Abstract:
Automated systems and method for processing blood and other fluids are disclosed. The system and methods utilize a disposable fluid circuit fig. 1 mounted on a re-usable hardware component or module 12. The system withdraws blood from a donor or patient 100, separates the blood into two or more components and further processes or treats the separated component.
Abstract:
Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.
Abstract:
A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least on microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selectedcharacteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.
Abstract:
Systems and methods rotate a chamber (14), in which whole blood is centrifugally separated into an interface between the packed red blood cells and the plasma constituent. The interface carries platelets and mononuclear cells. The systems and methods include an interface control unit which is operative in a first state to enable removal of platelet-poor plasma (PPP) in a first container for use as a diluting liquid, and in a second state, to retain mononuclear cells (MNC) in the chamber (14), while removing platelet-rich plasma (PRP) from the chamber (14), bypassing the platelet-poor collection container, thereby maintaining its platelet-poor character, and in a third state to enable the removal of mononuclear cells (MNC) from the chamber (14) in a path (T13) that leads to a second container, where the mononuclear cells are collected.
Abstract:
A blood separation system operates in a first mode to convey whole blood into the inlet region (48) of a blood processing chamber (38) for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber (38), while maintaining the interface within the chamber (38). The system operates in a second mode to remove the interface from the chamber (38) by conveying packed red blood cells into the inlet region (48). An outlet path (46) conveys the removed interface from the chamber (38). The outlet path (46) includes a first sensing element (OS) to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.
Abstract:
Blood processing systems and methods are disclosed. A processing chamber (14) rotating on a rotating element includes a first compartment (38) and a second compartment (40). Blood is conveyed into the first compartment (38) for centrifugal separation into components. A liquid free of blood occupies the second compartment (40) to counter-balance the first compartment (38) during rotation on the rotating element. In one embodiment, the second compartment (40) is served by a single fluid access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment (40). While vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment (40) through the single access, thereby priming the second compartment (40) for use.