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    ACOUSTIC PERFUSION DEVICES
    41.
    发明申请
    ACOUSTIC PERFUSION DEVICES 审中-公开
    声音佩戴装置

    公开(公告)号：WO2017039761A1

    公开(公告)日：2017-03-09

    申请号：PCT/US2016/029382

    申请日：2016-04-26

    Applicant: FLODESIGN SONICS, INC.

    Inventor： LIPKENS, Bart ,  MILLER, Erik ,  ROSS-JOHNSRUD, Benjamin ,  PRESZ, JR., Walter M. ,  CHITALE, Kedar ,  KENNEDY, III, Thomas J. ,  WINIARSKI, Lauryn

    IPC: C12M1/00 ,  B01D43/00 ,  B01D21/28 ,  C12M1/26

    CPC classification number: C12M29/10 ,  B01D21/283 ,  C12M33/00 ,  C12M47/02 ,  C12M47/10

    Abstract: Acoustic perfusion devices for separating biological cells from other material in a fluid mixture are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid mixture is being drawn.

    Abstract translation: 公开了用于将流体混合物中的生物细胞与其它材料分离的声学灌注装置。 这些装置包括连接到声学室的入口端口，出口端口和收集端口。 超声波换能器在声学室中产生声驻波，其允许通过收集口回收的流体的连续流动，同时将声室内的生物细胞保持回流到生物反应器，从该液体混合物被抽出。

    NON-PLANAR AND NON-SYMMETRICAL PIEZOLECTRIC CRYSTALS AND REFLECTORS
    42.
    发明申请
    NON-PLANAR AND NON-SYMMETRICAL PIEZOLECTRIC CRYSTALS AND REFLECTORS 审中-公开
    非平面和非对称压电晶体和反射器

    公开(公告)号：WO2017008066A1

    公开(公告)日：2017-01-12

    申请号：PCT/US2016/041664

    申请日：2016-07-09

    Applicant: FLODESIGN SONICS, INC

    Inventor： LIPKENS, Bart ,  PRESZ, Walter, M., Jr. ,  CHITALE, Kedar ,  KENNEDY, Thomas, J., III ,  GILMANSHIN, Rudolf ,  MEALEY, Dane ,  DUTRA, Brian ,  SOKOLOWSKI, David

    IPC: B06B1/06 ,  B01D21/28

    CPC classification number: B06B1/0238 ,  B01D21/0009 ,  B01D21/283 ,  B06B1/0644 ,  B06B3/04 ,  C12M47/02 ,  H03H9/17

    Abstract: An acoustophoretic device is disclosed. The acoustophoretic device includes an acoustic chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber emanating from a non-planar face of the piezoelectric material. A method for separating a second fluid or a particulate from a host fluid is also disclosed. The method includes flowing the mixture through an acoustophoretic device. A voltage signal is sent to drive the ultrasonic transducer to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.

    Abstract translation: 公开了一种声学设备。 声学设备包括声学室，超声换能器和反射器。 超声波换能器包括由电压信号驱动的压电材料，以在从压电材料的非平面发出的声室中产生多维声驻波。 还公开了一种用于从主体流体分离第二流体或颗粒的方法。 该方法包括使混合物流过声波装置。 发送电压信号以驱动超声波换能器以在声学室中产生多维声驻波，使得第二流体或颗粒被连续地捕获在驻波中，然后聚集，聚集，聚集或聚结在一起， 并随后由于浮力或重力而升高或沉降在主流体之外，并离开声室。

    ACOUSTIC PRE-CONDITIONER
    43.
    发明申请
    ACOUSTIC PRE-CONDITIONER 审中-公开
    声音预调节器

    公开(公告)号：WO2016179564A1

    公开(公告)日：2016-11-10

    申请号：PCT/US2016/031357

    申请日：2016-05-06

    Applicant: FLODESIGN SONICS, INC.

    Inventor： PRESZ, Walter, M., Jr. ,  LIPKENS, Bart ,  DIONNE, Jason ,  GILMANSHIN, Rudolf ,  MILLER, Erik

    IPC: B01D21/28 ,  B06B1/06

    CPC classification number: B01D21/283 ,  B01D21/0012 ,  B06B1/06 ,  B06B2201/71 ,  B06B2201/76 ,  C12M47/04

    Abstract: Devices and methods for pre-conditioning and/or post-conditioning a host fluid containing a second fluid or particulate are disclosed. The devices include a flow chamber having first opening and a particulate outlet. The devices can also include side openings and alignment, fluid, and particulate screens. An ultrasonic transducer can be driven to create an acoustic standing wave in the flow chamber, or alternatively be driven to excite the wall of the flow chamber in which it is located. This creates a uniformly stratified flow within the flow chamber, with the second fluid or particulate being aligned in planes in the fluid mixture. This permits the host fluid to be separated therefrom using the fluid screen and the particulate screen.

