公开(公告)号：US6015531A

公开(公告)日：2000-01-18

申请号：US983492

申请日：1998-03-05

Applicant: Bruno Colin ,  Cecile Jaravel ,  Philippe Cleuziat

Inventor： Bruno Colin ,  Cecile Jaravel ,  Philippe Cleuziat

IPC: G01N33/543 ,  B01L3/00 ,  G01N35/02 ,  G01N21/00

CPC classification number: B01L3/502

Abstract: The invention features an analysing device (1) comprising a body (2) in which are arranged or provided: an intake aperture (3) for a starting liquid sample, a liquid flow circuit (5) comprising at least one operating cell (6) for a processed liquid sample, obtained from all or part of the original sample, communicating with the said intake aperture (3), the said flow circuit defining, in at least two dimensions of the card, one determined geometric line, such that any alteration in the card orientation in a three-dimensional reference frame, causes the liquid to flow under gravity only, from one part of the said circuit to another,for instance from one side or another of the operating cell, (6) characterised in that, the flow circuit (5) is continuous, and looped on itself between the said aperture (3) and the said operating cell (6).

Abstract translation: PCT No.PCT / FR97 / 01020 Sec。 371日期：1998年3月5日 102（e）1998年3月5日PCT 1997年6月9日PCT公布。 WO97 / 46318 PCT公开号 日期1997年12月11日本发明的特征在于一种分析装置（1），包括其中布置或提供的主体（2）;用于起始液体样品的进气孔（3），包括至少一个 从所述原始样品的全部或部分获得的用于经处理的液体样品的操作室（6）与所述进气孔（3）连通，所述流动回路在卡的至少两个维度上限定一个确定的几何线 ，使得三维参考系中的卡方向的任何改变使得液体仅在重力作用下从所述电路的一部分流向另一部分，例如来自操作单元的一侧或另一侧（6 ），其特征在于，流动回路（5）是连续的，并且在所述孔（3）和所述操作单元（6）之间自身环绕。

公开(公告)号：US5773307A

公开(公告)日：1998-06-30

申请号：US615204

申请日：1996-03-11

Applicant: Bruno Colin ,  Michel Goudard ,  Alain Theretz

Inventor： Bruno Colin ,  Michel Goudard ,  Alain Theretz

IPC: G01N33/543 ,  G01N33/553 ,  B03C1/00 ,  C12M1/40 ,  G01N33/544

CPC classification number: G01N33/54366 ,  G01N33/54333 ,  G01N33/553 ,  Y10S436/806

Abstract: A method for determining an analyte in a sample which includes: providing the sample in liquid phase, the analyte of which has a ligand having at least one anti-ligand specific recognition site; providing at least one reagent containing metal particles, in suspension in liquid phase and non-separable from the liquid phase by a magnetic or electromagnetic force, each particle containing a metal core to which at least one anti-ligand is fixed directly or indirectly; contacting the sample and the at least one reagent in order to obtain metal clusters; placing the metal clusters in a magnetic field generated by a magnetic or magnetic field generating sensor in order to assemble the metal clusters; and detecting the assembled metal clusters to obtain a signal representative of the mass of metal in the clusters, which is correlated with the quantity of analyte present in the sample initially. A device for determining an analyte in a sample by the above process is also included.

Abstract translation: PCT No.PCT / FR94 / 01099 Sec。 371日期：1996年3月11日 102（e）1996年3月11日PCT PCT 1994年9月20日PCT公布。 公开号WO95 / 08769 日期1995年3月30日一种用于测定样品中分析物的方法，其包括：提供液相中的样品，其分析物具有至少一个抗配体特异性识别位点的配体; 提供至少一种含有金属颗粒的试剂，其以液相悬浮并且通过磁力或电磁力不能与液相分离，每个颗粒含有至少一种抗配体直接或间接固定的金属核; 使样品和至少一种试剂接触以获得金属簇; 将金属簇放置在由磁场或磁场产生传感器产生的磁场中，以便组装金属簇; 并检测组合的金属簇以获得代表簇中金属质量的信号，其与初始样品中存在的分析物的量相关。 还包括用于通过上述方法确定样品中的分析物的装置。

