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    PROCESS FOR PREPARING 1-PHENYLPYRAZOLES
    42.
    发明公开
    PROCESS FOR PREPARING 1-PHENYLPYRAZOLES 有权
    一种用于1-苯基吡唑的制备方法

    公开(公告)号：EP2473485A1

    公开(公告)日：2012-07-11

    申请号：EP10747888.5

    申请日：2010-09-03

    Applicant: BASF SE

    Inventor： DOCHNAHL, Maximilian ,  LIPOWSKY, Gunter

    IPC: C07D231/14

    CPC classification number: C07D231/20 ,  C07D231/14

    Abstract: The present invention to a process for preparing 1-phenylpyrazoles of the formula I in which each R
    1 is independently selected from chlorine, fluorine, alkyl, haloalkyl, alkoxy and haloalkoxy;n is 1, 2 or 3;each R
    2 is independently selected from cyano, nitro, halogen, alkyl, haloalkyl,alkoxy, haloalkoxy,alkylthio and alkoxycarbonyl; mis 0, 1 or 2;A is alkyl, aryl or aryl-C
    1 -C
    4 -alkyl, where A optionally bears 1, 2, 3 or 4 substituents comprising reacting a phenyl halide of the formula (II) with apyrazole derivative of the formula (III) in which X is chlorine, iodine or bromine; and R
    1 , n, R
    2 , m and A are each as defined above, in the presence of a base and a catalytic system comprising a ligand and a metal compound selected from palladium compounds, iron compounds and copper compounds.

    PROCESS FOR THE PREPARATION OF PYRAZOLE DERIVATIVES
    50.
    发明公开
    PROCESS FOR THE PREPARATION OF PYRAZOLE DERIVATIVES 有权
    用于生产吡唑

    公开(公告)号：EP2443093A1

    公开(公告)日：2012-04-25

    申请号：EP10707918.8

    申请日：2010-03-12

    Applicant: BASF SE

    Inventor： DOCHNAHL, Maximilian ,  SUKOPP, Martin ,  KORTE, Alexander

    IPC: C07D231/38 ,  A61K31/415

    CPC classification number: C07D231/38

    Abstract: The present invention refers to a process for the preparation of pyrazole derivatives of formula (I), wherein W is nitrogen or CR
    1 , R
    1 , R
    2 , R
    4 and R
    5 are each independently selected from hydrogen, halogen, C
    1 -C
    6 -alkyl, C
    1 -C
    6 -haloalkyl, C
    1 -C
    6 -alkoxy, C
    1 -C
    6 -haloalkoxy, R
    7 S(O)n, nitro, cyano, and pentafluorothio; R
    3 is hydrogen, halogen, C
    1 -C
    6 -alkyl, C
    1 -C
    6 -haloalkyl, C
    1 -C
    6 -alkoxy, C
    1 -C
    6- haloalkoxy, R
    7 S(O)n, nitro, cyano, pentafluorothio or phenyl which is unsubstituted or substituted by 1 to 5 members of the group consisting of halogen, C
    1 -C
    6 -alkyl, C
    1 -C
    6- haloalkyl, C
    1 -C
    6 -alkoxy, C
    1 -C
    6- haloalkoxy, R
    7 S(O)n, nitro, cyano, and pentafluorothio which are the same or different; R
    7 is C
    1 -C
    6 -alkyl or C
    1 -C
    6 -haloalkyl; and n is 0, 1, or 2; characterized in that hydrazines of formula (II) wherein W, R
    2 , R
    3 , R
    4 , and R
    5 are as defined for pyrazole derivatives of formula (I), are reacted with a compound of formula (III).

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