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    Assemblies for temporarily connecting microelectronic elements for testing and methods therefor
    41.
    发明授权
    Assemblies for temporarily connecting microelectronic elements for testing and methods therefor 有权
    用于临时连接用于测试的微电子元件的组件及其方法

    公开(公告)号：US07205659B2

    公开(公告)日：2007-04-17

    申请号：US10777804

    申请日：2004-02-12

    Applicant: Masud Beroz ,  David Light

    Inventor： Masud Beroz ,  David Light

    IPC: H01L23/48

    CPC classification number: H01L24/81 ,  H01L2224/13111 ,  H01L2224/13609 ,  H01L2224/81801 ,  H01L2224/81907 ,  H01L2224/9205 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01033 ,  H01L2924/01049 ,  H01L2924/0105 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/351 ,  H05K3/3436 ,  H05K2201/10674 ,  H05K2201/10992 ,  H05K2203/162 ,  H05K2203/176 ,  Y02P70/613 ,  H01L2924/00

    Abstract: A microelectronic assembly includes a first microelectronic element having a contact bearing face and at least one contact accessible at the contact bearing face, and a second microelectronic element opposing the first microelectronic element, the second microelectronic element having a first surface including at least one lead extending over the first surface. The microelectronic assembly includes the first fusible material engaging the at least one contact of the first microelectronic element, and a second fusible material engaging the at least one lead, whereby one of the first and second fusible materials has a higher melting temperature and one of the first and second fusible materials has a lower melting temperature. The first and second microelectronic elements are juxtaposed with one another so that the first and second fusible materials are in substantial alignment with one another, with one of the first and second fusible materials in a liquid state and one of the first and second fusible materials in a solid state.

    Abstract translation: 微电子组件包括第一微电子元件，其具有接触支承面和在接触支承面处可访问的至少一个触点，以及与第一微电子元件相对的第二微电子元件，第二微电子元件具有第一表面，第一表面包括至少一个引线延伸 在第一个表面。 微电子组件包括与第一微电子元件的至少一个触点接合的第一可熔材料和与该至少一个引线接合的第二可熔材料，其中第一和第二熔融材料之一具有较高的熔化温度， 第一和第二可熔材料具有较低的熔化温度。 第一和第二微电子元件彼此并置，使得第一和第二可熔材料彼此基本对齐，其中第一和第二可熔材料中的一个处于液体状态，第一和第二可熔材料中的一个在 固态。

    Hyperspectral sensor using tunable filter
    42.
    发明申请
    Hyperspectral sensor using tunable filter 审中-公开
    高光谱传感器采用可调滤波器

    公开(公告)号：US20070045545A1

    公开(公告)日：2007-03-01

    申请号：US11215204

    申请日：2005-08-26

    Applicant: David Light ,  Tommy Lum ,  William Pittman

    Inventor： David Light ,  Tommy Lum ,  William Pittman

    IPC: G01J5/02

    CPC classification number: G01J3/32 ,  G01J3/02 ,  G01J3/0289 ,  G01J3/1256 ,  G01J3/2823 ,  G01J2003/1247

    Abstract: A target-seeking-and-tracking system featuring hyperspectral sensing performed by a tunable filter and an infrared focal plane array is programmable to collect and process several hyperspectral bands of infrared radiation emanating from a target scenery. The programming is done by tuning the filter from time to time to collect several hyperspectral bands containing image data corresponding to several objects of interest in the scenery. The image data is further processed in the target recognition unit to identify the objects and aid in the selection and tracking of a particular target object for the ultimate goal of accurate destruction of the object. The programmability of hyperspectral sensing provides a degree of countermeasures immunity by allowing several bands to be combined to achieve the best signal-to-clutter ratio.