公开(公告)号：US5765490A

公开(公告)日：1998-06-16

申请号：US600845

申请日：1996-02-13

Applicant: Bruno Colin ,  Genevieve Bossy

Inventor： Bruno Colin ,  Genevieve Bossy

IPC: G01N1/28 ,  A61L2/04 ,  G01N1/34 ,  G01N35/00 ,  G01N35/10 ,  F23G5/00

CPC classification number: A61L2/04 ,  G01N35/1004 ,  G01N2035/00425 ,  G01N2035/1086

Abstract: Process for heating a hollow needle (2) consisting essentially of a metal tube (3), the inside and/or outside of which have previously been brought into contact with a contaminating medium, according to which an electric current is supplied to the said needle, flowing in the metal wall and over the length of the said tube (3) and dissipating thermal energy therein through the ohmic effect, characterized in that a predetermined quantity of electrical energy is supplied to the said needle (2), metered as a function of the electrical characteristics of the said tube (3), on the one hand to suffice for decontamination of the needle, both inside and outside, and on the other hand to limit the heating and preserve the integrity, including the original shape, of the said needle.

Abstract translation: 用于加热基本上由金属管（3）组成的中空针（2）的方法，其中内部和/或外部已经与污染介质接触，根据该中空针将电流提供给所述针 在金属壁中流动并超过所述管（3）的长度并通过欧姆效应在其中消散热能，其特征在于，将预定量的电能供应到所述针（2），作为功能计量 所述管（3）的电气特性一方面足以对内部和外部的针进行去污，另一方面限制加热并保持包括原始形状在内的完整性 说针。

公开(公告)号：US20130224884A1

公开(公告)日：2013-08-29

申请号：US13881960

申请日：2011-11-16

Applicant: Helene Briand ,  Bruno Colin ,  Cecile Paris

Inventor： Helene Briand ,  Bruno Colin ,  Cecile Paris

IPC: G01N33/558

CPC classification number: G01N33/558 ,  G01N33/54386 ,  G01N33/56988 ,  G01N33/5764 ,  G01N33/6854 ,  G01N2333/02 ,  G01N2333/11 ,  G01N2333/16

Abstract: A device for performing a test to determine the presence or the absence of at least one analyte in a liquid sample includes: a support and a matrix, fixed on the support. The matrix includes: a liquid sample application zone, a marking zone and at least one reaction zone. The one reaction zone includes: a test results display zone having at least a second immobilized binding partner which is able to bind to at least one analyte, and a monitoring zone downstream of the results display zone or parallel with the results display zone which allows monitoring of the correct functioning of the device and which includes at least one analogue of the at least one analyte which is able to bind to at least a first marked binding partner. The liquid sample application zone, marking zone and reaction zone are in fluid communication.

Abstract translation: 用于进行测试以确定液体样品中至少一种分析物的存在或不存在的装置包括：固定在载体上的载体和基质。 该基质包括：液体样品施加区域，标记区域和至少一个反应区域。 一个反应区包括：测试结果显示区，其具有能够结合至少一种分析物的至少第二固定化结合配偶体，以及结果显示区域下游的监测区域，或者与结果显示区域平行，允许监测 的装置的正确功能，并且其包括能够结合至少第一标记结合配偶体的至少一种分析物的至少一种类似物。 液体样品应用区，标记区和反应区处于流体连通状态。

公开(公告)号：US20110275110A1

公开(公告)日：2011-11-10

申请号：US13143879

申请日：2010-01-29

Applicant: Bruno Colin ,  Aurelien Costa

Inventor： Bruno Colin ,  Aurelien Costa

IPC: C12Q1/24 ,  C12N1/00

CPC classification number: C12Q1/04

Abstract: The invention relates to a method for isolating microorganisms on an agar culture medium, including the steps of: depositing, on said agar culture medium, a predetermined amount of a sample to be analyzed and optionally containing said microorganisms or a suspension of said microorganisms; applying a seeding means onto agar culture medium in contact with the volume of sample or suspension; moving the seeding means so as totally or partially spread the volume of sample or suspension over the surface of the agar culture medium, the movement of said seeding means being discontinuous so that during said movement the contact between the seeding means and the surface of the agar culture medium is interrupted and re-established at least once, thereby creating spreading segments and resulting in a depletion of the seeding means in terms of the sample or suspension; and incubating said agar culture medium under conditions enabling the growth of microorganisms.

