公开(公告)号：EP0096720A4

公开(公告)日：1984-05-29

申请号：EP83900387

申请日：1982-12-10

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D295/08 ,  A61K31/40 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13

CPC classification number: C07D295/088 ,  C07D295/13

Abstract: A process for the synthesis of 1-(3-isobutoxy-2-(phenylbenzyl)-amino)-propyl-pyrrolidino hydrochloride by preparation of 1-(3-isobutoxy-2-chloro) propyl pyrrolidine followed by condensation thereof with N-benzylaniline in the presence of an equimolecular amount of sodium hydride condensing agent.

公开(公告)号：NO940113L

公开(公告)日：1994-03-11

申请号：NO940113

申请日：1994-01-12

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: B01J23/44 ,  B01J27/232 ,  C07B61/00 ,  C07C20060101 ,  C07C29/00 ,  C07C29/132 ,  C07C33/26 ,  C07C201/10 ,  C07C201/12 ,  C07C205/04 ,  C07C205/16

公开(公告)号：CA2113563A1

公开(公告)日：1993-02-04

申请号：CA2113563

申请日：1991-07-15

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07C29/00 ,  C07C205/04 ,  C07C205/16 ,  C07C33/26 ,  C07C29/132 ,  C07C33/46 ,  C07C41/18 ,  C07C43/23

Abstract: A novel method for preparing 2-phenyl substituted-1,3-propanediols, useful intermediates in the synthesis of pharmaceutical preparations is disclosed.

公开(公告)号：DK161143C

公开(公告)日：1991-11-18

申请号：DK391983

申请日：1983-08-26

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：IT1128206B

公开(公告)日：1986-05-28

申请号：IT6705480

申请日：1980-01-16

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K20060101 ,  A61K

Abstract: Prepn. of 7-chloro-2-methyl-3, 3a-dihydro-2H, 9H-isoxazolo 3,2-b 1,3 benzoxazin-9-one (Ie is carried out by reacting asoln. of crotonaldehyde (II) in THF with 5-chlorosalicylhydroxamic acid (III). The reaction is pref. effected by treating a soln. of (II) in THF with a hydrogen halide (esp. HCl) at 15-35 degrees C adding (III), treating the mixt. of an aq. alkali metal hydroxide (esp. NaOH) or NH4OH at 30-40 degrees C and heating at 50-90 degrees C. (I) is an antiinflammatory and uricosuric agent. The process gives higher yields (e.g. 57-67%) than prior art processes (of US 3598814).

公开(公告)号：FI793863A

公开(公告)日：1980-06-30

申请号：FI793863

申请日：1979-12-11

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D498/04 ,  C07D

Abstract: The compound 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)-benzoxazin- 9-one is produced by reacting a mixture of tetrahydrofuran and crotonaldehyde with 5-chlorosalicylhydroxamic acid. The compound has demonstrated utility as a uricosuric agent.

公开(公告)号：DE68907596T2

公开(公告)日：1994-01-05

申请号：DE68907596

申请日：1989-08-15

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07C29/00 ,  C07C33/26 ,  C07C201/12 ,  C07C205/04 ,  C07C271/10

公开(公告)号：PT98496A

公开(公告)日：1993-01-29

申请号：PT9849691

申请日：1991-07-30

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07C20060101 ,  C07C

Abstract: This invention relates to a new process for the preparation of substituted 2-phenyl-1,3-propanediols characterized in that benzaldehyde oxime substituted with a phenyl group is oxidized with an oxidation agent to obtain phenyl-substituted nitromethyl benzene which is caused to react with a formaldehyde and a base.

公开(公告)号：AT32715T

公开(公告)日：1988-03-15

申请号：AT83900387

申请日：1982-12-10

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D295/08 ,  A61K31/40 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：MX154865A

公开(公告)日：1987-12-23

申请号：MX635482

申请日：1982-12-17

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D207/04