    Abstract translation: 公开了用于预处理和/或后处理含有第二流体或颗粒的主体流体的装置和方法。 这些装置包括具有第一开口和颗粒出口的流动室。 该装置还可以包括侧开口和对准，流体和颗粒筛。 可以驱动超声波换能器以在流动室中产生声驻波，或者可选地被驱动以激发其所在的流动室的壁。 这在流动室中产生均匀分层的流动，其中第二流体或颗粒在流体混合物中的平面中对准。 这允许使用流体筛网和颗粒筛网将主体流体与其分离。

    ACOUSTOPHORETIC DEVICE WITH PIEZOELECTRIC TRANSDUCER ARRAY
    44.
    发明申请
    ACOUSTOPHORETIC DEVICE WITH PIEZOELECTRIC TRANSDUCER ARRAY 审中-公开
    具有压电传感器阵列的防震装置

    公开(公告)号：WO2015172095A1

    公开(公告)日：2015-11-12

    申请号：PCT/US2015/030009

    申请日：2015-05-08

    Applicant: FLODESIGN SONICS, INC.

    Inventor： LIPKENS, Bart ,  DIONNE, Jason

    IPC: C12M1/00 ,  B06B1/06

    CPC classification number: B01D43/00 ,  B01D21/283 ,  B06B1/06 ,  B06B1/0625 ,  C12M47/02 ,  H01L41/0533

    Abstract: An apparatus for separating particles from a fluid stream includes a flow chamber that has at least one inlet and at least one outlet. At least one ultrasonic transducer is located on a wall of the flow chamber. The transducer includes a piezoelectric array with at least two piezoelectric elements. The piezoelectric array includes a piezoelectric material to create a multi-dimensional standing wave in the flow chamber. A reflector is located on the wall on the opposite side of the flow chamber from the at least one ultrasonic transducer.

    Abstract translation: 用于从流体流分离颗粒的装置包括具有至少一个入口和至少一个出口的流动室。 至少一个超声换能器位于流动室的壁上。 换能器包括具有至少两个压电元件的压电阵列。 压电阵列包括在流动室中产生多维驻波的压电材料。 反射器位于流动室的与至少一个超声换能器相反的一侧的壁上。

    BIOREACTOR USING ACOUSTIC STANDING WAVES
    46.
    发明申请
    BIOREACTOR USING ACOUSTIC STANDING WAVES 审中-公开
    使用声学波形的生物反应器

    公开(公告)号：WO2014124306A1

    公开(公告)日：2014-08-14

    申请号：PCT/US2014/015382

    申请日：2014-02-07

    Applicant: FLODESIGN SONICS, INC.

    Inventor： LIPKENS, Bart ,  MASI, Louis ,  KOWALSKI III, Stanley ,  PRESZ, Walter ,  DIONNE, Jason ,  DUTRA, Brian ,  KENNEDY III, Thomas ,  MARTIN, Arthur

    IPC: B01D21/28

    CPC classification number: C12M47/06 ,  B01D21/283 ,  C12M29/10 ,  C12M33/08 ,  C12M47/02

    Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor. The bioreactor includes a reaction vessel, an agitator, a feed inlet, and an outlet. A filtering device is included that has an inlet, a flow chamber and a sleeve surrounding the flow chamber, where the sleeve includes the ultrasonic transducer.

    Abstract translation: 灌注生物反应器包括至少一个可声学地产生多维驻波的超声换能器。 驻波可用于将细胞保留在生物反应器中，并且也可用于从生物反应器中生产的废物中脱水或进一步收获产品。 生物反应器包括反应容器，搅拌器，进料口和出口。 包括过滤装置，其具有入口，流动室和围绕流动室的套筒，其中套筒包括超声换能器。

    PARAMETERS FOR CONCENTRATION AND WASHING OF PARTICLES WITH ACOUSTICS
    49.
    发明申请
    PARAMETERS FOR CONCENTRATION AND WASHING OF PARTICLES WITH ACOUSTICS 审中-公开

    公开(公告)号：WO2020154334A1

    公开(公告)日：2020-07-30

    申请号：PCT/US2020/014492

    申请日：2020-01-21

    Applicant: FLODESIGN SONICS, INC.

    Inventor： ROSS-JOHNSRUD, Benjamin ,  LIPKENS, Bart

    IPC: C12N5/00 ,  C12M1/42 ,  C12M1/00 ,  C12M1/36

    Abstract: Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.

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