公开(公告)号：CA2547905C

公开(公告)日：2014-02-18

申请号：CA2547905

申请日：2004-12-16

Applicant: BAXTER INT

Inventor： MIN KYUNGYOON ,  AKONUR ALP ,  BROWN RICHARD I

IPC: B04B5/04 ,  A61M1/36 ,  A61M1/38

Abstract: A separation apparatus and method are employed using a spearation channel (210) for rotation abut an axis. Such channel includes radially spaced apart inner (206) and outer (208) side wall portions and an end wall portion (224). An inlet (226) conveys fluid into the channel. A barrier (232) is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with teh first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier (232) may joing the outer side wall portion (208) along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

公开(公告)号：AU2013204469A1

公开(公告)日：2013-05-09

申请号：AU2013204469

申请日：2013-04-12

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： MIN KYUNGYOON ,  BACKES LARRY ,  RAUSA III FRANCISCO M ,  BAIRSTOW SHAWN F ,  RAMACHANDRAN SINDHU ,  POKROPINSKI SHARON

IPC: A61M1/34 ,  A61M1/36

Abstract: A system for obtaining a pharmaceuticaly acceptable immunoglobulin product from blood of a donor including a first conduit configured to convey blood or blood component from the donor to a substrate, wherein said blood or blood component includes at least one first component and at least one second component, said first component inckding immunoglobulin, and wherein said substrate is adapted to bind immunoglobulin; a second condL it configured to convey at least a portion of the second component of the blood or blood component from the first conduit to the donor; a third conduit configured to convey an immunoglobulin product isolated frm said substrate; and a fourth conduit configured to convey the product directly to a recipient

公开(公告)号：DE69636398T2

公开(公告)日：2006-11-30

申请号：DE69636398

申请日：1996-05-22

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  MIN KYUNGYOON

IPC: A61K35/14 ,  B01D21/26 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

Abstract: A blood separation system for separating mono nuclear cells from whole blood is described. The system comprises a chamber (12) that is rotatable about a rotational axis (28). The chamber comprises first and second spaced apart walls (24, 26) that form a separation zone having a high-G side and a low-G side which is located closer to the rotational axis than the high-G side. The chamber also includes an inlet region (74) where whole blood enters the separation zone for separation into red blood cells (96), a plasma constituent carrying platelets (98), and an interface (58) carrying mono nuclear cells between the red blood cells and the plasma constituent. A plasma constituent collection region (76) is also provided in the chamber where the plasma constituent is collected for removal from the chamber. An outlet path (46, 206) communicates with the plasma constituent collection region (76) and provides for removal of the interface (58) from the chamber. The system is operated under the control of a controller (134) that is operable in first and second modes. In the first mode, whole blood is conveyed into the inlet region while red blood cells and the plasma constituent are removed from the chamber and while the interface (58) is maintained at a set location within the chamber. In the second mode, the controller operates to move the interface from the set location for removal from the chamber via the outlet path. Finally, the system is equipped with a sensing element (226) for detecting mono nuclear cells in the interface in the outlet path. A method of separating mono nuclear cells from whole blood is also described.

公开(公告)号：BR0314884A

公开(公告)日：2005-08-02

申请号：BR0314884

申请日：2003-10-21

Applicant: BAXTER INT

Inventor： MIN KYUNGYOON ,  BROWN RICHARD I ,  MORIARITY JULIE

IPC: A61M1/36 ,  A61M1/38 ,  B04B5/04 ,  B01D33/15 ,  B01D33/27 ,  B01D21/26 ,  B01D43/00 ,  B01D45/00 ,  B04B3/00 ,  B04B1/02 ,  B04B1/04 ,  B04B1/06 ,  B04B1/08 ,  B04B7/08 ,  B04B7/10 ,  B04B7/12 ,  B04B7/14

Abstract: Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.

公开(公告)号：DE69626832T2

公开(公告)日：2003-12-04

申请号：DE69626832

申请日：1996-05-22

Applicant: BAXTER INT

Inventor： BROWN I ,  MIN KYUNGYOON

IPC: A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

Abstract: A blood separation system for separating mono nuclear cells from whole blood is described. The system comprises a chamber (12) that is rotatable about a rotational axis (28). The chamber comprises first and second spaced apart walls (24, 26) that form a separation zone having a high-G side and a low-G side which is located closer to the rotational axis than the high-G side. The chamber also includes an inlet region (74) where whole blood enters the separation zone for separation into red blood cells (96), a plasma constituent carrying platelets (98), and an interface (58) carrying mono nuclear cells between the red blood cells and the plasma constituent. A plasma constituent collection region (76) is also provided in the chamber where the plasma constituent is collected for removal from the chamber. An outlet path (46, 206) communicates with the plasma constituent collection region (76) and provides for removal of the interface (58) from the chamber. The system is operated under the control of a controller (134) that is operable in first and second modes. In the first mode, whole blood is conveyed into the inlet region while red blood cells and the plasma constituent are removed from the chamber and while the interface (58) is maintained at a set location within the chamber. In the second mode, the controller operates to move the interface from the set location for removal from the chamber via the outlet path. Finally, the system is equipped with a sensing element (226) for detecting mono nuclear cells in the interface in the outlet path. A method of separating mono nuclear cells from whole blood is also described.