Abstract translation: 本发明涉及一种用于在琼脂培养基上分离微生物的方法，包括以下步骤：在所述琼脂培养基上沉积预定量的待分析样品，任选地含有所述微生物或所述微生物的悬浮液; 在接种体积的样品或悬浮液的琼脂培养基上施用播种装置; 移动接种装置以使样品或悬浮液的体积完全或部分地扩散到琼脂培养基的表面上，所述接种装置的移动是不连续的，使得在所述移动期间，接种装置和琼脂表面之间的接触 培养基被中断并重新建立至少一次，从而产生扩展段并导致播种装置在样品或悬浮液方面的消耗; 并在允许微生物生长的条件下培养所述琼脂培养基。

公开(公告)号：US20110020861A1

公开(公告)日：2011-01-27

申请号：US12918159

申请日：2009-03-12

Applicant: Bruno Colin ,  David Mosticone ,  Jean-Claude Raymond ,  Thierry Sofia ,  Antoine Vimont

Inventor： Bruno Colin ,  David Mosticone ,  Jean-Claude Raymond ,  Thierry Sofia ,  Antoine Vimont

IPC: C12Q1/06 ,  C12Q1/04 ,  C12M1/34

CPC classification number: G01N33/569 ,  C12Q1/04 ,  G01N33/5304

Abstract: A method for detecting at least one microorganism that may be present in a sample, comprising the steps of:a) bringing into contact, in a container: a culture medium that enables the growth and/or detection of microorganisms, said sample and a sensitized solid support;b) subjecting the whole to a temperature that promotes the growth and/or detection of microorganisms; andc) observing, in real time, the appearance of an agglutination indicating the presence of the microorganism(s) or confirming said presence when said microorganisms are detected in said culture medium, when step b) has been completed, anda method for detecting and identifying at least one target microorganism that may be present in a sample.

Abstract translation: 一种用于检测可能存在于样品中的至少一种微生物的方法，包括以下步骤：a）在容器中接触：使微生物生长和/或检测的培养基，所述样品和敏化的 坚实的支持 b）使整体处于促进微生物生长和/或检测的温度; 以及c）当步骤b）已经完成时，实时地观察表明微生物存在的凝集物的出现或者在所述培养基中检测到所述微生物时确认存在的情况，以及检测方法 并鉴定可能存在于样品中的至少一种靶微生物。

公开(公告)号：US20100168805A1

公开(公告)日：2010-07-01

申请号：US12594689

申请日：2008-04-04

Applicant: Bruno Colin ,  Yohan Payan

Inventor： Bruno Colin ,  Yohan Payan

IPC: A61N1/36 ,  A61N1/08

CPC classification number: A61B5/682 ,  A61F9/08 ,  A61N1/36007 ,  A61N1/36014 ,  A61N1/36103 ,  A61N1/36167 ,  G06F1/3203

Abstract: An oral prosthesis system comprising an electrical tongue stimulation unit associated with a wireless transceiver device and comprising two microcontrollers, the first microcontroller dedicated to transmit and receive operations, and the second microcontroller dedicated to the control of an electrical stimulation array.

Abstract translation: 一种口腔假体系统，包括与无线收发器设备相关联的电舌刺激单元，并且包括两个微控制器，专用于发送和接收操作的第一微控制器，以及专用于控制电刺激阵列的第二微控制器。

公开(公告)号：US07741129B2

公开(公告)日：2010-06-22

申请号：US12102830

申请日：2008-04-14

Applicant: Bruno Colin

Inventor： Bruno Colin

IPC: G01N33/553

CPC classification number: B03C1/288 ,  B03C1/035 ,  G01N35/0098

Abstract: A method for treating magnetic particles present in a solution in a container by redispersion, rinsing or displacement, the particles having novel characteristics under the effect of a specific magnet and being associated or not with biological entities. The magnetic particles undergo at least one low-intensity magnetization where they are disposed in filaments oriented according to the north-south axis of the magnet; the magnetization source and/or container is/are displaced while the magnetic effect is maintained on the magnetic particles; the magnetization source and/or container is/are displaced or the magnetization is stopped, in order to suppress the magnetic field on the magnetic particles. Preferably, the invention can be used in the field of biology.

