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    VEGF165 DELIVERED BY FIBRIN SEALANT TO REDUCE TISSUE NECROSIS
    1.
    发明申请
    VEGF165 DELIVERED BY FIBRIN SEALANT TO REDUCE TISSUE NECROSIS 审中-公开
    由FIBRIN密封剂递送的VEGF165减少组织坏死

    公开(公告)号：WO2009143429A3

    公开(公告)日：2010-01-07

    申请号：PCT/US2009044986

    申请日：2009-05-22

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  MITTERMAYR RAINER ,  HELGERSON SAM L ,  REDL HEINZ

    Inventor： MITTERMAYR RAINER ,  HELGERSON SAM L ,  REDL HEINZ

    IPC: A01N37/18 ,  A61K38/00 ,  A61K38/24 ,  A61K38/27

    CPC classification number: A61K38/363 ,  A61K38/1858 ,  A61K38/4833 ,  A61K2300/00

    Abstract: The present application demonstrates the clinical potential of fibrin sealants to locally deliver growth factors to ischemic tissue. More particularly, it demonstrates that hydrogels such as Fibrin Sealants can be used to deliver VEGF165 to prevent tissue necrosis caused by hypoxia or ischemia. Specifically, a Fibrin Sealant (FS) was used to deliver VEGF165 to treat tissue necrosis in both a rodent dorsal flap model and a rodent epigastric flap model. Flaps treated with FS spiked with (rh)VEGF165 developed less necrotic tissue. In addition, immunohistological studies revealed a greater numbers of blood vessels (angiogenesis).

    Abstract translation: 本申请表明纤维蛋白封闭剂局部递送生长因子到缺血组织的临床潜力。 更具体地说，它表明水凝胶如纤维蛋白密封剂可用于递送VEGF165以防止由缺氧或局部缺血引起的组织坏死。 具体来说，纤维蛋白密封剂（FS）用于递送VEGF165以在啮齿动物背侧皮瓣模型和啮齿动物上腹膜模型中治疗组织坏死。 用（rh）VEGF165掺入的FS处理的皮瓣发育较少的坏死组织。 此外，免疫组织化学研究显示出更多的血管（血管生成）。

    HAND TRIGGERED TISSUE SEALANT SPRAY APPARATUS AND SYSTEM
    3.
    发明申请
    HAND TRIGGERED TISSUE SEALANT SPRAY APPARATUS AND SYSTEM 审中-公开
    手触式组织密封喷雾装置和系统

    公开(公告)号：WO2006076427A3

    公开(公告)日：2006-09-28

    申请号：PCT/US2006000970

    申请日：2006-01-12

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  REDL HEINZ ,  KHAKPOUR ZAFAR ,  ARIAGNO SCOTT R ,  KELLNER ANDREAS ,  ZAKARIJA LILLIAN G

    Inventor： REDL HEINZ ,  KHAKPOUR ZAFAR ,  ARIAGNO SCOTT R ,  KELLNER ANDREAS ,  ZAKARIJA LILLIAN G

    IPC: A61B17/00 ,  B67D7/60 ,  B67D7/70

    CPC classification number: B05B7/0408 ,  A61B17/00491 ,  A61B2017/00495 ,  B05B7/0483 ,  B05C17/00516 ,  B05C17/00553 ,  B05C17/015

    Abstract: The present invention is generally directed to various structures for applying a sealant to a work surface. In one aspect of the invention, a sealant applicator assembly is provided for use with an apparatus of the type having an elongated body (2) defining an interior bore and having a piston (48, 50) movably positioned in the bore and a pusher member (53, 54) operatively associated with the piston. The assembly comprises a spray adaptor (12) adapted to communicate with the bore of the body and defining a distal outlet. A first gas passageway (8) is cooperatively associated with the distal outlet and configured to direct gas to create a spray discharge of the sealant. An actuating member (86) is adapted to be cooperative associated with a pusher member to eject sealant through the distal outlet and is operative to simultaneously actuate a supply of gas to the first gas passageway for creating a spray discharge of sealant.

