P3/02 ,  A61P3/06 ,  A61P9/10 ,  A61P29/00 ,  C07K16/40 ,  C11C3/00 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C12Q1/02 ,  C12N

    Abstract: The invention relates to novel elongase genes with the sequences stated in sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or their homologs, derivatives or analogs, to a gene construct comprising this gene or its homologs, derivatives and analogs, and to its use. The invention also relates to vectors or transgenic organisms comprising an elongase gene with the sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or its homologs, derivatives and analogs. The invention furthermore relates to the use of the elongase gene sequences alone or in combination with further elongases and/or further fatty acid biosynthesis genes. The present invention relates to a novel elongase gene with the sequence SEQ ID NO:1 or its homologs, derivatives and analogs. Furthermore, the invention relates to a process for the preparation of polyunsaturated fatty acids and to a process for introducing DNA into organisms which produce large amounts of oils and, in particular, oils with a high content of unsaturated fatty acids. Moreover, the invention relates to an oil and/or a fatty acid preparation with a higher content of polyunsaturated fatty acids with at least two double bonds and/or a triacylglycerol preparation with a higher content of polyunsaturated fatty acids with at least two double bonds.

    New elongase gene extends 16, 18 and 20 carbon fatty acids, useful to manipulate plants to produce polyunsaturated fatty acids for the foodstuffs, cosmetics and pharmaceutical industries
    9.
    发明专利
    New elongase gene extends 16, 18 and 20 carbon fatty acids, useful to manipulate plants to produce polyunsaturated fatty acids for the foodstuffs, cosmetics and pharmaceutical industries 未知

    公开(公告)号：DE10023893A1

    公开(公告)日：2001-11-22

    申请号：DE10023893

    申请日：2000-05-17

    Applicant: BASF AG

    Inventor： HEINZ ERNST ,  ZANK THORSTEN ,  RENZ ANDREAS ,  LERCHL JENS

    IPC: C12N1/21 ,  C12N9/10 ,  C12N15/82 ,  C12P7/64 ,  C07H21/00 ,  A01H5/00 ,  A23K1/00 ,  A23L1/00 ,  A61K7/00 ,  A61K31/23 ,  C07K14/00 ,  C12N9/00

    Abstract: An isolated nucleic acid from a plant or algae which encodes a polypeptide which extends a C16, C18 or C20 fatty acid having at least two double bonds by at least two carbon atoms, is new. Independent claims are also included for the following: (1) an isolated nucleic acid encoding a polypeptide which extends a C16, C18 or C20 fatty acid having at least two double bonds by at least two carbon atoms, and having the 1192, 687, 955 or 708 base pair (bp) sequence fully defined in the specification, a genetic code degenerate or derivative of one of those sequences, or encoding the 290, 195, 297 or 214 amino acid sequence fully defined in the specification, or a sequence with at least 50% homology to one of those sequences where the enzymatic activity is not substantially reduced; (2) a gene construct comprising one of the above nucleic acids linked to one or more regulatory sequences; (3) amino acid sequences encoded by the above nucleic acids or construct; (4) a vector comprising the above nucleic acids or construct; (5) an organism comprising the above nucleic acids, construct or vector; (6) an antibody which specifically binds to the product of the above nucleic acids; (7) an antisense nucleic acid molecule complementary to one of the above nucleic acids; (8) producing polyunsaturated fatty acids (PUFAs), comprising breeding organisms containing the above nucleic acids, construct or vector, encoding a polypeptide which extends a C16, C18 or C20 fatty acid having at least two double bonds by at least two carbon atoms, under PUFA forming conditions; (9) an oil, lipid, fatty acid or its fraction, produced by the above method; (10) an oil, lipid or fatty acid composition containing PUFAs from transgenic plants, preferably where the transgenic plant comprises the above nucleic acids, construct or vector; (11) identifying an elongase (ant)agonist comprising contacting cells expressing the polypeptide of the invention with a candidate compound, testing PSE activity and comparing activity with a control standard.

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