Abstract translation: 用于通过再分散，漂洗或置换来处理存在于容器中的溶液中的磁性颗粒的方法，所述颗粒在特定磁体的作用下具有新特性并且与生物实体相关联。 磁性颗粒经历至少一个低强度磁化，其中它们设置在根据磁体的南北轴线取向的长丝中; 当磁效应保持在磁性颗粒上时，磁化源和/或容器被移位; 磁化源和/或容器被移位或磁化被停止，以便抑制磁性颗粒上的磁场。 优选地，本发明可以用于生物学领域。

公开(公告)号：US07691600B2

公开(公告)日：2010-04-06

申请号：US10551989

申请日：2004-04-02

Applicant: Josep Vicent Mercader Badia ,  Bruno Colin ,  Vincent Atrache

Inventor： Josep Vicent Mercader Badia ,  Bruno Colin ,  Vincent Atrache

IPC: G01N27/447

CPC classification number: C12Q1/04 ,  B01L3/502 ,  B01L2300/0636 ,  B01L2300/0663 ,  B01L2300/0832 ,  B01L2300/18 ,  B01L2400/0442 ,  Y10S436/809

Abstract: The present invention relates to a method for detecting and/or identifying bacteria present in a liquid or solid sample, characterized in that: a. the sample that may contain said bacteria is placed in a liquid culture medium, in a first container, b. a second container comprising at least one system for detecting said bacteria is provided, c. a means of transfer between the first container and the second container is provided, d. a temperature T1 is applied inside the second container, then e. a temperature T2 is applied inside the second container, f. the temperature T1 is higher than the temperature T2 such that a defined volume of culture medium is transferred from the first container to the second container, g. the presence or absence of bacteria is determined and/or the bacteria are identified within the detection system.

Abstract translation: 本发明涉及一种用于检测和/或识别存在于液体或固体样品中的细菌的方法，其特征在于：a。 将含有所述细菌的样品置于第一容器中的液体培养基中，b。 提供了包含至少一个用于检测所述细菌的系统的第二容器，c。 提供了在第一容器和第二容器之间的转移装置，d。 在第二容器内施加温度T1， 在第二容器内施加温度T2，f。 温度T1高于温度T2，使得将限定体积的培养基从第一容器转移到第二容器，g。 确定细菌的存在或不存在和/或在检测系统内识别细菌。

公开(公告)号：US20080257825A1

公开(公告)日：2008-10-23

申请号：US12102830

申请日：2008-04-14

Applicant: Bruno Colin

Inventor： Bruno Colin

IPC: B03C1/24

CPC classification number: B03C1/288 ,  B03C1/035 ,  G01N35/0098

Abstract: A method for treating magnetic particles present in a solution in a container by redispersion, rinsing or displacement, the particles having novel characteristics under the effect of a specific magnet and being associated or not with biological entities. The magnetic particles undergo at least one low-intensity magnetisation where they are disposed in filaments oriented according to the north-south axis of the magnet; the magnetisation source and/or container is/are displaced while the magnetic effect is maintained on the magnetic particles; the magnetisation source and/or container is/are displaced or the magnetisation is stopped, in order to suppress the magnetic field on the magnetic particles. Preferably, the invention can be used in the field of biology.

Abstract translation: 用于通过再分散，漂洗或置换来处理存在于容器中的溶液中的磁性颗粒的方法，所述颗粒在特定磁体的作用下具有新特性并且与生物实体相关联。 磁性颗粒经历至少一个低强度磁化，其中它们被布置在根据磁体的南北轴线取向的长丝中; 当磁效应保持在磁性颗粒上时，磁化源和/或容器被移位; 磁化源和/或容器被移位或磁化停止，以便抑制磁性颗粒上的磁场。 优选地，本发明可以用于生物学领域。