    Abstract translation: 本发明一般涉及用于向工作表面施加密封剂的各种结构。 在本发明的一个方面，提供一种密封剂施加器组件，用于与具有限定内孔的细长主体（2）类型的装置一起使用，并且具有可移动地定位在孔中的活塞（48,50）和推动构件 （53,54）可操作地与活塞相关联。 组件包括适于与主体的孔连通并限定远侧出口的喷雾适配器（12）。 第一气体通道（8）与远端出口协作地相关联并且构造成引导气体以产生密封剂的喷射排放。 致动构件（86）适于与推动器构件协作关联以通过远端出口喷射密封剂，并且可操作以同时致动向第一气体通道供应气体，以产生密封剂的喷射排放。

    REDUCTION OR PREVENTION OF POST-SURGICAL ADHESION FORMATION WITH FIBRINOGEN
    5.
    发明申请
    REDUCTION OR PREVENTION OF POST-SURGICAL ADHESION FORMATION WITH FIBRINOGEN 审中-公开
    减少或预防与纤维蛋白结合的术后粘连形成

    公开(公告)号：WO0230446A3

    公开(公告)日：2003-07-24

    申请号：PCT/US0132044

    申请日：2001-10-12

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  REDL HEINZ ,  SPAETHE REINER ,  SIMUNEK MANUELA

    Inventor： REDL HEINZ ,  SPAETHE REINER ,  SIMUNEK MANUELA

    IPC: A61K38/36 ,  A61P41/00

    CPC classification number: A61K38/363

    Abstract: Reducing or preventing adhesions which would form in a patient during or after surgery by administering to the wound surface of a patient a fibrinogen solution in an amount of about 0.025 ml fibrinogen/cm to about 0.25 ml fibrinogen/cm of the surface being at risk for developing adhesions. User of fibrinogen in a preparation comprising fibrinogen at a concentration of 20 to 80 mg/ml for the reduction or prevention of post-surgical adhesion formation.

    Abstract translation: 通过向患者的伤口表面施用约0.025ml纤维蛋白原/ cm 2至约0.25ml纤维蛋白原/ cm 2的量的纤维蛋白原溶液来减少或预防在手术期间或手术后形成的粘连 表面有发生粘连的风险。 用于包含浓度为20至80mg / ml的纤维蛋白原的制剂中的纤维蛋白原用于减少或防止手术后粘连形成。

    9.
    发明专利
    未知

    公开(公告)号：BRPI0606642A2

    公开(公告)日：2009-07-14

    申请号：BRPI0606642

    申请日：2006-01-12

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： KHAKPOUR ZAFAR ,  ARIAGNO SCOTT R ,  KELLNER ANDREAS ,  ZAKARIJA LILLIAN G ,  REDL HEINZ

    IPC: A61B17/00 ,  B67D7/60 ,  B67D7/70

    Abstract: A control system for use with an apparatus comprising an elongated body defining an interior bore for containing sealant and having proximal and distal ends, a piston movably positioned in the bore, a distal outlet communicating with the bore, a first gas passageway cooperatively associated with the distal outlet and configured to direct gas to create a spray discharge of sealant, and an actuating member cooperatively associated with the piston is described. The system comprises: a control unit (4) comprising a supply valve (V1) and a pressure switch (PS2) for opening and closing the supply valve; and a timing delay control member (PFC1) that is operatively connected to the control unit via the pressure switch (PS2). The control unit is operable upon receipt of a control signal from the apparatus to open the supply valve and activate a flow of gas to the first gas passageway essentially simultaneously with a force being applied to the actuating member to eject sealant from the distal outlet so as to create a spray discharge of sealant. The timing delay control member prevents the pressure switch from closing the supply valve for a predetermined period of time after the applied force is removed from the actuating member to provide a discharge of gas after the user has stopped the ejection of sealant.

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