    Abstract translation: 由可调滤波器和红外焦平面阵列执行的具有高光谱感测的寻靶跟踪系统是可编程的，用于收集和处理从目标风景发出的红外辐射的多个高光谱带。 编程是通过不时地调整滤波器来收集几个包含与风景中感兴趣的几个对象相对应的图像数据的高光谱带。 图像数据在目标识别单元中被进一步处理以识别对象，并帮助特定目标对象的选择和跟踪，以达到准确地破坏对象的最终目的。 高光谱传感器的可编程性通过允许多个频带组合以实现最佳的信噪比提供了一定程度的对策抗扰度。

    Anti-mesothelin antibodies and uses thereof
    45.
    发明授权
    Anti-mesothelin antibodies and uses thereof 有权
    抗间皮素抗体及其用途

    公开(公告)号：US09023351B2

    公开(公告)日：2015-05-05

    申请号：US12744849

    申请日：2008-11-19

    Applicant: Antje Kahnert ,  David Light ,  Doug Schneider ,  Renate Parry ,  Noboru Satozawa ,  Tara Renee Heitner Hansen ,  Stefan Steidl ,  Ulrike Schubert

    Inventor： Antje Kahnert ,  David Light ,  Doug Schneider ,  Renate Parry ,  Noboru Satozawa ,  Tara Renee Heitner Hansen ,  Stefan Steidl ,  Ulrike Schubert

    IPC: C12P21/08 ,  C07K16/30

    CPC classification number: C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/77 ,  C07K2317/92

    Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

    Abstract translation: 本发明提供了重组抗原结合区和含有这样的抗原结合区的抗体和功能片段，所述抗原结合区对于多个肿瘤如胰腺和卵巢肿瘤间皮瘤中过表达的膜锚定的40kDa的间皮素多肽是特异性的 和肺癌细胞。 因此，这些抗体可用于治疗这些和其他病症和病症。 本发明的抗体也可用于诊断领域，以及进一步研究间皮素在与癌症相关疾病进展中的作用。 本发明还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。

    Polymer particles, nucleic acid polymer particles and methods of making and using the same
    46.
    发明授权
    Polymer particles, nucleic acid polymer particles and methods of making and using the same 有权
    聚合物颗粒，核酸聚合物颗粒及其制备和使用方法

    公开(公告)号：US08975302B2

    公开(公告)日：2015-03-10

    申请号：US13543642

    申请日：2012-07-06

    Applicant: David Light ,  Barnett Rosenblum

    Inventor： David Light ,  Barnett Rosenblum

    IPC: B01F3/08 ,  C12Q1/68 ,  C08F2/32 ,  C08F220/56

    CPC classification number: C12Q1/6834 ,  C08F2/32 ,  C08F220/56 ,  C08F222/385 ,  C08F251/00 ,  C12Q1/6869 ,  C12Q2563/155 ,  C12Q2563/159

    Abstract: The disclosure relates to methods of making polymer particles, said methods including the steps of: making an aqueous gel reaction mixture; forming an emulsion having dispersed aqueous phase micelles of gel reaction mixture in a continuous phase; adding an initiator oil comprising at least one polymerization initiator to the continuous phase; and performing a polymerization reaction in the micelles. Further, the initiator oil is present in a volume % relative to a volume of the aqueous gel reaction mixture of between about 1 vol % to about 20 vol %. The disclosure also relates to methods of making nucleic acid polymer particles having the same method steps and wherein the aqueous gel reaction mixture includes a nucleic acid fragment, such as a primer.

    Abstract translation: 本公开涉及制备聚合物颗粒的方法，所述方法包括以下步骤：制备水性凝胶反应混合物; 在连续相中形成具有分散的凝胶反应混合物的水相胶束的乳液; 向连续相中加入包含至少一种聚合引发剂的引发剂油; 并在胶束中进行聚合反应。 此外，引发剂油相对于水性凝胶反应混合物的体积的体积％为约1体积％至约20体积％。 本公开还涉及制备具有相同方法步骤的核酸聚合物颗粒的方法，并且其中所述水性凝胶反应混合物包括核酸片段，例如引物。

    PURIFICATION SYSTEMS AND METHODS
    48.
    发明申请
    PURIFICATION SYSTEMS AND METHODS 有权
    净化系统和方法

    公开(公告)号：US20120205294A1

    公开(公告)日：2012-08-16

    申请号：US13371264

    申请日：2012-02-10

    Applicant: Wolfgang Hinz ,  Ryan Jones ,  David Light

    Inventor： Wolfgang Hinz ,  Ryan Jones ,  David Light

    IPC: B07B1/00

    CPC classification number: C08J3/12 ,  B07B1/00 ,  C08J2300/14 ,  C12N15/1017

    Abstract: A method of preparing hydrogel particles includes applying a solution including a plurality of hydrogel particles to a stir cell. A retentate side of a filter defines a lower surface of the stir cell. The filter has the retentate side and a permeate side. The method further includes, while stirring the solution within the stir cell, dispensing a buffer solution at a first flow rate to the stir cell and drawing a permeate from the permeate side of the filter using a pump at a second flow rate, the permeate including a subset of the plurality of hydrogel particles.

