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公开(公告)号：CA2748492C
公开(公告)日：2017-05-30
申请号：CA2748492
申请日：2009-12-30
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： KHAKPOUR ZAFAR , FORTELNY RENE , REDL HEINZ
IPC: A61B17/00
Abstract: A laparoscopic tissue sealant spray apparatus and system having a laparoscopic tissue sealant spray assembly com-bined with a trocar assembly, the tissue sealant spray assembly having an elongate delivery tube. A spray outlet at a distal end of the elongate delivery tube may be rounded or angled. A ring member provided at the distal end of the elongate delivery tube di-rects a spray cone toward a portion of a target tissue site, and the spray cone may be repositioned to a different portion of the target tissue site by rotation of the elongate delivery tube. The trocar assembly includes a vent opening that connects to a venting valve member that provides a vent path which passively opens upon operation of the tissue sealant spray assembly, avoiding ex-cessive pressure build-up within a body cavity.
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公开(公告)号：CA2724527A1
公开(公告)日：2009-11-26
申请号：CA2724527
申请日：2009-05-22
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： MITTERMAYR RAINER , HELGERSON SAM L , REDL HEINZ
Abstract: The present application demonstrates the clinical potential of fibrin sealants to locally deliver growth factors to ischemic tissue. More particularly, it demonstrates that hydrogels such as Fibrin Sealants can be used to deliver VEGF165 to prevent tissue necrosis caused by hypoxia or ischemia. Specifically, a Fibrin Sealant (FS) was used to deliver VEGF165 to treat tissue necrosis in both a rodent dorsal flap model and a rodent epigastric flap model. Flaps treated with FS spiked with (rh)VEGF165 developed less necrotic tissue. In addition, immunohistological studies revealed a greater numbers of blood vessels (angiogenesis).
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公开(公告)号：ES2328452T3
公开(公告)日：2009-11-13
申请号：ES01973483
申请日：2001-09-25
Applicant: BAXTER INNOVATIONS GMBH , BAXTER INT
Inventor： REDL HEINZ , FUERST WALTER , KNEIDINGER RUDOLF , HELGERSON SAM L , LOOKER DOUGLAS L , INMAN ELISABETH M
IPC: A61K47/42 , C12N15/62 , A61K38/00 , A61K38/17 , A61K38/48 , A61K47/48 , C07K14/19 , C07K14/475 , C07K14/50 , C07K14/705 , C07K14/745 , C07K14/75 , C07K14/78 , C07K16/00 , C07K19/00 , C12N9/74 , C12N15/12 , C12N15/52
Abstract: Conjugado de unión fibrina/fibrinógeno que comprende una fracción de unión fibrina/fibrinógeno que comprende el dominio C-terminal de VEGF165, y una sustancia farmacéuticamente activa, donde dicha fracción de unión fibrina/fibrinógeno se une de manera covalente a dicha sustancia farmacéuticamente activa siendo dicho conjugado una proteína de fusión recombinante.
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公开(公告)号：DK1352070T3
公开(公告)日：2009-08-24
申请号：DK01973483
申请日：2001-09-25
Applicant: BAXTER INNOVATIONS GMBH , BAXTER INT
Inventor： LOOKER DOUGLAS L , RICHARDS JANE P , REDL HEINZ , FUERST WALTER , KNEIDINGER RUDOLF , HELGERSON SAM L , INMAN ELISABETH M , WONG CATALINA
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公开(公告)号：PT1352070E
公开(公告)日：2009-06-30
申请号：PT01973483
申请日：2001-09-25
Applicant: BAXTER INT , BAXTER INNOVATIONS GMBH
Inventor： REDL HEINZ , FUERST WALTER , KNEIDINGER RUDOLF , HELGERSON SAM L , LOOKER DOUGLAS L , INMAN ELISABETH M , RICHARDS JANE P , WONG CATALINA
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Patent Agency Ranking
公开(公告)号：DE60319377D1
公开(公告)日：2008-04-10
申请号：DE60319377
申请日：2003-05-28
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： REDL HEINZ , KHAKPOUR ZAFAR
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公开(公告)号：AU2001293055B2
公开(公告)日：2007-11-08
申请号：AU2001293055
申请日：2001-09-25
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： WONG CATALINA , KNEIDINGER RUDOLF , LOOKER DOUGLAS L , INMAN ELISABETH M , REDL HEINZ , RICHARDS JANE P , HELGERSON SAM L , FURST WALTER
IPC: A61K47/42 , A61K38/00 , A61K47/48 , C07K14/475 , C07K14/50 , C07K14/705 , C07K14/745 , C07K14/75 , C07K14/78 , C07K16/00 , C07K19/00 , C12N15/12
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公开(公告)号：RU2279890C2
公开(公告)日：2006-07-20
申请号：RU2003112017
申请日：2001-09-25
Applicant: BAXTER AKTIENGESELLSHAFT , BAXTER INT
Inventor： REDL HEINZ , FURST WALTER , KNEIDINGER RUDOLF , HELGERSON L SAM , LOOKER L DOUGLAS , INMAN M ELISABETH , RICHARDS P JANE , WONG CATALINA
IPC: A61K38/48 , A61K47/42 , A61K38/00 , A61K39/00 , A61K47/48 , C07K14/475 , C07K14/50 , C07K14/705 , C07K14/745 , C07K14/75 , C07K14/78 , C07K16/00 , C07K19/00 , C12N15/12
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公开(公告)号：CA2593973A1
公开(公告)日：2006-07-20
申请号：CA2593973
申请日：2006-01-12
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： KHAKPOUR ZAFAR , REDL HEINZ , ARIAGNO SCOTT R , KELLNER ANDREAS , ZAKARIJA LILLIAN G
Abstract: A control system for use with an apparatus comprising an elongated body defining an interior bore for containing sealant and having proximal and distal ends, a piston movably positioned in the bore, a distal outlet communicating with the bore, a first gas passageway cooperatively associated with the distal outlet and configured to direct gas to create a spray discharge of sealant, and an actuating member cooperatively associated with the piston is described. The system comprises: a control unit (4) comprising a supply valve (V1) and a pressure switch (PS2) for opening and closing the supply valve; and a timing delay control member (PFC1) that is operatively connected to the control unit via the pressure switch (PS2). The control unit is operable upon receipt of a control signal from the apparatus to open the supply valve and activate a flow of gas to the first gas passageway essentially simultaneously with a force being applied to the actuating member to eject sealant from the distal outlet so as to create a spray discharge of sealant. The timing delay control member prevents the pressure switch from closing the supply valve for a predetermined period of time after the applied force is removed from the actuating member to provide a discharge of gas after the user has stopped the ejection of sealant.
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公开(公告)号：AU2003242595A1
公开(公告)日：2003-12-19
申请号：AU2003242595
申请日：2003-05-28
Applicant: BAXTER INT
Inventor： REDL HEINZ , KHAKPOUR ZAFAR
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