公开(公告)号：CZ169697A3

公开(公告)日：1997-12-17

申请号：CZ169697

申请日：1997-06-02

Applicant: HOECHST AG

Inventor： WEICHERT ANDREAS DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHWARK JAN ROBERT DR ,  ALBUS UDO DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/165 ,  A01N1/02 ,  A01N47/44 ,  A61K31/155 ,  A61P3/00 ,  A61P3/06 ,  A61P7/04 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P35/00 ,  C07C279/22 ,  C07C319/20 ,  C07C323/62

Abstract: Ortho-substituted benzoyl-guanidines of formula (I) and their salts are new: R = H; F; Cl; Br; I; CN; NO2; 1-8 C alkyl; 1-8 C alkoxy; 3-8 C cycloalkyl; 3-8 C cycloalkoxy; Xa-(CH2)b-(CF2)c-CF3; SR ; OR ; CR R R ; Ph, etc.;R or R = OCOR and the other = R ;R , R = H; 1-4C alkyl; 1-4C alkoxy; etc.;X = e.g. O; a = 0 or 1;b = 0-2;c = 0-3;R = -CfH2f-Q;Q = e.g. 3-8 C cycloalkyl;f = 0-2; R , R = H; 1-4 C alkyl; or R ; R = e.g. 1-8C alkyl.

公开(公告)号：DE19621319A1

公开(公告)日：1997-12-04

申请号：DE19621319

申请日：1996-05-28

Applicant: HOECHST AG

Inventor： ALBUS UDO DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHOLZ WOLFGANG DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR

IPC: A61K31/165 ,  A61K31/155 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  C07C277/06 ,  C07C279/22 ,  C07C311/15 ,  C07C317/44 ,  C07C323/62 ,  A01N1/02 ,  C07C277/08

公开(公告)号：DK0603650T3

公开(公告)日：1997-10-20

申请号：DK93119784

申请日：1993-12-08

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR ,  WEICHERT ANDREAS DR ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR

IPC: A61K31/165 ,  A61K31/155 ,  A61K49/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/10 ,  A61P35/00 ,  A61P43/00 ,  C07C279/22

公开(公告)号：DE19603425A1

公开(公告)日：1997-08-07

申请号：DE19603425

申请日：1996-01-31

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  BRENDEL JOACHIM DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  LANG HANS JOCHEN DR ,  ALBUS UDO DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/165 ,  A61K31/155 ,  A61K31/17 ,  A61K31/18 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C279/22 ,  C07C311/21 ,  C07C311/60 ,  A61K31/44 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61K49/00 ,  C07C277/08 ,  C07C311/19 ,  C07D207/327 ,  C07D207/33

公开(公告)号：ES2100435T3

公开(公告)日：1997-06-16

申请号：ES93119784

申请日：1993-12-08

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  WEICHERT ANDREAS DR ,  KLEEMANN HEINZ-WERNER DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/165 ,  A61K31/155 ,  A61K49/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/10 ,  A61P35/00 ,  A61P43/00 ,  C07C279/22

公开(公告)号：DK0602523T3

公开(公告)日：1997-06-02

申请号：DK93119782

申请日：1993-12-08

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR ,  LANG HANS-JOCHEN DR

IPC: A61K31/165 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/472 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C279/22 ,  C07C311/08 ,  C07C317/44 ,  C07C323/62 ,  C07D207/32 ,  C07D213/64 ,  C07D213/643 ,  C07D213/65 ,  C07D213/66 ,  C07D213/68 ,  C07D213/70 ,  C07D215/20 ,  C07D215/26 ,  C07D217/02 ,  C07D217/24 ,  C07D233/54 ,  C07D249/08 ,  C07D521/00

公开(公告)号：ES2097409T3

公开(公告)日：1997-04-01

申请号：ES93114774

申请日：1993-09-14

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DR ,  WEICHERT ANDREAS DR ,  KLEEMANN HEINZ-WERNER DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/00 ,  A61K31/155 ,  A61K31/445 ,  A61P1/16 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C311/16 ,  C07C311/21 ,  C07C311/29 ,  C07C317/24 ,  C07C317/44 ,  C07C317/46 ,  C07C317/48 ,  C07C323/22 ,  C07C323/65 ,  C07D211/14 ,  C07D211/70 ,  C07D295/14 ,  C07D295/155 ,  A61K31/54 ,  A61K31/45 ,  A61K49/00

