公开(公告)号：HU187359B

公开(公告)日：1985-12-28

申请号：HU266481

申请日：1981-09-15

Applicant: HOECHST AG

Inventor： STURM KARL

IPC: C07D307/52 ,  C07C147/12 ,  C07C143/78

Abstract: 1. A process for the preparation of 5-sulfamoyl-orthanilic acids of the formula I see diagramm : EP0047973,P5,F1 in which R denotes N-methylanilino, phenylsulfonyl, phenoxy, which is optionally substituted by Cl, CH3 or OCH3 , or alkyl sulfonyl or cycloalkylsulfonyl or cycloalkylalkylsulfonyl having up to 10 carbon atoms in each case, and Ar denotes phenyl or furyl, in the form of their salts, which comprises hydrogenating an aryl ester of the formula II see diagramm : EP0047973,P5,F2 in which Z denotes aryl, in a solvent which is stable to hydrogenation and with the addition of at least one equivalent of a base, in the presence of a palladium catalyst, until one mol equivalent of hydrogen has been absorbed.

公开(公告)号：CA1190937A

公开(公告)日：1985-07-23

申请号：CA394605

申请日：1982-01-21

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN ,  HROPOT MAX

IPC: A61K31/63 ,  A61K31/635 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C311/39 ,  C07D307/52 ,  C07D333/20 ,  C07C143/78 ,  C07D333/24 ,  C07D307/54

Abstract: of the disclosure: The invention relates to base-substituted anthranilic acids of the formula I in which R denotes furyl, thienyl or phenyl, and to physiologically acceptable salts thereof, and also to a process for their preparation, to an agent containing these and to their use as medicaments.

公开(公告)号：FI65996C

公开(公告)日：1984-08-10

申请号：FI781305

申请日：1978-04-26

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN

IPC: A61K31/635 ,  A61P7/10 ,  C07D307/52 ,  C07D333/20

公开(公告)号：AU537230B2

公开(公告)日：1984-06-14

申请号：AU6819681

申请日：1981-03-10

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN

IPC: A61K31/18 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/63 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/32 ,  C07C303/40 ,  C07C311/39 ,  C07D307/52 ,  C07D333/20 ,  C07C143/80

Abstract: The present invention relates to compounds of the formula I wherein R is furyl, thienyl or phenyl, to physiologically acceptable salts thereof, to a process for their manufacture, to a composition comprising said compounds and to their use as a medicament.

公开(公告)号：AU536892B2

公开(公告)日：1984-05-31

申请号：AU6750781

申请日：1981-02-20

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN

IPC: A61K31/18 ,  A61K31/63 ,  A61P13/02 ,  A61P15/00 ,  C07C67/00 ,  C07C313/00 ,  C07C315/02 ,  C07C317/36 ,  C07D307/52 ,  C07D333/20 ,  C07C147/12

Abstract: What are disclosed are compounds of the formula I in which R denotes alkyl, alkenyl, cycloalkyl or cycloalkylalkyl, each of which has up to 10 C atoms, or phenyl and Ar denotes phenyl, thienyl or furyl and salts thereof, the preparation of these compounds and their use as medicaments and also medicaments of this type as such.

公开(公告)号：HU183722B

公开(公告)日：1984-05-28

申请号：HU330081

申请日：1981-11-05

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN ,  HROPOT MAX

IPC: C07D251/18 ,  A61K31/41 ,  A61P7/10 ,  C07D257/04 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12

Abstract: What are disclosed are salidiuretic compounds of the formula and physiologically acceptable salts thereof, wherein R is phenyl, furyl or thienyl, intermediates of said compounds, methods for making said compounds, salidiuretic pharmaceutical preparations containing said compounds or salts, and methods for treating humans and other mammals with such compounds or salts.

公开(公告)号：CA1155450A

公开(公告)日：1983-10-18

申请号：CA372677

申请日：1981-03-10

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN

IPC: A61K31/18 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/63 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/32 ,  C07C303/40 ,  C07C311/39 ,  C07D307/52 ,  C07D333/20 ,  C07C143/80

Abstract: The present invention relates to compounds of the formula I wherein R is furyl, thienyl or phenyl, to physiologically acceptable salts thereof, to a process for their manufacture, to a composition comprising said compounds and to their use as a medicament.

公开(公告)号：CA1155449A

公开(公告)日：1983-10-18

申请号：CA371434

申请日：1981-02-20

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN

IPC: A61K31/18 ,  A61K31/63 ,  A61P13/02 ,  A61P15/00 ,  C07C67/00 ,  C07C313/00 ,  C07C315/02 ,  C07C317/36 ,  C07D307/52 ,  C07D333/20 ,  C07C143/80

Abstract: : The invention relates to compounds of the formula I in which R denotes alkyl, alkenyl, cycloalkyl or cycloalkylalkyl, each of which has up to 10 C atoms, or phenyl and Ar denotes phenyl, thienyl or furyl and salts thereof, the preparation of these compounds and their use as medicaments and also medicaments of this type as such.

公开(公告)号：ZA8200393B

公开(公告)日：1982-12-29

申请号：ZA8200393

申请日：1982-01-21

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN ,  HROPOT MAX

IPC: A61K31/63 ,  A61K31/635 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C311/39 ,  C07D307/52 ,  C07D333/20 ,  C07D ,  A61K ,  C07C

CPC classification number: C07D307/52 ,  C07D333/20 ,  Y10S514/87

公开(公告)号：FI812861L

公开(公告)日：1982-03-17

申请号：FI812861

申请日：1981-09-14

Applicant: HOECHST AG

Inventor： STURM KARL

IPC: C07D307/52 ,  C07D

Abstract: 1. A process for the preparation of 5-sulfamoyl-orthanilic acids of the formula I see diagramm : EP0047973,P5,F1 in which R denotes N-methylanilino, phenylsulfonyl, phenoxy, which is optionally substituted by Cl, CH3 or OCH3 , or alkyl sulfonyl or cycloalkylsulfonyl or cycloalkylalkylsulfonyl having up to 10 carbon atoms in each case, and Ar denotes phenyl or furyl, in the form of their salts, which comprises hydrogenating an aryl ester of the formula II see diagramm : EP0047973,P5,F2 in which Z denotes aryl, in a solvent which is stable to hydrogenation and with the addition of at least one equivalent of a base, in the presence of a palladium catalyst, until one mol equivalent of hydrogen has been absorbed.