公开(公告)号：IT1119193B

公开(公告)日：1986-03-03

申请号：IT6888779

申请日：1979-09-28

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07C29/17 ,  C07C29/38 ,  C07C43/15 ,  C07C45/51 ,  C07C47/21 ,  C07C

Abstract: A process for the production of 2-methyl-2-sec. butyl-1,3-propanediol from crotyl alcohol is disclosed. The diol obtained is useful in the manufacture of 2-methyl-2-(1-methylpropyl)-1,3-propanediol dicarbamate a valuable antihypertensive agent.

公开(公告)号：FI69304C

公开(公告)日：1986-01-10

申请号：FI833016

申请日：1983-08-23

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：CA1192907A

公开(公告)日：1985-09-03

申请号：CA418556

申请日：1982-12-23

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D295/08 ,  A61K31/40 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13 ,  C07D207/04

Abstract: SYNTHESIS OF ETHERS OF N-PROPANOLDIAMINES A process for preparing .beta.-¢(2-methylpropoxy) methyl!-N-phenyl-N-(phenylmethyl)-l-pyrrolidineethanamine hydrochloride hydrate in which isobutanol is reacted with epichlorohydrin, the product is reacted with thionyl chloride, and the compound thus obtained condensed with n-benzylaniline. In accordance with the invention, the condensing step is carried out using sodium hydride as the condensing agent.

公开(公告)号：BR8208033A

公开(公告)日：1983-11-22

申请号：BR8208033

申请日：1982-12-10

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D295/08 ,  A61K31/40 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13 ,  C07D207/04

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：NO833071A

公开(公告)日：1983-08-26

申请号：NO833071

申请日：1983-08-26

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D295/08 ,  A61K31/40 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13 ,  C07D

CPC classification number: C07D295/088 ,  C07D295/13

公开(公告)号：IT8249760D0

公开(公告)日：1982-12-28

申请号：IT4976082

申请日：1982-12-28

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13 ,  A61K

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：CA1123011A

公开(公告)日：1982-05-04

申请号：CA336678

申请日：1979-09-28

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07C29/17 ,  C07C29/38 ,  C07C43/15 ,  C07C45/51 ,  C07C47/21

Abstract: IN THE CANADIAN PATENT OFFICE By: Frank J. Stiefel For: Chemical Process A process for the production of 2-methyl-2-sec. butyl-1,3-propanediol from crotyl alcohol is disclosed. The diol obtained is useful in the manufacture of 2-methyl-2(1-methylpropyl)-1,3-propanediol dicarbamate a valuable antihypertensive agent.

公开(公告)号：AU5423579A

公开(公告)日：1980-07-03

申请号：AU5423579

申请日：1979-12-28

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D498/04

Abstract: The compound 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)-benzoxazin- 9-one is produced by reacting a mixture of tetrahydrofuran and crotonaldehyde with 5-chlorosalicylhydroxamic acid. The compound has demonstrated utility as a uricosuric agent.