公开(公告)号：BR0205439A

公开(公告)日：2003-07-08

申请号：BR0205439

申请日：2002-06-04

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  MIN KYUNGYOON

IPC: G01N1/10 ,  A61M1/36 ,  B04B5/04 ,  C02F1/34 ,  C02F1/38 ,  C12M1/26 ,  C12M1/34 ,  C12N1/02 ,  G01N1/36 ,  B01D21/26

Abstract: Methods and apparatus for concentrating and recovering pathogens from a fluid other than blood are disclosed. The method includes concentrating the pathogens contained in the fluid by continuously feeding the fluid through one or more flexible chamber(s) and subjecting the chamber(s) to centrifugal forces. The concentrated pathogens may be re-suspended by shaking the chamber(s).

公开(公告)号：DK0851784T3

公开(公告)日：2003-05-05

申请号：DK96916696

申请日：1996-05-22

Applicant: BAXTER INT

Inventor： MIN KYUNGYOON ,  BROWN RICHARD I

IPC: A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

Abstract: A blood separation system for separating mono nuclear cells from whole blood is described. The system comprises a chamber (12) that is rotatable about a rotational axis (28). The chamber comprises first and second spaced apart walls (24, 26) that form a separation zone having a high-G side and a low-G side which is located closer to the rotational axis than the high-G side. The chamber also includes an inlet region (74) where whole blood enters the separation zone for separation into red blood cells (96), a plasma constituent carrying platelets (98), and an interface (58) carrying mono nuclear cells between the red blood cells and the plasma constituent. A plasma constituent collection region (76) is also provided in the chamber where the plasma constituent is collected for removal from the chamber. An outlet path (46, 206) communicates with the plasma constituent collection region (76) and provides for removal of the interface (58) from the chamber. The system is operated under the control of a controller (134) that is operable in first and second modes. In the first mode, whole blood is conveyed into the inlet region while red blood cells and the plasma constituent are removed from the chamber and while the interface (58) is maintained at a set location within the chamber. In the second mode, the controller operates to move the interface from the set location for removal from the chamber via the outlet path. Finally, the system is equipped with a sensing element (226) for detecting mono nuclear cells in the interface in the outlet path. A method of separating mono nuclear cells from whole blood is also described.

公开(公告)号：CA2407485A1

公开(公告)日：2002-09-12

申请号：CA2407485

申请日：2002-02-13

Applicant: BAXTER INT

Inventor： VISHNOI ROHIT ,  BROWN RICHARD I ,  WESTBERG TOM ,  ARMER ALAN ,  MIN KYUNGYOON

IPC: A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  B01D17/038

Abstract: Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit mounte d on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and furthe r processes or treats the separated component.

公开(公告)号：CA2418477C

公开(公告)日：2013-08-06

申请号：CA2418477

申请日：2002-06-04

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  MIN KYUNGYOON

IPC: C12N1/00 ,  G01N1/10 ,  A61M1/36 ,  B01D21/26 ,  B04B5/04 ,  C02F1/34 ,  C02F1/38 ,  C12M1/00 ,  C12M1/26 ,  C12M1/34 ,  C12N1/02 ,  G01N1/36

Abstract: Methods and apparatus for concentrating and recovering pathogens from a fluid other than blood are disclosed. The method includes concentrating the pathogens contained in the fluid by continuously feeding the fluid through one or more flexible chamber(s) and subjecting the chamber(s) to centrifugal forces. The concentrated pathogens may be re-suspended by shaking the chamber(s).

公开(公告)号：CA2407947C

公开(公告)日：2010-05-18

申请号：CA2407947

申请日：2002-02-13

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  MIN KYUNGYOON ,  VISHNOI ROHIT ,  THOM SANDRA ,  FARRELL LIAM ,  WESTBERG TOM

IPC: A61M1/02 ,  A61M1/36 ,  A61M1/38

Abstract: Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit selected from one of two or more circuits. The circuits are mounted on a re-usable hardware component or module. The system includes a programmable controller including programs for use with the fluid circuits.