    Abstract translation: 制备水凝胶颗粒的方法包括将包含多个水凝胶颗粒的溶液施加到搅拌槽。 过滤器的滞留侧限定了搅拌槽的下表面。 过滤器具有滞留侧和渗透侧。 该方法还包括在搅拌槽内搅拌溶液的同时，以第一流速向缓冲池分配缓冲溶液，并以第二流量使用泵从过滤器的渗透侧抽出渗透物，渗透物包括 多个水凝胶颗粒的一个子集。

    Methods of Primer Extension Using Porous Particle Supports
    49.
    发明申请
    Methods of Primer Extension Using Porous Particle Supports 审中-公开
    使用多孔粒子载体的引物延伸方法

    公开(公告)号：US20110201506A1

    公开(公告)日：2011-08-18

    申请号：US13029611

    申请日：2011-02-17

    Applicant: Wolfgang HINZ ,  John Leamon ,  David Light ,  Jonathan Rothberg

    Inventor： Wolfgang HINZ ,  John Leamon ,  David Light ,  Jonathan Rothberg

    IPC: C40B10/00 ,  C40B50/00

    CPC classification number: C12N15/1093 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00722 ,  C12Q1/6874 ,  C40B40/08 ,  C40B50/06 ,  Y10T428/2982

    Abstract: The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.

    Abstract translation: 本发明提供了在核酸分析中具有应用的颗粒组合物。 本发明的核酸聚合物颗粒允许多核苷酸在其整个体积中被连接，以便比仅通过表面附着可实现的更高的负载能力。 在一个方面，本发明的核酸聚合物颗粒包含具有低变异系数的具有均匀尺寸分布的聚丙烯酰胺颗粒，这导致分析测定中粒子与粒子变化的减少。 这种颗粒组合物用于各种扩增反应以制备来自核酸片段文库的扩增子文库。

    Tissue factor targeted thrombomodulin fusion proteins as anticoagulants
    50.
    发明授权
    Tissue factor targeted thrombomodulin fusion proteins as anticoagulants 失效
    组织因子靶向血栓调节蛋白融合蛋白作为抗凝剂

    公开(公告)号：US07250168B2

    公开(公告)日：2007-07-31

    申请号：US10427805

    申请日：2003-04-30

    Applicant: David Light ,  Kirk McLean

    Inventor： David Light ,  Kirk McLean

    IPC: A61K39/00

    CPC classification number: C07K16/36 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/485 ,  C07K14/7455 ,  C07K16/40 ,  C07K19/00 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/622 ,  C07K2319/00

    Abstract: This invention relates to novel fusion proteins which are comprised of a targeting protein that binds tissue factor (TF), which is operably linked to the thrombomodulin (TM) EGF456 domain alone or in combination with at least one other TM domain selected from the group consisting of the N-terminal hydrophobic region domain, the EGF123 domain, the interdomain loop between EGF3 and EGF4, and the O-glycosylated Ser/Thr-rich domain, or analogs, fragments, derivatives or variants thereof. The fusion protein binds at the site of injury and prevents the initiation of thrombosis. The fusion protein can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.

    Abstract translation: 本发明涉及新颖的融合蛋白，其由结合组织因子（TF）的靶向蛋白组成，其与单独的血栓调节蛋白EGF456结构域或与至少一种其它TM结构域可操作地连接，所述TM结构域选自 的N末端疏水区域，EGF123结构域，EGF3和EGF4之间的域间环和O-糖基化的Ser / Thr富集结构域，或其类似物，片段，衍生物或变体。 融合蛋白在损伤位点处结合并防止血栓形成的发生。 融合蛋白可用于治疗各种血栓形成病症，包括但不限于深静脉血栓形成，弥散性血管内凝血和急性冠状动脉综合征。

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