Abstract: The invention relates to benzoylguanidines of the formula I where R(1) or R(2) is equal to R(3)-S(O)n- or R(4)R(5)N-O2S- and the other substituent R(1) or R(2) is in each case equal to H, OH, F, Cl, Br, I, alkyl, alkoxy, benzyloxy or phenoxy, R(3)-S(O)n or R(4)R(5)N- or 3,4-dehydropiperidine and R(3) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(4) and R(5) are equal to alkyl or phenylalkyl or phenyl, and in which R(4) and R(5) together can also be a C4-C7-chain, and in which R(4) and R(5), together with the nitrogen atom to which they are bonded, can denote a dihydroindol, tetrahydroquinoline or tetrahydroisoquinoline system, and where n is equal to zero, 1 or 2 and their pharmaceutically tolerable salts are outstanding antiarrhythmic agents. They are obtained by a process in which compounds of the formula II in which X stands for a leaving group which can be easily nucleophilically substituted, are reacted with guanidine.

公开(公告)号：AT147375T

公开(公告)日：1997-01-15

申请号：AT93114774

申请日：1993-09-14

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DR ,  WEICHERT ANDREAS DR ,  KLEEMANN HEINZ-WERNER DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/00 ,  A61K31/155 ,  A61K31/445 ,  A61P1/16 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C311/16 ,  C07C311/21 ,  C07C311/29 ,  C07C317/24 ,  C07C317/44 ,  C07C317/46 ,  C07C317/48 ,  C07C323/22 ,  C07C323/65 ,  C07D211/14 ,  C07D211/70 ,  C07D295/14 ,  C07D295/155 ,  A61K31/54 ,  A61K31/45

Abstract: The invention relates to benzoylguanidines of the formula I where R(1) or R(2) is equal to R(3)-S(O)n- or R(4)R(5)N-O2S- and the other substituent R(1) or R(2) is in each case equal to H, OH, F, Cl, Br, I, alkyl, alkoxy, benzyloxy or phenoxy, R(3)-S(O)n or R(4)R(5)N- or 3,4-dehydropiperidine and R(3) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(4) and R(5) are equal to alkyl or phenylalkyl or phenyl, and in which R(4) and R(5) together can also be a C4-C7-chain, and in which R(4) and R(5), together with the nitrogen atom to which they are bonded, can denote a dihydroindol, tetrahydroquinoline or tetrahydroisoquinoline system, and where n is equal to zero, 1 or 2 and their pharmaceutically tolerable salts are outstanding antiarrhythmic agents. They are obtained by a process in which compounds of the formula II in which X stands for a leaving group which can be easily nucleophilically substituted, are reacted with guanidine.

公开(公告)号：DE19518796A1

公开(公告)日：1996-11-28

申请号：DE19518796

申请日：1995-05-22

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/165 ,  A61K31/155 ,  A61K31/16 ,  A61P1/16 ,  A61P3/08 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07C277/08 ,  C07C279/22 ,  C07C279/10

Abstract: Fluorocinnamoyl guanidine cpds. of formula (I) and their salts are new. R1-R5 = H or F, provided at least one is F; R6, R7 = H, 1-8C alkyl, 3-8C cycloalkyl, or phenyl (opt. substd. by 1-3 of F, Cl, CF3, Me, OMe and NR9R10; R9, R10 = H, 1-4C alkyl or 1-4C perfluoroalkyl.

公开(公告)号：DE59303357D1

公开(公告)日：1996-09-05

申请号：DE59303357

申请日：1993-10-18

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  KLEEMANN HEINZ-WERNER DR ,  REGNAT DIETER DR ,  KLEINER HANS-JERG DR

IPC: C07B39/00 ,  C07C17/14 ,  C07C22/04 ,  C07C67/307 ,  C07C67/343 ,  C07C69/65 ,  C07C69/76 ,  C07C205/12 ,  C07C255/50 ,  C07C257/12 ,  C07C257/20 ,  C07C311/05 ,  C07C311/18 ,  C07C311/53 ,  C07D275/04 ,  C07D275/06 ,  C07D333/24 ,  C07D333/60 ,  C07D333/68 ,  C07D333/70 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: Aromatic bromomethyl compounds play an important role in the synthesis of active substances. They can be obtained in particularly high purity by free-radical bromination of aromatic methyl compounds in the solvent chlorobenzene.